Nonfibrillar diffuse amyloid deposition due to a γ 42-secretase site mutation points to an essential role for N-truncated Aβ 42 in Alzheimer's disease

Human Molecular Genetics

Volumn 9, Issue 18, 2000, Pages 2589-2598

  Kumar Singh, Samir ^a   De Jonghe, Chris ^a   Cruts, Marc ^a   Kleinert, Reinhold ^b   Wang, Rong ^c   Mercken, Marc ^d   De Strooper, Bart ^e   Vanderstichele, Hugo ^f   Löfgren, Ann ^a   Vanderhoeven, Inge ^a   Backhovens, Hubert ^a   Vanmechelen, Eugeen ^f   Kroisel, Peter M ^b   Van Broeckhoven, Christine ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF GRAZ   (Austria)

^c ROCKEFELLER UNIVERSITY   (United States)

^d JANSSEN RESEARCH FOUNDATION   (Belgium)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f INNOGENETICS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE;

ADULT; ALZHEIMER DISEASE; ARTICLE; BIOACCUMULATION; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; MISSENSE MUTATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MUTATION, MISSENSE; PEDIGREE; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SENILE PLAQUES; SOLUBILITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 0034327364     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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