Phases of Aβ-deposition in the human brain and its relevance for the development of AD

Neurology

Volumn 58, Issue 12, 2002, Pages 1791-1800

  Thal, Dietmar R ^a,b,d   Rüb, Udo ^a   Orantes, Mario ^c   Braak, Heiko ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c Offenbach Hospital   (Germany)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DIENCEPHALON; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; FOREBRAIN; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NEOCORTEX; NERVE CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TEMPORAL LOBE;

EID: 0037172826     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.58.12.1791     Document Type: Article

References (51)

1. Neuropathological stageing of Alzheimer-related changes
2. The pathogenesis of senile plaques
3. Ageing and dementia
4. Amyloid plaque core protein in Alzheimer disease and Down syndrome
5. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients
6. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
7. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity
8. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
9. Progression of neurofibrillary changes and PHF-tau in end-stage Alzheimer's disease is different from plaque and cortical microglial pathology
10. Alzheimer-related taupathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia
11. Sequence of Abeta-protein deposition in the human medial temporal lobe
12. Laminar distribution of neocortical senile plaques in senile dementia of the Alzheimer type
13. Regional variation in the distribution of apolipoprotein E and A beta in Alzheimer's disease
14. Alzheimer's disease: Amyloid plaques in the cerebellum
15. Alzheimer's disease: Areal and laminar pathology in the occipital isocortex
16. Alzheimer's disease: Striatal amyloid deposits and neurofibrillary changes
17. Comparison of beta-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: Amorphic plaques and cytoskeletal changes occur independently
18. Alzheimer's disease affects limbic nuclei of the thalamus
19. Amyloid deposition in the nucleus basalis of Meynert complex: A topographic marker for degenerating cell clusters in Alzheimer's disease
20. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease
21. Distribution and morphology of brain stem plaques in Alzheimer's disease
22. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
23. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
24. Distribution of senile changes in brain stem nuclei
25. Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease
26. The selective vulnerability of brainstem nuclei to Alzheimer's disease
27. Focal pathology in the Edinger-Westphal nucleus explains pupillary hypersensitivity in Alzheimer's disease
28. A new clinical scale for the staging of dementia
29. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
30. Silver labeling of Alzheimer neurofibrillary changes and brain β-amyloid
31. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta
32. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
33. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
34. X2-test
35. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: Implications for initial events in amyloid plaque formation
36. Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: A regional quantitative analysis
37. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes
38. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
39. Pattern of brain destruction in Parkinson's and Alzheimer's diseases
40. Organization of the entorhinal-hippocampal system: A review of current anatomical data
41. Entorhinal-hippocampal connections: A speculative view of their function
42. Central gray
43. Auditory system
44. Anatomical organization of excitatory amino acid receptors and their pathways
45. Afferent connections of Gudden's tegmental nuclei in the rabbit
46. Afferent and efferent connections of the cholinoceptive medial pontine reticular formation (region of the ventral tegmental nucleus) in the cat
47. Origin of cerebellar projections to the region of the oculomotor complex, medial pontine reticular formation, and superior colliculus in New World monkeys: A retrograde horseradish peroxidase study
48. Clinical validity of A beta-protein deposition staging in brain aging and Alzheimer disease
49. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
50. Targeting Alzheimer amyloid plaques in vivo