Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

EMBO Molecular Medicine

Volumn 5, Issue 2, 2013, Pages 221-234

  Tsuiji, Hitomi ^a   Iguchi, Yohei ^b   Furuya, Asako ^a   Kataoka, Ayane ^a   Hatsuta, Hiroyuki ^c   Atsuta, Naoki ^b   Tanaka, Fumiaki ^b   Hashizume, Yoshio ^d   Akatsu, Hiroyasu ^d   Murayama, Shigeo ^c   Sobue, Gen ^b,e   Yamanaka, Koji ^a,e,f,g  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Tokyo Metropolitan Institute of Gerontology   (Japan)

^d NAGOYA CITY UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f SAITAMA UNIVERSITY   (Japan)

^g KYOTO UNIVERSITY   (Japan)

Author keywords

ALS; SMN; SnRNA; Spliceosome; TDP 43

Indexed keywords

FUSED IN SARCOMA PROTEIN; SMALL NUCLEAR RNA; TAR DNA BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; FRONTOTEMPORAL DEMENTIA; GEMINI OF COILED BODIES; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SPINAL MUSCULAR ATROPHY; SPLICEOSOME; TEMPORAL LOBE; UPREGULATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL NUCLEUS; DNA-BINDING PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; PROTEIN BINDING; RNA, SMALL NUCLEAR; RNA-BINDING PROTEIN FUS; SMN COMPLEX PROTEINS; SPLICEOSOMES;

EID: 84873314088     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201202303     Document Type: Article

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