Aβ oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

Journal of Neuroscience

Volumn 30, Issue 36, 2010, Pages 11938-11950

  Zempel, Hans ^a   Thies, Edda ^a   Mandelkow, Eckhard ^a,b   Mandelkow, Eva Maria ^a,b  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; CYCLIN DEPENDENT KINASE 5; EPITOPE; GLUTAMIC ACID; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN; ADENOSINE TRIPHOSPHATE; LACTATE DEHYDROGENASE; NEUROFILAMENT PROTEIN; PEPTIDE FRAGMENT; PROTEIN KINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; DENDRITE; ENZYME ACTIVITY; HIPPOCAMPUS; MICROTUBULE; MITOCHONDRION; NERVE FIBER; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; SPINE; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CHEMISTRY; CYTOLOGY; DENDRITIC SPINE; DRUG EFFECT; METABOLISM; METHODOLOGY; NERVE CELL; PHOSPHORYLATION; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT; TIME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM; CELLS, CULTURED; DENDRITES; DENDRITIC SPINES; EMBRYO, MAMMALIAN; HIPPOCAMPUS; L-LACTATE DEHYDROGENASE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MITOCHONDRIA; NEUROFILAMENT PROTEINS; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; TAU PROTEINS; TIME FACTORS;

EID: 77956587739     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2357-10.2010     Document Type: Article

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