-
1
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001;81(2):741-66.
-
(2001)
Physiol Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
2
-
-
0034718027
-
Biochemical detection of Abeta isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
-
Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim Biophys Acta 1502(1):172-87 (2000).
-
(2000)
Biochim Biophys Acta
, vol.1502
, Issue.1
, pp. 172-187
-
-
Golde, T.E.1
Eckman, C.B.2
Younkin, S.G.3
-
3
-
-
0034530634
-
Molecular genetics of chromosome 17 tauopathies
-
Hutton M. Molecular genetics of chromosome 17 tauopathies. Ann N Y Acad Sci 920:63-73 (2000).
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 63-73
-
-
Hutton, M.1
-
4
-
-
0029945015
-
New insights into the genetics of Alzheimer's disease
-
Hardy J. New insights into the genetics of Alzheimer's disease. Ann Med 28(3):255-8 (1996).
-
(1996)
Ann Med
, vol.28
, Issue.3
, pp. 255-258
-
-
Hardy, J.1
-
5
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393(6686):702-5 (1998).
-
(1998)
Nature
, vol.393
, Issue.6686
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
-
6
-
-
0026512066
-
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
-
Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, et al. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13(1):179-89 (1992).
-
(1992)
Neurobiol Aging
, vol.13
, Issue.1
, pp. 179-189
-
-
Dickson, D.W.1
Crystal, H.A.2
Mattiace, L.A.3
Masur, D.M.4
Blau, A.D.5
Davies, P.6
-
7
-
-
0029795517
-
Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration
-
Lue LF, Brachova L, Civin WH, Rogers J. Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J Neuropathol Exp Neurol 55(10):1083-8 (1996).
-
(1996)
J Neuropathol Exp Neurol
, vol.55
, Issue.10
, pp. 1083-1088
-
-
Lue, L.F.1
Brachova, L.2
Civin, W.H.3
Rogers, J.4
-
8
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155(3):853-62 (1999).
-
(1999)
Am J Pathol
, vol.155
, Issue.3
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
-
9
-
-
0029895870
-
Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging
-
Troncoso JC, Martin LJ, Dal Forno G, Kawas CH. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol Aging 17(3):365-71 (1996).
-
(1996)
Neurobiol Aging
, vol.17
, Issue.3
, pp. 365-371
-
-
Troncoso, J.C.1
Martin, L.J.2
Dal Forno, G.3
Kawas, C.H.4
-
10
-
-
0035168927
-
Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease
-
Morris JC, Price AL. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J Mol Neurosci 17(2):101-18 (2001).
-
(2001)
J Mol Neurosci
, vol.17
, Issue.2
, pp. 101-118
-
-
Morris, J.C.1
Price, A.L.2
-
11
-
-
0035928402
-
Imaging of onset and progression of Alzheimer's disease with voxel- compression mapping of serial magnetic resonance images
-
Fox NC, Crum WR, Scahill RI, Stevens JM, Janssen JC, Rossor MN. Imaging of onset and progression of Alzheimer's disease with voxel- compression mapping of serial magnetic resonance images. Lancet 358(9277):201-5 (2001).
-
(2001)
Lancet
, vol.358
, Issue.9277
, pp. 201-205
-
-
Fox, N.C.1
Crum, W.R.2
Scahill, R.I.3
Stevens, J.M.4
Janssen, J.C.5
Rossor, M.N.6
-
12
-
-
0037066123
-
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
-
Jack CR, Jr., Dickson DW, Parisi JE, Xu YC, Cha RH, O'Brien PC, et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 58(5):750-7 (2002).
-
(2002)
Neurology
, vol.58
, Issue.5
, pp. 750-757
-
-
Jack Jr., C.R.1
Dickson, D.W.2
Parisi, J.E.3
Xu, Y.C.4
Cha, R.H.5
O'Brien, P.C.6
-
13
-
-
33644832047
-
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humans
-
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humans. Ann Neurol 59(3): 512-19 (2006).
-
(2006)
Ann Neurol
, vol.59
, Issue.3
, pp. 512-519
-
-
Fagan, A.M.1
Mintun, M.A.2
Mach, R.H.3
Lee, S.Y.4
Dence, C.S.5
Shah, A.R.6
-
14
-
-
0032105394
-
The role of A beta 42 in Alzheimer's disease
-
Younkin SG. The role of A beta 42 in Alzheimer's disease. J Physiol Paris 92(3-4):289-92 (1998).
