Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

EMBO Journal

Volumn 32, Issue 22, 2013, Pages 2920-2937

  Zempel, Hans ^a   Luedtke, Julia ^a,b   Kumar, Yatender ^a,b   Biernat, Jacek ^a   Dawson, Hana ^c   Mandelkow, Eckhard ^a,b,d   Mandelkow, Eva Maria ^a,b,d  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b MPI for Neurological Research   (Germany)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

Author keywords

Abeta oligomers; Alzheimer disease; MARK par 1; spastin; Tau missorting

Indexed keywords

AMYLOID BETA PROTEIN; PEPTIDES AND PROTEINS; SPASTIN; TAU PROTEIN; TUBULIN TYROSINE LIGASE LIKE 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENDRITE; MICROTUBULE; MITOCHONDRION; MOUSE; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SPINE; SYNAPSE;

ADENOSINE TRIPHOSPHATASES; AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; GLUTAMIC ACID; MICE; MICE, KNOCKOUT; MICROTUBULES; PEPTIDE SYNTHASES; RATS; SYNAPSES; TAU PROTEINS;

MUS; MUS MUSCULUS;

EID: 84887828122     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.207     Document Type: Article

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