Exogenous induction of cerebral β-amyloidogenesis is governed bf agent and host

Science

Volumn 313, Issue 5794, 2006, Pages 1781-1784

  Meyer Luehmann, Melanie ^a   Coomaraswamy, Janaky ^a   Bolmont, Tristan ^a   Kaeser, Stephan ^a   Schaefer, Claudia ^a   Kilger, Ellen ^a   Neuenschwander, Anton ^a   Abramowski, Dorothee ^a   Frey, Peter ^a   Jaton, Anneliese L ^a   Vigouret, Jean Marie ^a   Paganetti, Paolo ^a   Walsh, Dominic M ^a   Mathews, Paul M ^a   Ghiso, Jorge ^a   Staufenbiel, Matthias ^a   Walker, Lary C ^a   Jucker, Mathias ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CONCENTRATION (PROCESS); IMMUNOLOGY; PROTEINS;

AMYLOIDOSIS; BIOLOGICAL ACTIVITIES;

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRAIN EXTRACT; PRION PROTEIN;

AGGREGATION; BRAIN; PROTEIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; BRAIN; BRAIN CHEMISTRY; BRAIN DISEASES; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, TRANSGENIC; PROTEIN DENATURATION; TIME FACTORS; TISSUE EXTRACTS;

MUS MUSCULUS;

EID: 33749020837     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1131864     Document Type: Article

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33. We thank H. LeVine (Lexington), J. Hardy (Bethesda), M. Mattson (Baltimore), M. Tolnay (Basel), F. Heppner (Zurich), B. Sahagan (Groton), and D. Selkoe (Boston) for helpful discussions. Aβ preparations were provided by P. Palumaa (Tallinn), J. Fryer and D. Holtzman (St. Louis), G. Multhaup (Berlin), C. Glabe and R. Kayed (Irvine), and U. Ebert and H. Hillen (Ludwigshafen). Antibodies were provided by K. Beyreuther (Heidelberg). The help of R. Radde (Tübingen) is gratefully acknowledged. Supported by grants from the Alzheimer Association (IIRG-02-4127; ZEN-06-27341), Swiss National Science Foundation (3100-068329.02), European Union contract LSHM-CT-2003-503330. (APOPIS), and German National Genome Network (NGFN2) (to M.J.); the Wellcome Trust (067660) (to D.M.W.); the National Institute of Neurological Disorders and Stroke (NS45357) (to P.M.M.); and the NIH (RR-00165) (to L.C.W.).