-
1
-
-
0031128758
-
Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis
-
PID: 10735278
-
Graeber MB, Kösel S, Egensperger R, Banati RB, Müller U, Bise K, Hoff P, Möller HJ, Fujisawa K, Mehraein P (1997) Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis. Neurogenetics 1(1):73–80. doi:10.1007/s100480050011
-
(1997)
Neurogenetics
, vol.1
, Issue.1
, pp. 73-80
-
-
Graeber, M.B.1
Kösel, S.2
Egensperger, R.3
Banati, R.B.4
Müller, U.5
Bise, K.6
Hoff, P.7
Möller, H.J.8
Fujisawa, K.9
Mehraein, P.10
-
2
-
-
0035066332
-
Alzheimer’s disease: genes, proteins, and therapy
-
PID: 11274343
-
Selkoe DJ (2001) Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81(2):741–766
-
(2001)
Physiol Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
3
-
-
84879077265
-
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
-
PID: 23390181
-
Hebert LE, Weuve J, Scherr PA, Evans DA (2013) Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology 80(19):1778–1783. doi:10.1212/WNL.0b013e31828726f5
-
(2013)
Neurology
, vol.80
, Issue.19
, pp. 1778-1783
-
-
Hebert, L.E.1
Weuve, J.2
Scherr, P.A.3
Evans, D.A.4
-
4
-
-
84875354777
-
2013 Alzheimer’s disease facts and figures
-
Thies W, Bleiler L (2013) 2013 Alzheimer’s disease facts and figures. Alzheimers Dement 9(2):208–245. doi:10.1016/j.jalz.2013.02.003
-
(2013)
Alzheimers Dement
, vol.9
, Issue.2
, pp. 208-245
-
-
Thies, W.1
Bleiler, L.2
-
5
-
-
84890204436
-
On the origin of Alzheimer’s disease. Trials and tribulations of the amyloid hypothesis
-
PID: 24252390
-
Castello MA, Soriano S (2014) On the origin of Alzheimer’s disease. Trials and tribulations of the amyloid hypothesis. Ageing Res Rev 13:10–12. doi:10.1016/j.arr.2013.10.001
-
(2014)
Ageing Res Rev
, vol.13
, pp. 10-12
-
-
Castello, M.A.1
Soriano, S.2
-
6
-
-
84903947419
-
Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
-
PID: 25024750
-
Cummings J, Morstorf T, Zhong K (2014) Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther 6(4):37
-
(2014)
Alzheimers Res Ther
, vol.6
, Issue.4
, pp. 37
-
-
Cummings, J.1
Morstorf, T.2
Zhong, K.3
-
7
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
PID: 12065827
-
Taylor JP, Hardy J, Fischbeck KH (2002) Toxic proteins in neurodegenerative disease. Science 296(5575):1991–1995. doi:10.1126/science.1067122
-
(2002)
Science
, vol.296
, Issue.5575
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
8
-
-
0024815331
-
The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects
-
PID: 2591522
-
Benowitz LI, Rodriguez W, Paskevich P, Mufson EJ, Schenk D, Neve RL (1989) The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp Neurol 106(3):237–250
-
(1989)
Exp Neurol
, vol.106
, Issue.3
, pp. 237-250
-
-
Benowitz, L.I.1
Rodriguez, W.2
Paskevich, P.3
Mufson, E.J.4
Schenk, D.5
Neve, R.L.6
-
9
-
-
0037172826
-
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
-
PID: 12084879
-
Thal DR, Rüb U, Orantes M, Braak H (2002) Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 58(12):1791–1800. doi:10.1212/wnl.58.12.1791
-
(2002)
Neurology
, vol.58
, Issue.12
, pp. 1791-1800
-
-
Thal, D.R.1
Rüb, U.2
Orantes, M.3
Braak, H.4
-
10
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
PID: 1759558
-
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239–259
-
(1991)
Acta Neuropathol
, vol.82
, Issue.4
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
11
-
-
0032894121
-
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease
-
PID: 10214737
-
Delacourte A, David JP, Sergeant N, Buee L, Wattez A, Vermersch P, Ghozali F, Fallet-Bianco C, Pasquier F, Lebert F, Petit H, Di Menza C (1999) The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease. Neurology 52(6):1158–1165
-
(1999)
Neurology
, vol.52
, Issue.6
, pp. 1158-1165
-
-
Delacourte, A.1
David, J.P.2
Sergeant, N.3
Buee, L.4
Wattez, A.5
Vermersch, P.6
Ghozali, F.7
Fallet-Bianco, C.8
Pasquier, F.9
Lebert, F.10
Petit, H.11
Di Menza, C.12
-
12
-
-
84865636225
-
Brain imaging in Alzheimer disease
-
PID: 22474610
-
Johnson KA, Fox NC, Sperling RA, Klunk WE (2012) Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med 2(4):a006213. doi:10.1101/cshperspect.a006213
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.4
, pp. a006213
-
-
Johnson, K.A.1
Fox, N.C.2
Sperling, R.A.3
Klunk, W.E.4
-
13
-
-
0037007045
-
Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI
-
PID: 11930016
-
Scahill RI, Schott JM, Stevens JM, Rossor MN, Fox NC (2002) Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI. Proc Natl Acad Sci U S A 99(7):4703–4707. doi:10.1073/pnas.052587399
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.7
, pp. 4703-4707
-
-
Scahill, R.I.1
Schott, J.M.2
Stevens, J.M.3
Rossor, M.N.4
Fox, N.C.5
-
14
-
-
0037007066
-
Imaging the progression of Alzheimer pathology through the brain
-
PID: 11929987
-
Smith AD (2002) Imaging the progression of Alzheimer pathology through the brain. Proc Natl Acad Sci U S A 99(7):4135–4137. doi:10.1073/pnas.082107399
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.7
, pp. 4135-4137
-
-
Smith, A.D.1
-
15
-
-
77249133010
-
Prion-like mechanisms in neurodegenerative diseases
-
PID: 20029438
-
Frost B, Diamond MI (2010) Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci 11(3):155–159. doi:10.1038/nrn2786
-
(2010)
Nat Rev Neurosci
, vol.11
, Issue.3
, pp. 155-159
-
-
Frost, B.1
Diamond, M.I.2
-
16
-
-
84867608942
-
The genetics of Alzheimer disease
-
PID: 23028126
-
Tanzi RE (2012) The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2(10):a006296. doi:10.1101/cshperspect.a006296
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.10
, pp. a006296
-
-
Tanzi, R.E.1
-
17
-
-
78649232442
-
Review article: genetics of Alzheimer disease
-
PID: 21045163
-
Bekris LM, Yu C-E, Bird TD, Tsuang DW (2010) Review article: genetics of Alzheimer disease. J Geriatr Psychiatry Neurol 23(4):213–227. doi:10.1177/0891988710383571
-
(2010)
J Geriatr Psychiatry Neurol
, vol.23
, Issue.4
, pp. 213-227
-
-
Bekris, L.M.1
Yu, C.-E.2
Bird, T.D.3
Tsuang, D.W.4
-
18
-
-
0035950188
-
New frontiers in Alzheimer’s disease genetics
-
PID: 11683989
-
Tanzi RE, Bertram L (2001) New frontiers in Alzheimer’s disease genetics. Neuron 32(2):181–184. doi:10.1016/S0896-6273(01)00476-7
-
(2001)
Neuron
, vol.32
, Issue.2
, pp. 181-184
-
-
Tanzi, R.E.1
Bertram, L.2
-
19
-
-
0036725818
-
Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian study of health and aging
-
PID: 12196314
-
Lindsay J, Laurin D, Verreault R, Hébert R, Helliwell B, Hill GB, McDowell I (2002) Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian study of health and aging. Am J Epidemiol 156(5):445–453. doi:10.1093/aje/kwf074
-
(2002)
Am J Epidemiol
, vol.156
, Issue.5
, pp. 445-453
-
-
Lindsay, J.1
Laurin, D.2
Verreault, R.3
Hébert, R.4
Helliwell, B.5
Hill, G.B.6
McDowell, I.7
-
20
-
-
84879305031
-
Epidemiology of Alzheimer disease
-
PID: 22908189
-
Mayeux R, Stern Y (2012) Epidemiology of Alzheimer disease. Cold Spring Harb Perspect Med 2(8):a006239. doi:10.1101/cshperspect.a006239
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.8
, pp. a006239
-
-
Mayeux, R.1
Stern, Y.2
-
21
-
-
84874998766
-
The ubiquitin–proteasome system and the autophagic–lysosomal system in Alzheimer disease
-
PID: 22908190
-
Ihara Y, Morishima-Kawashima M, Nixon R (2012) The ubiquitin–proteasome system and the autophagic–lysosomal system in Alzheimer disease. Cold Spring Harb Perspect Med 2(8):a006361. doi:10.1101/cshperspect.a006361
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.8
, pp. a006361
-
-
Ihara, Y.1
Morishima-Kawashima, M.2
Nixon, R.3
-
22
-
-
0037218826
-
The biology of aging
-
PID: 12516005
-
Troen BR (2003) The biology of aging. Mt Sinai J Med 70(1):3–22
-
(2003)
Mt Sinai J Med
, vol.70
, Issue.1
, pp. 3-22
-
-
Troen, B.R.1
-
23
-
-
0023105114
-
The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor
-
PID: 2881207
-
Kang J, Lemaire H-G, Unterbeck A, Salbaum JM, Masters CL, Grzeschik K-H, Multhaup G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325(6106):733–736
-
(1987)
Nature
, vol.325
, Issue.6106
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.-G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.-H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
24
-
-
0024431373
-
Alzheimer’s disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization
-
PID: 2476128
-
Ghiso J, Tagliavini F, Timmers WF, Frangione B (1989) Alzheimer’s disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization. Biochem Biophys Res Commun 163(1):430–437
-
(1989)
Biochem Biophys Res Commun
, vol.163
, Issue.1
, pp. 430-437
-
-
Ghiso, J.1
Tagliavini, F.2
Timmers, W.F.3
Frangione, B.4
-
25
-
-
0024165056
-
The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types
-
PID: 2904381
-
Autilio-Gambetti L, Morandi A, Tabaton M, Schaetzle B, Kovacs D, Perry G, Sharma S, Cornette J, Greenberg B, Gambetti P (1988) The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types. FEBS Lett 241(1–2):94–98
-
(1988)
FEBS Lett
, vol.241
, Issue.1-2
, pp. 94-98
-
-
Autilio-Gambetti, L.1
Morandi, A.2
Tabaton, M.3
Schaetzle, B.4
Kovacs, D.5
Perry, G.6
Sharma, S.7
Cornette, J.8
Greenberg, B.9
Gambetti, P.10
-
26
-
-
0024555395
-
Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex
-
PID: 2469380
-
Clark AW, Krekoski CA, Parhad IM, Liston D, Julien JP, Hoar DI (1989) Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex. Ann Neurol 25(4):331–339. doi:10.1002/ana.410250404
-
(1989)
Ann Neurol
, vol.25
, Issue.4
, pp. 331-339
-
-
Clark, A.W.1
Krekoski, C.A.2
Parhad, I.M.3
Liston, D.4
Julien, J.P.5
Hoar, D.I.6
-
27
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
PID: 3159021
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 82(12):4245–4249
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, Issue.12
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
28
-
-
0021207461
-
Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein
-
PID: 6236805
-
Glenner GG, Wong CW (1984) Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122(3):1131–1135
-
(1984)
Biochem Biophys Res Commun
, vol.122
, Issue.3
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
29
-
-
0021256895
-
Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
PID: 6375662
-
Glenner GG, Wong CW (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120(3):885–890. doi:10.1016/S0006-291X(84)80190-4
-
(1984)
Biochem Biophys Res Commun
, vol.120
, Issue.3
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
30
-
-
0023109592
-
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
PID: 2949367
-
Tanzi R, Gusella J, Watkins P, Bruns G, St George-Hyslop P, Van Keuren M, Patterson D, Pagan S, Kurnit D, Neve R (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235(4791):880–884. doi:10.1126/science.2949367
-
(1987)
Science
, vol.235
, Issue.4791
, pp. 880-884
-
-
Tanzi, R.1
Gusella, J.2
Watkins, P.3
Bruns, G.4
St George-Hyslop, P.5
Van Keuren, M.6
Patterson, D.7
Pagan, S.8
Kurnit, D.9
Neve, R.10
-
31
-
-
0024695466
-
The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05
-
PID: 2527801
-
Korenberg JR, Pulst SM, Neve RL, West R (1989) The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05. Genomics 5(1):124–127
-
(1989)
Genomics
, vol.5
, Issue.1
, pp. 124-127
-
-
Korenberg, J.R.1
Pulst, S.M.2
Neve, R.L.3
West, R.4
-
32
-
-
0031056184
-
Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down’s syndrome
-
PID: 9029078
-
Tokuda T, Fukushima T, Ikeda S, Sekijima Y, Shoji S, Yanagisawa N, Tamaoka A (1997) Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down’s syndrome. Ann Neurol 41(2):271–273. doi:10.1002/ana.410410220
-
(1997)
Ann Neurol
, vol.41
, Issue.2
, pp. 271-273
-
-
Tokuda, T.1
Fukushima, T.2
Ikeda, S.3
Sekijima, Y.4
Shoji, S.5
Yanagisawa, N.6
Tamaoka, A.7
-
33
-
-
33847304909
-
Increased amyloid β protein levels in children and adolescents with Down syndrome
-
PID: 17275850
-
Mehta PD, Capone G, Jewell A, Freedland RL (2007) Increased amyloid β protein levels in children and adolescents with Down syndrome. J Neurol Sci 254(1):22–27
-
(2007)
J Neurol Sci
, vol.254
, Issue.1
, pp. 22-27
-
-
Mehta, P.D.1
Capone, G.2
Jewell, A.3
Freedland, R.L.4
-
34
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease
-
PID: 1671712
-
Goate A, Chartier-Harlin M-C, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349(6311):704–706
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.-C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Talbot, C.15
Pericak-Vance, M.16
Roses, A.17
Williamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
35
-
-
0025950987
-
A mutation in the amyloid precursor protein associated with hereditary Alzheimer’s disease
-
PID: 1925564
-
Murrell J, Farlow M, Ghetti B, Benson M (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer’s disease. Science 254(5028):97–99. doi:10.1126/science.1925564
-
(1991)
Science
, vol.254
, Issue.5028
, pp. 97-99
-
-
Murrell, J.1
Farlow, M.2
Ghetti, B.3
Benson, M.4
-
36
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
PID: 8191290
-
Suzuki N, Cheung T, Cai X, Odaka A, Otvos L, Eckman C, Golde T, Younkin S (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264(5163):1336–1340. doi:10.1126/science.8191290
-
(1994)
Science
, vol.264
, Issue.5163
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.2
Cai, X.3
Odaka, A.4
Otvos, L.5
Eckman, C.6
Golde, T.7
Younkin, S.8
-
37
-
-
0034094214
-
Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene
-
PID: 10867787
-
Murrell JR, Hake AM, Quaid KA, Farlow MR, Ghetti B (2000) Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene. Arch Neurol 57(6):885–887. doi:10.1001/archneur.57.6.885
-
(2000)
Arch Neurol
, vol.57
, Issue.6
, pp. 885-887
-
-
Murrell, J.R.1
Hake, A.M.2
Quaid, K.A.3
Farlow, M.R.4
Ghetti, B.5
-
38
-
-
0033966705
-
Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta 42(43) peptide levels and induces apoptosis
-
PID: 10665499
-
Kwok JBJ, Li QX, Hallupp M, Whyte S, Ames D, Beyreuther K, Masters CL, Schofield PR (2000) Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta 42(43) peptide levels and induces apoptosis. Ann Neurol 47(2):249–253. doi:10.1002/1531-8249(200002)47:2<249::aid-ana18>3.0.co;2-8
-
(2000)
Ann Neurol
, vol.47
, Issue.2
, pp. 249-253
-
-
Kwok, J.B.J.1
Li, Q.X.2
Hallupp, M.3
Whyte, S.4
Ames, D.5
Beyreuther, K.6
Masters, C.L.7
Schofield, P.R.8
-
39
-
-
0034327364
-
Nonfibrillar diffuse amyloid deposition due to a γ 42‐secretase site mutation points to an essential role for N‐truncated Aβ42 in Alzheimer’s disease
-
PID: 11063718
-
Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C (2000) Nonfibrillar diffuse amyloid deposition due to a γ 42‐secretase site mutation points to an essential role for N‐truncated Aβ42 in Alzheimer’s disease. Hum Mol Genet 9(18):2589–2598. doi:10.1093/hmg/9.18.2589
-
(2000)
Hum Mol Genet
, vol.9
, Issue.18
, pp. 2589-2598
-
-
Kumar-Singh, S.1
De Jonghe, C.2
Cruts, M.3
Kleinert, R.4
Wang, R.5
Mercken, M.6
De Strooper, B.7
Vanderstichele, H.8
Löfgren, A.9
Vanderhoeven, I.10
Backhovens, H.11
Vanmechelen, E.12
Kroisel, P.M.13
Van Broeckhoven, C.14
-
40
-
-
0033616590
-
Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715 → Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease
-
PID: 10097173
-
Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, Campion D, Frébourg T, Checler F (1999) Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715 → Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease. Proc Natl Acad Sci U S A 96(7):4119–4124. doi:10.1073/pnas.96.7.4119
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.7
, pp. 4119-4124
-
-
Ancolio, K.1
Dumanchin, C.2
Barelli, H.3
Warter, J.M.4
Brice, A.5
Campion, D.6
Frébourg, T.7
Checler, F.8
-
41
-
-
9844261165
-
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of Aβ42(43)
-
PID: 9328472
-
Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Mihail Prada C, Younkin SG, Hutton M, Hardy J (1997) A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of Aβ42(43). Hum Mol Genet 6(12):2087–2089. doi:10.1093/hmg/6.12.2087
-
(1997)
Hum Mol Genet
, vol.6
, Issue.12
, pp. 2087-2089
-
-
Eckman, C.B.1
Mehta, N.D.2
Crook, R.3
Pereztur, J.4
Prihar, G.5
Pfeiffer, E.6
Graff-Radford, N.7
Hinder, P.8
Yager, D.9
Zenk, B.10
Refolo, L.M.11
Mihail Prada, C.12
Younkin, S.G.13
Hutton, M.14
Hardy, J.15
-
42
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer’s disease in the APP gene at the N-terminus of beta-amyloid
-
PID: 1302033
-
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L (1992) A pathogenic mutation for probable Alzheimer’s disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1(5):345–347. doi:10.1038/ng0892-345
-
(1992)
Nat Genet
, vol.1
, Issue.5
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
Lannfelt, L.7
-
43
-
-
0026879650
-
Presenile-dementia and cerebral-hemorrhage linked to a mutation at codon-692 of the beta-amyloid precursor protein gene
-
PID: 1303239
-
