메뉴 건너뛰기




Volumn 15, Issue 8, 2015, Pages 720-744

Autophagy regulators as potential cancer therapeutic agents: A review

Author keywords

Autolysosome; Autophagy; Autophagy inducers; Autophagy inhibitors; Beclin1; Cancer treatment; Drug discovery

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO [3, 4 D] PYRIMIDIN 3 YL) 1H INDOL 5 OL; 4 (4 AMINO 5 (7 METHOXY 1H INDOL 2 YL) IMIDAZO [5, 1 F] [1, 2, 4] TRIAZIN 7 YL) CYCLOHEXANECARBOXYLIC ACID; ANTINEOPLASTIC AGENT; AZD 8055; BECLIN 1; CHLOROQUINE; CYCLOHEXIMIDE; CYCLOVIROBUXINE D; DIHYDROARTEMISININ; ERLOTINIB; GEFITINIB; GERANIOL; HESPERIDIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NILOTINIB; OXALIPLATIN; PARTHENOLIDE; PAZOPANIB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; RESVERATROL; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84930918988     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026615666150302105343     Document Type: Article
Times cited : (37)

References (227)
  • 1
    • 84866122688 scopus 로고    scopus 로고
    • Autophagy modulation as a potential therapeutic target for diverse diseases
    • Rubinsztein, D. C.; Codogno, P.; Levine, B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov., 2012, 11 (9), 709-730.
    • (2012) Nat. Rev. Drug Discov , vol.11 , Issue.9 , pp. 709-730
    • Rubinsztein, D.C.1    Codogno, P.2    Levine, B.3
  • 3
    • 84897143522 scopus 로고    scopus 로고
    • To be or not to be? How selective autophagy and cell death govern cell fate
    • Green, D. R.; Levine, B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell, 2014, 157 (1), 65-75.
    • (2014) Cell , vol.157 , Issue.1 , pp. 65-75
    • Green, D.R.1    Levine, B.2
  • 4
    • 84884332903 scopus 로고    scopus 로고
    • The variability of autophagy and cell death susceptibility: Unanswered questions
    • Loos, B.; Engelbrecht, A. M.; Lockshin, R. A.; Klionsky, D. J.; Zakeri, Z. The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy, 2013, 9 (9), 1270-1285.
    • (2013) Autophagy , vol.9 , Issue.9 , pp. 1270-1285
    • Loos, B.1    Engelbrecht, A.M.2    Lockshin, R.A.3    Klionsky, D.J.4    Zakeri, Z.5
  • 6
    • 34250822281 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy
    • Dice, J. F. Chaperone-mediated autophagy. Autophagy, 2007, 3 (4), 295-299.
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 295-299
    • Dice, J.F.1
  • 7
    • 84864318195 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: A unique way to enter the lysosome world
    • Kaushik, S.; Cuervo, A. M. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol., 2012, 22 (8), 407-417.
    • (2012) Trends Cell Biol , vol.22 , Issue.8 , pp. 407-417
    • Kaushik, S.1    Cuervo, A.M.2
  • 8
    • 79251577061 scopus 로고    scopus 로고
    • The regulation of autophagy-unanswered questions
    • Chen, Y.; Klionsky, D. J. The regulation of autophagy-unanswered questions. J. Cell Sci., 2011, 124 (Pt 2), 161-170.
    • (2011) J. Cell Sci , vol.124 , pp. 161-170
    • Chen, Y.1    Klionsky, D.J.2
  • 9
    • 79959999581 scopus 로고    scopus 로고
    • Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum
    • Mijaljica, D.; Prescott, M.; Devenish, R. J. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy, 2011, 7 (7), 673-682.
    • (2011) Autophagy , vol.7 , Issue.7 , pp. 673-682
    • Mijaljica, D.1    Prescott, M.2    Devenish, R.J.3
  • 11
    • 84885593791 scopus 로고    scopus 로고
    • A novel crosstalk between two major protein degradation systems Regulation of proteasomal activity by autophagy
    • Wang, X. J.; Yu, J.; Wong, S. H.; Cheng, A. S. L.; Chan, F. K. L.; Ng, S. S. M.; Cho, C. H.; Sung, J. J. Y.; Wu, W. K. K. A novel crosstalk between two major protein degradation systems Regulation of proteasomal activity by autophagy. Autophagy, 2013, 9 (10), 1500-1508.
