Selective cytotoxicity of intracellular amyloid β peptide1-42 through p53 and Bax in cultured primary human neurons

Journal of Cell Biology

Volumn 156, Issue 3, 2002, Pages 519-529

  Zhang, Yan ^a,c   McLaughlin, Richard ^b   Goodyer, Cynthia ^a   LeBlanc, Andréa ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b Neurochem Inc   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Amylois peptide; Bax; Neurotoxicity; p53

Indexed keywords

AMYLOID BETA PEPTIDE[1-42]; AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; NEUTRALIZING ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; EXTRACELLULAR SPACE; FETUS; GENE FUNCTION; HUMAN; HUMAN CELL; MICROINJECTION; NERVE CELL NECROSIS; NEUROFILAMENT; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; APOPTOSIS; ASTROCYTES; BCL-2-ASSOCIATED X PROTEIN; BRAIN; CASPASES; CELLS, CULTURED; ENZYME INHIBITORS; FETUS; HUMANS; INTRACELLULAR FLUID; MICROSCOPY, ELECTRON; NEURONS; PEPTIDE FRAGMENTS; POLYMERS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SENILE PLAQUES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037017399     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200110119     Document Type: Article

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