Hendriks L, Vanduijn CM, Cras P, Cruts M, Vanhul W, Vanharskamp F, Warren A, McInnis MG, Antonarakis SE, Martin JJ, Hofman A, Vanbroeckhoven C (1992) Presenile-dementia and cerebral-hemorrhage linked to a mutation at codon-692 of the beta-amyloid precursor protein gene. Nat Genet 1(3):218–221. doi:10.1038/ng0692-218
-
(1992)
Nat Genet
, vol.1
, Issue.3
, pp. 218-221
-
-
Hendriks, L.1
Vanduijn, C.M.2
Cras, P.3
Cruts, M.4
Vanhul, W.5
Vanharskamp, F.6
Warren, A.7
McInnis, M.G.8
Antonarakis, S.E.9
Martin, J.J.10
Hofman, A.11
Vanbroeckhoven, C.12
-
44
-
-
84895096773
-
A novel APP mutation (D678H) in a Taiwanese patient exhibiting dementia and cerebral microvasculopathy
-
PID: 23931937
-
Lan M-Y, Liu J-S, Wu Y-S, Peng C-H, Chang Y-Y (2014) A novel APP mutation (D678H) in a Taiwanese patient exhibiting dementia and cerebral microvasculopathy. J Clin Neurosci 21(3):513–515. doi:10.1016/j.jocn.2013.03.038
-
(2014)
J Clin Neurosci
, vol.21
, Issue.3
, pp. 513-515
-
-
Lan, M.-Y.1
Liu, J.-S.2
Wu, Y.-S.3
Peng, C.-H.4
Chang, Y.-Y.5
-
45
-
-
84873454554
-
Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population
-
Kero M, Paetau A, Polvikoski T, Tanskanen M, Sulkava R, Jansson L, Myllykangas L, Tienari PJ (2013) Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population. Neurobiol Aging 34(5):1518.e1–1518.e3. doi:10.1016/j.neurobiolaging.2012.09.017
-
(2013)
Neurobiol Aging 34(5):1518
, vol.e3
, pp. e1-e1518
-
-
Kero, M.1
Paetau, A.2
Polvikoski, T.3
Tanskanen, M.4
Sulkava, R.5
Jansson, L.6
Myllykangas, L.7
Tienari, P.J.8
-
46
-
-
84891834844
-
Autosomal-dominant Alzheimer’s disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production
-
PID: 24117942
-
Suárez-Calvet M, Belbin O, Pera M, Badiola N, Magrané J, Guardia-Laguarta C, Muñoz L, Colom-Cadena M, Clarimón J, Lleó A (2014) Autosomal-dominant Alzheimer’s disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production. J Neurochem 128(2):330–339. doi:10.1111/jnc.12466
-
(2014)
J Neurochem
, vol.128
, Issue.2
, pp. 330-339
-
-
Suárez-Calvet, M.1
Belbin, O.2
Pera, M.3
Badiola, N.4
Magrané, J.5
Guardia-Laguarta, C.6
Muñoz, L.7
Colom-Cadena, M.8
Clarimón, J.9
Lleó, A.10
-
47
-
-
0035421638
-
Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability
-
PID: 11487570
-
De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B (2001) Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability. Hum Mol Genet 10(16):1665–1671. doi:10.1093/hmg/10.16.1665
-
(2001)
Hum Mol Genet
, vol.10
, Issue.16
, pp. 1665-1671
-
-
De Jonghe, C.1
Esselens, C.2
Kumar-Singh, S.3
Craessaerts, K.4
Serneels, S.5
Checler, F.6
Annaert, W.7
Van Broeckhoven, C.8
De Strooper, B.9
-
48
-
-
18744435477
-
Neurobiology: presenilin-1 mutations in Alzheimer’s disease
-
PID: 10850703
-
Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK (2000) Neurobiology: presenilin-1 mutations in Alzheimer’s disease. Nature 405(6786):531–532. doi:10.1038/35014735
-
(2000)
Nature
, vol.405
, Issue.6786
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
49
-
-
0023189941
-
The genetic defect in familial Alzheimer’s disease is not tightly linked to the amyloid [beta]-protein gene
-
PID: 2888020
-
Tanzi RE, George-Hyslop PHS, Haines JL, Polinsky RJ, Nee L, Foncin J-F, Neve RL, McClatchey AI, Conneally PM, Gusella JF (1987) The genetic defect in familial Alzheimer’s disease is not tightly linked to the amyloid [beta]-protein gene. Nature 329(6135):156–157
-
(1987)
Nature
, vol.329
, Issue.6135
, pp. 156-157
-
-
Tanzi, R.E.1
George-Hyslop, P.H.S.2
Haines, J.L.3
Polinsky, R.J.4
Nee, L.5
Foncin, J.-F.6
Neve, R.L.7
McClatchey, A.I.8
Conneally, P.M.9
Gusella, J.F.10
-
50
-
-
0023743084
-
Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer’s disease
-
PID: 3064874
-
Vitek MP, Rasool CG, de Sauvage F, Vitek SM, Bartus RT, Beer B, Ashton RA, Macq AF, Maloteaux JM, Blume AJ et al (1988) Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer’s disease. Brain Res 464(2):121–131
-
(1988)
Brain Res
, vol.464
, Issue.2
, pp. 121-131
-
-
Vitek, M.P.1
Rasool, C.G.2
de Sauvage, F.3
Vitek, S.M.4
Bartus, R.T.5
Beer, B.6
Ashton, R.A.7
Macq, A.F.8
Maloteaux, J.M.9
Blume, A.J.10
-
51
-
-
0030293676
-
Familial Alzheimer’s disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
-
PID: 8938131
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada C-M, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS (1996) Familial Alzheimer’s disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo. Neuron 17(5):1005–1013. doi:10.1016/S0896-6273(00)80230-5
-
(1996)
Neuron
, vol.17
, Issue.5
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.-M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
52
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
PID: 8837617
-
Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L (1996) The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nat Med 2(10):1146–1150
-
(1996)
Nat Med
, vol.2
, Issue.10
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
Lendon, C.L.4
Ossa, J.5
Saido, T.C.6
Yamaguchi, H.7
Ruiz, A.8
Martinez, A.9
Madrigal, L.10
-
53
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer’s disease
-
PID: 9106355
-
Hardy J (1997) Amyloid, the presenilins and Alzheimer’s disease. Trends Neurosci 20(4):154–159. doi:10.1016/S0166-2236(96)01030-2
-
(1997)
Trends Neurosci
, vol.20
, Issue.4
, pp. 154-159
-
-
Hardy, J.1
-
54
-
-
0027327267
-
Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer’s disease
-
PID: 8350998
-
Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD (1993) Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 43(8):1467–1472
-
(1993)
Neurology
, vol.43
, Issue.8
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
George-Hyslop, P.H.4
Pericak-Vance, M.A.5
Joo, S.H.6
Rosi, B.L.7
Gusella, J.F.8
Crapper-MacLachlan, D.R.9
Alberts, M.J.10
Hulette, C.11
Crain, B.12
Goldgaber, D.13
Roses, A.D.14
-
55
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families
-
PID: 8346443
-
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261(5123):921–923
-
(1993)
Science
, vol.261
, Issue.5123
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
56
-
-
0029914688
-
Apolipoprotein E and Alzheimer’s disease
-
PID: 8833436
-
Strittmatter WJ, Roses AD (1996) Apolipoprotein E and Alzheimer’s disease. Annu Rev Neurosci 19(1):53–77. doi:10.1146/annurev.ne.19.030196.000413
-
(1996)
Annu Rev Neurosci
, vol.19
, Issue.1
, pp. 53-77
-
-
Strittmatter, W.J.1
Roses, A.D.2
-
57
-
-
84927175748
-
ApoE4: the most prevalent yet understudied risk factor for Alzheimer’s disease
-
PID: 25217293
-
Michaelson DM (2014) ApoE4: the most prevalent yet understudied risk factor for Alzheimer’s disease. Alzheimers Dement. doi:10.1016/j.jalz.2014.06.015
-
(2014)
Alzheimers Dement
-
-
Michaelson, D.M.1
-
58
-
-
0033959110
-
Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein
-
PID: 10674623
-
Fergusson J, Landon M, Lowe J, Ward L, van Leeuwen FW, Mayer RJ (2000) Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein. Neurosci Lett 279(2):69–72. doi:10.1016/S0304-3940(99)00917-9
-
(2000)
Neurosci Lett
, vol.279
, Issue.2
, pp. 69-72
-
-
Fergusson, J.1
Landon, M.2
Lowe, J.3
Ward, L.4
van Leeuwen, F.W.5
Mayer, R.J.6
-
59
-
-
6844258835
-
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer’s and Down patients
-
PID: 9422699
-
van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Koycu S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Peter J, Burbach H, Hol EM (1998) Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer’s and Down patients. Science 279(5348):242–247
-
(1998)
Science
, vol.279
, Issue.5348
, pp. 242-247
-
-
van Leeuwen, F.W.1
de Kleijn, D.P.2
van den Hurk, H.H.3
Neubauer, A.4
Sonnemans, M.A.5
Sluijs, J.A.6
Koycu, S.7
Ramdjielal, R.D.8
Salehi, A.9
Martens, G.J.10
Grosveld, F.G.11
Peter, J.12
Burbach, H.13
Hol, E.M.14
-
60
-
-
0024472693
-
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer’s disease
-
PID: 2474201
-
Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer’s disease. Science 245(4916):417–420
-
(1989)
Science
, vol.245
, Issue.4916
, pp. 417-420
-
-
Yankner, B.A.1
Dawes, L.R.2
Fisher, S.3
Villa-Komaroff, L.4
Oster-Granite, M.L.5
Neve, R.L.6
-
61
-
-
0034516988
-
Toward a comprehensive theory for Alzheimer’s disease. Hypothesis: Alzheimer’s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
-
PID: 11193794
-
Selkoe DJ (2000) Toward a comprehensive theory for Alzheimer’s disease. Hypothesis: Alzheimer’s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924:17–25
-
(2000)
Ann N Y Acad Sci
, vol.924
, pp. 17-25
-
-
Selkoe, D.J.1
-
62
-
-
0032211830
-
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer’s disease
-
PID: 9854312
-
Selkoe DJ (1998) The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol 8(11):447–453. doi:10.1016/S0962-8924(98)01363-4
-
(1998)
Trends Cell Biol
, vol.8
, Issue.11
, pp. 447-453
-
-
Selkoe, D.J.1
-
63
-
-
38349049307
-
Neuropathology for the neuroradiologist: plaques and tangles
-
PID: 17925367
-
Wippold FJ, Cairns N, Vo K, Holtzman DM, Morris JC (2008) Neuropathology for the neuroradiologist: plaques and tangles. Am J Neuroradiol 29(1):18–22. doi:10.3174/ajnr.A0781
-
(2008)
Am J Neuroradiol
, vol.29
, Issue.1
, pp. 18-22
-
-
Wippold, F.J.1
Cairns, N.2
Vo, K.3
Holtzman, D.M.4
Morris, J.C.5
-
64
-
-
84879829589
-
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
-
Masters CL, Selkoe DJ (2012) Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med a006262. doi: 10.1101/cshperspect.a006262
-
(2012)
Cold Spring Harb Perspect Med
, vol.a006262
-
-
Masters, C.L.1
Selkoe, D.J.2
-
65
-
-
0024447098
-
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease
-
PID: 2675616
-
Joachim CL, Morris JH, Selkoe DJ (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am J Pathol 135(2):309–319
-
(1989)
Am J Pathol
, vol.135
, Issue.2
, pp. 309-319
-
-
Joachim, C.L.1
Morris, J.H.2
Selkoe, D.J.3
-
66
-
-
79959205998
-
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer’s disease
-
PID: 21514441
-
Lord A, Philipson O, Klingstedt T, Westermark G, Hammarstrom P, Nilsson KP, Nilsson LN (2011) Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer’s disease. Am J Pathol 178(5):2286–2298. doi:10.1016/j.ajpath.2011.01.052
-
(2011)
Am J Pathol
, vol.178
, Issue.5
, pp. 2286-2298
-
-
Lord, A.1
Philipson, O.2
Klingstedt, T.3
Westermark, G.4
Hammarstrom, P.5
Nilsson, K.P.6
Nilsson, L.N.7
-
67
-
-
40249114896
-
A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis
-
PID: 18278038
-
Ma QH, Futagawa T, Yang WL, Jiang XD, Zeng L, Takeda Y, Xu RX, Bagnard D, Schachner M, Furley AJ, Karagogeos D, Watanabe K, Dawe GS, Xiao ZC (2008) A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol 10(3):283–294. doi:10.1038/ncb1690
-
(2008)
Nat Cell Biol
, vol.10
, Issue.3
, pp. 283-294
-
-
Ma, Q.H.1
Futagawa, T.2
Yang, W.L.3
Jiang, X.D.4
Zeng, L.5
Takeda, Y.6
Xu, R.X.7
Bagnard, D.8
Schachner, M.9
Furley, A.J.10
Karagogeos, D.11
Watanabe, K.12
Dawe, G.S.13
Xiao, Z.C.14
-
68
-
-
0001067847
-
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues
-
PID: 3140239
-
Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T (1988) Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A 85(19):7341–7345
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, Issue.19
, pp. 7341-7345
-
-
Selkoe, D.J.1
Podlisny, M.B.2
Joachim, C.L.3
Vickers, E.A.4
Lee, G.5
Fritz, L.C.6
Oltersdorf, T.7
-
69
-
-
0024847273
-
Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer’s disease brain
-
PID: 2514687
-
Tanaka S, Shiojiri S, Takahashi Y, Kitaguchi N, Ito H, Kameyama M, Kimura J, Nakamura S, Ueda K (1989) Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer’s disease brain. Biochem Biophys Res Commun 165(3):1406–1414
-
(1989)
Biochem Biophys Res Commun
, vol.165
, Issue.3
, pp. 1406-1414
-
-
Tanaka, S.1
Shiojiri, S.2
Takahashi, Y.3
Kitaguchi, N.4
Ito, H.5
Kameyama, M.6
Kimura, J.7
Nakamura, S.8
Ueda, K.9
-
70
-
-
0023816219
-
Selective reduction of mRNA for the β-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains
-
PID: 2460367
-
Johnson SA, Pasinetti GM, May PC, Ponte PA, Cordell B, Finch CE (1988) Selective reduction of mRNA for the β-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains. Exp Neurol 102(2):264–268. doi:10.1016/0014-4886(88)90104-5
-
(1988)
Exp Neurol
, vol.102
, Issue.2
, pp. 264-268
-
-
Johnson, S.A.1
Pasinetti, G.M.2
May, P.C.3
Ponte, P.A.4
Cordell, B.5
Finch, C.E.6
-
71
-
-
0024760628
-
APP-695 transcript prevalence is selectively reduced during Alzheimer’s disease in cortex and hippocampus but not in cerebellum
-
PID: 2483450
-
Johnson SA, Rogers J, Finch CE (1989) APP-695 transcript prevalence is selectively reduced during Alzheimer’s disease in cortex and hippocampus but not in cerebellum. Neurobiol Aging 10(6):755–760
-
(1989)
Neurobiol Aging
, vol.10
, Issue.6
, pp. 755-760
-
-
Johnson, S.A.1
Rogers, J.2
Finch, C.E.3
-
72
-
-
0026325645
-
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
-
PID: 1744690
-
Haass C, Hung AY, Selkoe DJ (1991) Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J Neurosci 11(12):3783–3793
-
(1991)
J Neurosci
, vol.11
, Issue.12
, pp. 3783-3793
-
-
Haass, C.1
Hung, A.Y.2
Selkoe, D.J.3
-
73
-
-
0023850791
-
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer’s disease
-
PID: 2893290
-
Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer’s disease. Nature 331(6156):528–530
-
(1988)
Nature
, vol.331
, Issue.6156
, pp. 528-530
-
-
Tanzi, R.E.1
McClatchey, A.I.2
Lamperti, E.D.3
Villa-Komaroff, L.4
Gusella, J.F.5
Neve, R.L.6
-
74
-
-
0023872043
-
Novel precursor of Alzheimer’s disease amyloid protein shows protease inhibitory activity
-
PID: 2893291
-
Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H (1988) Novel precursor of Alzheimer’s disease amyloid protein shows protease inhibitory activity. Nature 331(6156):530–532. doi:10.1038/331530a0
-
(1988)
Nature
, vol.331
, Issue.6156
, pp. 530-532
-
-
Kitaguchi, N.1
Takahashi, Y.2
Tokushima, Y.3
Shiojiri, S.4
Ito, H.5
-
75
-
-
0028213567
-
A heparin-binding domain in the amyloid protein precursor of Alzheimer’s disease is involved in the regulation of neurite outgrowth
-
PID: 8158260
-
Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL (1994) A heparin-binding domain in the amyloid protein precursor of Alzheimer’s disease is involved in the regulation of neurite outgrowth. J Neurosci 14(4):2117–2127
-
(1994)
J Neurosci
, vol.14
, Issue.4
, pp. 2117-2127
-
-
Small, D.H.1
Nurcombe, V.2
Reed, G.3
Clarris, H.4
Moir, R.5
Beyreuther, K.6
Masters, C.L.7
-
76
-
-
18844473445
-
Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer’s disease
-
PID: 9357988
-
Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, Clarris HJ, Sawyer WH, Beyreuther K, Masters CL, Small DH (1997) Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer’s disease. FEBS Lett 415(3):303–307. doi:10.1016/S0014-5793(97)01146-0
-
(1997)
FEBS Lett
, vol.415
, Issue.3
, pp. 303-307
-
-
Mok, S.S.1
Sberna, G.2
Heffernan, D.3
Cappai, R.4
Galatis, D.5
Clarris, H.J.6
Sawyer, W.H.7
Beyreuther, K.8
Masters, C.L.9
Small, D.H.10
-
77
-
-
0032945805
-
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
-
PID: 10201399
-
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW (1999) Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6(4):327–331
-
(1999)
Nat Struct Biol
, vol.6
, Issue.4
, pp. 327-331
-
-
Rossjohn, J.1
Cappai, R.2
Feil, S.C.3
Henry, A.4
McKinstry, W.J.5
Galatis, D.6
Hesse, L.7
Multhaup, G.8
Beyreuther, K.9
Masters, C.L.10
Parker, M.W.11
-
78
-
-
0037931743
-
Structure of the Alzheimer’s disease amyloid precursor protein copper binding domain: a regulator of neuronal copper homeostasis
-
PID: 12611883
-
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R (2003) Structure of the Alzheimer’s disease amyloid precursor protein copper binding domain: a regulator of neuronal copper homeostasis. J Biol Chem 278(19):17401–17407. doi:10.1074/jbc.M300629200
-
(2003)
J Biol Chem
, vol.278
, Issue.19
, pp. 17401-17407
-
-
Barnham, K.J.1
McKinstry, W.J.2
Multhaup, G.3
Galatis, D.4
Morton, C.J.5
Curtain, C.C.6
Williamson, N.A.7
White, A.R.8
Hinds, M.G.9
Norton, R.S.10
Beyreuther, K.11
Masters, C.L.12
Parker, M.W.13
Cappai, R.14
-
79
-
-
0027221517
-
Amino acid sequence RERMS represents the active domain of amyloid β/A4 protein precursor that promotes fibroblast growth
-
PID: 8491779
-
Ninomiya H, Roch JM, Sundsmo MP, Otero DAC, Saitoh T (1993) Amino acid sequence RERMS represents the active domain of amyloid β/A4 protein precursor that promotes fibroblast growth. J Cell Biol 121(4):879–886
-
(1993)
J Cell Biol
, vol.121
, Issue.4
, pp. 879-886
-
-
Ninomiya, H.1
Roch, J.M.2
Sundsmo, M.P.3
Otero, D.A.C.4
Saitoh, T.5
-
80
-
-
84863601480
-
All in the family: how the APPs regulate neurogenesis
-
PID: 22675290
-
Lazarov O, Demars MP (2012) All in the family: how the APPs regulate neurogenesis. Front Neurosci 6:81. doi:10.3389/fnins.2012.00081
-
(2012)
Front Neurosci
, vol.6
, pp. 81
-
-
Lazarov, O.1
Demars, M.P.2
-
81
-
-
79959886270
-
Amyloid precursor protein processing and Alzheimer’s disease
-
PID: 21456963
-
