Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: Toward targeted treatments for immunosenescence

Blood

Volumn 123, Issue 2, 2014, Pages 239-248

  Sapey, Elizabeth ^a   Greenwood, Hannah ^a   Walton, Georgia ^a   Mann, Elizabeth ^a   Love, Alexander ^a   Aaronson, Natasha ^a   Insall, Robert H ^b   Stockley, Robert A ^a   Lord, Janet M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Constitutive PI3K activity is associated with less accurate neutrophil migration in healthy aged adults; This is associated with increased primary granule release and neutrophil elastase activity and may contribute to inflammation and infection

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; COMPLEMENT COMPONENT C5A; CXCL1 CHEMOKINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FPR1 PROTEIN; INTERLEUKIN 8; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEINASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL SURFACE; CELL VIABILITY; CHEMOKINESIS; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN EXPERIMENT; IMMUNE DEFICIENCY; IMMUNOSENESCENCE; INFLAMMATION; MIDDLE AGED; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NEUTROPHIL FUNCTION; NORMAL HUMAN; PATHOGEN CLEARANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SENESCENCE; SIGNAL TRANSDUCTION; TISSUE INJURY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CELL DEGRANULATION; CHEMOTAXIS, LEUKOCYTE; CROSS-SECTIONAL STUDIES; CYTOKINES; ENZYME ACTIVATION; HUMANS; IMMUNE SYSTEM DISEASES; INTERLEUKIN-8; LEUKOCYTE DISORDERS; MIDDLE AGED; MYELOBLASTIN; NEUTROPHILS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84892640743     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-08-519520     Document Type: Article

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