Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

Journal of Neurochemistry

Volumn 125, Issue 1, 2013, Pages 144-156

  Kretner, Benedikt ^a   Fukumori, Akio ^a   Kuhn, Peer Hendrik ^a,b   Pérez Revuelta, Blanca Isabel ^a,b   Lichtenthaler, Stefan F ^a,b,c,d   Haass, Christian ^a,b,d   Steiner, Harald ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Technische Universität München Munich Cluster for Systems Neurology   (Germany)

Author keywords

secretase; Alzheimer s disease; amyloid peptide; GxGD type protease; intramembrane proteolysis; presenilin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GLYCINE; HERMES ANTIGEN; NOTCH1 RECEPTOR; PRESENILIN; PROTEINASE;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; DRUG TARGETING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYTIC DOMAIN; GLYCINE; HEK293 CELLS; HUMANS; LEUCINE; MUTATION; PRESENILIN-1; SUBSTRATE SPECIFICITY;

EID: 84875266748     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12124     Document Type: Article

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