O’Brien RJ, Wong PC (2011) Amyloid precursor protein processing and Alzheimer’s disease. Annu Rev Neurosci 34:185–204. doi:10.1146/annurev-neuro-061010-113613
-
(2011)
Annu Rev Neurosci
, vol.34
, pp. 185-204
-
-
O’Brien, R.J.1
Wong, P.C.2
-
82
-
-
67349132229
-
Amyloid precursor protein increases cortical neuron size in transgenic mice
-
PID: 18304698
-
Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC (2009) Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiol Aging 30(8):1238–1244. doi:10.1016/j.neurobiolaging.2007.12.024
-
(2009)
Neurobiol Aging
, vol.30
, Issue.8
, pp. 1238-1244
-
-
Oh, E.S.1
Savonenko, A.V.2
King, J.F.3
Fangmark Tucker, S.M.4
Rudow, G.L.5
Xu, G.6
Borchelt, D.R.7
Troncoso, J.C.8
-
83
-
-
84901188020
-
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer’s disease
-
Dawkins E, Small DH (2014) Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer’s disease. J Neurochem 756–769. doi: 10.1111/jnc.12675
-
(2014)
J Neurochem
, pp. 756-769
-
-
Dawkins, E.1
Small, D.H.2
-
84
-
-
0031453752
-
The β-amyloid precursor protein of Alzheimer’s disease enhances neuron viability and modulates neuronal polarity
-
PID: 9390996
-
Perez RG, Zheng H, Van der Ploeg LHT, Koo EH (1997) The β-amyloid precursor protein of Alzheimer’s disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17(24):9407–9414
-
(1997)
J Neurosci
, vol.17
, Issue.24
, pp. 9407-9414
-
-
Perez, R.G.1
Zheng, H.2
Van der Ploeg, L.H.T.3
Koo, E.H.4
-
85
-
-
84890796720
-
The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110
-
PID: 23919582
-
Corrigan F, Thornton E, Roisman LC, Leonard AV, Vink R, Blumbergs PC, van den Heuvel C, Cappai R (2014) The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110. J Neurochem 128(1):196–204. doi:10.1111/jnc.12391
-
(2014)
J Neurochem
, vol.128
, Issue.1
, pp. 196-204
-
-
Corrigan, F.1
Thornton, E.2
Roisman, L.C.3
Leonard, A.V.4
Vink, R.5
Blumbergs, P.C.6
van den Heuvel, C.7
Cappai, R.8
-
86
-
-
0033582159
-
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
-
PID: 9892704
-
Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H (1999) Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides. Proc Natl Acad Sci U S A 96(2):742–747. doi:10.1073/pnas.96.2.742
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.2
, pp. 742-747
-
-
Greenfield, J.P.1
Tsai, J.2
Gouras, G.K.3
Hai, B.4
Thinakaran, G.5
Checler, F.6
Sisodia, S.S.7
Greengard, P.8
Xu, H.9
-
87
-
-
0029933153
-
The role of APP processing and trafficking pathways in the formation of amyloid β-protein
-
PID: 8624127
-
Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C (1996) The role of APP processing and trafficking pathways in the formation of amyloid β-protein. Ann N Y Acad Sci 777(1):57–64. doi:10.1111/j.1749-6632.1996.tb34401.x
-
(1996)
Ann N Y Acad Sci
, vol.777
, Issue.1
, pp. 57-64
-
-
Selkoe, D.J.1
Yamazaki, T.2
Citron, M.3
Podlisny, M.B.4
Koo, E.H.5
Teplow, D.B.6
Haass, C.7
-
88
-
-
0033609449
-
Cleavage of Alzheimer’s amyloid precursor protein by α-secretase occurs at the surface of neuronal cells
-
Parvathy S, Hussain I, Karran EH, Turner AJ, Hooper NM (1999) Cleavage of Alzheimer’s amyloid precursor protein by α-secretase occurs at the surface of neuronal cells. Biochemistry (Mosc) 38(30):9728–9734. doi:10.1021/bi9906827
-
(1999)
Biochemistry (Mosc)
, vol.38
, Issue.30
, pp. 9728-9734
-
-
Parvathy, S.1
Hussain, I.2
Karran, E.H.3
Turner, A.J.4
Hooper, N.M.5
-
89
-
-
0034723418
-
Protein kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network
-
PID: 10644715
-
Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM-Y (2000) Protein kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network. J Biol Chem 275(4):2568–2575. doi:10.1074/jbc.275.4.2568
-
(2000)
J Biol Chem
, vol.275
, Issue.4
, pp. 2568-2575
-
-
Skovronsky, D.M.1
Moore, D.B.2
Milla, M.E.3
Doms, R.W.4
Lee, V.M.-Y.5
-
90
-
-
0842297602
-
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid
-
PID: 2503832
-
Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG (1989) The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci U S A 86(16):6338–6342
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, Issue.16
, pp. 6338-6342
-
-
Palmert, M.R.1
Podlisny, M.B.2
Witker, D.S.3
Oltersdorf, T.4
Younkin, L.H.5
Selkoe, D.J.6
Younkin, S.G.7
-
91
-
-
84655176404
-
Functions of Abeta, sAPPalpha and sAPPbeta: similarities and differences
-
PID: 22150401
-
Chasseigneaux S, Allinquant B (2012) Functions of Abeta, sAPPalpha and sAPPbeta: similarities and differences. J Neurochem 120(Suppl 1):99–108. doi:10.1111/j.1471-4159.2011.07584.x
-
(2012)
J Neurochem
, vol.120
, pp. 99-108
-
-
Chasseigneaux, S.1
Allinquant, B.2
-
92
-
-
79551546647
-
Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway
-
PID: 21298006
-
Chasseigneaux S, Dinc L, Rose C, Chabret C, Coulpier F, Topilko P, Mauger G, Allinquant B (2011) Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. PLoS ONE 6(1):e16301
-
(2011)
PLoS ONE
, vol.6
, Issue.1
, pp. e16301
-
-
Chasseigneaux, S.1
Dinc, L.2
Rose, C.3
Chabret, C.4
Coulpier, F.5
Topilko, P.6
Mauger, G.7
Allinquant, B.8
-
93
-
-
84878922963
-
Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons
-
PID: 23776568
-
Hartl D, Klatt S, Roch M, Konthur Z, Klose J, Willnow TE, Rohe M (2013) Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons. PLoS ONE 8(6):e65920
-
(2013)
PLoS ONE
, vol.8
, Issue.6
, pp. e65920
-
-
Hartl, D.1
Klatt, S.2
Roch, M.3
Konthur, Z.4
Klose, J.5
Willnow, T.E.6
Rohe, M.7
-
94
-
-
50449084262
-
Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell‐derived neurons via activation of the MAPK pathway
-
PID: 18717733
-
Gakhar‐Koppole N, Hundeshagen P, Mandl C, Weyer SW, Allinquant B, Müller U, Ciccolini F (2008) Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell‐derived neurons via activation of the MAPK pathway. Eur J Neurosci 28(5):871–882
-
(2008)
Eur J Neurosci
, vol.28
, Issue.5
, pp. 871-882
-
-
Gakhar‐Koppole, N.1
Hundeshagen, P.2
Mandl, C.3
Weyer, S.W.4
Allinquant, B.5
Müller, U.6
Ciccolini, F.7
-
95
-
-
84862697779
-
Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells
-
PID: 22147523
-
Baratchi S, Evans J, Tate WP, Abraham WC, Connor B (2012) Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus 22(7):1517–1527
-
(2012)
Hippocampus
, vol.22
, Issue.7
, pp. 1517-1527
-
-
Baratchi, S.1
Evans, J.2
Tate, W.P.3
Abraham, W.C.4
Connor, B.5
-
96
-
-
80053918665
-
Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
-
PID: 21878106
-
Demars MP, Bartholomew A, Strakova Z, Lazarov O (2011) Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin. Stem Cell Res Ther 2:36
-
(2011)
Stem Cell Res Ther
, vol.2
, pp. 36
-
-
Demars, M.P.1
Bartholomew, A.2
Strakova, Z.3
Lazarov, O.4
-
97
-
-
84892752054
-
Soluble β-amyloid precursor protein alpha binds to p75 neurotrophin receptor to promote neurite outgrowth
-
PID: 24358169
-
Hasebe N, Fujita Y, Ueno M, Yoshimura K, Fujino Y, Yamashita T (2013) Soluble β-amyloid precursor protein alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS ONE 8(12):e82321
-
(2013)
PLoS ONE
, vol.8
, Issue.12
, pp. e82321
-
-
Hasebe, N.1
Fujita, Y.2
Ueno, M.3
Yoshimura, K.4
Fujino, Y.5
Yamashita, T.6
-
98
-
-
0037474447
-
Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase
-
PID: 12535668
-
Asai M, Hattori C, Szabó B, Sasagawa N, Maruyama K, S-i T, Ishiura S (2003) Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase. Biochem Biophys Res Commun 301(1):231–235. doi:10.1016/S0006-291X(02)02999-6
-
(2003)
Biochem Biophys Res Commun
, vol.301
, Issue.1
, pp. 231-235
-
-
Asai, M.1
Hattori, C.2
Szabó, B.3
Sasagawa, N.4
Maruyama, K.5
Ishiura, S.6
-
99
-
-
0242330374
-
ADAMs family members as amyloid precursor protein alpha-secretases
-
PID: 14598310
-
Allinson TM, Parkin ET, Turner AJ, Hooper NM (2003) ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res 74(3):342–352. doi:10.1002/jnr.10737
-
(2003)
J Neurosci Res
, vol.74
, Issue.3
, pp. 342-352
-
-
Allinson, T.M.1
Parkin, E.T.2
Turner, A.J.3
Hooper, N.M.4
-
100
-
-
42149110867
-
Part-time-secretases: the functional biology of ADAM 9, 10 and 17
-
PID: 18393804
-
Deuss M, Reiss K, Hartmann D (2008) Part-time-secretases: the functional biology of ADAM 9, 10 and 17. Curr Alzheimer Res 5(2):187–201
-
(2008)
Curr Alzheimer Res
, vol.5
, Issue.2
, pp. 187-201
-
-
Deuss, M.1
Reiss, K.2
Hartmann, D.3
-
101
-
-
84869859202
-
α-Cleavage of cellular prion protein
-
PID: 23052041
-
Liang J, Kong Q (2012) α-Cleavage of cellular prion protein. Prion 6(5):453–460
-
(2012)
Prion
, vol.6
, Issue.5
, pp. 453-460
-
-
Liang, J.1
Kong, Q.2
-
102
-
-
84866531672
-
A disintegrin and metalloproteases: molecular scissors in angiogenesis, inflammation and atherosclerosis
-
PID: 22698791
-
van der Vorst EP, Keijbeck AA, de Winther MP, Donners MM (2012) A disintegrin and metalloproteases: molecular scissors in angiogenesis, inflammation and atherosclerosis. Atherosclerosis 224(2):302–308
-
(2012)
Atherosclerosis
, vol.224
, Issue.2
, pp. 302-308
-
-
van der Vorst, E.P.1
Keijbeck, A.A.2
de Winther, M.P.3
Donners, M.M.4
-
103
-
-
0033152184
-
ADAM family proteins in the immune system
-
PID: 10354553
-
Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N, Matsuura K (1999) ADAM family proteins in the immune system. Immunol Today 20(6):278–284. doi:10.1016/S0167-5699(99)01464-4
-
(1999)
Immunol Today
, vol.20
, Issue.6
, pp. 278-284
-
-
Yamamoto, S.1
Higuchi, Y.2
Yoshiyama, K.3
Shimizu, E.4
Kataoka, M.5
Hijiya, N.6
Matsuura, K.7
-
104
-
-
21744443240
-
Shedding light on ADAM metalloproteinases
-
PID: 15949939
-
Huovila A-PJ, Turner AJ, Pelto-Huikko M, Kärkkäinen I, Ortiz RM (2005) Shedding light on ADAM metalloproteinases. Trends Biochem Sci 30(7):413–422. doi:10.1016/j.tibs.2005.05.006
-
(2005)
Trends Biochem Sci
, vol.30
, Issue.7
, pp. 413-422
-
-
Huovila, A.-P.J.1
Turner, A.J.2
Pelto-Huikko, M.3
Kärkkäinen, I.4
Ortiz, R.M.5
-
105
-
-
0035168194
-
Implication of APP secretases in notch signaling
-
PID: 11816790
-
Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B (2001) Implication of APP secretases in notch signaling. J Mol Neurosci 17(2):171–181
-
(2001)
J Mol Neurosci
, vol.17
, Issue.2
, pp. 171-181
-
-
Hartmann, D.1
Tournoy, J.2
Saftig, P.3
Annaert, W.4
De Strooper, B.5
-
106
-
-
0036796421
-
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
-
PID: 12354787
-
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lubke T, Lena Illert A, von Figura K, Saftig P (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 11(21):2615–2624
-
(2002)
Hum Mol Genet
, vol.11
, Issue.21
, pp. 2615-2624
-
-
Hartmann, D.1
de Strooper, B.2
Serneels, L.3
Craessaerts, K.4
Herreman, A.5
Annaert, W.6
Umans, L.7
Lubke, T.8
Lena Illert, A.9
von Figura, K.10
Saftig, P.11
-
107
-
-
33747341626
-
The ADAMs family: coordinators of nervous system development, plasticity and repair
-
PID: 16824663
-
Yang P, Baker KA, Hagg T (2006) The ADAMs family: coordinators of nervous system development, plasticity and repair. Prog Neurobiol 79(2):73–94
-
(2006)
Prog Neurobiol
, vol.79
, Issue.2
, pp. 73-94
-
-
Yang, P.1
Baker, K.A.2
Hagg, T.3
-
108
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
-
PID: 15146243
-
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 113(10):1456–1464. doi:10.1172/JCI20864
-
(2004)
J Clin Invest
, vol.113
, Issue.10
, pp. 1456-1464
-
-
Postina, R.1
Schroeder, A.2
Dewachter, I.3
Bohl, J.4
Schmitt, U.5
Kojro, E.6
Prinzen, C.7
Endres, K.8
Hiemke, C.9
Blessing, M.10
Flamez, P.11
Dequenne, A.12
Godaux, E.13
van Leuven, F.14
Fahrenholz, F.15
-
109
-
-
78049476184
-
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease
-
PID: 20805102
-
Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell’Agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M (2010) Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease. Brain 133(11):3323–3335. doi:10.1093/brain/awq217
-
(2010)
Brain
, vol.133
, Issue.11
, pp. 3323-3335
-
-
Epis, R.1
Marcello, E.2
Gardoni, F.3
Vastagh, C.4
Malinverno, M.5
Balducci, C.6
Colombo, A.7
Borroni, B.8
Vara, H.9
Dell’Agli, M.10
Cattabeni, F.11
Giustetto, M.12
Borsello, T.13
Forloni, G.14
Padovani, A.15
Di Luca, M.16
-
110
-
-
69249098287
-
ADAM17 as a therapeutic target in multiple diseases
-
PID: 19601834
-
Arribas J, Esselens C (2009) ADAM17 as a therapeutic target in multiple diseases. Curr Pharm Des 15(20):2319–2335
-
(2009)
Curr Pharm Des
, vol.15
, Issue.20
, pp. 2319-2335
-
-
Arribas, J.1
Esselens, C.2
-
111
-
-
84876110045
-
ADAM17, shedding, TACE as therapeutic targets
-
PID: 23415892
-
Rose-John S (2013) ADAM17, shedding, TACE as therapeutic targets. Pharmacol Res 71:19–22
-
(2013)
Pharmacol Res
, vol.71
, pp. 19-22
-
-
Rose-John, S.1
-
112
-
-
79960923986
-
ADAM17: a molecular switch to control inflammation and tissue regeneration
-
PID: 21752713
-
Scheller J, Chalaris A, Garbers C, Rose-John S (2011) ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 32(8):380–387
-
(2011)
Trends Immunol
, vol.32
, Issue.8
, pp. 380-387
-
-
Scheller, J.1
Chalaris, A.2
Garbers, C.3
Rose-John, S.4
-
113
-
-
18744364692
-
Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons
-
PID: 12472889
-
Blacker M, Noe MC, Carty TJ, Goodyer CG, LeBlanc AC (2002) Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons. J Neurochem 83(6):1349–1357
-
(2002)
J Neurochem
, vol.83
, Issue.6
, pp. 1349-1357
-
-
Blacker, M.1
Noe, M.C.2
Carty, T.J.3
Goodyer, C.G.4
LeBlanc, A.C.5
-
114
-
-
0036288958
-
A secreted form of human ADAM9 has an α-secretase activity for APP
-
PID: 12054541
-
Hotoda N, Koike H, Sasagawa N, Ishiura S (2002) A secreted form of human ADAM9 has an α-secretase activity for APP. Biochem Biophys Res Commun 293(2):800–805. doi:10.1016/S0006-291X(02)00302-9
-
(2002)
Biochem Biophys Res Commun
, vol.293
, Issue.2
, pp. 800-805
-
-
Hotoda, N.1
Koike, H.2
Sasagawa, N.3
Ishiura, S.4
-
115
-
-
0034721842
-
Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme: the Alzheimer’s disease β-secretase
-
PID: 10924510
-
Huse JT, Pijak DS, Leslie GJ, Lee VM-Y, Doms RW (2000) Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme: the Alzheimer’s disease β-secretase. J Biol Chem 275(43):33729–33737. doi:10.1074/jbc.M004175200
-
(2000)
J Biol Chem
, vol.275
, Issue.43
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.-Y.4
Doms, R.W.5
-
116
-
-
47149092572
-
Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
-
PID: 18585048
-
Taylor CJ, Ireland DR, Ballagh I, Bourne K, Marechal NM, Turner PR, Bilkey DK, Tate WP, Abraham WC (2008) Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiol Dis 31(2):250–260. doi:10.1016/j.nbd.2008.04.011
-
(2008)
Neurobiol Dis
, vol.31
, Issue.2
, pp. 250-260
-
-
Taylor, C.J.1
Ireland, D.R.2
Ballagh, I.3
Bourne, K.4
Marechal, N.M.5
Turner, P.R.6
Bilkey, D.K.7
Tate, W.P.8
Abraham, W.C.9
-
117
-
-
4644357534
-
Reticulon family members modulate BACE1 activity and amyloid-[beta] peptide generation
-
PID: 15286784
-
He W, Lu Y, Qahwash I, Hu X-Y, Chang A, Yan R (2004) Reticulon family members modulate BACE1 activity and amyloid-[beta] peptide generation. Nat Med 10(9):959–965. doi:10.1038/nm1088
-
(2004)
Nat Med
, vol.10
, Issue.9
, pp. 959-965
-
-
He, W.1
Lu, Y.2
Qahwash, I.3
Hu, X.-Y.4
Chang, A.5
Yan, R.6
-
118
-
-
33749998298
-
Brain site-specific gene expression analysis in Alzheimer’s disease patients
-
Yokota T, Mishra M, Akatsu H, Tani Y, Miyauchi T, Yamamoto T, Kosaka K, Nagai Y, Sawada T, Heese K (2006) Brain site-specific gene expression analysis in Alzheimer’s disease patients. Eur J Clin Investig 36(11):820–830. doi:10.1111/j.1365-2362.2006.01722.x
-
(2006)
Eur J Clin Investig
, vol.36
, Issue.11
, pp. 820-830
-
-
Yokota, T.1
Mishra, M.2
Akatsu, H.3
Tani, Y.4
Miyauchi, T.5
Yamamoto, T.6
Kosaka, K.7
Nagai, Y.8
Sawada, T.9
Heese, K.10
-
119
-
-
84907994602
-
Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition
-
PID: 25319692
-
Shi Q, Ge Y, Sharoar MG, He W, Xiang R, Zhang Z, Hu X, Yan R (2014) Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition. J Neurosci 34(42):13954–13962. doi:10.1523/jneurosci. 1588-14.2014
-
(2014)
J Neurosci
, vol.34
, Issue.42
, pp. 13954-13962
-
-
Shi, Q.1
Ge, Y.2
Sharoar, M.G.3
He, W.4
Xiang, R.5
Zhang, Z.6
Hu, X.7
Yan, R.8
-
120
-
-
65549140727
-
Gamma-secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer’s disease
-
PID: 19299585
-
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horre K, Van Houtvin T, Esselmann H, Paul S, Schafer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D’Hooge R, De Strooper B (2009) Gamma-secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer’s disease. Science 324(5927):639–642. doi:10.1126/science.1171176
-
(2009)
Science
, vol.324
, Issue.5927
, pp. 639-642
-
-
Serneels, L.1
Van Biervliet, J.2
Craessaerts, K.3
Dejaegere, T.4
Horre, K.5
Van Houtvin, T.6
Esselmann, H.7
Paul, S.8
Schafer, M.K.9
Berezovska, O.10
Hyman, B.T.11
Sprangers, B.12
Sciot, R.13
Moons, L.14
Jucker, M.15
Yang, Z.16
May, P.C.17
Karran, E.18
Wiltfang, J.19
D’Hooge, R.20
De Strooper, B.21
more..