-
(1998)
J Physiol Paris
, vol.92
, Issue.3-4
, pp. 289-292
-
-
Younkin, S.G.1
-
15
-
-
0027258525
-
PTL. The carboxy terminus of β amyloid protein is critical for the seeding of amyloid formation: Implications for pathogenesis of Alzheimer's disease
-
Jarrett JT, Berger EP, Jr. PTL. The carboxy terminus of β amyloid protein is critical for the seeding of amyloid formation: Implications for pathogenesis of Alzheimer's disease. Biochem 32:4693-4697 (1993).
-
(1993)
Biochem
, vol.32
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger Jr., E.P.2
-
16
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with and-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with and-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13:45-53 (1994).
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
17
-
-
0028915895
-
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
-
Gravina SA, Ho L, Eckman CB, Long KE, Otvos L, Jr., Younkin LH, et al. Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). Journal of Biological Chemistry 270(13):7013-6 (1995).
-
(1995)
Journal of Biological Chemistry
, vol.270
, Issue.13
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
Long, K.E.4
Otvos Jr., L.5
Younkin, L.H.6
-
18
-
-
22544482926
-
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice
-
McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47(2):191-9 (2005).
-
(2005)
Neuron
, vol.47
, Issue.2
, pp. 191-199
-
-
McGowan, E.1
Pickford, F.2
Kim, J.3
Onstead, L.4
Eriksen, J.5
Yu, C.6
-
19
-
-
0032837741
-
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging
-
Wang J, Dickson DW, Trojanowski JQ, Lee VM. The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging. Exp Neurol 158(2):328-37 (1999).
-
(1999)
Exp Neurol
, vol.158
, Issue.2
, pp. 328-337
-
-
Wang, J.1
Dickson, D.W.2
Trojanowski, J.Q.3
Lee, V.M.4
-
20
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel HA, Hartley D, Petre BM, Walz T, Lansbury PT, Jr. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature 418(6895):291 (2002).
-
(2002)
Nature
, vol.418
, Issue.6895
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury Jr., P.T.5
-
21
-
-
0031781988
-
Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
-
Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, et al. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch Neurol 55(9):1185-91 (1998).
-
(1998)
Arch Neurol
, vol.55
, Issue.9
, pp. 1185-1191
-
-
Haroutunian, V.1
Perl, D.P.2
Purohit, D.P.3
Marin, D.4
Khan, K.5
Lantz, M.6
-
22
-
-
0037195163
-
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease
-
Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, et al. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci USA 99(22):13990-5 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.22
, pp. 13990-13995
-
-
Urbanc, B.1
Cruz, L.2
Le, R.3
Sanders, J.4
Ashe, K.H.5
Duff, K.6
-
23
-
-
0036678856
-
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease
-
DeMattos RB, O'Dell M A, Parsadanian M, Taylor JW, Harmony JA, Bales KR, et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 99(16):10843-8 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.16
, pp. 10843-10848
-
-
DeMattos, R.B.1
O'Dell, M.A.2
Parsadanian, M.3
Taylor, J.W.4
Harmony, J.A.5
Bales, K.R.6
-
24
-
-
4143138471
-
In vivo effects of ApoE and clusterin on amyloidbeta metabolism and neuropathology
-
Holtzman DM. In vivo effects of ApoE and clusterin on amyloidbeta metabolism and neuropathology. J Mol Neurosci 23(3):247-54 (2004).
-
(2004)
J Mol Neurosci
, vol.23
, Issue.3
, pp. 247-254
-
-
Holtzman, D.M.1
-
25
-
-
0036679142
-
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
-
Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, et al. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci USA 99(16):10837-10842 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.16
, pp. 10837-10842
-
-
Wyss-Coray, T.1
Yan, F.2
Lin, A.H.3
Lambris, J.D.4
Alexander, J.J.5
Quigg, R.J.6
-
26
-
-
0030805991
-
Frequency of stages of Alzheimer-related lesions in different age categories
-
Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 18(4):351-7 (1997).
-
(1997)
Neurobiol Aging
, vol.18
, Issue.4
, pp. 351-357
-
-
Braak, H.1
Braak, E.2
-
27
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-6 (2002).
