Cleavage of Alzheimer's amyloid precursor protein by α-secretase occurs at the surface of neuronal cells

Biochemistry

Volumn 38, Issue 30, 1999, Pages 9728-9734

  Parvathy, S ^b   Hussain, Ishrut ^c   Karran, Eric H ^a,c   Turner, Anthony J ^b   Hooper, Nigel M ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BATIMASTAT; CELL MEMBRANE PROTEIN; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LOCALIZATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NERVE CELL MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEINASE INHIBITION; TEMPERATURE SENSITIVITY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; ENDOPEPTIDASES; GOLGI APPARATUS; HUMANS; HYDROLYSIS; INTRACELLULAR FLUID; MEMBRANE PROTEINS; NEUROBLASTOMA; NEURONS; PROTEASE INHIBITORS; TUMOR CELLS, CULTURED;

EID: 0033609449     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9906827     Document Type: Article

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