The ubiquitin proteasome system in neurodegenerative diseases: Culprit, accomplice or victim?

Progress in Neurobiology

Volumn 96, Issue 2, 2012, Pages 190-207

  Dennissen, F J A ^a   Kholod, N ^a   van Leeuwen, F W ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; Frontotemporal dementia; Huntington's disease; Neurodegenerative diseases; Parkinson's disease; Protein degradation; Ubiquitin; Ubiquitin proteasome system; Ubiquitin like proteins

Indexed keywords

ALPHA SYNUCLEIN; AUTOPHAGY RELATED PROTEIN 12; AUTOPHAGY RELATED PROTEIN 8; DJ 1 PROTEIN; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 90; I KAPPA B; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE; NEDD8 PROTEIN; PROTEIN; PROTEIN P53; PROTEIN TYROSINE KINASE A; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; TAU PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; AUTOPHAGY; CELL CYCLE REGULATION; CREUTZFELDT JAKOB DISEASE; DNA DAMAGE; DNA REPAIR; EMBRYO DEVELOPMENT; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME ACTIVATION; ENZYME STABILITY; EPIGENETICS; FRONTOTEMPORAL DEMENTIA; HUMAN; HUNTINGTON CHOREA; HYDROPHOBICITY; IMMUNE RESPONSE; MACROAUTOPHAGY; MISSENSE MUTATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; SUMOYLATION; UBIQUITIN PROTEASOME SYSTEM; UBIQUITINATION;

ANIMALS; HUMANS; MODELS, MOLECULAR; NEURODEGENERATIVE DISEASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATION;

EID: 84856977664     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2012.01.003     Document Type: Review

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