Frameshift mutants of β amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

Science

Volumn 279, Issue 5348, 1998, Pages 242-247

  Van Leeuwen, Fred W ^a   De Kleijn, Dominique P V ^a   Van Den Hurk, Helma H ^b   Neubauer, Andrea ^a   Sonnemans, Marc A F ^a   Sluijs, Jacqueline A ^a   Köycü, Soner ^a   Ramdjielal, Ravindra D J ^a   Salehi, Ahmad ^a   Martens, Gerard J M ^b   Grosveld, Frank G ^c   Burbach, J Peter H ^d   Hol, Elly M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; UBIQUITIN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; FRAMESHIFT MUTATION; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA EDITING; SENILE PLAQUE;

AGED; AGING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; BASE SEQUENCE; BRAIN CHEMISTRY; CEREBRAL CORTEX; CLONING, MOLECULAR; DOWN SYNDROME; FEMALE; FRAMESHIFT MUTATION; HIPPOCAMPUS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; NEURITES; NEUROFIBRILLARY TANGLES; NEUROPIL; POLYMERASE CHAIN REACTION; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA EDITING; SEQUENCE DELETION; TRANSCRIPTION, GENETIC; UBIQUITINS;

EID: 6844258835     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5348.242     Document Type: Article

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38. We thank J. Verhaagen, D. F. Swaab, C. W. Pool, J. J. van Heerikhuize, T. P. van der Woude, J. Wortel, A. Holtrop, J. Wouda, M. Kooreman, O. Pach, and G. van der Meulen for their help and R. T. Baker, I. Grundke-lqbal, P. Davies, T. Hartmann, and J. M. Octave for generously providing us with plasmid antisera and advice. Supported by Het Stimulerings-fonds Nederlandse Organisatie voor Wetenschappelijk Onderzoek-prioriteitsorogramma Geheugen processenen Dementie, an Koninklijke Nederlandse Akademie van Wetenschappen grant, the Matty Brand Foundation, and the Jan Dekker and Ludgardine Bouwman Foundation.