    • (2013) Autophagy , vol.9 , Issue.10 , pp. 1500-1508
    • Wang, X.J.1    Yu, J.2    Wong, S.H.3    Cheng, A.S.L.4    Chan, F.K.L.5    Ng, S.S.M.6    Cho, C.H.7    Sung, J.J.Y.8    Wu, W.K.K.9
  • 12
    • 84903819099 scopus 로고    scopus 로고
    • Role of autophagy and its significance in cellular homeostasis
    • Awan, M. U.; Deng, Y. Role of autophagy and its significance in cellular homeostasis. Appl. Microbiol. Biotechnol., 2014, 98 (12), 5319-5328.
    • (2014) Appl. Microbiol. Biotechnol , vol.98 , Issue.12 , pp. 5319-5328
    • Awan, M.U.1    Deng, Y.2
  • 14
    • 79955681859 scopus 로고    scopus 로고
    • Discovery of small molecules that target autophagy for cancer treatment
    • Wu, L.; Yan, B. Discovery of small molecules that target autophagy for cancer treatment. Curr. Med. Chem., 2011, 18 (12), 1866-1873.
    • (2011) Curr. Med. Chem , vol.18 , Issue.12 , pp. 1866-1873
    • Wu, L.1    Yan, B.2
  • 15
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang, L.; Li, P.; Fu, S.; Calay, E. S.; Hotamisligil, G. S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab., 2010, 11 (6), 467-478.
    • (2010) Cell Metab , vol.11 , Issue.6 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 17
    • 70350550208 scopus 로고    scopus 로고
    • Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
    • Spencer, B.; Potkar, R.; Trejo, M.; Rockenstein, E.; Patrick, C.; Gindi, R.; Adame, A.; Wyss-Coray, T.; Masliah, E. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci., 2009, 29 (43), 13578-13588.
    • (2009) J. Neurosci , vol.29 , Issue.43 , pp. 13578-13588
    • Spencer, B.1    Potkar, R.2    Trejo, M.3    Rockenstein, E.4    Patrick, C.5    Gindi, R.6    Adame, A.7    Wyss-Coray, T.8    Masliah, E.9
  • 18
    • 74249103961 scopus 로고    scopus 로고
    • Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3
    • Menzies, F. M.; Huebener, J.; Renna, M.; Bonin, M.; Riess, O.; Rubinsztein, D. C. Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain, 2010, 133 (Pt 1), 93-104.
    • (2010) Brain , vol.133 , pp. 93-104
    • Menzies, F.M.1    Huebener, J.2    Renna, M.3    Bonin, M.4    Riess, O.5    Rubinsztein, D.C.6
  • 19
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • Rubinsztein, D. C. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature, 2006, 443 (7113), 780-786.
    • (2006) Nature , vol.443 , Issue.7113 , pp. 780-786
    • Rubinsztein, D.C.1
  • 20
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine, B.; Mizushima, N.; Virgin, H. W. Autophagy in immunity and inflammation. Nature, 2011, 469 (7330), 323-335.
    • (2011) Nature , vol.469 , Issue.7330 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 21
    • 65249108735 scopus 로고    scopus 로고
    • Autophagy genes in immunity
    • Virgin, H. W.; Levine, B. Autophagy genes in immunity. Nat. Immunol., 2009, 10 (5), 461-470.
    • (2009) Nat. Immunol , vol.10 , Issue.5 , pp. 461-470
    • Virgin, H.W.1    Levine, B.2
  • 23
    • 77951247552 scopus 로고    scopus 로고
    • Targeting cancer cells through autophagy for anticancer therapy
    • Turcotte, S.; Giaccia, A. J. Targeting cancer cells through autophagy for anticancer therapy. Curr. Opin. Cell Biol., 2010, 22 (2), 246-251.
    • (2010) Curr. Opin. Cell Biol , vol.22 , Issue.2 , pp. 246-251
    • Turcotte, S.1    Giaccia, A.J.2
  • 24
    • 84898803580 scopus 로고    scopus 로고
    • Metabolic stress and cancer: Is autophagy the common denominator and a feasible target?
    • Giuliani, C. M.; Dass, C. R. Metabolic stress and cancer: is autophagy the common denominator and a feasible target? J. Pharm. Pharmacol., 2014, 66 (5), 597-614.
    • (2014) J. Pharm. Pharmacol , vol.66 , Issue.5 , pp. 597-614
    • Giuliani, C.M.1    Dass, C.R.2
  • 26
    • 84855645313 scopus 로고    scopus 로고
    • Mechanisms of autophagosome biogenesis
    • Rubinsztein, D. C.; Shpilka, T.; Elazar, Z. Mechanisms of autophagosome biogenesis. Curr. Biol., 2012, 22 (1), R29-34.