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
28
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
Price DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Annual Review of Neuroscience 21:479-505 (1998).
-
(1998)
Annual Review of Neuroscience
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
29
-
-
0032491494
-
Genetic neurodegenerative diseases: The human illness and transgenic models
-
Price DL, Sisodia SS, Borchelt DR. Genetic neurodegenerative diseases: the human illness and transgenic models. Science 282(5391):1079-83 (1998).
-
(1998)
Science
, vol.282
, Issue.5391
, pp. 1079-1083
-
-
Price, D.L.1
Sisodia, S.S.2
Borchelt, D.R.3
-
30
-
-
0036489445
-
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
-
Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, et al. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 22(5):1858-67 (2002).
-
(2002)
J Neurosci
, vol.22
, Issue.5
, pp. 1858-1867
-
-
Westerman, M.A.1
Cooper-Blacketer, D.2
Mariash, A.3
Kotilinek, L.4
Kawarabayashi, T.5
Younkin, L.H.6
-
31
-
-
14644442872
-
Intraneuronal Abeta causes the onset of early Alzheimer's diseaserelated cognitive deficits in transgenic mice
-
Billings LM, Oddo S, Green KN, McGaugh JL, Laferla FM. Intraneuronal Abeta causes the onset of early Alzheimer's diseaserelated cognitive deficits in transgenic mice. Neuron 45(5):675-88 (2005).
-
(2005)
Neuron
, vol.45
, Issue.5
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
McGaugh, J.L.4
Laferla, F.M.5
-
32
-
-
0035674312
-
Learning and memory in transgenic mice modeling Alzheimer's disease
-
Ashe KH. Learning and memory in transgenic mice modeling Alzheimer's disease. Learn Mem 8(6):301-8 (2001).
-
(2001)
Learn Mem
, vol.8
, Issue.6
, pp. 301-308
-
-
Ashe, K.H.1
-
33
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 5(5):452-7 (2002).
-
(2002)
Nat Neurosci
, vol.5
, Issue.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
DeMattos, R.B.5
Mathis, C.6
-
34
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408(6815):979-982 (2000).
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
-
35
-
-
0036703483
-
Reversible memory loss in a mouse transgenic model of Alzheimer's disease
-
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, et al. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 22(15):6331-5 (2002).
-
(2002)
J Neurosci
, vol.22
, Issue.15
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
Kawarabayashi, T.4
Younkin, L.5
Hyman, B.T.6
-
36
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 430(7000):631-9 (2004).
-
(2004)
Nature
, vol.430
, Issue.7000
, pp. 631-639
-
-
Mattson, M.P.1
-
37
-
-
2442594971
-
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
-
Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, et al. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 279(19):20296-306 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.19
, pp. 20296-20306
-
-
Davis, J.1
Xu, F.2
Deane, R.3
Romanov, G.4
Previti, M.L.5
Zeigler, K.6
-
38
-
-
29444442794
-
-
Rovelet-Lecrux A, Hannequin D, Raux G, Meur NL, Laquerriere A, Vital A, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38(1):24-6 (2006).
-
Rovelet-Lecrux A, Hannequin D, Raux G, Meur NL, Laquerriere A, Vital A, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38(1):24-6 (2006).
-
-
-
-
39
-
-
0035433962
-
Alzheimer's disease and Abeta toxicity: From top to bottom
-
Small DH, Mok SS, Bornstein JC. Alzheimer's disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci 2(8):595-8 (2001).
-
(2001)
Nat Rev Neurosci
, vol.2
, Issue.8
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
40
-
-
27744435409
-
Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
-
Ribe EM, Perez M, Puig B, Gich I, Lim F, Cuadrado M, et al. Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice. Neurobiol Dis 20(3):814-22 (2005).
-
(2005)
Neurobiol Dis
, vol.20
, Issue.3
, pp. 814-822
-
-
Ribe, E.M.1
Perez, M.2
Puig, B.3
Gich, I.4
Lim, F.5
Cuadrado, M.6
-
41
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293(5534):1491-5 (2001).
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
42
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293(5534):1487-91 (2001).
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
-
43
-
-
0035834076
-
beta-amyloid peptides enhance alphasynuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
-
Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, et al. beta-amyloid peptides enhance alphasynuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci USA 98(21):12245-50 (2001).
