Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

Genes and Development

Volumn 14, Issue 2, 2000, Pages 163-176

  Yu, Qin ^a   Stamenkovic, Ivan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

CD44; MMP 9; TGF ; tumor angiogenesis; tumor invasion

Indexed keywords

CELL SURFACE PROTEIN; GELATINASE A; GELATINASE B; HERMES ANTIGEN; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CONTROLLED STUDY; KERATINOCYTE; MOLECULAR BIOLOGY; MOUSE; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT;

ANIMALS; ANTIGENS, CD44; CELL MEMBRANE; CULTURE MEDIA, CONDITIONED; ENDOTHELIUM, VASCULAR; HYDROLYSIS; KERATINOCYTES; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED A; MICE, MUTANT STRAINS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDE HYDROLASES; PROTEIN ISOFORMS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034650486     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Aruffo, A., I. Stamenkovic, M. Melnick, C.B. Underhill, and B. Seed. 1990. CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313.
2. Bartolazzi, A., R. Peach, A. Aruffo, and I. Stamenkovic. 1994. Interaction between CD44 and hyaluronan is directly implicated in the regulation of tumor development. J. Exp. Med. 180: 53-66.
3. Border, W.A. and E. Ruoslahti. 1992. Transforming growth factor-β in disease: The dark-side of tissue repair. J. Clin. Invest. 90:1-7.
4. 3, 8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J. Cell Physiol. 176: 206-215.
5. Brooks, P.C., S. Stromblad, L.C. Sanders, T.L. von Schalscha, R.T. Aimes, W.G. Stetler-Stevenson, J.P. Quigley, and D.A. Cheresh. 1996. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell 85: 683-693.
6. Brooks, P.C., S. Silletti, T.L. von Schalscha, M. Friedlander, and D.A. Cheresh. 1998. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 92: 391-400.
7. Crawford, S.E., V. Stellmach, J.E. Murphy-Ullrich, S.M. Ribeiro, J. Lawler, R.O. Hynes, G.P. Boivin, and N. Bouck. 1998. Thrombospondin-1 is a major activator of TGF-betal in vivo. Cell 93: 1159-1170.
8. Culty, M., M. Shizari, E.W. Thompson, and C.B. Underhill. 1994. Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: Correlation with invasive potential. J. Cell Physiol. 160: 275-286.
9. Frisch, S. and E. Ruoslahti. 1997. Integrins and anoikis. Curr. Opin. Cell Biol. 9: 701-706.
10. Gunthert, U., M. Hofmann, W. Rudy, S. Reber, M. Zoller, I. Haussmann, S. Matzku, A. Wenzel, H. Ponta, and P. Herrlich. 1991. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65: 13-24.
11. Kim J., W. Yu, K. Kovalski, and L. Ossowski. 1998. Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell 94: 353-362.
12. Lamb, R.F., R.F. Hennigan, K. Turnbull, K.D. Katsanakis, E.D. MacKenzie, G.D. Birnie, and B.W. Ozanne. 1997. Ap-1 mediated invasion requires increased expression of the hyaluronan receptor CD44. Mol. Cell Biol. 17: 963-976.
13. Li, D.Y., L.K. Sorensen, B.S. Brooke, L.D. Urness, E.C. Davis, D.G. Taylor, B.B. Boak, and D.P. Wendel. 1999. Defective angiogenesis in mice lacking endoglin. Science 284: 1534-1537.
14. Lyons, R.M., L.E. Gentry, A.F. Purchio, and H.L. Moses. 1990. Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J. Cell Biol. 110: 1361-1367.
15. Massague, J. 1990. The transforming growth factor-β family. Annu. Rev. Cell Biol. 6: 597-641.
16. Montesano, R., M.S. Pepper, and L. Orci. 1993. Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J. Cell Sci. 105: 1013-1024.
17. Moses, L.H., E.Y. Yang, and J.A. Pietenpol. 1990. TGF-beta stimulation and inhibition of cell proliferation: New mechanistic insights. Cell 63: 245-247.
18. Munger, J.S., J.G. Harpel, P.-E. Gleizes, R. Mazzieri, I. Nunes, and D.B. Rifkin. 1997. Latent transforming growth factor-β: Structural features and mechanisms of activation. Kidney Internat. 51: 1376-1382.