    • (2012) Curr. Biol , vol.22 , Issue.1 , pp. 29-34
    • Rubinsztein, D.C.1    Shpilka, T.2    Elazar, Z.3
  • 27
    • 71649087199 scopus 로고    scopus 로고
    • A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
    • Hayashi-Nishino, M.; Fujita, N.; Noda, T.; Yamaguchi, A.; Yoshimori, T.; Yamamoto, A. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol., 2009, 11 (12), 1433-1437.
    • (2009) Nat. Cell Biol , vol.11 , Issue.12 , pp. 1433-1437
    • Hayashi-Nishino, M.1    Fujita, N.2    Noda, T.3    Yamaguchi, A.4    Yoshimori, T.5    Yamamoto, A.6
  • 28
    • 77955131007 scopus 로고    scopus 로고
    • Plasma membrane contributes to the formation of preautophagosomal structures
    • Ravikumar, B.; Moreau, K.; Jahreiss, L.; Puri, C.; Rubinsztein, D. C. Plasma membrane contributes to the formation of preautophagosomal structures. Nat. Cell Biol., 2010, 12 (8), 747-757.
    • (2010) Nat. Cell Biol , vol.12 , Issue.8 , pp. 747-757
    • Ravikumar, B.1    Moreau, K.2    Jahreiss, L.3    Puri, C.4    Rubinsztein, D.C.5
  • 32
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic develop ment, is a haploinsufficient tumor suppressor
    • Yue, Z. Y.; Jin, S. K.; Yang, C. W.; Levine, A. J.; Heintz, N. Beclin 1, an autophagy gene essential for early embryonic develop ment, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA, 2003, 100 (25), 15077-15082.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.25 , pp. 15077-15082
    • Yue, Z.Y.1    Jin, S.K.2    Yang, C.W.3    Levine, A.J.4    Heintz, N.5
  • 33
    • 34247133465 scopus 로고    scopus 로고
    • Regulation of class III (Vps34) PI3Ks
    • Yan, Y.; Backer, J. M. Regulation of class III (Vps34) PI3Ks. Biochem. Soc. Trans., 2007, 35 (Pt 2), 239-241.
    • (2007) Biochem. Soc. Trans , vol.35 , pp. 239-241
    • Yan, Y.1    Backer, J.M.2
  • 34
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • Backer, J. M. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J., 2008, 410 (1), 1-17.
    • (2008) Biochem. J , vol.410 , Issue.1 , pp. 1-17
    • Backer, J.M.1
  • 35
    • 38749136302 scopus 로고    scopus 로고
    • Regulation of macroautophagy by mTOR and Beclin 1 complexes
    • Pattingre, S.; Espert, L.; Biard-Piechaczyk, M.; Codogno, P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie, 2008, 90 (2), 313-323.
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 313-323
    • Pattingre, S.1    Espert, L.2    Biard-Piechaczyk, M.3    Codogno, P.4
  • 36
    • 34447099450 scopus 로고    scopus 로고
    • Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
    • Nakatogawa, H.; Ichimura, Y.; Ohsumi, Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell, 2007, 130 (1), 165-178.
    • (2007) Cell , vol.130 , Issue.1 , pp. 165-178
    • Nakatogawa, H.1    Ichimura, Y.2    Ohsumi, Y.3
  • 37
    • 43949112966 scopus 로고    scopus 로고
    • LAMP-2-A control step for phagosome and autophagosome maturation
    • Saftig, P.; Beertsen, W.; Eskelinen, E. L. LAMP-2-A control step for phagosome and autophagosome maturation. Autophagy, 2008, 4 (4), 510-512.
    • (2008) Autophagy , vol.4 , Issue.4 , pp. 510-512
    • Saftig, P.1    Beertsen, W.2    Eskelinen, E.L.3
  • 38
    • 53549084325 scopus 로고    scopus 로고
    • Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?
    • Klionsky, D. J.; Elazar, Z.; Seglen, P. O.; Rubinsztein, D. C. Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy, 2008, 4 (7), 849-850.
    • (2008) Autophagy , vol.4 , Issue.7 , pp. 849-850
    • Klionsky, D.J.1    Elazar, Z.2    Seglen, P.O.3    Rubinsztein, D.C.4
  • 39
    • 34250900953 scopus 로고    scopus 로고
    • LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: Caution in the interpretation of LC3 localization
    • Kuma, A.; Matsui, M.; Mizushima, N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy, 2007, 3 (4), 323-328.
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 323-328
    • Kuma, A.1    Matsui, M.2    Mizushima, N.3
  • 40
    • 38749136302 scopus 로고    scopus 로고
    • Regulation of macroautophagy by mTOR and Beclin 1 complexes
    • Pattingre, S.; Espert, L.; Biard-Piechaczyk, M.; Codogno, P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie, 2008, 90 (2), 313-323.