-
121
-
-
42149109088
-
Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer’s disease
-
PID: 18393798
-
Dries DR, Yu G (2008) Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer’s disease. Curr Alzheimer Res 5(2):132–146
-
(2008)
Curr Alzheimer Res
, vol.5
, Issue.2
, pp. 132-146
-
-
Dries, D.R.1
Yu, G.2
-
122
-
-
33645559774
-
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase
-
PID: 16597736
-
Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H (2006) The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. J Neurosci 26(14):3821–3828. doi:10.1523/jneurosci. 5354-05.2006
-
(2006)
J Neurosci
, vol.26
, Issue.14
, pp. 3821-3828
-
-
Yamasaki, A.1
Eimer, S.2
Okochi, M.3
Smialowska, A.4
Kaether, C.5
Baumeister, R.6
Haass, C.7
Steiner, H.8
-
123
-
-
84875266748
-
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase
-
PID: 23237322
-
Kretner B, Fukumori A, Kuhn P-H, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H (2013) Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. J Neurochem 125(1):144–156. doi:10.1111/jnc.12124
-
(2013)
J Neurochem
, vol.125
, Issue.1
, pp. 144-156
-
-
Kretner, B.1
Fukumori, A.2
Kuhn, P.-H.3
Pérez-Revuelta, B.I.4
Lichtenthaler, S.F.5
Haass, C.6
Steiner, H.7
-
124
-
-
0026794746
-
Mass spectrometry of purified amyloid beta protein in Alzheimer’s disease
-
PID: 1512246
-
Mori H, Takio K, Ogawara M, Selkoe DJ (1992) Mass spectrometry of purified amyloid beta protein in Alzheimer’s disease. J Biol Chem 267(24):17082–17086
-
(1992)
J Biol Chem
, vol.267
, Issue.24
, pp. 17082-17086
-
-
Mori, H.1
Takio, K.2
Ogawara, M.3
Selkoe, D.J.4
-
125
-
-
80053309666
-
Novel aβ isoforms in Alzheimer’s disease—their role in diagnosis and treatment
-
PID: 21728980
-
Portelius E, Mattsson N, Andreasson U, Blennow K, Zetterberg H (2011) Novel aβ isoforms in Alzheimer’s disease—their role in diagnosis and treatment. Curr Pharm Des 17(25):2594–2602
-
(2011)
Curr Pharm Des
, vol.17
, Issue.25
, pp. 2594-2602
-
-
Portelius, E.1
Mattsson, N.2
Andreasson, U.3
Blennow, K.4
Zetterberg, H.5
-
126
-
-
34247234602
-
The Alzheimer’s peptides Aβ40 and 42 adopt distinct conformations in water: a combined MD/NMR study
-
PID: 17397862
-
Sgourakis NG, Yan Y, McCallum SA, Wang C, Garcia AE (2007) The Alzheimer’s peptides Aβ40 and 42 adopt distinct conformations in water: a combined MD/NMR study. J Mol Biol 368(5):1448–1457. doi:10.1016/j.jmb.2007.02.093
-
(2007)
J Mol Biol
, vol.368
, Issue.5
, pp. 1448-1457
-
-
Sgourakis, N.G.1
Yan, Y.2
McCallum, S.A.3
Wang, C.4
Garcia, A.E.5
-
127
-
-
33845802653
-
Characterizations of distinct amyloidogenic conformations of the Aβ (1–40) and (1–42) peptides
-
PID: 17184733
-
Lim KH, Collver HH, Le YTH, Nagchowdhuri P, Kenney JM (2007) Characterizations of distinct amyloidogenic conformations of the Aβ (1–40) and (1–42) peptides. Biochem Biophys Res Commun 353(2):443–449. doi:10.1016/j.bbrc.2006.12.043
-
(2007)
Biochem Biophys Res Commun
, vol.353
, Issue.2
, pp. 443-449
-
-
Lim, K.H.1
Collver, H.H.2
Le, Y.T.H.3
Nagchowdhuri, P.4
Kenney, J.M.5
-
128
-
-
0037017399
-
Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons
-
PID: 11815632
-
Zhang Y, McLaughlin R, Goodyer C, LeBlanc A (2002) Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156(3):519–529. doi:10.1083/jcb.200110119
-
(2002)
J Cell Biol
, vol.156
, Issue.3
, pp. 519-529
-
-
Zhang, Y.1
McLaughlin, R.2
Goodyer, C.3
LeBlanc, A.4
-
129
-
-
0034213718
-
High-level neuronal expression of Aβ1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
-
PID: 10818140
-
Mucke L, Masliah E, Yu G-Q, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L (2000) High-level neuronal expression of Aβ1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20(11):4050–4058
-
(2000)
J Neurosci
, vol.20
, Issue.11
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.-Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
130
-
-
0026595567
-
Assembly and aggregation properties of synthetic Alzheimer’s A4/beta amyloid peptide analogs
-
PID: 1730616
-
Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C (1992) Assembly and aggregation properties of synthetic Alzheimer’s A4/beta amyloid peptide analogs. J Biol Chem 267(1):546–554
-
(1992)
J Biol Chem
, vol.267
, Issue.1
, pp. 546-554
-
-
Burdick, D.1
Soreghan, B.2
Kwon, M.3
Kosmoski, J.4
Knauer, M.5
Henschen, A.6
Yates, J.7
Cotman, C.8
Glabe, C.9
-
131
-
-
16044366039
-
Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1
-
PID: 8878479
-
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Pereztur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1. Nature 383(6602):710–713. doi:10.1038/383710a0
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Pereztur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
132
-
-
57149145222
-
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity
-
PID: 18694930
-
Jan A, Gokce O, Luthi-Carter R, Lashuel HA (2008) The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. J Biol Chem 283(42):28176–28189. doi:10.1074/jbc.M803159200
-
(2008)
J Biol Chem
, vol.283
, Issue.42
, pp. 28176-28189
-
-
Jan, A.1
Gokce, O.2
Luthi-Carter, R.3
Lashuel, H.A.4
-
133
-
-
0035955693
-
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
-
PID: 11544248
-
Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276(43):40288–40292. doi:10.1074/jbc.C100447200
-
(2001)
J Biol Chem
, vol.276
, Issue.43
, pp. 40288-40292
-
-
Kimberly, W.T.1
Zheng, J.B.2
Guenette, S.Y.3
Selkoe, D.J.4
-
134
-
-
0035909901
-
The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
-
PID: 11742091
-
Gao Y, Pimplikar SW (2001) The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A 98(26):14979–14984. doi:10.1073/pnas.261463298
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.26
, pp. 14979-14984
-
-
Gao, Y.1
Pimplikar, S.W.2
-
135
-
-
0034839287
-
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
-
PID: 11553691
-
Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B (2001) The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem 78(5):1168–1178
-
(2001)
J Neurochem
, vol.78
, Issue.5
, pp. 1168-1178
-
-
Cupers, P.1
Orlans, I.2
Craessaerts, K.3
Annaert, W.4
De Strooper, B.5
-
136
-
-
45749151774
-
A putative role of the amyloid precursor protein intracellular domain (AICD) in transcription
-
Slomnicki LP, Lesniak W (2008) A putative role of the amyloid precursor protein intracellular domain (AICD) in transcription. Acta Neurobiol Exp (Wars) 68(2):219–228
-
(2008)
Acta Neurobiol Exp (Wars)
, vol.68
, Issue.2
, pp. 219-228
-
-
Slomnicki, L.P.1
Lesniak, W.2
-
137
-
-
83555176204
-
Nuclear signalling by membrane protein intracellular domains: the AICD enigma
-
PID: 22024280
-
Beckett C, Nalivaeva NN, Belyaev ND, Turner AJ (2012) Nuclear signalling by membrane protein intracellular domains: the AICD enigma. Cell Signal 24(2):402–409. doi:10.1016/j.cellsig.2011.10.007
-
(2012)
Cell Signal
, vol.24
, Issue.2
, pp. 402-409
-
-
Beckett, C.1
Nalivaeva, N.N.2
Belyaev, N.D.3
Turner, A.J.4
-
138
-
-
0035816661
-
A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60
-
PID: 11441186
-
Cao X, Südhof TC (2001) A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293(5527):115–120. doi:10.1126/science.1058783
-
(2001)
Science
, vol.293
, Issue.5527
, pp. 115-120
-
-
Cao, X.1
Südhof, T.C.2
-
139
-
-
34748897213
-
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
-
PID: 17920016
-
Liu Q, Zerbinatti CV, Zhang J, Hoe H-S, Wang B, Cole SL, Herz J, Muglia L, Bu G (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66–78. doi:10.1016/j.neuron.2007.08.008
-
(2007)
Neuron
, vol.56
, Issue.1
, pp. 66-78
-
-
Liu, Q.1
Zerbinatti, C.V.2
Zhang, J.3
Hoe, H.-S.4
Wang, B.5
Cole, S.L.6
Herz, J.7
Muglia, L.8
Bu, G.9
-
140
-
-
5444275067
-
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
-
von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci 117(19):4435–4448. doi:10.1242/jcs.01323
-
(2004)
J Cell Sci
, vol.117
, Issue.19
, pp. 4435-4448
-
-
von Rotz, R.C.1
Kohli, B.M.2
Bosset, J.3
Meier, M.4
Suzuki, T.5
Nitsch, R.M.6
Konietzko, U.7
-
141
-
-
27544442991
-
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain
-
PID: 16230462
-
Ryan KA, Pimplikar SW (2005) Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol 171(2):327–335. doi:10.1083/jcb.200505078
-
(2005)
J Cell Biol
, vol.171
, Issue.2
, pp. 327-335
-
-
Ryan, K.A.1
Pimplikar, S.W.2
-
142
-
-
33845324145
-
C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3β expression
-
Kim H-S, Kim E-M, Lee J-P, Park CH, Kim S, Seo J-H, Chang K-A, Yu E, Jeong S-J, Chong YH, Suh Y-H (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3β expression. FASEB J 17(13):1951–1953. doi: 10.1096/fj.03-0106fje
-
(2003)
FASEB J
, vol.17
, Issue.13
, pp. 1951-1953
-
-
Kim, H.-S.1
Kim, E.-M.2
Lee, J.-P.3
Park, C.H.4
Kim, S.5
Seo, J.-H.6
Chang, K.-A.7
Yu, E.8
Jeong, S.-J.9
Chong, Y.H.10
Suh, Y.-H.11
-
143
-
-
34548699654
-
The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53
-
PID: 17908046
-
Checler F, Sunyach C, Pardossi-Piquard R, Sevalle J, Vincent B, Kawarai T, Girardot N, St George-Hyslop P, da Costa CA (2007) The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53. Curr Alzheimer Res 4(4):423–426
-
(2007)
Curr Alzheimer Res
, vol.4
, Issue.4
, pp. 423-426
-
-
Checler, F.1
Sunyach, C.2
Pardossi-Piquard, R.3
Sevalle, J.4
Vincent, B.5
Kawarai, T.6
Girardot, N.7
St George-Hyslop, P.8
da Costa, C.A.9
-
144
-
-
34547539177
-
Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression
-
Y-w Z, Wang R, Liu Q, Zhang H, Liao F-F, Xu H (2007) Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A 104(25):10613–10618. doi:10.1073/pnas.0703903104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.25
, pp. 10613-10618
-
-
Wang, R.1
Liu, Q.2
Zhang, H.3
Liao, F.-F.4
Xu, H.5
-
145
-
-
79959925796
-
The AICD interacting protein DAB1 is up-regulated in Alzheimer frontal cortex brain samples and causes deregulation of proteins involved in gene expression changes
-
PID: 21453247
-
Muller T, Loosse C, Schrotter A, Schnabel A, Helling S, Egensperger R, Marcus K (2011) The AICD interacting protein DAB1 is up-regulated in Alzheimer frontal cortex brain samples and causes deregulation of proteins involved in gene expression changes. Curr Alzheimer Res 8(5):573–582
-
(2011)
Curr Alzheimer Res
, vol.8
, Issue.5
, pp. 573-582
-
-
Muller, T.1
Loosse, C.2
Schrotter, A.3
Schnabel, A.4
Helling, S.5
Egensperger, R.6
Marcus, K.7
-
146
-
-
51349120462
-
The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis
-
PID: 18722509
-
Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H (2008) The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis. Neurosci Lett 444(2):127–131. doi:10.1016/j.neulet.2008.08.034
-
(2008)
Neurosci Lett
, vol.444
, Issue.2
, pp. 127-131
-
-
Nakayama, K.1
Ohkawara, T.2
Hiratochi, M.3
Koh, C.S.4
Nagase, H.5
-
147
-
-
0037076398
-
The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling
-
PID: 12011466
-
Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D’Adamio L (2002) The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci U S A 99(10):7102–7107. doi:10.1073/pnas.102192599
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.10
, pp. 7102-7107
-
-
Roncarati, R.1
Sestan, N.2
Scheinfeld, M.H.3
Berechid, B.E.4
Lopez, P.A.5
Meucci, O.6
McGlade, J.C.7
Rakic, P.8
D’Adamio, L.9
-
148
-
-
10744233414
-
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
-
PID: 14567914
-
Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC (2003) F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 115(2):163–175
-
(2003)
Cell
, vol.115
, Issue.2
, pp. 163-175
-
-
Hu, Q.D.1
Ang, B.T.2
Karsak, M.3
Hu, W.P.4
Cui, X.Y.5
Duka, T.6
Takeda, Y.7
Chia, W.8
Sankar, N.9
Ng, Y.K.10
Ling, E.A.11
Maciag, T.12
Small, D.13
Trifonova, R.14
Kopan, R.15
Okano, H.16
Nakafuku, M.17
Chiba, S.18
Hirai, H.19
Aster, J.C.20
Schachner, M.21
Pallen, C.J.22
Watanabe, K.23
Xiao, Z.C.24
more..
-
149
-
-
70450235497
-
Alzheimer’s disease-like pathological features in transgenic mice expressing the APP intracellular domain
-
PID: 19837693
-
Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW (2009) Alzheimer’s disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc Natl Acad Sci U S A 106(43):18367–18372. doi:10.1073/pnas.0907652106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.43
, pp. 18367-18372
-
-
Ghosal, K.1
Vogt, D.L.2
Liang, M.3
Shen, Y.4
Lamb, B.T.5
Pimplikar, S.W.6
-
150
-
-
84857720147
-
AICD nuclear signaling and its possible contribution to Alzheimer’s disease
-
PID: 21605035
-
Konietzko U (2012) AICD nuclear signaling and its possible contribution to Alzheimer’s disease. Curr Alzheimer Res 9(2):200–216
-
(2012)
Curr Alzheimer Res
, vol.9
, Issue.2
, pp. 200-216
-
-
Konietzko, U.1
-
151
-
-
0024990330
-
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides
-
PID: 2218531
-
Yankner B, Duffy L, Kirschner D (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250(4978):279–282. doi:10.1126/science.2218531
-
(1990)
Science
, vol.250
, Issue.4978
, pp. 279-282
-
-
Yankner, B.1
Duffy, L.2
Kirschner, D.3
-
152
-
-
0024543836
-
Amyloid beta protein enhances the survival of hippocampal neurons in vitro
-
PID: 2928783
-
Whitson J, Selkoe D, Cotman C (1989) Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science 243(4897):1488–1490. doi:10.1126/science.2928783
-
(1989)
Science
, vol.243
, Issue.4897
, pp. 1488-1490
-
-
Whitson, J.1
Selkoe, D.2
Cotman, C.3
-
153
-
-
60849095497
-
A[beta]40 promotes neuronal cell fate in neural progenitor cells
-
PID: 18566600
-
Chen Y, Dong C (2008) A[beta]40 promotes neuronal cell fate in neural progenitor cells. Cell Death Differ 16(3):386–394
-
(2008)
Cell Death Differ
, vol.16
, Issue.3
, pp. 386-394
-
-
Chen, Y.1
Dong, C.2
-
154
-
-
84880726942
-
Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer’s disease
-
PID: 22886436
-
Giuffrida M, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A (2012) Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer’s disease. Mol Neurobiol 46(3):605–613. doi:10.1007/s12035-012-8313-6
-
(2012)
Mol Neurobiol
, vol.46
, Issue.3
, pp. 605-613
-
-
Giuffrida, M.1
Tomasello, F.2
Caraci, F.3
Chiechio, S.4
Nicoletti, F.5
Copani, A.6
-
155
-
-
33344460074
-
Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid
-
PID: 15964102
-
Calafiore M, Battaglia G, Zappala A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A (2006) Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid. Neurobiol Aging 27(4):606–613. doi:10.1016/j.neurobiolaging.2005.03.019
-
(2006)
Neurobiol Aging
, vol.27
, Issue.4
, pp. 606-613
-
-
Calafiore, M.1
Battaglia, G.2
Zappala, A.3
Trovato-Salinaro, E.4
Caraci, F.5
Caruso, M.6
Vancheri, C.7
Sortino, M.A.8
Nicoletti, F.9
Copani, A.10
-
156
-
-
2942530513
-
Neurogenic effect of beta-amyloid peptide in the development of neural stem cells
-
PID: 15190117
-
Lopez-Toledano MA, Shelanski ML (2004) Neurogenic effect of beta-amyloid peptide in the development of neural stem cells. J Neurosci 24(23):5439–5444. doi:10.1523/JNEUROSCI. 0974-04.2004
-
(2004)
J Neurosci
, vol.24
, Issue.23
, pp. 5439-5444
-
-
Lopez-Toledano, M.A.1
Shelanski, M.L.2
-
157
-
-
67649803186
-
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer’s disease
-
PID: 19358844
-
Reddy PH (2009) Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer’s disease. Exp Neurol 218(2):286–292. doi:10.1016/j.expneurol.2009.03.042
-
(2009)
Exp Neurol
, vol.218
, Issue.2
, pp. 286-292
-
-
Reddy, P.H.1
-
158
-
-
0033401851
-
In vitro and in vivo protein oxidation induced by Alzheimer’s disease amyloid beta-peptide (1-42)
-
PID: 10672245
-
Butterfield DA, Yatin SM, Link CD (1999) In vitro and in vivo protein oxidation induced by Alzheimer’s disease amyloid beta-peptide (1-42). Ann N Y Acad Sci 893:265–268
-
(1999)
Ann N Y Acad Sci
, vol.893
, pp. 265-268
-
-
Butterfield, D.A.1
Yatin, S.M.2
Link, C.D.3
-
159
-
-
0033133579
-
In vitro and in vivo oxidative stress associated with Alzheimer’s amyloid beta-peptide (1-42)
-
PID: 10588580, discussion 339–342
-
Yatin SM, Varadarajan S, Link CD, Butterfield DA (1999) In vitro and in vivo oxidative stress associated with Alzheimer’s amyloid beta-peptide (1-42). Neurobiol Aging 20(3):325–330, discussion 339–342
-
(1999)
Neurobiol Aging
, vol.20
, Issue.3
, pp. 325-330
-
-
Yatin, S.M.1
Varadarajan, S.2
Link, C.D.3
Butterfield, D.A.4
-
160
-
-
0032429784
-
Temporal relations among amyloid beta-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses
-
PID: 10344789
-
Yatin SM, Aksenova M, Aksenov M, Markesbery WR, Aulick T, Butterfield DA (1998) Temporal relations among amyloid beta-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses. J Mol Neurosci 11(3):183–197. doi:10.1385/JMN:11:3:183
-
(1998)
J Mol Neurosci
, vol.11
, Issue.3
, pp. 183-197
-
-
Yatin, S.M.1
Aksenova, M.2
Aksenov, M.3
Markesbery, W.R.4
Aulick, T.5
Butterfield, D.A.6
-
161
-
-
33646461282
-
β-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
PID: 16624948
-
Almeida CG, Takahashi RH, Gouras GK (2006) β-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26(16):4277–4288. doi:10.1523/jneurosci. 5078-05.2006
-
(2006)
J Neurosci
, vol.26
, Issue.16
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
162
-
-
0028986916
-
β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding
-
PID: 7718249
-
Busciglio J, Lorenzo A, Yeh J, Yankner BA (1995) β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14(4):879–888. doi:10.1016/0896-6273(95)90232-5
-
(1995)
Neuron
, vol.14
, Issue.4
, pp. 879-888
-
-
Busciglio, J.1
Lorenzo, A.2
Yeh, J.3
Yankner, B.A.4
-
163
-
-
77956587739
-
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
-
PID: 20826658
-
Zempel H, Thies E, Mandelkow E, Mandelkow EM (2010) Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci 30(36):11938–11950. doi:10.1523/jneurosci. 2357-10.2010
-
(2010)
J Neurosci
, vol.30
, Issue.36
, pp. 11938-11950
-
-
Zempel, H.1
Thies, E.2
Mandelkow, E.3
Mandelkow, E.M.4
-
164
-
-
0035194145
-
Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid β-peptide
-
PID: 11733217
-
Butterfield DA, Drake J, Pocernich C, Castegna A (2001) Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid β-peptide. Trends Mol Med 7(12):548–554. doi:10.1016/S1471-4914(01)02173-6
-
(2001)
Trends Mol Med
, vol.7
, Issue.12
, pp. 548-554
-
-
Butterfield, D.A.1
Drake, J.2
Pocernich, C.3
Castegna, A.4
-
165
-
-
79955064557
-
Oxidative stress and cell membranes in the pathogenesis of Alzheimer’s disease
-
PID: 21357903
-
Axelsen PH, Komatsu H, Murray IVJ (2011) Oxidative stress and cell membranes in the pathogenesis of Alzheimer’s disease. Physiology 26(1):54–69. doi:10.1152/physiol.00024.2010
-
(2011)
Physiology
, vol.26
, Issue.1
, pp. 54-69
-
-
Axelsen, P.H.1
Komatsu, H.2
Murray, I.V.J.3
-
166
-
-
71549144988
-
Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities
-
PID: 19624272
-
Adibhatla RM, Hatcher JF (2010) Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 12(1):125–169. doi:10.1089/ars.2009.2668
-
(2010)
Antioxid Redox Signal
, vol.12
, Issue.1
, pp. 125-169
-
-
Adibhatla, R.M.1
Hatcher, J.F.2
-
167
-
-
84865254323
-
Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis
-
PID: 22827877
-
Rauchova H, Vokurkova M, Koudelova J (2012) Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis. Physiol Res 61(Suppl 1):S89–S101
-
(2012)
Physiol Res
, vol.61
, pp. S89-S101
-
-
Rauchova, H.1
Vokurkova, M.2
Koudelova, J.3
-
168
-
-
84946148242
-
Brain tissue oxygen monitoring in neurocritical care
-
PID: 24710714
-
De Georgia MA (2014) Brain tissue oxygen monitoring in neurocritical care. J Intensive Care Med. doi:10.1177/0885066614529254
-
(2014)
J Intensive Care Med
-
-
De Georgia, M.A.1
-
169
-
-
84905923659
-
Link between oxidative stress and acute brain ischemia
-
PID: 24132856
-
Radak D, Resanovic I, Isenovic ER (2014) Link between oxidative stress and acute brain ischemia. Angiology 65(8):667–676. doi:10.1177/0003319713506516
-
(2014)
Angiology
, vol.65
, Issue.8
, pp. 667-676
-
-
Radak, D.1
Resanovic, I.2
Isenovic, E.R.3
-
170
-
-
84882759058
-
Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities
-
PID: 23469845
-
Rodrigo R, Fernandez-Gajardo R, Gutierrez R, Matamala JM, Carrasco R, Miranda-Merchak A, Feuerhake W (2013) Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord Drug Targets 12(5):698–714
-
(2013)
CNS Neurol Disord Drug Targets
, vol.12
, Issue.5
, pp. 698-714
-
-
Rodrigo, R.1
Fernandez-Gajardo, R.2
Gutierrez, R.3
Matamala, J.M.4
Carrasco, R.5
Miranda-Merchak, A.6
Feuerhake, W.7
-
171
-
-
0031981072
-
Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress
-
PID: 9572310
-
Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PLR, Siedlak SL, Tabaton M, Perry G (1998) Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem 70(5):2212–2215. doi:10.1046/j.1471-4159.1998.70052212.x
-
(1998)
J Neurochem
, vol.70
, Issue.5
, pp. 2212-2215
-
-
Smith, M.A.1
Hirai, K.2
Hsiao, K.3
Pappolla, M.A.4
Harris, P.L.R.5
Siedlak, S.L.6
Tabaton, M.7
Perry, G.8
-
172