19. Munger, J.S., X.Z. Huang, H. Kawakatsu, M.J.D. Griffiths, S.L. Dalton, J. Wu, J.-F. Pittet, N. Kaminski, C. Garat, M.A. Matthay et al. 1999. The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell 96: 319-328.
20. Nagase, H. 1997. Activation mechanisms of matrix metalloproteinases. Biol. Chem. 378: 151-160.
21. Oft, M., J. Peli, C. Rudaz, H. Schwartz, H. Beug, and E. Reichmann. 1996. TGF-β1 and Ha-Ras collaborate in modulating the phenotype plasticity and invasiveness of epithelial tumor cells. Genes & Dev. 10: 2462-2477.
22. Oft, M., K.H. Heider, and H. Beug. 1998. TGF-beta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr. Biol. 8: 1243-1252.
23. Pepper, M.M. 1997. Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine & Growth Factor Rev. 8: 21-43.
24. Roberts, A. and M.B. Sporn. 1993. Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8: 1-9.
25. Roberts, A.B., M.B. Sporn, R.K. Assoian, J.M. Smith, N.S. Roche, L.M. Wakefield, U.I. Heine, L.A. Liotta, V. Falanga, J.H. Kehrl, and A.S. Fauci. 1986. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. 83: 4167-4171.
26. Sankar, S., N. Mahooti-Brooks, L. Bensen, T.L. McCarthy, M. Centrella, and J.A. Madri. 1996. Modulation of transforming growth factor b receptor levels of microvascular endothelial cells during in vitro angiogenesis. J. Clin. Invest. 97: 1436-1446.
27. Sato, Y., R. Tsuboi, H. Moses, and D.B. Rifkin. 1990. Characterization of the activation of latent TGF-β by co-cultures of endothelial cells and pericytes or smooth muscle cells: A self-regulating system. J. Cell Biol. 111: 757-763.
28. Schultz-Cherry, S., J. Lawler, and J.E. Murphy-Ullrich. 1994. The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J. Biol. Chem. 269: 26783-26788.
29. Seiter S., R. Arch, S. Reber, D. Komitowski, M. Hofmann, H. Ponta, P. Herrlich, S. Matzku, and M. Zoller. 1993. Prevention of tumor metastasis formation by anti-variant CD44. J. Exp. Med. 177: 443-455.
30. Sternlicht, M.D., A. Lochter, C.J. Sympson, B. Huey, J.P. Rougier, J.W. Gray, D. Pinkel, M.J. Bissell, and Z. Werb. 1999. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98: 137-146.
31. Stetler-Stevenson, W.G., S. Aznavoorian, and L.A. Liotta. 1993. Tumor cell interactions with the extracellular matrix duing invasion and metastasis. Annu. Rev. Cell Biol. 9: 541-573.
32. Sy, M.S., Y-J. Guo, and I. Stamenkovic. 1991. Distinct effects of two CD44 isoforms on tumor growth in vivo. J. Exp. Med. 174: 859-866.
33. Taipale J., J. Saharinen, and J. Keski-Oja. 1998. Extracellular matrix-associated transforming growth factor-β: Role in cancer cell growth and invasion. Adv. Cancer Res. 75: 87-134.
34. Ueki N., M. Nakazato, T. Ohkawa, T. Ikeda, Y. Amuro, T. Hada, and K. Higashino. 1992. Excessive production of transforming growth factor-β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: Validity of neutralizing antibodies to block tumor growth. Biochim. Biophys. Acta. 1137: 189-196.
35. Varner, J.A. and D.A. Cheresh. 1996. Integrins and cancer. Curr. Op. Cell Biol. 8: 724-730.
36. Vu, T.H., J.M. Shipley, G. Bergers, J.E. Berger, J.A. Helms, D. Hanahan, S.D. Shapiro, R.M. Senior, and Z. Werb. 1998. MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93: 411-422.
37. Welch, D.R., A. Fabra, and M. Nakajima. 1990. Transforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potential. Proc. Natl. Acad. Sci. 87: 7678-7682.
38. Werb, Z. 1997. ECM and cell surface proteolysis: Regulationg cellular ecology. Cell 91: 439-442.
39. Yu, Q. and I. Stamenkovic. 1999. Localization of matrix metalloproteinase 9 (MMP-9) to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes & Dev. 13: 35-48.
40. Yu, Q., B.P. Toole, and I. Stamenkovic. 1997. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J. Exp. Med. 186: 1985-1196.