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 313-323
    • Pattingre, S.1    Espert, L.2    Biard-Piechaczyk, M.3    Codogno, P.4
  • 42
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo, Y.; Kanzawa, T.; Sawaya, R.; Kondo, S. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer, 2005, 5 (9), 726-734.
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.9 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 44
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • Behrends, C.; Sowa, M. E.; Gygi, S. P.; Harper, J. W. Network organization of the human autophagy system. Nature, 2010, 466 (7302), 68-76.
    • (2010) Nature , vol.466 , Issue.7302 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 45
    • 80052697287 scopus 로고    scopus 로고
    • The role of autophagy in cancer: Therapeutic implications
    • Yang, Z. J.; Chee, C. E.; Huang, S.; Sinicrope, F. A. The role of autophagy in cancer: therapeutic implications. Mol. Cancer Ther., 2011, 10 (9), 1533-1541.
    • (2011) Mol. Cancer Ther , vol.10 , Issue.9 , pp. 1533-1541
    • Yang, Z.J.1    Chee, C.E.2    Huang, S.3    Sinicrope, F.A.4
  • 46
    • 70350449062 scopus 로고    scopus 로고
    • mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex
    • Chan, E. Y. mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex. Sci. Signal., 2009, 2 (84).
    • (2009) Sci. Signal , vol.2 , Issue.84
    • Chan, E.Y.1
  • 49
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
    • Bellot, G.; Garcia-Medina, R.; Gounon, P.; Chiche, J.; Roux, D.; Pouyssegur, J.; Mazure, N. M. Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains. Mol. Cell. Biol., 2009, 29 (10), 2570-2581.
    • (2009) Mol. Cell. Biol , vol.29 , Issue.10 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouyssegur, J.6    Mazure, N.M.7
  • 50
    • 60749108379 scopus 로고    scopus 로고
    • Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment
    • Azad, M. B.; Chen, Y. Q.; Gibson, S. B. Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment. Antioxid. Redox Signal., 2009, 11 (4), 777-790.
    • (2009) Antioxid. Redox Signal , vol.11 , Issue.4 , pp. 777-790
    • Azad, M.B.1    Chen, Y.Q.2    Gibson, S.B.3
  • 51
    • 38349043984 scopus 로고    scopus 로고
    • Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
    • Chen, Y.; McMillan-Ward, E.; Kong, J.; Israels, S. J.; Gibson, S. B. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J. Cell Sci., 2007, 120 (Pt 23), 4155-4166.
    • (2007) J. Cell Sci , vol.120 , pp. 4155-4166
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 52
    • 77957656802 scopus 로고    scopus 로고
    • A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy
    • Gibson, S. B. A matter of balance between life and death: targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. Autophagy, 2010, 6 (7), 835-837.
    • (2010) Autophagy , vol.6 , Issue.7 , pp. 835-837
    • Gibson, S.B.1
  • 53
    • 80054087824 scopus 로고    scopus 로고
    • Mitochondrial ROS generation for regulation of autophagic pathways in cancer
    • Li, Z. Y.; Yang, Y.; Ming, M.; Liu, B. Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochem. Biophys. Res. Commun., 2011, 414 (1), 5-8.
    • (2011) Biochem. Biophys. Res. Commun , vol.414 , Issue.1 , pp. 5-8
    • Li, Z.Y.1    Yang, Y.2    Ming, M.3    Liu, B.4
  • 54
    • 34250825929 scopus 로고    scopus 로고
    • Oxidation as a posttranslational modification that regulates autophagy
    • Scherz-Shouval, R.; Shvets, E.; Elazar, Z. Oxidation as a posttranslational modification that regulates autophagy. Autophagy, 2007, 3 (4), 371-373.
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 371-373
    • Scherz-Shouval, R.1    Shvets, E.2    Elazar, Z.3
  • 56
    • 78751492210 scopus 로고    scopus 로고
    • Autophagy and cancer therapy
    • Maycotte, P.; Thorburn, A. Autophagy and cancer therapy. Cancer Biol. Ther., 2011, 11 (2), 127-137.
    • (2011) Cancer Biol. Ther , vol.11 , Issue.2 , pp. 127-137
    • Maycotte, P.1    Thorburn, A.2
  • 57
    • 33847026354 scopus 로고    scopus 로고
    • Autophagy delays apoptotic death in breast cancer cells following DNA damage
    • Abedin, M. J.; Wang, D.; McDonnell, M. A.; Lehmann, U.; Kelekar, A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ., 2007, 14 (3), 500-510.