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.21
, pp. 12245-12250
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Sagara, Y.4
Mallory, M.5
Hashimoto, M.6
-
44
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39(3):409-21 (2003).
-
(2003)
Neuron
, vol.39
, Issue.3
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
-
45
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43(3):321-32 (2004).
-
(2004)
Neuron
, vol.43
, Issue.3
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
LaFerla, F.M.5
-
46
-
-
0019153066
-
Amyloid deposits and amyloidosis
-
Glenner GG. Amyloid deposits and amyloidosis. New Engl Med 302:1283-1292 (1980).
-
(1980)
New Engl Med
, vol.302
, pp. 1283-1292
-
-
Glenner, G.G.1
-
47
-
-
23444448170
-
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
-
Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 25(31):7278-87 (2005).
-
(2005)
J Neurosci
, vol.25
, Issue.31
, pp. 7278-7287
-
-
Spires, T.L.1
Meyer-Luehmann, M.2
Stern, E.A.3
McLean, P.J.4
Skoch, J.5
Nguyen, P.T.6
-
48
-
-
6344282962
-
Neuronal structure is altered by amyloid plaques
-
Spires TL, Hyman BT. Neuronal structure is altered by amyloid plaques. Rev Neurosci 15(4):267-78 (2004).
-
(2004)
Rev Neurosci
, vol.15
, Issue.4
, pp. 267-278
-
-
Spires, T.L.1
Hyman, B.T.2
-
49
-
-
7044220336
-
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
-
Tsai J, Grutzendler J, Duff K, Gan WB. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 7(11):1181-3 (2004).
-
(2004)
Nat Neurosci
, vol.7
, Issue.11
, pp. 1181-1183
-
-
Tsai, J.1
Grutzendler, J.2
Duff, K.3
Gan, W.B.4
-
50
-
-
85047691873
-
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
-
Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, et al. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest 115(2):428-33 (2005).
-
(2005)
J Clin Invest
, vol.115
, Issue.2
, pp. 428-433
-
-
Brendza, R.P.1
Bacskai, B.J.2
Cirrito, J.R.3
Simmons, K.A.4
Skoch, J.M.5
Klunk, W.E.6
-
51
-
-
0035077553
-
Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia
-
Ghiso J, Frangione B. Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia. J Alzheimers Dis 3(1):65-73 (2001).
-
(2001)
J Alzheimers Dis
, vol.3
, Issue.1
, pp. 65-73
-
-
Ghiso, J.1
Frangione, B.2
-
52
-
-
0024990330
-
Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachynin neuropeptides
-
Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachynin neuropeptides. Science 250:279-282 (1990).
-
(1990)
Science
, vol.250
, pp. 279-282
-
-
Yankner, B.A.1
Duffy, L.K.2
Kirschner, D.A.3
-
53
-
-
0025244165
-
Nerve growth factor potentiates the neurotoxicity of beta amyloid
-
Yankner BA, Caceres A, Duffy LK. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci USA 87:9020-9023 (1990).
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9020-9023
-
-
Yankner, B.A.1
Caceres, A.2
Duffy, L.K.3
-
54
-
-
0026686938
-
Commentary and perspective on studies of beta amyloid neurotoxicity
-
Yankner BA. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging 13(5):615-6 (1992).
-
(1992)
Neurobiol Aging
, vol.13
, Issue.5
, pp. 615-616
-
-
Yankner, B.A.1
-
55
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16(5):921-32(1996).
-
(1996)
Neuron
, vol.16
, Issue.5
, pp. 921-932
-
-
Yankner, B.A.1
-
56
-
-
0031824782
-
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
-
Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 4(7):827-31 (1998).
-
(1998)
Nat Med
, vol.4
, Issue.7
, pp. 827-831
-
-
Geula, C.1
Wu, C.K.2
Saroff, D.3
Lorenzo, A.4
Yuan, M.5
Yankner, B.A.6
-
57
-
-
0141884305
-
-
Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron 40(2):401-13 (2003).
-
Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron 40(2):401-13 (2003).
-
-
-
-
58
-
-
4344573714
-
Adult neuron survival strategies - slamming on the brakes
-
Benn SC, Woolf CJ. Adult neuron survival strategies - slamming on the brakes. Nat Rev Neurosci 5(9):686-700 (2004).
