Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability

Human Molecular Genetics

Volumn 10, Issue 16, 2001, Pages 1665-1671

  De Jonghe, Chris ^a   Esselens, Cary ^a   Kumar Singh, Samir ^a   Craessaerts, Katleen ^a   Serneels, Sally ^a   Checler, Frédéric ^b   Annaert, Wim ^a   Van Broeckhoven, Christine ^a   De Strooper, Bart ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CELL PROTEIN; GAMMA SECRETASE; NERVE PROTEIN;

ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; FAMILIAL DISEASE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; MISSENSE MUTATION; MOUSE; NERVE CELL; NONHUMAN; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; HUMANS; MICE; MUTATION; NEURONS; PEPTIDE FRAGMENTS; PRECIPITIN TESTS; TRANSDUCTION, GENETIC;

ANIMALIA;

EID: 0035421638     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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