    • (2007) Cell Death Differ , vol.14 , Issue.3 , pp. 500-510
    • Abedin, M.J.1    Wang, D.2    McDonnell, M.A.3    Lehmann, U.4    Kelekar, A.5
  • 58
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
    • Zhong, Y.; Wang, Q. J.; Li, X.; Yan, Y.; Backer, J. M.; Chait, B. T.; Heintz, N.; Yue, Z. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol., 2009, 11 (4), 468-476.
    • (2009) Nat. Cell Biol , vol.11 , Issue.4 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6    Heintz, N.7    Yue, Z.8
  • 59
  • 62
    • 77951237303 scopus 로고    scopus 로고
    • The Beclin 1 interactome
    • He, C.; Levine, B. The Beclin 1 interactome. Curr. Opin. Cell Biol., 2010, 22 (2), 140-149.
    • (2010) Curr. Opin. Cell Biol , vol.22 , Issue.2 , pp. 140-149
    • He, C.1    Levine, B.2
  • 63
    • 84856748733 scopus 로고    scopus 로고
    • Cell death by autophagy: Facts and apparent artefacts
    • Denton, D.; Nicolson, S.; Kumar, S. Cell death by autophagy: facts and apparent artefacts. Cell Death Differ., 2012, 19 (1), 87-95.
    • (2012) Cell Death Differ , vol.19 , Issue.1 , pp. 87-95
    • Denton, D.1    Nicolson, S.2    Kumar, S.3
  • 64
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri, M. C.; Zalckvar, E.; Kimchi, A.; Kroemer, G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol., 2007, 8 (9), 741-752.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 68
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • Kimmelman, A. C. The dynamic nature of autophagy in cancer. Genes Dev., 2011, 25 (19), 1999-2010.
    • (2011) Genes Dev , vol.25 , Issue.19 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 69
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum, J. J.; Bauer, D. E.; Kong, M.; Harris, M. H.; Li, C.; Lindsten, T.; Thompson, C. B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell, 2005, 120 (2), 237-248.
    • (2005) Cell , vol.120 , Issue.2 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 70
    • 84893825919 scopus 로고    scopus 로고
    • The four faces of autophagy: Implications for cancer therapy
    • Gewirtz, D. A. The four faces of autophagy: implications for cancer therapy. Cancer Res., 2014, 74 (3), 647-651.
    • (2014) Cancer Res , vol.74 , Issue.3 , pp. 647-651
    • Gewirtz, D.A.1
  • 71
    • 84884340172 scopus 로고    scopus 로고
    • Cytoprotective and nonprotective autophagy in cancer therapy
    • Gewirtz, D. A. Cytoprotective and nonprotective autophagy in cancer therapy. Autophagy, 2013, 9 (9), 1263-1265.
    • (2013) Autophagy , vol.9 , Issue.9 , pp. 1263-1265
    • Gewirtz, D.A.1
  • 73
    • 77957656802 scopus 로고    scopus 로고
    • A matter of balance between life and death Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy
    • Gibson, S. B. A matter of balance between life and death Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. Autophagy, 2010, 6 (7), 835-837.
    • (2010) Autophagy , vol.6 , Issue.7 , pp. 835-837
    • Gibson, S.B.1
  • 74
    • 84908665469 scopus 로고    scopus 로고
    • Temsirolimus, the mTOR inhibitor, induces autophagy in adenoid cystic carcinoma: In vitro and in vivo
    • Liu, W.; Huang, S.; Chen, Z.; Wang, H.; Wu, H.; Zhang, D. Temsirolimus, the mTOR inhibitor, induces autophagy in adenoid cystic carcinoma: In vitro and in vivo. Pathol. Res. Pract., 2014.
    • (2014) Pathol. Res. Pract
    • Liu, W.1    Huang, S.2    Chen, Z.3    Wang, H.4    Wu, H.5    Zhang, D.6
  • 76
    • 84879486831 scopus 로고    scopus 로고
    • Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux
    • Li, J. R.; Cheng, C. L.; Yang, C. R.; Ou, Y. C.; Wu, M. J.; Ko, J. L. Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux. Toxicol. Lett., 2013, 220 (3), 267-276.
    • (2013) Toxicol. Lett , vol.220 , Issue.3 , pp. 267-276
    • Li, J.R.1    Cheng, C.L.2    Yang, C.R.3    Ou, Y.C.4    Wu, M.J.5    Ko, J.L.6
  • 77
    • 84880184328 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma
    • Dong, L. H.; Cheng, S.; Zheng, Z.; Wang, L.; Shen, Y.; Shen, Z. X.; Chen, S. J.; Zhao, W. L. Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma. J. Hematol. Oncol., 2013, 6.