-
(2004)
Nat Rev Neurosci
, vol.5
, Issue.9
, pp. 686-700
-
-
Benn, S.C.1
Woolf, C.J.2
-
59
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 21(3):383-421 (2000).
-
(2000)
Neurobiol Aging
, vol.21
, Issue.3
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
-
60
-
-
0036685522
-
Inflammation in neurodegenerative disease - a double-edged sword
-
Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease - a double-edged sword. Neuron 35(3):419-32 (2002).
-
(2002)
Neuron
, vol.35
, Issue.3
, pp. 419-432
-
-
Wyss-Coray, T.1
Mucke, L.2
-
61
-
-
4644241244
-
Innate immunity, local inflammation, and degenerative disease
-
McGeer PL, McGeer EG. Innate immunity, local inflammation, and degenerative disease. Sci Aging Knowledge Environ 2002;2002(29):re3.
-
(2002)
Sci Aging Knowledge Environ
, vol.2002
, Issue.29
-
-
McGeer, P.L.1
McGeer, E.G.2
-
62
-
-
0032450274
-
Glial cell reactions in neurodegenerative diseases: Pathophysiology and therapeutic interventions
-
McGeer PL, McGeer EG. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzh Dis Assoc Disord 12(Suppl 2):S1-6 (1998).
-
(1998)
Alzh Dis Assoc Disord
, vol.12
, Issue.SUPPL. 2
-
-
McGeer, P.L.1
McGeer, E.G.2
-
64
-
-
0030038809
-
Scavenging of Alzheimer's amyloid beta-protein by microglia in culture
-
Ard MD, Cole GM, Wei J, Mehrle AP, Fratkin JD. Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J Neurosci Res 43(2):190-202 (1996).
-
(1996)
J Neurosci Res
, vol.43
, Issue.2
, pp. 190-202
-
-
Ard, M.D.1
Cole, G.M.2
Wei, J.3
Mehrle, A.P.4
Fratkin, J.D.5
-
65
-
-
0029811105
-
Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
-
Giulian D, Haverkamp LJ, Yu JH, Karshin W, Tom D, Li J, et al. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci 16(19):6021-37 (1996).
-
(1996)
J Neurosci
, vol.16
, Issue.19
, pp. 6021-6037
-
-
Giulian, D.1
Haverkamp, L.J.2
Yu, J.H.3
Karshin, W.4
Tom, D.5
Li, J.6
-
66
-
-
14944385354
-
Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
-
Floden AM, Li S, Combs CK. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci 25(10):2566-75 (2005).
-
(2005)
J Neurosci
, vol.25
, Issue.10
, pp. 2566-2575
-
-
Floden, A.M.1
Li, S.2
Combs, C.K.3
-
67
-
-
0033900999
-
Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice
-
Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E. Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am J Pathol 156(1):139-50 (2000).
-
(2000)
Am J Pathol
, vol.156
, Issue.1
, pp. 139-150
-
-
Wyss-Coray, T.1
Lin, C.2
Sanan, D.A.3
Mucke, L.4
Masliah, E.5
-
68
-
-
0037394788
-
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
-
Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, et al. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med 9(4):453-7 (2003).
-
(2003)
Nat Med
, vol.9
, Issue.4
, pp. 453-457
-
-
Wyss-Coray, T.1
Loike, J.D.2
Brionne, T.C.3
Lu, E.4
Anankov, R.5
Yan, F.6
-
69
-
-
3142781310
-
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
-
Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, et al. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 10(7):719-26 (2004).
-
(2004)
Nat Med
, vol.10
, Issue.7
, pp. 719-726
-
-
Koistinaho, M.1
Lin, S.2
Wu, X.3
Esterman, M.4
Koger, D.5
Hanson, J.6
-
70
-
-
2942611429
-
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
-
Schwab C, Hosokawa M, McGeer PL. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease. Exp Neurol 188(1):52-64 (2004).
-
(2004)
Exp Neurol
, vol.188
, Issue.1
, pp. 52-64
-
-
Schwab, C.1
Hosokawa, M.2
McGeer, P.L.3
-
71
-
-
0029811901
-
Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies [see comments]
-
McGeer PL, Schulzer M, McGeer EG. Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies [see comments]. Neurology 47(2):425-32 (1996).
