Syk mediates airway contractility independent of leukocyte function

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 70, Issue 4, 2015, Pages 429-435

  Wang, X ^a   Khanna, N ^a   Wu, J ^a   Godri Pollitt, K ^b   Evans, G J ^b   Chow, C W ^a,b,c,d   Scott, J A ^b,d,e,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e LAKEHEAD UNIVERSITY   (Canada)

^f NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

Author keywords

air pollution; airway contractility; Syk

Indexed keywords

GELATINASE B; INTERLEUKIN 6; INTERLEUKIN 8; METHACHOLINE; PROTEIN KINASE SYK; VASCULOTROPIN; AIR POLLUTANT; METHACHOLINE CHLORIDE; PARTICULATE MATTER; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ADULT; AIR POLLUTANT; AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREATHING MECHANICS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; GENE DELETION; HEMATOPOIETIC CELL; IN VIVO STUDY; LEUKOCYTE DIFFERENTIAL COUNT; LEUKOCYTE FUNCTION; LUNG LAVAGE; LUNG RESISTANCE; LUNG SLICE; MOUSE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE CONTRACTILITY; VIDEO MICROSCOPY; ADVERSE EFFECTS; AIRWAY RESISTANCE; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNOLOGY; INHALATION TEST; KNOCKOUT MOUSE; LEUKOCYTE; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE; RESPIRATORY TRACT ALLERGY;

AIR POLLUTANTS; AIRWAY RESISTANCE; ANIMALS; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DISEASE MODELS, ANIMAL; GENE DELETION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES; METHACHOLINE CHLORIDE; MICE; MICE, KNOCKOUT; PARTICULATE MATTER; PHENOTYPE; PROTEIN-TYROSINE KINASES; RESPIRATORY HYPERSENSITIVITY;

EID: 84925813748     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12564     Document Type: Article

References (23)

1. Renz H, von Mutius E, Brandtzaeg P, Cookson WO, Autenrieth IB, Haller D,. Gene-environment interactions in chronic inflammatory disease. Nat Immunol 2011; 12: 273-277.
2. Holgate ST,. Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? J Allergy Clin Immunol 2011; 128: 495-505.
3. Lau C, Castellanos P, Ranev D, Wang X, Chow CW,. HRV signaling in airway epithelial cells is regulated by ITAM-mediated recruitment and activation of Syk. Protein Pept Lett 2011; 18: 518-529.
4. Lau C, Wang X, Song L, North M, Wiehler S, Proud D, et al. Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization. J Immunol 2008; 180: 870-880.
5. Penton PC, Wang X, Amatullah H, Cooper J, Godri K, North ML, et al. Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma. J Allergy Clin Immunol 2013; 131: 512-520.
6. Wang X, Lau C, Wiehler S, Pow A, Mazzulli T, Gutierrez C, et al. Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cells. J Immunol 2006; 177: 6859-6870.
7. Wang X, Mychajlowycz M, Lau C, Gutierrez C, Scott JA, Chow C-W,. Spleen tyrosine kinase mediates BEAS-2B cell migration and proliferation and human rhinovirus-induced expression of vascular endothelial growth factor and interleukin-8. J Pharmacol Exp Ther 2012; 340: 277-285.
8. Yang IA, Fong KM, Zimmerman PV, Holgate ST, Holloway JW,. Genetic susceptibility to the respiratory effects of air pollution. Thorax 2008; 63: 555-563.
9. D'Amato G, Liccardi G, D'Amato M, Holgate S,. Environmental risk factors and allergic bronchial asthma. Clin Exp Allergy 2005; 35: 1113-1124.
10. Mocsai A, Ruland J, Tybulewicz VL,. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 2010; 10: 387-402.
11. Matsubara S, Koya T, Takeda K, Joetham A, Miyahara N, Pine P, et al. Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol 2006; 34: 426-433.
12. Matsubara S, Li G, Takeda K, Loader JE, Pine P, Masuda ES, et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med 2006; 173: 56-63.
13. Wex E, Bouyssou T, Duechs MJ, Erb KJ, Gantner F, Sanderson MP, et al. Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo. Eur J Immunol 2011; 41: 3208-3218.
14. North ML, Khanna N, Marsden PA, Grasemann H, Scott JA,. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol 2009; 296: L911-L920.
15. North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, et al. Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma. Respir Res 2011; 12: 19.
16. Ketterer J, Wallace J, Evans GJ,. Emissions from compression ignition engines with animal-fat-derived biodiesel fuels. SAE Technical Paper 2014;2014-01-1600.
17. Akhtar US, McWhinney RD, Rastogi N, Abbatt JP, Evans GJ, Scott JA,. Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles. Inhal Toxicol 2010; 22 (Suppl 2): 37-47.
18. Karman J, Tedstone JL, Gumlaw NK, Zhu Y, Yew N, Siegel C, et al. Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma. Int Immunol 2010; 22: 593-603.
19. Moy LY, Jia Y, Caniga M, Lieber G, Gil M, Fernandez X, et al. Inhibition of spleen tyrosine kinase (SYK) attenuates allergen-mediated airway constriction. Am J Respir Cell Mol Biol 2013; 49: 1085-1092.
20. Stenton GR, Kim MK, Nohara O, Chen CF, Hirji N, Wills FL, et al. Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation. J Immunol 2000; 164: 3790-3797.
21. Stenton GR, Ulanova M, Dery RE, Merani S, Kim MK, Gilchrist M, et al. Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. J Immunol 2002; 169: 1028-1036.
22. Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther 2003; 306: 1174-1181.
23. Akhtar US, Rastogi N, McWhinney RD, Urch B, Chow C-W, Evans GJ, et al. The combined effects of physicochemical properties of size-fractionated ambient particulate matter on in vitro toxicity in human A549 lung epithelial cells. Toxicol Rep 2014; 1: 145-156.