    • (2013) J. Hematol. Oncol , pp. 6
    • Dong, L.H.1    Cheng, S.2    Zheng, Z.3    Wang, L.4    Shen, Y.5    Shen, Z.X.6    Chen, S.J.7    Zhao, W.L.8
  • 81
    • 84892422431 scopus 로고    scopus 로고
    • AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma
    • Hu, M.; Huang, H. L.; Zhao, R.; Li, P.; Li, M. Y.; Miao, H. L.; Chen, N. P.; Chen, M. AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma. Oncol. Rep., 2014, 31 (2), 649-656.
    • (2014) Oncol. Rep , vol.31 , Issue.2 , pp. 649-656
    • Hu, M.1    Huang, H.L.2    Zhao, R.3    Li, P.4    Li, M.Y.5    Miao, H.L.6    Chen, N.P.7    Chen, M.8
  • 84
    • 79952265072 scopus 로고    scopus 로고
    • Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1, 6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer
    • Liu, Q.; Wang, J.; Kang, S. A.; Thoreen, C. C.; Hur, W.; Ahmed, T.; Sabatini, D. M.; Gray, N. S. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1, 6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J. Med. Chem., 2011, 54 (5), 1473-1480.
    • (2011) J. Med. Chem , vol.54 , Issue.5 , pp. 1473-1480
    • Liu, Q.1    Wang, J.2    Kang, S.A.3    Thoreen, C.C.4    Hur, W.5    Ahmed, T.6    Sabatini, D.M.7    Gray, N.S.8
  • 86
    • 84876408458 scopus 로고    scopus 로고
    • Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
    • Zhou, J.; Tan, S. H.; Nicolas, V.; Bauvy, C.; Yang, N. D.; Zhang, J.; Xue, Y.; Codogno, P.; Shen, H. M. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res., 2013, 23 (4), 508-523.
    • (2013) Cell Res , vol.23 , Issue.4 , pp. 508-523
    • Zhou, J.1    Tan, S.H.2    Nicolas, V.3    Bauvy, C.4    Yang, N.D.5    Zhang, J.6    Xue, Y.7    Codogno, P.8    Shen, H.M.9
  • 87
    • 68849091778 scopus 로고    scopus 로고
    • NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
    • Liu, T. J.; Koul, D.; LaFortune, T.; Tiao, N.; Shen, R. J.; Maira, S. M.; Garcia-Echevrria, C.; Yung, W. K. NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol. Cancer Ther., 2009, 8 (8), 2204-2210.
    • (2009) Mol. Cancer Ther , vol.8 , Issue.8 , pp. 2204-2210
    • Liu, T.J.1    Koul, D.2    LaFortune, T.3    Tiao, N.4    Shen, R.J.5    Maira, S.M.6    Garcia-Echevrria, C.7    Yung, W.K.8
  • 88
    • 84897861325 scopus 로고    scopus 로고
    • Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions
    • Kuger, S.; Corek, E.; Polat, B.; Kammerer, U.; Flentje, M.; Djuzenova, C. S. Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions. Breast Cancer (Auckl), 2014, 8, 39-49.
    • (2014) Breast Cancer (Auckl) , vol.8 , pp. 39-49
    • Kuger, S.1    Corek, E.2    Polat, B.3    Kammerer, U.4    Flentje, M.5    Djuzenova, C.S.6
  • 90
    • 84890434182 scopus 로고    scopus 로고
    • Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application
    • Aronson, L. I.; Davenport, E. L.; Mirabella, F.; Morgan, G. J.; Davies, F. E. Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application. Leukemia, 2013, 27 (12), 2397-2403.
    • (2013) Leukemia , vol.27 , Issue.12 , pp. 2397-2403
    • Aronson, L.I.1    Davenport, E.L.2    Mirabella, F.3    Morgan, G.J.4    Davies, F.E.5
  • 91
    • 79957963599 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells
    • Han, W.; Pan, H.; Chen, Y.; Sun, J.; Wang, Y.; Li, J.; Ge, W.; Feng, L.; Lin, X.; Wang, X.; Wang, X.; Jin, H. EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS ONE, 2011, 6 (6), e18691.
    • (2011) PLoS ONE , vol.6 , Issue.6
    • Han, W.1    Pan, H.2    Chen, Y.3    Sun, J.4    Wang, Y.5    Li, J.6    Ge, W.7    Feng, L.8    Lin, X.9    Wang, X.10    Wang, X.11    Jin, H.12
  • 92
    • 84880070521 scopus 로고    scopus 로고
    • Nilotinib Induces Autophagy in Hepatocellular Carcinoma through AMPK Activation
    • Yu, H. C.; Lin, C. S.; Tai, W. T.; Liu, C. Y.; Shiau, C. W.; Chen, K. F. Nilotinib Induces Autophagy in Hepatocellular Carcinoma through AMPK Activation. J. Biol. Chem., 2013, 288 (25), 18249-18259.