-
(1996)
Neurology
, vol.47
, Issue.2
, pp. 425-432
-
-
McGeer, P.L.1
Schulzer, M.2
McGeer, E.G.3
-
72
-
-
0030897133
-
Risk of Alzheimer's disease and duration of NSAID use [see comments]
-
Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use [see comments]. Neurology 48(3):626-32 (1997).
-
(1997)
Neurology
, vol.48
, Issue.3
, pp. 626-632
-
-
Stewart, W.F.1
Kawas, C.2
Corrada, M.3
Metter, E.J.4
-
73
-
-
0035936004
-
-
in t' Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 345(21):1515-21 (2001).
-
in t' Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 345(21):1515-21 (2001).
-
-
-
-
74
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414(6860):212-6 (2001).
-
(2001)
Nature
, vol.414
, Issue.6860
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
-
75
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target gammasecretase and lower Abeta 42 in vivo
-
Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, et al. NSAIDs and enantiomers of flurbiprofen target gammasecretase and lower Abeta 42 in vivo. J Clin Invest 112(3):440-9 (2003).
-
(2003)
J Clin Invest
, vol.112
, Issue.3
, pp. 440-449
-
-
Eriksen, J.L.1
Sagi, S.A.2
Smith, T.E.3
Weggen, S.4
Das, P.5
McLendon, D.C.6
-
76
-
-
27144513779
-
Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
-
Hirohata M, Ono K, Naiki H, Yamada M. Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Neuropharmacology 2005.
-
(2005)
Neuropharmacology
-
-
Hirohata, M.1
Ono, K.2
Naiki, H.3
Yamada, M.4
-
77
-
-
0037017399
-
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
-
Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156(3):519-29(2002).
-
(2002)
J Cell Biol
, vol.156
, Issue.3
, pp. 519-529
-
-
Zhang, Y.1
McLaughlin, R.2
Goodyer, C.3
LeBlanc, A.4
-
78
-
-
0034668842
-
Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8
-
Zhang Y, Goodyer C, LeBlanc A. Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8. J Neurosci 20(22):8384-9 (2000).
-
(2000)
J Neurosci
, vol.20
, Issue.22
, pp. 8384-8389
-
-
Zhang, Y.1
Goodyer, C.2
LeBlanc, A.3
-
79
-
-
0028981717
-
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
-
LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 9(1):21-30 (1995).
-
(1995)
Nat Genet
, vol.9
, Issue.1
, pp. 21-30
-
-
LaFerla, F.M.1
Tinkle, B.T.2
Bieberich, C.J.3
Haudenschild, C.C.4
Jay, G.5
-
80
-
-
0033622324
-
Intraneuronal Abeta42 accumulation in human brain
-
Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, et al. Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 156(1):15-20 (2000).
-
(2000)
Am J Pathol
, vol.156
, Issue.1
, pp. 15-20
-
-
Gouras, G.K.1
Tsai, J.2
Naslund, J.3
Vincent, B.4
Edgar, M.5
Checler, F.6
-
81
-
-
19944434132
-
Intracellular Abeta42 activates p53 promoter: A pathway to neurodegeneration in Alzheimer's disease
-
Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, et al. Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease. FASEB J 19(2):255-7 (2005).
-
(2005)
FASEB J
, vol.19
, Issue.2
, pp. 255-257
-
-
Ohyagi, Y.1
Asahara, H.2
Chui, D.H.3
Tsuruta, Y.4
Sakae, N.5
Miyoshi, K.6
-
82
-
-
0038578900
-
Selective increase in cellular A beta 42 is related to apoptosis but not necrosis
-
Ohyagi Y, Yamada T, Nishioka K, Clarke NJ, Tomlinson AJ, Naylor S, et al. Selective increase in cellular A beta 42 is related to apoptosis but not necrosis. Neuroreport 11(1):167-71 (2000).
-
(2000)
Neuroreport
, vol.11
, Issue.1
, pp. 167-171
-
-
Ohyagi, Y.1
Yamada, T.2
Nishioka, K.3
Clarke, N.J.4
Tomlinson, A.J.5
Naylor, S.6
-
83
-
-
0037461730
-
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
-
Sanchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature 421(6921):373-9 (2003).
-
(2003)
Nature
, vol.421
, Issue.6921
, pp. 373-379
-
-
Sanchez, I.1
Mahlke, C.2
Yuan, J.3
-
84
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300(5618):486-9 (2003).