-
-
84877338411
-
Rapid cell death is preceded by amyloid plaque-mediated oxidative stress
-
PID: 23610434
-
Xie H, Hou S, Jiang J, Sekutowicz M, Kelly J, Bacskai BJ (2013) Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proc Natl Acad Sci U S A 110(19):7904–7909. doi:10.1073/pnas.1217938110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.19
, pp. 7904-7909
-
-
Xie, H.1
Hou, S.2
Jiang, J.3
Sekutowicz, M.4
Kelly, J.5
Bacskai, B.J.6
-
173
-
-
0028233494
-
Hydrogen peroxide mediates amyloid β protein toxicity
-
PID: 8004671
-
Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77(6):817–827. doi:10.1016/0092-8674(94)90131-7
-
(1994)
Cell
, vol.77
, Issue.6
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
174
-
-
0035178803
-
Amyloid-β is an antioxidant for lipoproteins in cerebrospinal fluid and plasma
-
PID: 11134902
-
Kontush A, Berndt C, Weber W, Akopyan V, Arlt S, Schippling S, Beisiegel U (2001) Amyloid-β is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. Free Radic Biol Med 30(1):119–128. doi:10.1016/S0891-5849(00)00458-5
-
(2001)
Free Radic Biol Med
, vol.30
, Issue.1
, pp. 119-128
-
-
Kontush, A.1
Berndt, C.2
Weber, W.3
Akopyan, V.4
Arlt, S.5
Schippling, S.6
Beisiegel, U.7
-
175
-
-
0035209719
-
Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-β content
-
PID: 11767409
-
Kontush A, Donarski N, Beisiegel U (2001) Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-β content. Free Radic Res 35(5):507–517. doi:10.1080/10715760100301521
-
(2001)
Free Radic Res
, vol.35
, Issue.5
, pp. 507-517
-
-
Kontush, A.1
Donarski, N.2
Beisiegel, U.3
-
176
-
-
0037096251
-
A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage
-
PID: 12077180
-
Zou K, Gong JS, Yanagisawa K, Michikawa M (2002) A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci 22(12):4833–4841
-
(2002)
J Neurosci
, vol.22
, Issue.12
, pp. 4833-4841
-
-
Zou, K.1
Gong, J.S.2
Yanagisawa, K.3
Michikawa, M.4
-
177
-
-
0036829434
-
Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain
-
PID: 12398927
-
Smith MA, Casadesus G, Joseph JA, Perry G (2002) Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med 33(9):1194–1199. doi:10.1016/S0891-5849(02)01021-3
-
(2002)
Free Radic Biol Med
, vol.33
, Issue.9
, pp. 1194-1199
-
-
Smith, M.A.1
Casadesus, G.2
Joseph, J.A.3
Perry, G.4
-
178
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer’s disease
-
PID: 9165306
-
Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer’s disease. Free Radic Biol Med 23(1):134–147. doi:10.1016/S0891-5849(96)00629-6
-
(1997)
Free Radic Biol Med
, vol.23
, Issue.1
, pp. 134-147
-
-
Markesbery, W.R.1
-
179
-
-
84862842525
-
Alzheimer’s disease and amyloid: culprit or coincidence
-
PID: 22748834
-
Skaper SD (2012) Alzheimer’s disease and amyloid: culprit or coincidence. Int Rev Neurobiol 102:277–316
-
(2012)
Int Rev Neurobiol
, vol.102
, pp. 277-316
-
-
Skaper, S.D.1
-
180
-
-
33846101613
-
Filling the gaps in the a cascade hypothesis of Alzheimer’s disease
-
PID: 17168641
-
Golde TE, Dickson D, Hutton M (2006) Filling the gaps in the a cascade hypothesis of Alzheimer’s disease. Curr Alzheimer Res 3(5):421–430
-
(2006)
Curr Alzheimer Res
, vol.3
, Issue.5
, pp. 421-430
-
-
Golde, T.E.1
Dickson, D.2
Hutton, M.3
-
181
-
-
84899639780
-
The amyloid hypothesis, time to move on: amyloid is the downstream result, not cause, of Alzheimer’s disease
-
PID: 24589433
-
Drachman DA (2014) The amyloid hypothesis, time to move on: amyloid is the downstream result, not cause, of Alzheimer’s disease. Alzheimers Dement 10(3):372–380
-
(2014)
Alzheimers Dement
, vol.10
, Issue.3
, pp. 372-380
-
-
Drachman, D.A.1
-
182
-
-
85005781374
-
The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer’s disease
-
PID: 24252346
-
Krstic D, Knuesel I (2013) The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer’s disease. Acta Neuropathol Commun 1(1):62. doi:10.1186/2051-5960-1-62
-
(2013)
Acta Neuropathol Commun
, vol.1
, Issue.1
, pp. 62
-
-
Krstic, D.1
Knuesel, I.2
-
183
-
-
84860214055
-
Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton
-
PID: 22156588
-
Zempel H, Mandelkow E-M (2011) Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton. Neurodegener Dis 10(1–4):64–72
-
(2011)
Neurodegener Dis
, vol.10
, Issue.1-4
, pp. 64-72
-
-
Zempel, H.1
Mandelkow, E.-M.2
-
184
-
-
84887828122
-
Amyloid-beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin
-
PID: 24065130
-
Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, Mandelkow EM (2013) Amyloid-beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J 32(22):2920–2937. doi:10.1038/emboj.2013.207
-
(2013)
EMBO J
, vol.32
, Issue.22
, pp. 2920-2937
-
-
Zempel, H.1
Luedtke, J.2
Kumar, Y.3
Biernat, J.4
Dawson, H.5
Mandelkow, E.6
Mandelkow, E.M.7
-
185
-
-
0030879686
-
Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ
-
PID: 9245504
-
Ferreira A, Lu Q, Orecchio L, Kosik KS (1997) Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ. Mol Cell Neurosci 9(3):220–234. doi:10.1006/mcne.1997.0615
-
(1997)
Mol Cell Neurosci
, vol.9
, Issue.3
, pp. 220-234
-
-
Ferreira, A.1
Lu, Q.2
Orecchio, L.3
Kosik, K.S.4
-
186
-
-
84857676337
-
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
-
PID: 22156579
-
Yu W, Polepalli J, Wagh D, Rajadas J, Malenka R, Lu B (2012) A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Hum Mol Genet 21(6):1384–1390
-
(2012)
Hum Mol Genet
, vol.21
, Issue.6
, pp. 1384-1390
-
-
Yu, W.1
Polepalli, J.2
Wagh, D.3
Rajadas, J.4
Malenka, R.5
Lu, B.6
-
187
-
-
84876078566
-
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through tau phosphorylation
-
PID: 23583109
-
Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F (2013) The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through tau phosphorylation. Neuron 78(1):94–108
-
(2013)
Neuron
, vol.78
, Issue.1
, pp. 94-108
-
-
Mairet-Coello, G.1
Courchet, J.2
Pieraut, S.3
Courchet, V.4
Maximov, A.5
Polleux, F.6
-
188
-
-
0037110601
-
Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures
-
PID: 12401334
-
Zheng W-H, Bastianetto S, Mennicken F, Ma W, Kar S (2002) Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience 115(1):201–211
-
(2002)
Neuroscience
, vol.115
, Issue.1
, pp. 201-211
-
-
Zheng, W.-H.1
Bastianetto, S.2
Mennicken, F.3
Ma, W.4
Kar, S.5
-
189
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
PID: 11520987
-
Lewis J, Dickson DW, Lin W-L, Chisholm L, Corral A, Jones G, Yen S-H, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293(5534):1487–1491. doi:10.1126/science.1058189
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.-L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.-H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
190
-
-
0003374626
-
Tau protein pathology in neurodegenerative diseases
-
PID: 9786340
-
Spillantini MG, Goedert M (1998) Tau protein pathology in neurodegenerative diseases. Trends Neurosci 21(10):428–433. doi:10.1016/S0166-2236(98)01337-X
-
(1998)
Trends Neurosci
, vol.21
, Issue.10
, pp. 428-433
-
-
Spillantini, M.G.1
Goedert, M.2
-
191
-
-
0032211829
-
Tau in Alzheimer’s disease
-
PID: 9854307
-
Mandelkow E-M, Mandelkow E (1998) Tau in Alzheimer’s disease. Trends Cell Biol 8(11):425–427. doi:10.1016/S0962-8924(98)01368-3
-
(1998)
Trends Cell Biol
, vol.8
, Issue.11
, pp. 425-427
-
-
Mandelkow, E.-M.1
Mandelkow, E.2
-
192
-
-
0033142961
-
Review: tau protein pathology in Alzheimer’s disease and related disorders
-
PID: 10417659
-
Tolnay P (1999) Review: tau protein pathology in Alzheimer’s disease and related disorders. Neuropathol Appl Neurobiol 25(3):171–187. doi:10.1046/j.1365-2990.1999.00182.x
-
(1999)
Neuropathol Appl Neurobiol
, vol.25
, Issue.3
, pp. 171-187
-
-
Tolnay, P.1
-
193
-
-
10944241542
-
Tau alteration and neuronal degeneration in tauopathies: mechanisms and models
-
Brandt R, Hundelt M, Shahani N (2005) Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochim Biophys Acta (BBA)-Mol Basis Dis 1739(2):331–354
-
(2005)
Biochim Biophys Acta (BBA)-Mol Basis Dis
, vol.1739
, Issue.2
, pp. 331-354
-
-
Brandt, R.1
Hundelt, M.2
Shahani, N.3
-
194
-
-
60049091402
-
Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
-
PID: 19364361
-
Ludolph A, Kassubek J, Landwehrmeyer B, Mandelkow E, Mandelkow EM, Burn D, Caparros‐Lefebvre D, Frey K, De Yebenes J, Gasser T (2009) Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur J Neurol 16(3):297–309
-
(2009)
Eur J Neurol
, vol.16
, Issue.3
, pp. 297-309
-
-
Ludolph, A.1
Kassubek, J.2
Landwehrmeyer, B.3
Mandelkow, E.4
Mandelkow, E.M.5
Burn, D.6
Caparros‐Lefebvre, D.7
Frey, K.8
De Yebenes, J.9
Gasser, T.10
-
195
-
-
0020605726
-
Antibodies to paired helical filaments in Alzheimer’s disease do not recognize normal brain proteins
-
PID: 6350889
-
Ihara Y, Abraham C, Selkoe DJ (1983) Antibodies to paired helical filaments in Alzheimer’s disease do not recognize normal brain proteins. Nature 304(5928):727–730
-
(1983)
Nature
, vol.304
, Issue.5928
, pp. 727-730
-
-
Ihara, Y.1
Abraham, C.2
Selkoe, D.J.3
-
196
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
PID: 3084478
-
Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM (1986) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261(13):6084–6089
-
(1986)
J Biol Chem
, vol.261
, Issue.13
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
197
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
PID: 3088567
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83(13):4913–4917
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, Issue.13
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
198
-
-
0017649032
-
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
-
PID: 599557
-
Cleveland DW, Hwo S-Y, Kirschner MW (1977) Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 116(2):207–225
-
(1977)
J Mol Biol
, vol.116
, Issue.2
, pp. 207-225
-
-
Cleveland, D.W.1
Hwo, S.-Y.2
Kirschner, M.W.3
-
199
-
-
0008538685
-
A protein factor essential for microtubule assembly
-
PID: 1057175
-
Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A 72(5):1858–1862
-
(1975)
Proc Natl Acad Sci U S A
, vol.72
, Issue.5
, pp. 1858-1862
-
-
Weingarten, M.D.1
Lockwood, A.H.2
Hwo, S.Y.3
Kirschner, M.W.4
-
200
-
-
0017193352
-
Tubulin requires tau for growth onto microtubule initiating sites
-
PID: 1069293
-
Witman GB, Cleveland DW, Weingarten MD, Kirschner MW (1976) Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A 73(11):4070–4074
-
(1976)
Proc Natl Acad Sci U S A
, vol.73
, Issue.11
, pp. 4070-4074
-
-
Witman, G.B.1
Cleveland, D.W.2
Weingarten, M.D.3
Kirschner, M.W.4
-
201
-
-
0027936669
-
Diverse distribution and function of fibrous microtubule-associated proteins in the nervous system
-
PID: 7912236
-
Schoenfeld TA, Obar RA (1994) Diverse distribution and function of fibrous microtubule-associated proteins in the nervous system. Int Rev Cytol 151:67–137
-
(1994)
Int Rev Cytol
, vol.151
, pp. 67-137
-
-
Schoenfeld, T.A.1
Obar, R.A.2
-
202
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
PID: 10967355
-
Buée L, Bussière T, Buée-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 33(1):95–130. doi:10.1016/S0165-0173(00)00019-9
-
(2000)
Brain Res Rev
, vol.33
, Issue.1
, pp. 95-130
-
-
Buée, L.1
Bussière, T.2
Buée-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
203
-
-
0022365608
-
The distribution of tau in the mammalian central nervous system
-
PID: 3930508
-
Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101(4):1371–1378. doi:10.1083/jcb.101.4.1371
-
(1985)
J Cell Biol
, vol.101
, Issue.4
, pp. 1371-1378
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
204
-
-
0037085947
-
Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity
-
PID: 11891784
-
González-Billault C, Engelke M, Jiménez-Mateos EM, Wandosell F, Cáceres A, Avila J (2002) Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res 67(6):713–719. doi:10.1002/jnr.10161
-
(2002)
J Neurosci Res
, vol.67
, Issue.6
, pp. 713-719
-
-
González-Billault, C.1
Engelke, M.2
Jiménez-Mateos, E.M.3
Wandosell, F.4
Cáceres, A.5
Avila, J.6
-
205
-
-
0026713275
-
Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation
-
PID: 1389180
-
Caceres A, Mautino J, Kosik KS (1992) Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron 9(4):607–618. doi:10.1016/0896-6273(92)90025-9
-
(1992)
Neuron
, vol.9
, Issue.4
, pp. 607-618
-
-
Caceres, A.1
Mautino, J.2
Kosik, K.S.3
-
206
-
-
0032976176
-
Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons
-
PID: 10401579
-
Liu C-wA, Lee G, Jay DG (1999) Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons. Cell Motil Cytoskeleton 43(3):232–242. doi:10.1002/(SICI)1097-0169(1999)43:3<232::AID-CM6>3.0.CO;2-7
-
(1999)
Cell Motil Cytoskeleton
, vol.43
, Issue.3
, pp. 232-242
-
-
Liu, C.-W.A.1
Lee, G.2
Jay, D.G.3
-
207
-
-
0029812945
-
Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner
-
PID: 8795614
-
Kempf M, Clement A, Faissner A, Lee G, Brandt R (1996) Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci 16(18):5583–5592
-
(1996)
J Neurosci
, vol.16
, Issue.18
, pp. 5583-5592
-
-
Kempf, M.1
Clement, A.2
Faissner, A.3
Lee, G.4
Brandt, R.5
-
208
-
-
0032476645
-
Overexpression of Tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer’s disease
-
PID: 9813097
-
Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E-M, Mandelkow E (1998) Overexpression of Tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer’s disease. J Cell Biol 143(3):777–794. doi:10.1083/jcb.143.3.777
-
(1998)
J Cell Biol
, vol.143
, Issue.3
, pp. 777-794
-
-
Ebneth, A.1
Godemann, R.2
Stamer, K.3
Illenberger, S.4
Trinczek, B.5
Mandelkow, E.-M.6
Mandelkow, E.7
-
209
-
-
0036047004
-
Axonal transport, tau protein, and neurodegeneration in Alzheimer’s disease
-
Terwel D, Dewachter I, Van Leuven F (2002) Axonal transport, tau protein, and neurodegeneration in Alzheimer’s disease. Neuromol Med 2(2):151–165. doi:10.1385/NMM:2:2:151
-
(2002)
Neuromol Med
, vol.2
, Issue.2
, pp. 151-165
-
-
Terwel, D.1
Dewachter, I.2
Van Leuven, F.3
-
210
-
-
84879796952
-
Axonal degeneration in Alzheimer’s disease: when signaling abnormalities meet the axonal transport system
-
PID: 22721767
-
Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA (2013) Axonal degeneration in Alzheimer’s disease: when signaling abnormalities meet the axonal transport system. Exp Neurol 246:44–53. doi:10.1016/j.expneurol.2012.06.003
-
(2013)
Exp Neurol
, vol.246
, pp. 44-53
-
-
Kanaan, N.M.1
Pigino, G.F.2
Brady, S.T.3
Lazarov, O.4
Binder, L.I.5
Morfini, G.A.6
-
211
-
-
70350455072
-
Axonal transport defects in neurodegenerative diseases
-
PID: 19828789
-
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave K-A, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST (2009) Axonal transport defects in neurodegenerative diseases. J Neurosci 29(41):12776–12786. doi:10.1523/jneurosci. 3463-09.2009
-
(2009)
J Neurosci
, vol.29
, Issue.41
, pp. 12776-12786
-
-
Morfini, G.A.1
Burns, M.2
Binder, L.I.3
Kanaan, N.M.4
LaPointe, N.5
Bosco, D.A.6
Brown, R.H.7
Brown, H.8
Tiwari, A.9
Hayward, L.10
Edgar, J.11
Nave, K.-A.12
Garberrn, J.13
Atagi, Y.14
Song, Y.15
Pigino, G.16
Brady, S.T.17
-
212
-
-
48249102303
-
Role of axonal transport in neurodegenerative diseases
-
PID: 18558852
-
De Vos KJ, Grierson AJ, Ackerley S, Miller CCJ (2008) Role of axonal transport in neurodegenerative diseases. Annu Rev Neurosci 31(1):151–173. doi:10.1146/annurev.neuro.31.061307.090711
-
(2008)
Annu Rev Neurosci
, vol.31
, Issue.1
, pp. 151-173
-
-
De Vos, K.J.1
Grierson, A.J.2
Ackerley, S.3
Miller, C.C.J.4
-
213
-
-
0024094998
-
Tau proteins: the molecular structure and mode of binding on microtubules
-
PID: 3139677
-
Hirokawa N, Shiomura Y, Okabe S (1988) Tau proteins: the molecular structure and mode of binding on microtubules. J Cell Biol 107(4):1449–1459
-
(1988)
J Cell Biol
, vol.107
, Issue.4
, pp. 1449-1459
-
-
Hirokawa, N.1
Shiomura, Y.2
Okabe, S.3
-
214
-
-
1642289188
-
Role of tau protein in both physiological and pathological conditions
-
PID: 15044677
-
Avila J, Lucas JJ, Perez M, Hernandez F (2004) Role of tau protein in both physiological and pathological conditions. Physiol Rev 84(2):361–384. doi:10.1152/physrev.00024.2003
-
(2004)
Physiol Rev
, vol.84
, Issue.2
, pp. 361-384
-
-
Avila, J.1
Lucas, J.J.2
Perez, M.3
Hernandez, F.4
-
215
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease
-
PID: 2484340
-
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron 3(4):519–526. doi:10.1016/0896-6273(89)90210-9
-
(1989)
Neuron
, vol.3
, Issue.4
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
216
-
-
0026595846
-
Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms
-
PID: 1530909
-
Goedert M, Spillantini MG, Cairns NJ, Crowther RA (1992) Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8(1):159–168. doi:10.1016/0896-6273(92)90117-V
-
(1992)
Neuron
, vol.8
, Issue.1
, pp. 159-168
-
-
Goedert, M.1
Spillantini, M.G.2
Cairns, N.J.3
Crowther, R.A.4
-
217
-
-
33745140951
-
Tau phosphorylation and aggregation in Alzheimer’s disease pathology
-
PID: 16529745
-
Avila J (2006) Tau phosphorylation and aggregation in Alzheimer’s disease pathology. FEBS Lett 580(12):2922–2927. doi:10.1016/j.febslet.2006.02.067
-
(2006)
FEBS Lett
, vol.580
, Issue.12
, pp. 2922-2927
-
-
Avila, J.1
-
218
-
-
25844458239
-
Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer’s disease and tauopathies
-
Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribe E, Dalfo E, Avila J (2005) Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer’s disease and tauopathies. Curr Alzheimers Res 2(1):3–18
-
(2005)
Curr Alzheimers Res
, vol.2
, Issue.1
, pp. 3-18
-
-
Ferrer, I.1
Gomez-Isla, T.2
Puig, B.3
Freixes, M.4
Ribe, E.5
Dalfo, E.6
Avila, J.7
-
219
-
-
55249086251
-
Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease
-
PID: 18855662
-
Gong CX, Iqbal K (2008) Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Curr Med Chem 15(23):2321–2328
-
(2008)
Curr Med Chem
, vol.15
, Issue.23
, pp. 2321-2328
-
-
Gong, C.X.1
Iqbal, K.2
-
220
-
-
84890445848
-
Phosphorylation of human tau protein by microtubule affinity-regulating kinase 2
-
Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E, Zweckstetter M (2013) Phosphorylation of human tau protein by microtubule affinity-regulating kinase 2. Biochemistry (Mosc) 52(50):9068–9079. doi:10.1021/bi401266n
-
(2013)
Biochemistry (Mosc)
, vol.52
, Issue.50
, pp. 9068-9079
-
-
Schwalbe, M.1
Biernat, J.2
Bibow, S.3
Ozenne, V.4
Jensen, M.R.5
Kadavath, H.6
Blackledge, M.7
Mandelkow, E.8
Zweckstetter, M.9
-
221
-
-
0026549985
-
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state
-
PID: 1376245
-
Drewes G, Lichtenberg-Kraag B, Doring F, Mandelkow EM, Biernat J, Goris J, Doree M, Mandelkow E (1992) Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J 11(6):2131–2138
-
(1992)
EMBO J
, vol.11
, Issue.6
, pp. 2131-2138
-
-
Drewes, G.1
Lichtenberg-Kraag, B.2
Doring, F.3
Mandelkow, E.M.4
Biernat, J.5
Goris, J.6
Doree, M.7
Mandelkow, E.8
-
222
-
-
0026619584
-
Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau
-
PID: 1334849
-
Mandelkow EM, Drewes G, Biernat J, Gustke N, Van Lint J, Vandenheede JR, Mandelkow E (1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett 314(3):315–321
-
(1992)
FEBS Lett
, vol.314
, Issue.3
, pp. 315-321
-
-
Mandelkow, E.M.1
Drewes, G.2
Biernat, J.3
Gustke, N.4
Van Lint, J.5
Vandenheede, J.R.6
Mandelkow, E.7
-
223
-
-
77951251848
-
Calcium signaling and amyloid toxicity in Alzheimer disease
-
PID: 20212036
-
Demuro A, Parker I, Stutzmann GE (2010) Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem 285(17):12463–12468. doi:10.1074/jbc.R109.080895
-
(2010)
J Biol Chem
, vol.285
, Issue.17
, pp. 12463-12468
-
-
Demuro, A.1
Parker, I.2
Stutzmann, G.E.3
-
224
-
-
2342468029
-
Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity
-
PID: 15090032
-
Lin K-F, Chang RC-C, Suen K-C, So K-F, Hugon J (2004) Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity. Eur J Neurosci 19(8):2047–2055. doi:10.1111/j.0953-816X.2004.03245.x
-
(2004)
Eur J Neurosci
, vol.19
, Issue.8
, pp. 2047-2055
-
-
Lin, K.-F.1
Chang, R.C.-C.2
Suen, K.-C.3
So, K.-F.4
Hugon, J.5
-
225
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease—is this type 3 diabetes?
-
PID: 15750215
-
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease—is this type 3 diabetes? J Alzheimers Dis 7(1):63–80
-
(2005)
J Alzheimers Dis
, vol.7
, Issue.1
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
de la Monte, S.M.9
-
226
-
-
79952449386
-
Insulin-resistant brain state: the culprit in sporadic Alzheimer’s disease?
-
PID: 21262392
-
Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA (2011) Insulin-resistant brain state: the culprit in sporadic Alzheimer’s disease? Ageing Res Rev 10(2):264–273. doi:10.1016/j.arr.2011.01.001
-
(2011)
Ageing Res Rev
, vol.10
, Issue.2
, pp. 264-273
-
-
Correia, S.C.1
Santos, R.X.2
Perry, G.3
Zhu, X.4
Moreira, P.I.5
Smith, M.A.6
-
227
-
-
0035577767
-
Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?