    • (2013) J. Biol. Chem , vol.288 , Issue.25 , pp. 18249-18259
    • Yu, H.C.1    Lin, C.S.2    Tai, W.T.3    Liu, C.Y.4    Shiau, C.W.5    Chen, K.F.6
  • 95
    • 84894086087 scopus 로고    scopus 로고
    • Dihydroartemisinin potentiates the anticancer effect of cisplatin via mTOR inhibition in cisplatin-resistant ovarian cancer cells: Involvement of apoptosis and autophagy
    • Feng, X.; Li, L.; Jiang, H.; Jiang, K.; Jin, Y.; Zheng, J. Dihydroartemisinin potentiates the anticancer effect of cisplatin via mTOR inhibition in cisplatin-resistant ovarian cancer cells: involvement of apoptosis and autophagy. Biochem. Biophys. Res. Commun., 2014, 444 (3), 376-381.
    • (2014) Biochem. Biophys. Res. Commun , vol.444 , Issue.3 , pp. 376-381
    • Feng, X.1    Li, L.2    Jiang, H.3    Jiang, K.4    Jin, Y.5    Zheng, J.6
  • 96
    • 84898640642 scopus 로고    scopus 로고
    • Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo
    • Yuan, G.; Yan, S. F.; Xue, H.; Zhang, P.; Sun, J. T.; Li, G. Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo. J. Biol. Chem., 2014, 289 (15), 10607-10619.
    • (2014) J. Biol. Chem , vol.289 , Issue.15 , pp. 10607-10619
    • Yuan, G.1    Yan, S.F.2    Xue, H.3    Zhang, P.4    Sun, J.T.5    Li, G.6
  • 97
    • 84874062469 scopus 로고    scopus 로고
    • Beta-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK/ERK and PI3K/Akt/mTOR Signalling Pathways
    • Zhan, Y. H.; Liu, J.; Qu, X. J.; Hou, K. Z.; Wang, K. F.; Liu, Y. P.; Wu, B. beta-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK/ERK and PI3K/Akt/mTOR Signalling Pathways. Asian Pac. J. Cancer Prev., 2012, 13 (6), 2739-2744.
    • (2012) Asian Pac. J. Cancer Prev , vol.13 , Issue.6 , pp. 2739-2744
    • Zhan, Y.H.1    Liu, J.2    Qu, X.J.3    Hou, K.Z.4    Wang, K.F.5    Liu, Y.P.6    Wu, B.7
  • 98
    • 83555174943 scopus 로고    scopus 로고
    • ss-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells
    • Liu, J.; Hu, X. J.; Jin, B.; Qu, X. J.; Hou, K. Z.; Liu, Y. P. ss-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells. J. Pharm. Pharmacol., 2012, 64 (1), 146-153.
    • (2012) J. Pharm. Pharmacol , vol.64 , Issue.1 , pp. 146-153
    • Liu, J.1    Hu, X.J.2    Jin, B.3    Qu, X.J.4    Hou, K.Z.5    Liu, Y.P.6
  • 99
    • 84860312860 scopus 로고    scopus 로고
    • Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells
    • Kim, S. H.; Park, E. J.; Lee, C. R.; Chun, J. N.; Cho, N. H.; Kim, I. G.; Lee, S.; Kim, T. W.; Park, H. H.; So, I.; Jeon, J. H. Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. Int. J. Oncol., 2012, 40 (5), 1683-1690.
    • (2012) Int. J. Oncol , vol.40 , Issue.5 , pp. 1683-1690
    • Kim, S.H.1    Park, E.J.2    Lee, C.R.3    Chun, J.N.4    Cho, N.H.5    Kim, I.G.6    Lee, S.7    Kim, T.W.8    Park, H.H.9    So, I.10    Jeon, J.H.11
  • 100
    • 77955355798 scopus 로고    scopus 로고
    • Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
    • Suh, Y.; Afaq, F.; Khan, N.; Johnson, J. J.; Khusro, F. H.; Mukhtar, H. Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis, 2010, 31 (8), 1424-1433.
    • (2010) Carcinogenesis , vol.31 , Issue.8 , pp. 1424-1433
    • Suh, Y.1    Afaq, F.2    Khan, N.3    Johnson, J.J.4    Khusro, F.H.5    Mukhtar, H.6
  • 101
    • 84893477310 scopus 로고    scopus 로고
    • Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways
    • Xia, J.; Guo, S.; Fang, T.; Feng, D.; Zhang, X.; Zhang, Q.; Liu, J.; Liu, B.; Li, M.; Zhu, R. Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways. Food Chem. Toxicol., 2014, 66, 7-13.
