APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

Alzheimer's and Dementia

Volumn 10, Issue 6, 2014, Pages 861-868

  Michaelson, Daniel M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Alzheimer's disease; ApoE4; Immunotherapy; Lipidation; Therapy

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4; APOLIPOPROTEIN E4 RECEPTOR; LIPOPROTEIN RECEPTOR; MONOCLONAL ANTIBODY; PROTEINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BIOMIMETICS; CARDIOVASCULAR SYSTEM; CLINICAL GENETICS; ENCEPHALITIS; GENETIC EPIDEMIOLOGY; GENETIC RISK; HUMAN; LOSS OF FUNCTION MUTATION; MOLECULAR EPIDEMIOLOGY; MOLECULAR PATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; TRAUMATIC BRAIN INJURY; GENETICS; RISK FACTOR;

ALZHEIMER DISEASE; APOLIPOPROTEIN E4; HUMANS; RISK FACTORS;

EID: 84927175748     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.06.015     Document Type: Review

References (52)

1. E. Giacobini, and G. Gold Alzheimer disease therapy-moving from amyloid-beta to tau Nature Rev Neurol 9 2013 677 686
2. E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, and G.W. Small Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
3. A.M. Saunders, W.J. Strittmatter, D. Schmechel, P.H. George-Hyslop, M.A. Pericak-Vance, and S.H. Joo Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease Neurology 43 1993 1467 1472
4. A.D. Roses Apolipoprotein E alleles as risk factors in Alzheimer's disease Annu Rev Med 47 1996 387 400
5. M.P. Burns, W.J. Noble, V. Olm, K. Gaynor, E. Casey, and J. LaFrancois Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques Brain Res Mol Brain Res 110 2003 119 125
6. W. Hartig, G. Bruckner, C. Schmidt, K. Brauer, G. Bodewitz, and J.D. Turner Co-localization of beta-amyloid peptides, apolipoprotein E and glial markers in senile plaques in the prefrontal cortex of old rhesus monkeys Brain Res 751 1997 315 322
7. L.A. Hansen, D. Galasko, W. Samuel, Y. Xia, X. Chen, and T. Saitoh Apolipoprotein-E epsilon-4 is associated with increased neurofibrillary pathology in the Lewy body variant of Alzheimer's disease Neurosci Lett 182 1994 63 65
8. D.E. Schmechel, A.M. Saunders, W.J. Strittmatter, B.J. Crain, C.M. Hulette, and S.H. Joo Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease Proc Natl Acad Sci U S A 90 1993 9649 9653
9. H. Barthel, H.J. Gertz, S. Dresel, O. Peters, P. Bartenstein, and K. Buerger Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study Lancet Neurol 10 2011 424 435
10. T. Hashimoto, A. Serrano-Pozo, Y. Hori, K.W. Adams, S. Takeda, and A.O. Banerji Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide J Neurosci 32 2012 15181 15192
11. L.M. Tai, T. Bilousova, L. Jungbauer, S.K. Roeske, K.L. Youmans, and C. Yu Levels of soluble apolipoprotein E/amyloid-beta (Abeta) complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples J Biol Chem 288 2013 5914 5926
12. T. Arendt, C. Schindler, M.K. Bruckner, K. Eschrich, V. Bigl, and D. Zedlick Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele J Neurosci 17 1997 516 529
13. B. Teter ApoE-dependent plasticity in Alzheimer's disease J Mol Neurosci 23 2004 167 179
14. Y. Ji, Y. Gong, W. Gan, T. Beach, D.M. Holtzman, and T. Wisniewski Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients Neuroscience 122 2003 305 315
15. E.M. Reiman, R.J. Caselli, L.S. Yun, K. Chen, D. Bandy, and S. Minoshima Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E N Engl J Med 334 1996 752 758
16. R. Egensperger, S. Kosel, U. von Eitzen, and M.B. Graeber Microglial activation in Alzheimer disease: association with APOE genotype Brain Pathol 8 1998 439 447
17. C.A. Szekely, J.C. Breitner, A.L. Fitzpatrick, T.D. Rea, B.M. Psaty, and L.H. Kuller NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type Neurology 70 2008 17 24
18. B.V. Zlokovic Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurol 70 2013 440 444
19. C.C. Liu, T. Kanekiyo, H. Xu, and G. Bu Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy Nat Rev 9 2013 106 118
20. J. Chapman, A.D. Korczyn, D.M. Karussis, and D.M. Michaelson The effects of APOE genotype on age at onset and progression of neurodegenerative diseases Neurology 57 2001 1482 1485
21. W. Zhou, D. Xu, X. Peng, Q. Zhang, J. Jia, and K.A. Crutcher Meta-analysis of APOE4 allele and outcome after traumatic brain injury J Neurotrauma 25 2008 279 290
22. E.M. Reiman, A. Uecker, R.J. Caselli, S. Lewis, D. Bandy, and M.J. de Leon Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease Ann Neurol 44 1998 288 291
23. P. Shaw, J.P. Lerch, J.C. Pruessner, K.N. Taylor, A.B. Rose, and D. Greenstein Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study Lancet Neurol 6 2007 494 500