-
PID: 11746411
-
Blass JP (2001) Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? J Neurosci Res 66(5):851–856. doi:10.1002/jnr.10087
-
(2001)
J Neurosci Res
, vol.66
, Issue.5
, pp. 851-856
-
-
Blass, J.P.1
-
228
-
-
0021338217
-
Phosphorylation affects the ability of tau protein to promote microtubule assembly
-
PID: 6425287
-
Lindwall G, Cole RD (1984) Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem 259(8):5301–5305
-
(1984)
J Biol Chem
, vol.259
, Issue.8
, pp. 5301-5305
-
-
Lindwall, G.1
Cole, R.D.2
-
229
-
-
0026683725
-
The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs
-
PID: 1644173
-
Gustke N, Steiner B, Mandelkow EM, Biernat J, Meyer HE, Goedert M, Mandelkow E (1992) The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. FEBS Lett 307(2):199–205
-
(1992)
FEBS Lett
, vol.307
, Issue.2
, pp. 199-205
-
-
Gustke, N.1
Steiner, B.2
Mandelkow, E.M.3
Biernat, J.4
Meyer, H.E.5
Goedert, M.6
Mandelkow, E.7
-
230
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
PID: 16262633
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22(8):1942–1950. doi:10.1111/j.1460-9568.2005.04391.x
-
(2005)
Eur J Neurosci
, vol.22
, Issue.8
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
231
-
-
0033548661
-
Deamidation and isoaspartate formation in smeared tau in paired helical filaments: unusual properties of the microtubule-binding domain of tau
-
PID: 10066801
-
Watanabe A, Takio K, Ihara Y (1999) Deamidation and isoaspartate formation in smeared tau in paired helical filaments: unusual properties of the microtubule-binding domain of tau. J Biol Chem 274(11):7368–7378. doi:10.1074/jbc.274.11.7368
-
(1999)
J Biol Chem
, vol.274
, Issue.11
, pp. 7368-7378
-
-
Watanabe, A.1
Takio, K.2
Ihara, Y.3
-
232
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
PID: 20869593
-
Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67(6):953–966. doi:10.1016/j.neuron.2010.08.044
-
(2010)
Neuron
, vol.67
, Issue.6
, pp. 953-966
-
-
Min, S.-W.1
Cho, S.-H.2
Zhou, Y.3
Schroeder, S.4
Haroutunian, V.5
Seeley, W.W.6
Huang, E.J.7
Shen, Y.8
Masliah, E.9
Mukherjee, C.10
Meyers, D.11
Cole, P.A.12
Ott, M.13
Gan, L.14
-
233
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
PID: 21427723
-
Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VMY (2011) The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun 2:252. doi:10.1038/ncomms1255
-
(2011)
Nat Commun
, vol.2
, pp. 252
-
-
Cohen, T.J.1
Guo, J.L.2
Hurtado, D.E.3
Kwong, L.K.4
Mills, I.P.5
Trojanowski, J.Q.6
Lee, V.M.Y.7
-
234
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
PID: 17304350
-
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L (2007) The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 117(3):648–658. doi:10.1172/JCI29715
-
(2007)
J Clin Invest
, vol.117
, Issue.3
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
Patterson, C.11
Dickson, D.W.12
Nahman, N.S.13
Hutton, M.14
Burrows, F.15
Petrucelli, L.16
-
235
-
-
0036803243
-
Intrinsically unstructured proteins
-
PID: 12368089
-
Tompa P (2002) Intrinsically unstructured proteins. Trends Biochem Sci 27(10):527–533. doi:10.1016/S0968-0004(02)02169-2
-
(2002)
Trends Biochem Sci
, vol.27
, Issue.10
, pp. 527-533
-
-
Tompa, P.1
-
236
-
-
48249097986
-
Intrinsically disordered proteins in human diseases: introducing the D2 concept
-
PID: 18573080
-
Uversky VN, Oldfield CJ, Dunker AK (2008) Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys 37(1):215–246. doi:10.1146/annurev.biophys.37.032807.125924
-
(2008)
Annu Rev Biophys
, vol.37
, Issue.1
, pp. 215-246
-
-
Uversky, V.N.1
Oldfield, C.J.2
Dunker, A.K.3
-
237
-
-
33845524844
-
Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis
-
Skrabana R, Sevcik J, Novak M (2006) Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis. Cell Mol Neurobiol 26(7–8):1083–1095. doi:10.1007/s10571-006-9083-3
-
(2006)
Cell Mol Neurobiol
, vol.26
, Issue.7-8
, pp. 1083-1095
-
-
Skrabana, R.1
Sevcik, J.2
Novak, M.3
-
238
-
-
14644435825
-
Intrinsically unstructured proteins and their functions
-
PID: 15738986
-
Dyson HJ, Wright PE (2005) Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 6(3):197–208
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, Issue.3
, pp. 197-208
-
-
Dyson, H.J.1
Wright, P.E.2
-
239
-
-
77954992237
-
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept
-
PID: 20653509
-
Uversky VN (2010) Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept. Expert Rev Proteomics 7(4):543–564. doi:10.1586/epr.10.36
-
(2010)
Expert Rev Proteomics
, vol.7
, Issue.4
, pp. 543-564
-
-
Uversky, V.N.1
-
240
-
-
84885484356
-
Prion-like properties of pathological TDP-43 aggregates from diseased brains
-
PID: 23831027
-
Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M (2013) Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep 4(1):124–134. doi:10.1016/j.celrep.2013.06.007
-
(2013)
Cell Rep
, vol.4
, Issue.1
, pp. 124-134
-
-
Nonaka, T.1
Masuda-Suzukake, M.2
Arai, T.3
Hasegawa, Y.4
Akatsu, H.5
Obi, T.6
Yoshida, M.7
Murayama, S.8
Mann, D.M.9
Akiyama, H.10
Hasegawa, M.11
-
241
-
-
84873314088
-
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA
-
PID: 23255347
-
Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K (2013) Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med 5(2):221–234. doi:10.1002/emmm.201202303
-
(2013)
EMBO Mol Med
, vol.5
, Issue.2
, pp. 221-234
-
-
Tsuiji, H.1
Iguchi, Y.2
Furuya, A.3
Kataoka, A.4
Hatsuta, H.5
Atsuta, N.6
Tanaka, F.7
Hashizume, Y.8
Akatsu, H.9
Murayama, S.10
Sobue, G.11
Yamanaka, K.12
-
242
-
-
69149098707
-
Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation
-
PID: 19622727
-
Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M (2009) Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Sci U S A 106(31):12926–12931. doi:10.1073/pnas.0903200106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.31
, pp. 12926-12931
-
-
Eisele, Y.S.1
Bolmont, T.2
Heikenwalder, M.3
Langer, F.4
Jacobson, L.H.5
Yan, Z.X.6
Roth, K.7
Aguzzi, A.8
Staufenbiel, M.9
Walker, L.C.10
Jucker, M.11
-
243
-
-
80054010366
-
Soluble Abeta seeds are potent inducers of cerebral beta-amyloid deposition
-
PID: 21994365
-
Langer F, Eisele YS, Fritschi SK, Staufenbiel M, Walker LC, Jucker M (2011) Soluble Abeta seeds are potent inducers of cerebral beta-amyloid deposition. J Neurosci 31(41):14488–14495. doi:10.1523/JNEUROSCI. 3088-11.2011
-
(2011)
J Neurosci
, vol.31
, Issue.41
, pp. 14488-14495
-
-
Langer, F.1
Eisele, Y.S.2
Fritschi, S.K.3
Staufenbiel, M.4
Walker, L.C.5
Jucker, M.6
-
244
-
-
77949848854
-
Prion-like transmission of protein aggregates in neurodegenerative diseases
-
PID: 20308987
-
Brundin P, Melki R, Kopito R (2010) Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 11(4):301–307. doi:10.1038/nrm2873
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, Issue.4
, pp. 301-307
-
-
Brundin, P.1
Melki, R.2
Kopito, R.3
-
245
-
-
84883688262
-
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
-
PID: 24005412
-
Jucker M, Walker LC (2013) Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 501(7465):45–51. doi:10.1038/nature12481
-
(2013)
Nature
, vol.501
, Issue.7465
, pp. 45-51
-
-
Jucker, M.1
Walker, L.C.2
-
246
-
-
79958110883
-
Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?
-
PID: 21516512
-
Braak H, Del Tredici K (2011) Alzheimer’s pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathol 121(5):589–595. doi:10.1007/s00401-011-0825-z
-
(2011)
Acta Neuropathol
, vol.121
, Issue.5
, pp. 589-595
-
-
Braak, H.1
Del Tredici, K.2
-
247
-
-
78649907008
-
Cell-to-cell transmission of non-prion protein aggregates
-
PID: 21045796
-
Lee S-J, Desplats P, Sigurdson C, Tsigelny I, Masliah E (2010) Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 6(12):702–706
-
(2010)
Nat Rev Neurol
, vol.6
, Issue.12
, pp. 702-706
-
-
Lee, S.-J.1
Desplats, P.2
Sigurdson, C.3
Tsigelny, I.4
Masliah, E.5
-
248
-
-
84862620376
-
A unifying role for prions in neurodegenerative diseases
-
PID: 22723400
-
Prusiner SB (2012) A unifying role for prions in neurodegenerative diseases. Science 336(6088):1511–1513
-
(2012)
Science
, vol.336
, Issue.6088
, pp. 1511-1513
-
-
Prusiner, S.B.1
-
249
-
-
77954385676
-
The propagation of prion-like protein inclusions in neurodegenerative diseases
-
PID: 20493564
-
Goedert M, Clavaguera F, Tolnay M (2010) The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci 33(7):317–325. doi:10.1016/j.tins.2010.04.003
-
(2010)
Trends Neurosci
, vol.33
, Issue.7
, pp. 317-325
-
-
Goedert, M.1
Clavaguera, F.2
Tolnay, M.3
-
250
-
-
78149392229
-
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis
-
PID: 20966215
-
Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 330(6006):980–982. doi:10.1126/science.1194516
-
(2010)
Science
, vol.330
, Issue.6006
, pp. 980-982
-
-
Eisele, Y.S.1
Obermuller, U.2
Heilbronner, G.3
Baumann, F.4
Kaeser, S.A.5
Wolburg, H.6
Walker, L.C.7
Staufenbiel, M.8
Heikenwalder, M.9
Jucker, M.10
-
251
-
-
33749020837
-
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
-
PID: 16990547
-
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M (2006) Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 313(5794):1781–1784. doi:10.1126/science.1131864
-
(2006)
Science
, vol.313
, Issue.5794
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
Coomaraswamy, J.2
Bolmont, T.3
Kaeser, S.4
Schaefer, C.5
Kilger, E.6
Neuenschwander, A.7
Abramowski, D.8
Frey, P.9
Jaton, A.L.10
Vigouret, J.M.11
Paganetti, P.12
Walsh, D.M.13
Mathews, P.M.14
Ghiso, J.15
Staufenbiel, M.16
Walker, L.C.17
Jucker, M.18
-
252
-
-
33644816759
-
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates
-
PID: 16473510
-
Soto C, Estrada L, Castilla J (2006) Amyloids, prions and the inherent infectious nature of misfolded protein aggregates. Trends Biochem Sci 31(3):150–155. doi:10.1016/j.tibs.2006.01.002
-
(2006)
Trends Biochem Sci
, vol.31
, Issue.3
, pp. 150-155
-
-
Soto, C.1
Estrada, L.2
Castilla, J.3
-
253
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
PID: 19503072
-
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11(7):909–913. doi:10.1038/ncb1901
-
(2009)
Nat Cell Biol
, vol.11
, Issue.7
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
Fraser, G.7
Stalder, A.K.8
Beibel, M.9
Staufenbiel, M.10
Jucker, M.11
Goedert, M.12
Tolnay, M.13
-
254
-
-
67649273927
-
Propagation of tau misfolding from the outside to the inside of a cell
-
PID: 19282288
-
Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284(19):12845–12852. doi:10.1074/jbc.M808759200
-
(2009)
J Biol Chem
, vol.284
, Issue.19
, pp. 12845-12852
-
-
Frost, B.1
Jacks, R.L.2
Diamond, M.I.3
-
255
-
-
79955441814
-
Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles
-
PID: 21372138
-
Guo JL, Lee VM-Y (2011) Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem 286(17):15317–15331. doi:10.1074/jbc.M110.209296
-
(2011)
J Biol Chem
, vol.286
, Issue.17
, pp. 15317-15331
-
-
Guo, J.L.1
Lee, V.M.-Y.2
-
256
-
-
84878723720
-
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
-
PID: 23690619
-
Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M (2013) Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc Natl Acad Sci U S A 110(23):9535–9540. doi:10.1073/pnas.1301175110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.23
, pp. 9535-9540
-
-
Clavaguera, F.1
Akatsu, H.2
Fraser, G.3
Crowther, R.A.4
Frank, S.5
Hench, J.6
Probst, A.7
Winkler, D.T.8
Reichwald, J.9
Staufenbiel, M.10
Ghetti, B.11
Goedert, M.12
Tolnay, M.13
-
257
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
-
PID: 19651612
-
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 106(31):13010–13015. doi:10.1073/pnas.0903691106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.31
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
Spencer, B.7
Masliah, E.8
Lee, S.J.9
-
258
-
-
84863433677
-
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
-
PID: 21813214
-
Mougenot A-L, Nicot S, Bencsik A, Morignat E, Verchère J, Lakhdar L, Legastelois S, Baron T (2012) Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging 33(9):2225–2228. doi:10.1016/j.neurobiolaging.2011.06.022
-
(2012)
Neurobiol Aging
, vol.33
, Issue.9
, pp. 2225-2228
-
-
Mougenot, A.-L.1
Nicot, S.2
Bencsik, A.3
Morignat, E.4
Verchère, J.5
Lakhdar, L.6
Legastelois, S.7
Baron, T.8
-
259
-
-
84876057762
-
Prion-like spreading of pathological alpha-synuclein in brain
-
PID: 23466394
-
Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M (2013) Prion-like spreading of pathological alpha-synuclein in brain. Brain 136(Pt 4):1128–1138. doi:10.1093/brain/awt037
-
(2013)
Brain
, vol.136
, pp. 1128-1138
-
-
Masuda-Suzukake, M.1
Nonaka, T.2
Hosokawa, M.3
Oikawa, T.4
Arai, T.5
Akiyama, H.6
Mann, D.M.7
Hasegawa, M.8
-
260
-
-
59649095699
-
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
-
PID: 19151706
-
Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, Kopito RR (2009) Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol 11(2):219–225. doi:10.1038/ncb1830
-
(2009)
Nat Cell Biol
, vol.11
, Issue.2
, pp. 219-225
-
-
Ren, P.H.1
Lauckner, J.E.2
Kachirskaia, I.3
Heuser, J.E.4
Melki, R.5
Kopito, R.R.6
-
261
-
-
79952743365
-
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
-
PID: 21321227
-
Münch C, O’Brien J, Bertolotti A (2011) Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci U S A 108(9):3548–3553. doi:10.1073/pnas.1017275108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.9
, pp. 3548-3553
-
-
Münch, C.1
O’Brien, J.2
Bertolotti, A.3
-
262
-
-
80053563923
-
Misfolded protein aggregates: mechanisms, structures and potential for disease transmission
-
PID: 21571086
-
Moreno-Gonzalez I, Soto C (2011) Misfolded protein aggregates: mechanisms, structures and potential for disease transmission. Semin Cell Dev Biol 22(5):482–487. doi:10.1016/j.semcdb.2011.04.002
-
(2011)
Semin Cell Dev Biol
, vol.22
, Issue.5
, pp. 482-487
-
-
Moreno-Gonzalez, I.1
Soto, C.2
-
263
-
-
35348883642
-
Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes
-
PID: 17715060
-
Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM (2007) Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes. Proc Natl Acad Sci U S A 104(35):14151–14156. doi:10.1073/pnas.0704935104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.35
, pp. 14151-14156
-
-
Jaiswal, J.K.1
Fix, M.2
Takano, T.3
Nedergaard, M.4
Simon, S.M.5
-
264
-
-
84879232559
-
Spreading of tau pathology in Alzheimer’s disease by cell-to-cell transmission
-
PID: 23773063
-
Mohamed NV, Herrou T, Plouffe V, Piperno N, Leclerc N (2013) Spreading of tau pathology in Alzheimer’s disease by cell-to-cell transmission. Eur J Neurosci 37(12):1939–1948. doi:10.1111/ejn.12229
-
(2013)
Eur J Neurosci
, vol.37
, Issue.12
, pp. 1939-1948
-
-
Mohamed, N.V.1
Herrou, T.2
Plouffe, V.3
Piperno, N.4
Leclerc, N.5
-
265
-
-
61849178720
-
Prions hijack tunnelling nanotubes for intercellular spread
-
PID: 19198598
-
Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman DT, Chenouard N, de Chaumont F, Martino A, Enninga J, Olivo-Marin JC, Mannel D, Zurzolo C (2009) Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol 11(3):328–336. doi:10.1038/ncb1841
-
(2009)
Nat Cell Biol
, vol.11
, Issue.3
, pp. 328-336
-
-
Gousset, K.1
Schiff, E.2
Langevin, C.3
Marijanovic, Z.4
Caputo, A.5
Browman, D.T.6
Chenouard, N.7
de Chaumont, F.8
Martino, A.9
Enninga, J.10
Olivo-Marin, J.C.11
Mannel, D.12
Zurzolo, C.13
-
266
-
-
0141987860
-
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
-
PID: 14556719
-
Ciechanover A, Brundin P (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40(2):427–446. doi:10.1016/S0896-6273(03)00606-8
-
(2003)
Neuron
, vol.40
, Issue.2
, pp. 427-446
-
-
Ciechanover, A.1
Brundin, P.2
-
267
-
-
84885122581
-
Brain site-specific proteome changes in aging-related dementia
-
PID: 24008896
-
Manavalan A, Mishra M, Feng L, Sze SK, Akatsu H, Heese K (2013) Brain site-specific proteome changes in aging-related dementia. Exp Mol Med 45:e39. doi:10.1038/emm.2013.76
-
(2013)
Exp Mol Med
, vol.45
, pp. e39
-
-
Manavalan, A.1
Mishra, M.2
Feng, L.3
Sze, S.K.4
Akatsu, H.5
Heese, K.6
-
268
-
-
0018772190
-
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP
-
PID: 290989
-
Hershko A, Ciechanover A, Rose IA (1979) Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A 76(7):3107–3110
-
(1979)
Proc Natl Acad Sci U S A
, vol.76
, Issue.7
, pp. 3107-3110
-
-
Hershko, A.1
Ciechanover, A.2
Rose, I.A.3
-
269
-
-
38649091048
-
Ubiquitin-proteasome system as a modulator of cell fate
-
PID: 17981502
-
Thompson SJ, Loftus LT, Ashley MD, Meller R (2008) Ubiquitin-proteasome system as a modulator of cell fate. Curr Opin Pharmacol 8(1):90–95. doi:10.1016/j.coph.2007.09.010
-
(2008)
Curr Opin Pharmacol
, vol.8
, Issue.1
, pp. 90-95
-
-
Thompson, S.J.1
Loftus, L.T.2
Ashley, M.D.3
Meller, R.4
-
270
-
-
84857703860
-
Protein homeostasis and aging: role of ubiquitin protein ligases
-
PID: 22353631
-
Jana NR (2012) Protein homeostasis and aging: role of ubiquitin protein ligases. Neurochem Int 60(5):443–447. doi:10.1016/j.neuint.2012.02.009
-
(2012)
Neurochem Int
, vol.60
, Issue.5
, pp. 443-447
-
-
Jana, N.R.1
-
271
-
-
80051978811
-
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation
-
PID: 21860393
-
Weissman AM, Shabek N, Ciechanover A (2011) The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat Rev Mol Cell Biol 12(9):605–620
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, Issue.9
, pp. 605-620
-
-
Weissman, A.M.1
Shabek, N.2
Ciechanover, A.3
-
272
-
-
84856977664
-
The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim?
