Amyloid precursor protein increases cortical neuron size in transgenic mice

Neurobiology of Aging

Volumn 30, Issue 8, 2009, Pages 1238-1244

  Oh, Esther S ^a   Savonenko, Alena V ^a   King, Julie F ^a   Fangmark Tucker, Stina M ^a   Rudow, Gay L ^a   Xu, Guilian ^b   Borchelt, David R ^b   Troncoso, Juan C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Amyloid precursor protein; Neuron size; Stereology; Transgenic mouse models of Alzheimer's disease

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL SIZE; CONTROLLED STUDY; GENE MUTATION; HYPERTROPHY; MOUSE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE; WILD TYPE;

AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; CELL SIZE; CEREBRAL CORTEX; FEMALE; MALE; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; PRESENILIN-1; RECEPTORS, CELL SURFACE; SEX CHARACTERISTICS;

EID: 67349132229     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.12.024     Document Type: Article

References (35)

1. Alpar A., Ueberham U., Bruckner M.K., Arendt T., and Gartner U. The expression of wild-type human amyloid precursor protein affects the dendritic phenotype of neocortical pyramidal neurons in transgenic mice. Int. J. Dev. Neurosci. 24 (2006) 133-140
2. Bondolfi L., Calhoun M., Ermini F., Kuhn H.G., Wiederhold K.H., Walker L., Staufenbiel M., and Jucker M. Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. J. Neurosci. 22 (2002) 515-522
3. Borchelt D.R., Davis J., Fischer M., Lee M.K., Slunt H.H., Ratovitsky T., Regard J., Copeland N.G., Jenkins N.A., Sisodia S.S., and Price D.L. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet. Anal. 13 (1996) 159-163
4. Breen K.C., Bruce M., and Anderton B.H. Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion. J. Neurosci. Res. 28 (1991) 90-100
5. Calhoun M.E., Wiederhold K.H., Abramowski D., Phinney A.L., Probst A., Sturchler-Pierrat C., Staufenbiel M., Sommer B., and Jucker M. Neuron loss in APP transgenic mice. Nature 395 (1998) 755-756
6. Chen M., and Yankner B.A. An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci. Lett. 125 (1991) 223-226
7. Cooke B.M. Steroid-dependent plasticity in the medial amygdala. Neuroscience 138 (2006) 997-1005
8. De Strooper B., Van Leuven F., and Van Den Berghe H. The amyloid β protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochim. Biophys. Acta: Gene Struct. Expr. 1129 (1991) 141-143
9. Finch C.E. Neuron atrophy during aging: programmed or sporadic?. Trends Neurosci. 16 (1993) 104-110
10. Fischer W., Chen K.S., Gage F.H., and Bjorklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol. Aging 13 (1992) 9-23
11. Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemens J., Donaldson T., and Gillespie F. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373 (1995) 523-527
12. Han P., Dou F., Li F., Zhang X., Zhang Y.W., Zheng H., Lipton S.A., Xu H., and Liao F.F. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J. Neurosci. 25 (2005) 11542-11552
13. Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
14. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., and Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274 (1996) 99-102
15. Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., and Hyman B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 56 (1997) 965-973
16. Irizarry M.C., Soriano F., McNamara M., Page K.J., Schenk D., Games D., and Hyman B.T. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17 (1997) 7053-7059
17. Jankowsky J.L., Fadale D.J., Anderson J., Xu G.M., Gonzales V., Jenkins N.A., Copeland N.G., Lee M.K., Younkin L.H., Wagner S.L., Younkin S.G., and Borchelt D.R. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum. Mol. Genet. 13 (2004) 159-170
18. Lamb B.T., Sisodia S.S., Lawler A.M., Slunt H.H., Kitt C.A., Kearns W.G., Pearson P.L., Price D.L., and Gearhart J.D. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nat. Genet. 5 (1993) 22-30 (corrected)
19. Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., Finch C.E., Krafft G.A., and Klein W.L. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 6448-6453
20. Lesne S., Koh M.T., Kotilinek L., Kayed R., Glabe C.G., Yang A., Gallagher M., and Ashe K.H. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440 (2006) 352-357
21. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., and Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 4245-4249
22. Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., Metherate R., Mattson M.P., Akbari Y., and LaFerla F.M. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39 (2003) 409-421
23. Perez R.G., Zheng H., Van der Ploeg L.H., and Koo E.H. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 17 (1997) 9407-9414
24. Price D.L., and Sisodia S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21 (1998) 479-505
25. Price D.L., Sisodia S.S., and Borchelt D.R. Genetic neurodegenerative diseases: the human illness and transgenic models. Science 282 (1998) 1079-1083
26. Qiu W.Q., Ferreira A., Miller C., Koo E.H., and Selkoe D.J. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J. Neurosci. 15 (1995) 2157-2167
27. Riudavets M.A., Iacono D., Resnick S.M., O'Brien R., Zonderman A.B., Martin L.J., Rudow G., Pletnikova O., and Troncoso J.C. Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiol. Aging 28 (2007) 1484-1492
28. Savonenko A., Xu G.M., Melnikova T., Morton J.L., Gonzales V., Wong M.P., Price D.L., Tang F., Markowska A.L., and Borchelt D.R. Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neurobiol. Dis. 18 (2005) 602-617
29. Selkoe D.J. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 275 (1997) 630-631
30. Soba P., Eggert S., Wagner K., Zentgraf H., Siehl K., Kreger S., Lower A., Langer A., Merdes G., Paro R., Masters C.L., Muller U., Kins S., and Beyreuther K. Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J. 24 (2005) 3624-3634
31. Sturchler-Pierrat C., Abramowski D., Duke M., Wiederhold K.H., Mistl C., Rothacher S., Ledermann B., Burki K., Frey P., Paganetti P.A., Waridel C., Calhoun M.E., Jucker M., Probst A., Staufenbiel M., and Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 13287-13292
32. Turner P.R., O'Connor K., Tate W.P., and Abraham W.C. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog. Neurobiol. 70 (2003) 1-32
33. Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
34. West M.J., Slomianka L., and Gundersen H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231 (1991) 482-497
35. Zheng H., and Koo E.H. The amyloid precursor protein: beyond amyloid. Mol. Neurodegener. 1 (2006) 5