Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

Journal of Cell Biology

Volumn 157, Issue 3, 2002, Pages 417-427

  Lindsten, Kristina ^a   De Vrij, Femke M S ^b   Verhoef, Lisette G G C ^a   Fischer, David F ^b   Van Leeuwen, Fred W ^b   Hol, Elly M ^b   Masucci, Maria G ^a   Dantuma, Nico P ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

Aggregate; Neurodegeneration; Polyglutamine disorders; Proteasome; Tauopathies

Indexed keywords

LYSINE; PROTEASOME; UBIQUITIN;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING;

CELL CYCLE; CYSTEINE ENDOPEPTIDASES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; LYSINE; MULTIENZYME COMPLEXES; MUTATION; NEURODEGENERATIVE DISEASES; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; UBIQUITIN;

EID: 0037193469     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200111034     Document Type: Article

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