-
PID: 22270043
-
Dennissen FJ, Kholod N, van Leeuwen FW (2012) The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim? Prog Neurobiol 96(2):190–207. doi:10.1016/j.pneurobio.2012.01.003
-
(2012)
Prog Neurobiol
, vol.96
, Issue.2
, pp. 190-207
-
-
Dennissen, F.J.1
Kholod, N.2
van Leeuwen, F.W.3
-
273
-
-
9744227183
-
Ubiquitin: structures, functions, mechanisms
-
Pickart CM, Eddins MJ (2004) Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta (BBA) - Mol Cell Res 1695(1–3):55–72. doi:10.1016/j.bbamcr.2004.09.019
-
(2004)
Biochim Biophys Acta (BBA) - Mol Cell Res
, vol.1695
, Issue.1-3
, pp. 55-72
-
-
Pickart, C.M.1
Eddins, M.J.2
-
274
-
-
0028898424
-
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
-
PID: 7800044
-
Scheffner M, Nuber U, Huibregtse JM (1995) Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373(6509):81–83
-
(1995)
Nature
, vol.373
, Issue.6509
, pp. 81-83
-
-
Scheffner, M.1
Nuber, U.2
Huibregtse, J.M.3
-
275
-
-
9644272423
-
The ubiquitin system: pathogenesis of human diseases and drug targeting
-
Ciechanover A, Schwartz AL (2004) The ubiquitin system: pathogenesis of human diseases and drug targeting. Biochim Biophys Acta (BBA) - Mol Cell Res 1695(1–3):3–17. doi:10.1016/j.bbamcr.2004.09.018
-
(2004)
Biochim Biophys Acta (BBA) - Mol Cell Res
, vol.1695
, Issue.1-3
, pp. 3-17
-
-
Ciechanover, A.1
Schwartz, A.L.2
-
276
-
-
27244444559
-
TRIM family proteins: retroviral restriction and antiviral defence
-
PID: 16175175
-
Nisole S, Stoye JP, Saib A (2005) TRIM family proteins: retroviral restriction and antiviral defence. Nat Rev Microbiol 3(10):799–808. doi:10.1038/nrmicro1248
-
(2005)
Nat Rev Microbiol
, vol.3
, Issue.10
, pp. 799-808
-
-
Nisole, S.1
Stoye, J.P.2
Saib, A.3
-
277
-
-
80054848955
-
TRIM proteins and cancer
-
PID: 21979307
-
Hatakeyama S (2011) TRIM proteins and cancer. Nat Rev Cancer 11(11):792–804. doi:10.1038/nrc3139
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.11
, pp. 792-804
-
-
Hatakeyama, S.1
-
278
-
-
30444452500
-
TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases
-
PID: 16237670
-
Meroni G, Diez-Roux G (2005) TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases. Bioessays 27(11):1147–1157. doi:10.1002/bies.20304
-
(2005)
Bioessays
, vol.27
, Issue.11
, pp. 1147-1157
-
-
Meroni, G.1
Diez-Roux, G.2
-
279
-
-
0033918327
-
Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism
-
PID: 10888877
-
Avela K, Lipsanen-Nyman M, Idänheimo N, Seemanová E, Rosengren S, Mäkelä TP, Perheentupa J, de la Chapelle A, Lehesjoki A-E (2000) Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. Nat Genet 25(3):298–301
-
(2000)
Nat Genet
, vol.25
, Issue.3
, pp. 298-301
-
-
Avela, K.1
Lipsanen-Nyman, M.2
Idänheimo, N.3
Seemanová, E.4
Rosengren, S.5
Mäkelä, T.P.6
Perheentupa, J.7
de la Chapelle, A.8
Lehesjoki, A.-E.9
-
280
-
-
10744221161
-
RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties
-
PID: 14578165
-
Horn EJ, Albor A, Liu Y, El-Hizawi S, Vanderbeek GE, Babcock M, Bowden GT, Hennings H, Lozano G, Weinberg WC, Kulesz-Martin M (2004) RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties. Carcinogenesis 25(2):157–167. doi:10.1093/carcin/bgh003
-
(2004)
Carcinogenesis
, vol.25
, Issue.2
, pp. 157-167
-
-
Horn, E.J.1
Albor, A.2
Liu, Y.3
El-Hizawi, S.4
Vanderbeek, G.E.5
Babcock, M.6
Bowden, G.T.7
Hennings, H.8
Lozano, G.9
Weinberg, W.C.10
Kulesz-Martin, M.11
-
281
-
-
61349191567
-
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors
-
PID: 19269368
-
Schwamborn JC, Berezikov E, Knoblich JA (2009) The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell 136(5):913–925. doi:10.1016/j.cell.2008.12.024
-
(2009)
Cell
, vol.136
, Issue.5
, pp. 913-925
-
-
Schwamborn, J.C.1
Berezikov, E.2
Knoblich, J.A.3
-
282
-
-
27644438336
-
Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin
-
PID: 16243356
-
Kudryashova E, Kudryashov D, Kramerova I, Spencer MJ (2005) Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin. J Mol Biol 354(2):413–424. doi:10.1016/j.jmb.2005.09.068
-
(2005)
J Mol Biol
, vol.354
, Issue.2
, pp. 413-424
-
-
Kudryashova, E.1
Kudryashov, D.2
Kramerova, I.3
Spencer, M.J.4
-
283
-
-
63149150621
-
Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component
-
PID: 19155210
-
Kudryashova E, Wu J, Havton LA, Spencer MJ (2009) Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum Mol Genet 18(7):1353–1367. doi:10.1093/hmg/ddp036
-
(2009)
Hum Mol Genet
, vol.18
, Issue.7
, pp. 1353-1367
-
-
Kudryashova, E.1
Wu, J.2
Havton, L.A.3
Spencer, M.J.4
-
284
-
-
36348972414
-
Concurrence of TDP-43, tau and α-synuclein pathology in brains of Alzheimer’s disease and dementia with Lewy bodies
-
PID: 17963732
-
Higashi S, Iseki E, Yamamoto R, Minegishi M, Hino H, Fujisawa K, Togo T, Katsuse O, Uchikado H, Furukawa Y, Kosaka K, Arai H (2007) Concurrence of TDP-43, tau and α-synuclein pathology in brains of Alzheimer’s disease and dementia with Lewy bodies. Brain Res 1184:284–294. doi:10.1016/j.brainres.2007.09.048
-
(2007)
Brain Res
, vol.1184
, pp. 284-294
-
-
Higashi, S.1
Iseki, E.2
Yamamoto, R.3
Minegishi, M.4
Hino, H.5
Fujisawa, K.6
Togo, T.7
Katsuse, O.8
Uchikado, H.9
Furukawa, Y.10
Kosaka, K.11
Arai, H.12
-
285
-
-
0037383761
-
Colocalization of Tau and alpha‐synuclein epitopes in lewy bodies
-
Ishizawa T, Mattila P, Davies P, Wang D, Dickson DW (2003) Colocalization of Tau and alpha‐synuclein epitopes in lewy bodies. J Neuropathol Exp Neurol 62(4):389–397
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, Issue.4
, pp. 389-397
-
-
Ishizawa, T.1
Mattila, P.2
Davies, P.3
Wang, D.4
Dickson, D.W.5
-
286
-
-
0012641135
-
Parkin: clinical aspects and neurobiology
-
Zhang Y, Dawson VL, Dawson TM (2001) Parkin: clinical aspects and neurobiology. Clin Neurosci Res 1(6):467–482. doi:10.1016/S1566-2772(01)00025-1
-
(2001)
Clin Neurosci Res
, vol.1
, Issue.6
, pp. 467-482
-
-
Zhang, Y.1
Dawson, V.L.2
Dawson, T.M.3
-
287
-
-
0242363670
-
Molecular pathways of neurodegeneration in Parkinson’s disease
-
PID: 14593166
-
Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson’s disease. Science 302(5646):819–822. doi:10.1126/science.1087753
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
288
-
-
0037036904
-
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats
-
PID: 12167769
-
McNaught KSP, Björklund LM, Belizaire R, Isacson O, Jenner P, Olanow CW (2002) Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport 13(11):1437–1441
-
(2002)
Neuroreport
, vol.13
, Issue.11
, pp. 1437-1441
-
-
McNaught, K.S.P.1
Björklund, L.M.2
Belizaire, R.3
Isacson, O.4
Jenner, P.5
Olanow, C.W.6
-
289
-
-
0036316947
-
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
-
PID: 12064477
-
McNaught KSP, Mytilineou C, JnoBaptiste R, Yabut J, Shashidharan P, Jenner P, Olanow CW (2002) Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures. J Neurochem 81(2):301–306. doi:10.1046/j.1471-4159.2002.00821.x
-
(2002)
J Neurochem
, vol.81
, Issue.2
, pp. 301-306
-
-
McNaught, K.S.P.1
Mytilineou, C.2
JnoBaptiste, R.3
Yabut, J.4
Shashidharan, P.5
Jenner, P.6
Olanow, C.W.7
-
290
-
-
79960904538
-
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
-
PID: 21829535
-
van Eersel J, Ke YD, Gladbach A, Bi M, Götz J, Kril JJ, Ittner LM (2011) Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons. PLoS ONE 6(7):e22850. doi:10.1371/journal.pone.0022850
-
(2011)
PLoS ONE
, vol.6
, Issue.7
, pp. e22850
-
-
van Eersel, J.1
Ke, Y.D.2
Gladbach, A.3
Bi, M.4
Götz, J.5
Kril, J.J.6
Ittner, L.M.7
-
291
-
-
84871150225
-
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis
-
PID: 23095749
-
Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R (2012) Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem 287(51):42984–42994. doi:10.1074/jbc.M112.417600
-
(2012)
J Biol Chem
, vol.287
, Issue.51
, pp. 42984-42994
-
-
Tashiro, Y.1
Urushitani, M.2
Inoue, H.3
Koike, M.4
Uchiyama, Y.5
Komatsu, M.6
Tanaka, K.7
Yamazaki, M.8
Abe, M.9
Misawa, H.10
Sakimura, K.11
Ito, H.12
Takahashi, R.13
-
292
-
-
84877118567
-
Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain
-
PID: 23667697
-
Giannini C, Kloß A, Gohlke S, Mishto M, Nicholson TP, Sheppard PW, Kloetzel P-M, Dahlmann B (2013) Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain. PLoS ONE 8(5):e64042. doi:10.1371/journal.pone.0064042
-
(2013)
PLoS ONE
, vol.8
, Issue.5
, pp. e64042
-
-
Giannini, C.1
Kloß, A.2
Gohlke, S.3
Mishto, M.4
Nicholson, T.P.5
Sheppard, P.W.6
Kloetzel, P.-M.7
Dahlmann, B.8
-
293
-
-
34948845308
-
Proteasome activator enhances survival of Huntington’s disease neuronal model cells
-
PID: 17327906
-
Seo H, Sonntag K-C, Kim W, Cattaneo E, Isacson O (2007) Proteasome activator enhances survival of Huntington’s disease neuronal model cells. PLoS ONE 2(2):e238. doi:10.1371/journal.pone.0000238
-
(2007)
PLoS ONE
, vol.2
, Issue.2
, pp. e238
-
-
Seo, H.1
Sonntag, K.-C.2
Kim, W.3
Cattaneo, E.4
Isacson, O.5
-
294
-
-
65549142204
-
A role for ubiquitin in selective autophagy
-
PID: 19450525
-
Kirkin V, McEwan DG, Novak I, Dikic I (2009) A role for ubiquitin in selective autophagy. Mol Cell 34(3):259–269. doi:10.1016/j.molcel.2009.04.026
-
(2009)
Mol Cell
, vol.34
, Issue.3
, pp. 259-269
-
-
Kirkin, V.1
McEwan, D.G.2
Novak, I.3
Dikic, I.4
-
295
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
PID: 15751225
-
Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM (2005) Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 64(2):113–122
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, Issue.2
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
296
-
-
77954116814
-
Autophagy gone awry in neurodegenerative diseases
-
PID: 20581817
-
Wong E, Cuervo AM (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13(7):805–811
-
(2010)
Nat Neurosci
, vol.13
, Issue.7
, pp. 805-811
-
-
Wong, E.1
Cuervo, A.M.2
-
297
-
-
56449094841
-
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection
-
Nedelsky NB, Todd PK, Taylor JP (2008) Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta (BBA) - Mol Basis Dis 1782(12):691–699. doi:10.1016/j.bbadis.2008.10.002
-
(2008)
Biochim Biophys Acta (BBA) - Mol Basis Dis
, vol.1782
, Issue.12
, pp. 691-699
-
-
Nedelsky, N.B.1
Todd, P.K.2
Taylor, J.P.3
-
298
-
-
79955969705
-
Autophagy failure in Alzheimer’s disease—locating the primary defect
-
PID: 21296668
-
Nixon RA, Yang D-S (2011) Autophagy failure in Alzheimer’s disease—locating the primary defect. Neurobiol Dis 43(1):38–45. doi:10.1016/j.nbd.2011.01.021
-
(2011)
Neurobiol Dis
, vol.43
, Issue.1
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.-S.2
-
299
-
-
0032489016
-
The Hsp70 and Hsp60 chaperone machines
-
PID: 9476895
-
Bukau B, Horwich AL (1998) The Hsp70 and Hsp60 chaperone machines. Cell 92(3):351–366
-
(1998)
Cell
, vol.92
, Issue.3
, pp. 351-366
-
-
Bukau, B.1
Horwich, A.L.2
-
300
-
-
84878948560
-
Molecular chaperone functions in protein folding and proteostasis
-
PID: 23746257
-
Kim YE, Hipp MS, Bracher A, Hayer-Hartl M, Ulrich Hartl F (2013) Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem 82(1):323–355. doi:10.1146/annurev-biochem-060208-092442
-
(2013)
Annu Rev Biochem
, vol.82
, Issue.1
, pp. 323-355
-
-
Kim, Y.E.1
Hipp, M.S.2
Bracher, A.3
Hayer-Hartl, M.4
Ulrich Hartl, F.5
-
301
-
-
78649346692
-
The heat shock response: life on the verge of death
-
PID: 20965420
-
Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40(2):253–266
-
(2010)
Mol Cell
, vol.40
, Issue.2
, pp. 253-266
-
-
Richter, K.1
Haslbeck, M.2
Buchner, J.3
-
302
-
-
33746364784
-
Structure and mechanism of the Hsp90 molecular chaperone machinery
-
PID: 16756493
-
Pearl LH, Prodromou C (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu Rev Biochem 75:271–294. doi:10.1146/annurev.biochem.75.103004.142738
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 271-294
-
-
Pearl, L.H.1
Prodromou, C.2
-
303
-
-
17044387386
-
Hsp70 chaperones: cellular functions and molecular mechanism
-
PID: 15770419
-
Mayer MP, Bukau B (2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62(6):670–684. doi:10.1007/s00018-004-4464-6
-
(2005)
Cell Mol Life Sci
, vol.62
, Issue.6
, pp. 670-684
-
-
Mayer, M.P.1
Bukau, B.2
-
304
-
-
84884589727
-
Hsp70 chaperone dynamics and molecular mechanism
-
PID: 24012426
-
Mayer MP (2013) Hsp70 chaperone dynamics and molecular mechanism. Trends Biochem Sci 38(10):507–514. doi:10.1016/j.tibs.2013.08.001
-
(2013)
Trends Biochem Sci
, vol.38
, Issue.10
, pp. 507-514
-
-
Mayer, M.P.1
-
305
-
-
84886446627
-
Protein rescue from aggregates by powerful molecular chaperone machines
-
PID: 24061228
-
Doyle SM, Genest O, Wickner S (2013) Protein rescue from aggregates by powerful molecular chaperone machines. Nat Rev Mol Cell Biol 14(10):617–629. doi:10.1038/nrm3660
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, Issue.10
, pp. 617-629
-
-
Doyle, S.M.1
Genest, O.2
Wickner, S.3
-
306
-
-
77954947810
-
The HSP70 chaperone machinery: J proteins as drivers of functional specificity
-
PID: 20651708
-
Kampinga HH, Craig EA (2010) The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol 11(8):579–592. doi:10.1038/nrm2941
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, Issue.8
, pp. 579-592
-
-
Kampinga, H.H.1
Craig, E.A.2
-
307
-
-
77950224150
-
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage
-
Pratt WB, Morishima Y, Peng HM, Osawa Y (2010) Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) 235(3):278–289. doi:10.1258/ebm.2009.009250
-
(2010)
Exp Biol Med (Maywood)
, vol.235
, Issue.3
, pp. 278-289
-
-
Pratt, W.B.1
Morishima, Y.2
Peng, H.M.3
Osawa, Y.4
-
308
-
-
80054828829
-
FKBP immunophilins and Alzheimer’s disease: a chaperoned affair
-
PID: 21799260
-
Cao W, Konsolaki M (2011) FKBP immunophilins and Alzheimer’s disease: a chaperoned affair. J Biosci 36(3):493–498
-
(2011)
J Biosci
, vol.36
, Issue.3
, pp. 493-498
-
-
Cao, W.1
Konsolaki, M.2
-
309
-
-
0027439390
-
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin
-
PID: 7678431
-
Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J (1993) Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol 229(1):105–124
-
(1993)
J Mol Biol
, vol.229
, Issue.1
, pp. 105-124
-
-
Van Duyne, G.D.1
Standaert, R.F.2
Karplus, P.A.3
Schreiber, S.L.4
Clardy, J.5
-
310
-
-
44949254975
-
Structure-based classification of 45 FK506-binding proteins
-
Somarelli JA, Lee SY, Skolnick J, Herrera RJ (2008) Structure-based classification of 45 FK506-binding proteins. Proteins Struct Funct Bioinforma 72(1):197–208. doi:10.1002/prot.21908
-
(2008)
Proteins Struct Funct Bioinforma
, vol.72
, Issue.1
, pp. 197-208
-
-
Somarelli, J.A.1
Lee, S.Y.2
Skolnick, J.3
Herrera, R.J.4
-
311
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
PID: 1715244
-
Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66(4):807–815. doi:10.1016/0092-8674(91)90124-H
-
(1991)
Cell
, vol.66
, Issue.4
, pp. 807-815
-
-
Liu, J.1
Farmer, J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
Schreiber, S.L.6
-
312
-
-
57149093203
-
FKBP family proteins: immunophilins with versatile biological functions
-
PID: 18635947
-
Kang CB, Hong Y, Dhe-Paganon S, Yoon HS (2008) FKBP family proteins: immunophilins with versatile biological functions. Neurosignals 16(4):318–325
-
(2008)
Neurosignals
, vol.16
, Issue.4
, pp. 318-325
-
-
Kang, C.B.1
Hong, Y.2
Dhe-Paganon, S.3
Yoon, H.S.4
-
313
-
-
0028138492
-
-
Charters AR, Kobayashi M, Butcher SP (1994) The subcellular distribution of FK506 binding proteins in rat brain. Biochem Soc Trans 22(4):412 s
-
Charters AR, Kobayashi M, Butcher SP (1994) The subcellular distribution of FK506 binding proteins in rat brain. Biochem Soc Trans 22(4):412 s
-
-
-
-
314
-
-
0037227946
-
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
-
PID: 12510191
-
Shirane M, Nakayama KI (2003) Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol 5(1):28–37. doi:10.1038/ncb894
-
(2003)
Nat Cell Biol
, vol.5
, Issue.1
, pp. 28-37
-
-
Shirane, M.1
Nakayama, K.I.2
-
315
-
-
25844499702
-
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2
-
PID: 15905180
-
Wang H-Q, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M (2005) Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum Mol Genet 14(13):1889–1902. doi:10.1093/hmg/ddi195
-
(2005)
Hum Mol Genet
, vol.14
, Issue.13
, pp. 1889-1902
-
-
Wang, H.-Q.1
Nakaya, Y.2
Du, Z.3
Yamane, T.4
Shirane, M.5
Kudo, T.6
Takeda, M.7
Takebayashi, K.8
Noda, Y.9
Nakayama, K.I.10
Nishimura, M.11
-
316
-
-
0345144024
-
Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
-
PID: 12538866
-
Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J (2003) Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A 100(3):868–873. doi:10.1073/pnas.0231020100
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.3
, pp. 868-873
-
-
Sinars, C.R.1
Cheung-Flynn, J.2
Rimerman, R.A.3
Scammell, J.G.4
Smith, D.F.5
Clardy, J.6
-
317
-
-
2942593899
-
3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
-
PID: 15159550
-
Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z (2004) 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci U S A 101(22):8348–8353
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.22
, pp. 8348-8353
-
-
Wu, B.1
Li, P.2
Liu, Y.3
Lou, Z.4
Ding, Y.5
Shu, C.6
Ye, S.7
Bartlam, M.8
Shen, B.9
Rao, Z.10
-
318
-
-
84900436398
-
Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs
-
PID: 24272907
-
Boudko SP, Ishikawa Y, Nix J, Chapman MS, Bachinger HP (2014) Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs. Protein Sci 23(1):67–75. doi:10.1002/pro.2391
-
(2014)
Protein Sci
, vol.23
, Issue.1
, pp. 67-75
-
-
Boudko, S.P.1
Ishikawa, Y.2
Nix, J.3
Chapman, M.S.4
Bachinger, H.P.5
-
319
-
-
84873137008
-
FKBP14 is an essential gene that regulates presenilin protein levels and Notch signaling in Drosophila
-
PID: 23318643
-
van de Hoef DL, Bonner JM, Boulianne GL (2013) FKBP14 is an essential gene that regulates presenilin protein levels and Notch signaling in Drosophila. Development 140(4):810–819. doi:10.1242/dev.081356
-
(2013)
Development
, vol.140
, Issue.4
, pp. 810-819
-
-
van de Hoef, D.L.1
Bonner, J.M.2
Boulianne, G.L.3
-
320
-
-
33745959291
-
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species
-
PID: 16807328
-
Dickey CA, Yue M, Lin W-L, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AMK, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L (2006) Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J Neurosci 26(26):6985–6996. doi:10.1523/jneurosci. 0746-06.2006
-
(2006)
J Neurosci
, vol.26
, Issue.26
, pp. 6985-6996
-
-
Dickey, C.A.1
Yue, M.2
Lin, W.-L.3
Dickson, D.W.4
Dunmore, J.H.5
Lee, W.C.6
Zehr, C.7
West, G.8
Cao, S.9
Clark, A.M.K.10
Caldwell, G.A.11
Caldwell, K.A.12
Eckman, C.13
Patterson, C.14
Hutton, M.15
Petrucelli, L.16
-
321
-
-
84877358032
-
Reconstructing the Hsp90/Tau machine
-
PID: 23798910
-
Jinwal UK, Koren J 3rd, Dickey CA (2013) Reconstructing the Hsp90/Tau machine. Curr Enzym Inhib 9(1):41–45. doi:10.2174/1573408011309010006
-
(2013)
Curr Enzym Inhib
, vol.9
, Issue.1
, pp. 41-45
-
-
Jinwal, U.K.1
Koren, J.2
Dickey, C.A.3
-
322
-
-
84896837095
-
Hsp90-Tau complex reveals molecular basis for specificity in chaperone action
-
PID: 24581495
-
Karagoz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Moran Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rudiger SG (2014) Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell 156(5):963–974. doi:10.1016/j.cell.2014.01.037
-
(2014)
Cell
, vol.156
, Issue.5
, pp. 963-974
-
-
Karagoz, G.E.1
Duarte, A.M.2
Akoury, E.3
Ippel, H.4
Biernat, J.5
Moran Luengo, T.6
Radli, M.7
Didenko, T.8
Nordhues, B.A.9
Veprintsev, D.B.10
Dickey, C.A.11
Mandelkow, E.12
Zweckstetter, M.13
Boelens, R.14
Madl, T.15
Rudiger, S.G.16
-
323
-
-
33646133424
-
Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans
-
PID: 16600994
-
Kraemer BC, Burgess JK, Chen JH, Thomas JH, Schellenberg GD (2006) Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Hum Mol Genet 15(9):1483–1496. doi:10.1093/hmg/ddl067
-
(2006)
Hum Mol Genet
, vol.15
, Issue.9
, pp. 1483-1496
-
-
Kraemer, B.C.1
Burgess, J.K.2
Chen, J.H.3
Thomas, J.H.4
Schellenberg, G.D.5
-
324
-
-
74949110831
-
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
-
PID: 20071522
-
Jinwal UK, Koren J 3rd, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O’Leary JC 3rd, Jin Y, Buchner J, Cox MB, Dickey CA (2010) The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci 30(2):591–599. doi:10.1523/jneurosci. 4815-09.2010
-
(2010)
J Neurosci
, vol.30
, Issue.2
, pp. 591-599
-
-
Jinwal, U.K.1
Koren, J.2
Borysov, S.I.3
Schmid, A.B.4
Abisambra, J.F.5
Blair, L.J.6
Johnson, A.G.7
Jones, J.R.8
Shults, C.L.9
O’Leary, J.C.10
Jin, Y.11
Buchner, J.12
Cox, M.B.13
Dickey, C.A.14
-
325
-
-
84885054226
-
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
-
PID: 23999428
-
Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O’Leary JC 3rd, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA (2013) Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest 123(10):4158–4169. doi:10.1172/jci69003
-
(2013)
J Clin Invest
, vol.123
, Issue.10
, pp. 4158-4169
-
-
Blair, L.J.1
Nordhues, B.A.2
Hill, S.E.3
Scaglione, K.M.4
O’Leary, J.C.5
Fontaine, S.N.6
Breydo, L.7
Zhang, B.8
Li, P.9
Wang, L.10
Cotman, C.11
Paulson, H.L.12
Muschol, M.13
Uversky, V.N.14
Klengel, T.15
Binder, E.B.16
Kayed, R.17
Golde, T.E.18
Berchtold, N.19
Dickey, C.A.20
more..