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
-
85
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
-
Caughey B, Lansbury PT. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 26:267-98 (2003).
-
(2003)
Annu Rev Neurosci
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
86
-
-
0036669881
-
Amyloid-beta oligomers: Their production, toxicity and therapeutic inhibition
-
Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans 30(4):552-7 (2002).
-
(2002)
Biochem Soc Trans
, vol.30
, Issue.4
, pp. 552-557
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Rowan, M.J.4
Selkoe, D.J.5
-
87
-
-
2542427690
-
Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration
-
Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett 11(3):213-28 (2004).
-
(2004)
Protein Pept Lett
, vol.11
, Issue.3
, pp. 213-228
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
88
-
-
22144462135
-
Neurotoxic protein oligomers - what you see is not always what you get
-
Bitan G, Fradinger EA, Spring SM, Teplow DB. Neurotoxic protein oligomers - what you see is not always what you get. Amyloid 12(2):88-95 (2005).
-
(2005)
Amyloid
, vol.12
, Issue.2
, pp. 88-95
-
-
Bitan, G.1
Fradinger, E.A.2
Spring, S.M.3
Teplow, D.B.4
-
89
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America 95(11):6448-53 (1998).
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.11
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
-
90
-
-
2542455537
-
Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease
-
Klein WL, Stine WB, Jr., Teplow DB. Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol Aging 2004;25(5):569-80.
-
(2004)
Neurobiol Aging
, vol.25
, Issue.5
, pp. 569-580
-
-
Klein, W.L.1
Stine Jr., W.B.2
Teplow, D.B.3
-
91
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416(6880):535-9 (2002).
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
92
-
-
15944426127
-
Amyloid accumulation and pathogensis of Alzheimer's disease: Significance of monomeric, oligomeric and fibrillar Abeta
-
Glabe CC. Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta. Subcell Biochem 38:167-77 (2005).
-
(2005)
Subcell Biochem
, vol.38
, pp. 167-177
-
-
Glabe, C.C.1
-
93
-
-
8744220663
-
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases
-
Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, et al. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem 279(45):46363-6 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.45
, pp. 46363-46366
-
-
Kayed, R.1
Sokolov, Y.2
Edmonds, B.3
McIntire, T.M.4
Milton, S.C.5
Hall, J.E.6
-
94
-
-
20844458090
-
Synaptic targeting by Alzheimer's-related amyloid beta oligomers
-
Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, et al. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 24(45):10191-200 (2004).
-
(2004)
J Neurosci
, vol.24
, Issue.45
, pp. 10191-10200
-
-
Lacor, P.N.1
Buniel, M.C.2
Chang, L.3
Fernandez, S.J.4
Gong, Y.5
Viola, K.L.6
-
95
-
-
0037271080
-
Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein
-
Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, et al. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. FASEB J 17(1):118-20 (2003).
-
(2003)
FASEB J
, vol.17
, Issue.1
, pp. 118-120
-
-
Kim, H.J.1
Chae, S.C.2
Lee, D.K.3
Chromy, B.4
Lee, S.C.5
Park, Y.C.6
-
96
-
-
0035812658
-
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis
-
Kirkitadze MD, Condron MM, Teplow DB. Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. J Mol Biol 312(5):1103-19 (2001).
-
(2001)
J Mol Biol
, vol.312
, Issue.5
, pp. 1103-1119
-
-
Kirkitadze, M.D.1
Condron, M.M.2
Teplow, D.B.3
-
97
-
-
18944407388
-
Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death
-
Wogulis M, Wright S, Cunningham D, Chilcote T, Powell K, Rydel RE. Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death. J Neurosci 25(5):1071-80 (2005).
-
(2005)
J Neurosci
, vol.25
, Issue.5
, pp. 1071-1080
-
-
Wogulis, M.1
Wright, S.2
Cunningham, D.3
Chilcote, T.4
Powell, K.5
Rydel, R.E.6
-
98
-
-
0037248301
-
Alzheimer disease therapy: Can the amyloid cascade be halted?
-
Golde TE. Alzheimer disease therapy: Can the amyloid cascade be halted? J Clin Invest 111(1):11-8 (2003).
-
(2003)
J Clin Invest
, vol.111
, Issue.1
, pp. 11-18
-
-
Golde, T.E.1
|