24. D.C. Dean 3rd, B.A. Jerskey, K. Chen, H. Protas, P. Thiyyagura, and A. Roontiva Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional Imaging Study JAMA Neurol 71 2014 11 22
25. J. Kim, J.M. Basak, and D.M. Holtzman The role of apolipoprotein E in Alzheimer's disease Neuron 63 2009 287 303
26. M. Morikawa, J.D. Fryer, P.M. Sullivan, E.A. Christopher, S.E. Wahrle, and R.B. DeMattos Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta Neurobiol Dis 19 2005 66 76
27. H. Belinson, and D.M. Michaelson Pathological synergism between amyloid-beta and apolipoprotein E4-the most prevalent yet understudied genetic risk factor for Alzheimer's disease J Alzheimers Dis 17 2009 469 481
28. P.M. Sullivan, B.E. Mace, N. Maeda, and D.E. Schmechel Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice Neuroscience 124 2004 725 733
29. D.M. Holtzman, J. Herz, and G. Bu Apolipoprotein E and apolipoprotein e receptors: normal biology and roles in Alzheimer disease Cold Spring Harb Perspect Med 2 2012 a006312
30. D.G. Crenshaw, W.K. Gottschalk, M.W. Lutz, I. Grossman, A.M. Saunders, and J.R. Burke Using genetics to enable studies on the prevention of Alzheimer's disease Clin Pharmacol Ther 93 2012 177 185
31. R.W. Mahley, and Y. Huang Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology J Med Chem 55 2012 8997 9008
32. J.E. Vance, and H. Hayashi Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim Biophys Acta 1801 2010 806 818
33. R. Koldamova, M. Staufenbiel, and I. Lefterov Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice J Biol Chem 280 2005 43224 43235
34. S.E. Wahrle, H. Jiang, M. Parsadanian, J. Kim, A. Li, and A. Knoten Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease J Clin Invest 118 2008 671 682
35. P.E. Cramer, J.R. Cirrito, D.W. Wesson, C.Y. Lee, J.C. Karlo, and A.E. Zinn ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models Science 335 2012 1503 1506
36. M. Michikawa, Q.W. Fan, I. Isobe, and K. Yanagisawa Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture J Neurochem 74 2000 1008 1016
37. Z. Kariv-Inbal, S. Yacobson, R. Berkecz, M. Peter, T. Janaky, and D. Lutjohann The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol J Alzheimers Dis 28 2012 667 683
38. A. Boehm-Cagan, and D. Michaelson Pharmacological treatment reverses the pathological and cognitive effects of apoE4, the main genetic risk factor for Alzheimer's disease J Mol Neurosci Supplementary 1 2014
39. O. Liraz, A. Boehm-Cagan, and D.M. Michaelson ApoE4 induces Abeta42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice Mol Neurodegener 8 2013 May 17 16
40. M.J. Sadowski, J. Pankiewicz, H. Scholtzova, P.D. Mehta, F. Prelli, and D. Quartermain Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease Proc Natl Acad Sci U S A 103 2006 18787 18792
41. I. Luz, O. Liraz, A. Nakaryakov, N.I. Smorodinsky, and D. Michaelson Anti-apoE4 immunotherapy: a novel approach to the treatment of Alzheimer's disease (AD) J Mol Neurosc 51 Supplementary 1 2013 S75 S76
42. D.T. Laskowitz, P. Song, H. Wang, B. Mace, P.M. Sullivan, and M.P. Vitek Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic J Neurotrauma 27 2010 1983 1995
43. M.P. Vitek, D.J. Christensen, D. Wilcock, J. Davis, W.E. Van Nostrand, and F.Q. Li APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics Neurodegener Dis 10 2012 122 126
44. H. Wang, L.G. Anderson, C.D. Lascola, M.L. James, T.N. Venkatraman, and E.R. Bennett ApolipoproteinE mimetic peptides improve outcome after focal ischemia Exp Neurol 241 2012 67 74
45. X. Yao, M.P. Vitek, A.T. Remaley, and S.J. Levine Apolipoprotein mimetic peptides: a new approach for the treatment of asthma Front Pharmacol 3 2012 37
46. J. Poirier Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease Alzheimers Dement 4 2008 S91 S97
47. H.L. West, G.W. Rebeck, and B.T. Hyman Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease Neurosci Lett 175 1994 46 48
48. E. Hudry, J. Dashkoff, A.D. Roe, S. Takeda, R.M. Koffie, and T. Hashimoto Gene transfer of human apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain Sci Transl Med 5 2013 212ra161
49. J. Herz Apolipoprotein E receptors in the nervous system Curr Opin Lipidol 20 2009 190 196
50. M. Gilat-Frenkel, A. Boehm-Cagan, O. Liraz, X. Xian, J. Herz, and D. Michaelson Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo Curr Alzheimer Res 11 6 2014 549 557
51. R.W. Mahley, and Y. Huang Apolipoprotein e sets the stage: response to injury triggers neuropathology Neuron 76 2012 871 885
52. R.D. Bell, E.A. Winkler, I. Singh, A.P. Sagare, R. Deane, and Z. Wu Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature 485 2012 512 516