-
326
-
-
34548485298
-
The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation
-
PID: 17435176
-
Chambraud B, Belabes H, Fontaine-Lenoir V, Fellous A, Baulieu EE (2007) The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. FASEB J 21(11):2787–2797. doi:10.1096/fj.06-7667com
-
(2007)
FASEB J
, vol.21
, Issue.11
, pp. 2787-2797
-
-
Chambraud, B.1
Belabes, H.2
Fontaine-Lenoir, V.3
Fellous, A.4
Baulieu, E.E.5
-
327
-
-
77952482502
-
Control of Alzheimer’s amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila
-
PID: 20084280
-
Sanokawa-Akakura R, Cao W, Allan K, Patel K, Ganesh A, Heiman G, Burke R, Kemp FW, Bogden JD, Camakaris J, Birge RB, Konsolaki M (2010) Control of Alzheimer’s amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila. PLoS ONE 5(1):e8626. doi:10.1371/journal.pone.0008626
-
(2010)
PLoS ONE
, vol.5
, Issue.1
, pp. e8626
-
-
Sanokawa-Akakura, R.1
Cao, W.2
Allan, K.3
Patel, K.4
Ganesh, A.5
Heiman, G.6
Burke, R.7
Kemp, F.W.8
Bogden, J.D.9
Camakaris, J.10
Birge, R.B.11
Konsolaki, M.12
-
328
-
-
0036951854
-
Immunophilins and their ligands: insights into survival and growth of human neurons
-
PID: 12526984
-
Avramut M, Achim CL (2002) Immunophilins and their ligands: insights into survival and growth of human neurons. Physiol Behav 77(4–5):463–468. doi:10.1016/S0031-9384(02)00934-4
-
(2002)
Physiol Behav
, vol.77
, Issue.4-5
, pp. 463-468
-
-
Avramut, M.1
Achim, C.L.2
-
329
-
-
65749119808
-
A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles
-
PID: 19414059
-
Sugata H, Matsuo K, Nakagawa T, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T (2009) A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles. Neurosci Lett 459(2):96–99
-
(2009)
Neurosci Lett
, vol.459
, Issue.2
, pp. 96-99
-
-
Sugata, H.1
Matsuo, K.2
Nakagawa, T.3
Takahashi, M.4
Mukai, H.5
Ono, Y.6
Maeda, K.7
Akiyama, H.8
Kawamata, T.9
-
330
-
-
84896038572
-
FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines
-
PID: 24499793
-
Liu FL, Liu TY, Kung FL (2014) FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines. J Biosci 39(1):85–95
-
(2014)
J Biosci
, vol.39
, Issue.1
, pp. 85-95
-
-
Liu, F.L.1
Liu, T.Y.2
Kung, F.L.3
-
331
-
-
33749324414
-
The intracellular domain of amyloid precursor protein interacts with FKBP12
-
PID: 17011518
-
Liu F-L, Liu P-H, Shao H-W, Kung F-L (2006) The intracellular domain of amyloid precursor protein interacts with FKBP12. Biochem Biophys Res Commun 350(2):472–477. doi:10.1016/j.bbrc.2006.09.073
-
(2006)
Biochem Biophys Res Commun
, vol.350
, Issue.2
, pp. 472-477
-
-
Liu, F.-L.1
Liu, P.-H.2
Shao, H.-W.3
Kung, F.-L.4
-
332
-
-
77249126934
-
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson’s disease-like pathology
-
PID: 20164329
-
Gerard M, Deleersnijder A, Daniels V, Schreurs S, Munck S, Reumers V, Pottel H, Engelborghs Y, Van den Haute C, Taymans JM, Debyser Z, Baekelandt V (2010) Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson’s disease-like pathology. J Neurosci 30(7):2454–2463. doi:10.1523/JNEUROSCI. 5983-09.2010
-
(2010)
J Neurosci
, vol.30
, Issue.7
, pp. 2454-2463
-
-
Gerard, M.1
Deleersnijder, A.2
Daniels, V.3
Schreurs, S.4
Munck, S.5
Reumers, V.6
Pottel, H.7
Engelborghs, Y.8
Van den Haute, C.9
Taymans, J.M.10
Debyser, Z.11
Baekelandt, V.12
-
333
-
-
79960692455
-
Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation
-
PID: 21652707
-
Deleersnijder A, Van Rompuy AS, Desender L, Pottel H, Buee L, Debyser Z, Baekelandt V, Gerard M (2011) Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation. J Biol Chem 286(30):26687–26701. doi:10.1074/jbc.M110.182303
-
(2011)
J Biol Chem
, vol.286
, Issue.30
, pp. 26687-26701
-
-
Deleersnijder, A.1
Van Rompuy, A.S.2
Desender, L.3
Pottel, H.4
Buee, L.5
Debyser, Z.6
Baekelandt, V.7
Gerard, M.8
-
334
-
-
0043069764
-
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
-
PID: 12891359
-
Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP (2003) Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424(6948):556–561. doi:10.1038/nature01832
-
(2003)
Nature
, vol.424
, Issue.6948
, pp. 556-561
-
-
Liou, Y.C.1
Sun, A.2
Ryo, A.3
Zhou, X.Z.4
Yu, Z.X.5
Huang, H.K.6
Uchida, T.7
Bronson, R.8
Bing, G.9
Li, X.10
Hunter, T.11
Lu, K.P.12
-
335
-
-
0036938198
-
Inverse association of Pin1 and tau accumulation in Alzheimer’s disease hippocampus
-
PID: 12410395
-
Holzer M, Gartner U, Stobe A, Hartig W, Gruschka H, Bruckner MK, Arendt T (2002) Inverse association of Pin1 and tau accumulation in Alzheimer’s disease hippocampus. Acta Neuropathol 104(5):471–481. doi:10.1007/s00401-002-0581-1
-
(2002)
Acta Neuropathol
, vol.104
, Issue.5
, pp. 471-481
-
-
Holzer, M.1
Gartner, U.2
Stobe, A.3
Hartig, W.4
Gruschka, H.5
Bruckner, M.K.6
Arendt, T.7
-
336
-
-
33645300736
-
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
-
PID: 16554819
-
Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP (2006) The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature 440(7083):528–534. doi:10.1038/nature04543
-
(2006)
Nature
, vol.440
, Issue.7083
, pp. 528-534
-
-
Pastorino, L.1
Sun, A.2
Lu, P.J.3
Zhou, X.Z.4
Balastik, M.5
Finn, G.6
Wulf, G.7
Lim, J.8
Li, S.H.9
Li, X.10
Xia, W.11
Nicholson, L.K.12
Lu, K.P.13
-
337
-
-
0001521232
-
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains
-
PID: 3033674
-
Perry G, Friedman R, Shaw G, Chau V (1987) Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc Natl Acad Sci U S A 84(9):3033–3036
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, Issue.9
, pp. 3033-3036
-
-
Perry, G.1
Friedman, R.2
Shaw, G.3
Chau, V.4
-
338
-
-
0034667727
-
Defective ubiquitination of cerebral proteins in Alzheimer’s disease
-
PID: 11020223
-
López Salon M, Morelli L, Castaño EM, Soto EF, Pasquini JM (2000) Defective ubiquitination of cerebral proteins in Alzheimer’s disease. J Neurosci Res 62(2):302–310. doi:10.1002/1097-4547(20001015)62:2<302::AID-JNR15>3.0.CO;2-L
-
(2000)
J Neurosci Res
, vol.62
, Issue.2
, pp. 302-310
-
-
López Salon, M.1
Morelli, L.2
Castaño, E.M.3
Soto, E.F.4
Pasquini, J.M.5
-
339
-
-
0034131044
-
Impaired proteasome function in Alzheimer’s disease
-
PID: 10854289
-
Keller JN, Hanni KB, Markesbery WR (2000) Impaired proteasome function in Alzheimer’s disease. J Neurochem 75(1):436–439. doi:10.1046/j.1471-4159.2000.0750436.x
-
(2000)
J Neurochem
, vol.75
, Issue.1
, pp. 436-439
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
340
-
-
0037381710
-
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer’s disease
-
PID: 12641733
-
Keck S, Nitsch R, Grune T, Ullrich O (2003) Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer’s disease. J Neurochem 85(1):115–122
-
(2003)
J Neurochem
, vol.85
, Issue.1
, pp. 115-122
-
-
Keck, S.1
Nitsch, R.2
Grune, T.3
Ullrich, O.4
-
341
-
-
0038689039
-
Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration
-
PID: 12787787
-
Berke SJS, Paulson HL (2003) Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration. Curr Opin Genet Dev 13(3):253–261. doi:10.1016/S0959-437X(03)00053-4
-
(2003)
Curr Opin Genet Dev
, vol.13
, Issue.3
, pp. 253-261
-
-
Berke, S.J.S.1
Paulson, H.L.2
-
342
-
-
0037193469
-
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
-
PID: 11980917
-
Lindsten K, de Vrij FMS, Verhoef LGGC, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP (2002) Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. J Cell Biol 157(3):417–427. doi:10.1083/jcb.200111034
-
(2002)
J Cell Biol
, vol.157
, Issue.3
, pp. 417-427
-
-
Lindsten, K.1
de Vrij, F.M.S.2
Verhoef, L.G.G.C.3
Fischer, D.F.4
van Leeuwen, F.W.5
Hol, E.M.6
Masucci, M.G.7
Dantuma, N.P.8
-
343
-
-
0141428795
-
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders
-
PID: 14522239
-
Layfield R, Cavey JR, Lowe J (2003) Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders. Ageing Res Rev 2(4):343–356. doi:10.1016/S1568-1637(03)00025-4
-
(2003)
Ageing Res Rev
, vol.2
, Issue.4
, pp. 343-356
-
-
Layfield, R.1
Cavey, J.R.2
Lowe, J.3
-
344
-
-
0035203294
-
Mutant ubiquitin expressed in Alzheimer’s disease causes neuronal death
-
PID: 11726544
-
de Vrij FMS, Jacqueline A, Gregori LF, David F, Hermens WTJMC, Goldgaber D, Verhaagen J, Van Leeuwen FW, Hol EM (2001) Mutant ubiquitin expressed in Alzheimer’s disease causes neuronal death. FASEB J 15(14):2680–2688. doi:10.1096/fj.01-0438com
-
(2001)
FASEB J
, vol.15
, Issue.14
, pp. 2680-2688
-
-
de Vrij, F.M.S.1
Jacqueline, A.2
Gregori, L.F.3
David, F.4
Hermens, W.T.J.M.C.5
Goldgaber, D.6
Verhaagen, J.7
Van Leeuwen, F.W.8
Hol, E.M.9
-
345
-
-
78650678688
-
Decreased clearance of CNS β-amyloid in Alzheimer’s disease
-
PID: 21148344
-
Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ (2010) Decreased clearance of CNS β-amyloid in Alzheimer’s disease. Science 330(6012):1774. doi:10.1126/science.1197623
-
(2010)
Science
, vol.330
, Issue.6012
, pp. 1774
-
-
Mawuenyega, K.G.1
Sigurdson, W.2
Ovod, V.3
Munsell, L.4
Kasten, T.5
Morris, J.C.6
Yarasheski, K.E.7
Bateman, R.J.8
-
346
-
-
80051605043
-
Proteasome degradation of brain cytosolic tau in Alzheimer’s disease
-
PID: 21577325
-
Yen SS (2011) Proteasome degradation of brain cytosolic tau in Alzheimer’s disease. Int J Clin Exp Pathol 4(4):385–402
-
(2011)
Int J Clin Exp Pathol
, vol.4
, Issue.4
, pp. 385-402
-
-
Yen, S.S.1
-
347
-
-
27644522515
-
Amyloid peptide attenuates the proteasome activity in neuronal cells
-
PID: 16153690
-
Oh S, Hong HS, Hwang E, Sim HJ, Lee W, Shin SJ, Mook-Jung I (2005) Amyloid peptide attenuates the proteasome activity in neuronal cells. Mech Ageing Dev 126(12):1292–1299. doi:10.1016/j.mad.2005.07.006
-
(2005)
Mech Ageing Dev
, vol.126
, Issue.12
, pp. 1292-1299
-
-
Oh, S.1
Hong, H.S.2
Hwang, E.3
Sim, H.J.4
Lee, W.5
Shin, S.J.6
Mook-Jung, I.7
-
348
-
-
51449096696
-
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
-
PID: 17544172
-
Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM (2008) Aβ inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging 29(11):1607–1618. doi:10.1016/j.neurobiolaging.2007.04.014
-
(2008)
Neurobiol Aging
, vol.29
, Issue.11
, pp. 1607-1618
-
-
Tseng, B.P.1
Green, K.N.2
Chan, J.L.3
Blurton-Jones, M.4
LaFerla, F.M.5
-
349
-
-
0031026231
-
Binding of amyloid β protein to the 20 S proteasome
-
PID: 8995227
-
Gregori L, Hainfeld JF, Simon MN, Goldgaber D (1997) Binding of amyloid β protein to the 20 S proteasome. J Biol Chem 272(1):58–62. doi:10.1074/jbc.272.1.58
-
(1997)
J Biol Chem
, vol.272
, Issue.1
, pp. 58-62
-
-
Gregori, L.1
Hainfeld, J.F.2
Simon, M.N.3
Goldgaber, D.4
-
350
-
-
0033712579
-
-
Shringarpure R, Grune T, Sitte N, Davies* KJA (2000) 4-Hydroxynonenal-modified amyloid-β peptide inhibits the proteasome: possible importance in Alzheimer’s disease*. CMLS, Cell Mol Life Sci 57(12):1802–1809
-
Shringarpure R, Grune T, Sitte N, Davies* KJA (2000) 4-Hydroxynonenal-modified amyloid-β peptide inhibits the proteasome: possible importance in Alzheimer’s disease*. CMLS, Cell Mol Life Sci 57(12):1802–1809. doi: 10.1007/PL00000660
-
-
-
-
351
-
-
0028979993
-
Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro
-
PID: 7649980
-
Gregori L, Fuchs C, Figueiredo-Pereira ME, Van Nostrand WE, Goldgaber D (1995) Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro. J Biol Chem 270(34):19702–19708. doi:10.1074/jbc.270.34.19702
-
(1995)
J Biol Chem
, vol.270
, Issue.34
, pp. 19702-19708
-
-
Gregori, L.1
Fuchs, C.2
Figueiredo-Pereira, M.E.3
Van Nostrand, W.E.4
Goldgaber, D.5
-
352
-
-
0034730172
-
Inhibition of the ubiquitin-proteasome system in Alzheimer’s disease
-
PID: 10944193
-
Lam YA, Pickart CM, Alban A, Landon M, Jamieson C, Ramage R, Mayer RJ, Layfield R (2000) Inhibition of the ubiquitin-proteasome system in Alzheimer’s disease. Proc Natl Acad Sci U S A 97(18):9902–9906. doi:10.1073/pnas.170173897
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.18
, pp. 9902-9906
-
-
Lam, Y.A.1
Pickart, C.M.2
Alban, A.3
Landon, M.4
Jamieson, C.5
Ramage, R.6
Mayer, R.J.7
Layfield, R.8
-
353
-
-
0035900877
-
The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin
-
PID: 11744159
-
Klettner A, Baumgrass R, Zhang Y, Fischer G, Bürger E, Herdegen T, Mielke K (2001) The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin. Mol Brain Res 97(1):21–31. doi:10.1016/S0169-328X(01)00286-8
-
(2001)
Mol Brain Res
, vol.97
, Issue.1
, pp. 21-31
-
-
Klettner, A.1
Baumgrass, R.2
Zhang, Y.3
Fischer, G.4
Bürger, E.5
Herdegen, T.6
Mielke, K.7
-
354
-
-
77951499639
-
Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture
-
PID: 20226231
-
Lee KH, Won R, Kim UJ, Kim GM, Chung M-A, Sohn J-H, Lee BH (2010) Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture. Neurosci Lett 474(3):126–130. doi:10.1016/j.neulet.2010.03.009
-
(2010)
Neurosci Lett
, vol.474
, Issue.3
, pp. 126-130
-
-
Lee, K.H.1
Won, R.2
Kim, U.J.3
Kim, G.M.4
Chung, M.-A.5
Sohn, J.-H.6
Lee, B.H.7
-
355
-
-
0032761420
-
The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle
-
Winter C, Schenkel J, Bürger E, Eickmeier C, Zimmermann M, Herdegen T (1999) The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. Neuroscience 95(3):753–762. doi:10.1016/S0306-4522(99)00486-8
-
(1999)
Neuroscience
, vol.95
, Issue.3
, pp. 753-762
-
-
Winter, C.1
Schenkel, J.2
Bürger, E.3
Eickmeier, C.4
Zimmermann, M.5
Herdegen, T.6
-
356
-
-
84876818146
-
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents
-
PID: 23576755
-
Karapetyan YE, Sferrazza GF, Zhou M, Ottenberg G, Spicer T, Chase P, Fallahi M, Hodder P, Weissmann C, Lasmézas CI (2013) Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. Proc Natl Acad Sci U S A 110(17):7044–7049. doi:10.1073/pnas.1303510110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.17
, pp. 7044-7049
-
-
Karapetyan, Y.E.1
Sferrazza, G.F.2
Zhou, M.3
Ottenberg, G.4
Spicer, T.5
Chase, P.6
Fallahi, M.7
Hodder, P.8
Weissmann, C.9
Lasmézas, C.I.10
-
357
-
-
84891871121
-
Emerging therapeutics for Alzheimer’s disease
-
PID: 24392696
-
Chiang K, Koo EH (2014) Emerging therapeutics for Alzheimer’s disease. Annu Rev Pharmacol Toxicol 54(1):381–405. doi:10.1146/annurev-pharmtox-011613-135932
-
(2014)
Annu Rev Pharmacol Toxicol
, vol.54
, Issue.1
, pp. 381-405
-
-
Chiang, K.1
Koo, E.H.2
-
358
-
-
67349187297
-
O1-06-04: methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer’s disease
-
Harrington C, Rickard JE, Horsley D, Harrington KA, Hindley KP, Riedel G, Theuring F, Seng KM, Wischik CM (2008) O1-06-04: methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer’s disease. Alzheimers Dement 4(Supplement 4):T120–T121. doi:10.1016/j.jalz.2008.05.259
-
(2008)
Alzheimers Dement
, vol.4
, pp. T120-T121
-
-
Harrington, C.1
Rickard, J.E.2
Horsley, D.3
Harrington, K.A.4
Hindley, K.P.5
Riedel, G.6
Theuring, F.7
Seng, K.M.8
Wischik, C.M.9
-
359
-
-
67349200953
-
O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer’s disease over 50 weeks
-
Wischik CM, Bentham P, Wischik DJ, Seng KM (2008) O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer’s disease over 50 weeks. Alzheimers Dement 4(Supplement 4):T167. doi:10.1016/j.jalz.2008.05.438
-
(2008)
Alzheimers Dement
, vol.4
, pp. T167
-
-
Wischik, C.M.1
Bentham, P.2
Wischik, D.J.3
Seng, K.M.4
-
360
-
-
84892982159
-
Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer’s disease mouse model
-
PID: 24105468
-
Hong X, Liu J, Zhu G, Zhuang Y, Suo H, Wang P, Huang D, Xu J, Huang Y, Yu M, Bian M, Sheng Z, Fei J, Song H, Behnisch T, Huang F (2014) Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer’s disease mouse model. Hum Mol Genet 23(4):1056–1072. doi:10.1093/hmg/ddt501
-
(2014)
Hum Mol Genet
, vol.23
, Issue.4
, pp. 1056-1072
-
-
Hong, X.1
Liu, J.2
Zhu, G.3
Zhuang, Y.4
Suo, H.5
Wang, P.6
Huang, D.7
Xu, J.8
Huang, Y.9
Yu, M.10
Bian, M.11
Sheng, Z.12
Fei, J.13
Song, H.14
Behnisch, T.15
Huang, F.16
-
361
-
-
67649964217
-
RING domain E3 ubiquitin ligases
-
PID: 19489725
-
Deshaies RJ, Joazeiro CAP (2009) RING domain E3 ubiquitin ligases. Annu Rev Biochem 78(1):399–434. doi:10.1146/annurev.biochem.78.101807.093809
-
(2009)
Annu Rev Biochem
, vol.78
, Issue.1
, pp. 399-434
-
-
Deshaies, R.J.1
Joazeiro, C.A.P.2
-
362
-
-
78449257695
-
Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival
-
PID: 20949081
-
Mukherjee A, Morales-Scheihing D, Gonzalez-Romero D, Green K, Taglialatela G, Soto C (2010) Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival. PLoS Pathog 6(10):e1001138. doi:10.1371/journal.ppat.1001138
-
(2010)
PLoS Pathog
, vol.6
, Issue.10
, pp. e1001138
-
-
Mukherjee, A.1
Morales-Scheihing, D.2
Gonzalez-Romero, D.3
Green, K.4
Taglialatela, G.5
Soto, C.6
-
363
-
-
80051668635
-
Targeting FKBP isoforms with small-molecule ligands
-
PID: 21803654
-
Blackburn EA, Walkinshaw MD (2011) Targeting FKBP isoforms with small-molecule ligands. Curr Opin Pharmacol 11(4):365–371. doi:10.1016/j.coph.2011.04.007
-
(2011)
Curr Opin Pharmacol
, vol.11
, Issue.4
, pp. 365-371
-
-
Blackburn, E.A.1
Walkinshaw, M.D.2
|