Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 25, 2007, Pages 10613-10618

  Zhang, Yun Wu ^a,b   Wang, Ruishan ^a,b   Liu, Qiang ^c   Zhang, Han ^a,b   Liao, Francesca Fang ^a   Xu, Huaxi ^a,b  

^a BURNHAM INSTITUTE   (United States)

^b XIAMEN UNIVERSITY   (China)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amyloid precursor protein intracellular domain; Alzheimer's disease; Transcriptional regulation; Tumorigenesis

Indexed keywords

AMYLOID PRECURSOR PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CARCINOMA; CELL NUCLEUS; CONTROLLED STUDY; EGFR GENE; ENZYME ACTIVITY; FIBROBLAST; GENE; GENE DOSAGE; GENE EXPRESSION REGULATION; IN VIVO STUDY; KERATINOCYTE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PS1 GENE; PS2 GENE; RECEPTOR UPREGULATION; SKIN TUMOR; TRANSCRIPTION REGULATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; FIBROBLASTS; LUCIFERASES; MICE; MICE, KNOCKOUT; PRESENILINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, EPIDERMAL GROWTH FACTOR;

MUS;

EID: 34547539177     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703903104     Document Type: Article

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