Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis

Science

Volumn 330, Issue 6006, 2010, Pages 980-982

  Eisele, Yvonne S ^a,b   Obermüller, Ulrike ^a,b   Heilbronner, Götz ^a,b,c   Baumann, Frank ^a,b   Kaeser, Stephan A ^a,b   Wolburg, Hartwig ^c   Walker, Lary C ^d   Staufenbiel, Matthias ^e   Heikenwalder, Mathias ^f   Jucker, Mathias ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN 23; BRAIN EXTRACT; UNCLASSIFIED DRUG;

BRAIN; HOST-PATHOGEN INTERACTION; PATHOLOGY; PROTEIN; RODENT;

AGED; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; FEMALE; IMMUNOREACTIVITY; INCUBATION TIME; INOCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL; BRAIN; BRAIN LEVEL; CHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PRION; PROTEIN FOLDING; TIME; VASCULAR AMYLOIDOSIS; VASCULARIZATION;

MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; BRAIN CHEMISTRY; CEREBRAL AMYLOID ANGIOPATHY; FEMALE; INJECTIONS, INTRAPERITONEAL; MICE; MICE, TRANSGENIC; PLAQUE, AMYLOID; PRIONS; PROTEIN FOLDING; TIME FACTORS;

EID: 78149392229     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1194516     Document Type: Article

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17. We thank M.-J. Runser, L. Jacobson (Basel), F. Langer, J. Coomaraswamy, S. Grathwohl, N. Varvel, T. Hamaguchi, C. Schäfer, A. Bosch, G. Frommer-Kästle, U. Scheurlen (Tübingen) for experimental help and A. Aguzzi (Zürich) for insightful comments. This work was supported by the Competence Network on Degenerative Dementias (BMBF-01GI0705), the Bundesministerium für Bildung und Forschung as part of ERA-Net NEURON (MIPROTRAN), the Center for Integrative Neuroscience (Deutsche Forschungsgemeinschaft), and NIH RR-00165.