Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model

FASEB Journal

Volumn 20, Issue 3, 2006, Pages 455-465

  Lee, Kyung S ^a   Lee, Ho K ^a   Hayflick, Joel S ^b   Lee, Yong C ^a   Puri, Kamal D ^b  

^a Chonbuk National University Medical School   (South Korea)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Allergy; Cell activation; Cytokines; Inflammation; Lung; Signal transduction

Indexed keywords

CHEMOKINE; CYTOKINE; EOTAXIN; IC 87114; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LEUKOTRIENE C4; METHACHOLINE; OVALBUMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RANTES; VASCULAR CELL ADHESION MOLECULE 1; 1 PHOSPHATIDYLINOSITOL 3 KINASE P110 SUBUNIT, MOUSE; 1-PHOSPHATIDYLINOSITOL 3-KINASE P110 SUBUNIT, MOUSE; ADENINE; CELL ADHESION MOLECULE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; METHACHOLINE CHLORIDE; QUINAZOLINE DERIVATIVE;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG TISSUE LEVEL; ENZYME INHIBITION; EOSINOPHILIA; INFLAMMATION; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT DISEASE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BRONCHUS HYPERREACTIVITY; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; INHALATION TEST; LUNG; LUNG LAVAGE; METABOLISM; MUCUS; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SECRETION;

MURINAE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENINE; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CELL ADHESION MOLECULES; CHEMOKINES; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; EOSINOPHILIA; FEMALE; LUNG; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; MUCUS; OVALBUMIN; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES;

EID: 33645827963     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5045com     Document Type: Article

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