    • (2014) Food Chem. Toxicol , vol.66 , pp. 7-13
    • Xia, J.1    Guo, S.2    Fang, T.3    Feng, D.4    Zhang, X.5    Zhang, Q.6    Liu, J.7    Liu, B.8    Li, M.9    Zhu, R.10
  • 102
  • 103
    • 85027939699 scopus 로고    scopus 로고
    • Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis
    • Saiprasad, G.; Chitra, P.; Manikandan, R.; Sudhandiran, G. Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur. J. Cancer, 2014.
    • (2014) Eur. J. Cancer
    • Saiprasad, G.1    Chitra, P.2    Manikandan, R.3    Sudhandiran, G.4
  • 104
    • 84878225538 scopus 로고    scopus 로고
    • A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway
    • Zhang, X.; Wei, H.; Liu, Z.; Yuan, Q.; Wei, A.; Shi, D.; Yang, X.; Ruan, J. A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway. Toxicol. Appl. Pharmacol., 2013, 270 (2), 122-128.
    • (2013) Toxicol. Appl. Pharmacol , vol.270 , Issue.2 , pp. 122-128
    • Zhang, X.1    Wei, H.2    Liu, Z.3    Yuan, Q.4    Wei, A.5    Shi, D.6    Yang, X.7    Ruan, J.8
  • 105
    • 84882574643 scopus 로고    scopus 로고
    • Marchantin M: A novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells
    • Jiang, H.; Sun, J.; Xu, Q.; Liu, Y.; Wei, J.; Young, C. Y.; Yuan, H.; Lou, H. Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis., 2013, 4, e761.
    • (2013) Cell Death Dis , vol.4
    • Jiang, H.1    Sun, J.2    Xu, Q.3    Liu, Y.4    Wei, J.5    Young, C.Y.6    Yuan, H.7    Lou, H.8
  • 106
    • 84884538218 scopus 로고    scopus 로고
    • Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells
    • Poornima, P.; Weng, C. F.; Padma, V. V. Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. Food Chem., 2013, 141 (4), 3598-3605.
    • (2013) Food Chem , vol.141 , Issue.4 , pp. 3598-3605
    • Poornima, P.1    Weng, C.F.2    Padma, V.V.3
  • 107
    • 70350317873 scopus 로고    scopus 로고
    • 6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT/mTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells
    • Hung, J. Y.; Hsu, Y. L.; Li, C. T.; Ko, Y. C.; Ni, W. C.; Huang, M. S.; Kuo, P. L. 6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT/mTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells. J. Agric. Food Chem., 2009, 57 (20), 9809-9816.
    • (2009) J. Agric. Food Chem , vol.57 , Issue.20 , pp. 9809-9816
    • Hung, J.Y.1    Hsu, Y.L.2    Li, C.T.3    Ko, Y.C.4    Ni, W.C.5    Huang, M.S.6    Kuo, P.L.7
  • 108
    • 38049125764 scopus 로고    scopus 로고
    • Magnolol-induced H460 cells death via autophagy but not apoptosis
    • Li, H. B.; Yi, X.; Gao, J. M.; Ying, X. X.; Guan, H. Q.; Li, J. C. Magnolol-induced H460 cells death via autophagy but not apoptosis. Arch. Pharm. Res., 2007, 30 (12), 1566-1574.
    • (2007) Arch. Pharm. Res , vol.30 , Issue.12 , pp. 1566-1574
    • Li, H.B.1    Yi, X.2    Gao, J.M.3    Ying, X.X.4    Guan, H.Q.5    Li, J.C.6
  • 109
    • 80155194987 scopus 로고    scopus 로고
    • Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells
    • Wu, J. C.; Lai, C. S.; Badmaev, V.; Nagabhushanam, K.; Ho, C. T.; Pan, M. H. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol. Nutr. Food Res., 2011, 55 (11), 1646-1654.
    • (2011) Mol. Nutr. Food Res , vol.55 , Issue.11 , pp. 1646-1654
    • Wu, J.C.1    Lai, C.S.2    Badmaev, V.3    Nagabhushanam, K.4    Ho, C.T.5    Pan, M.H.6
  • 110
    • 84891826180 scopus 로고    scopus 로고
    • Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway
    • Kumar, D.; Shankar, S.; Srivastava, R. K. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Lett., 2014, 343 (2), 179-189.
    • (2014) Cancer Lett , vol.343 , Issue.2 , pp. 179-189
    • Kumar, D.1    Shankar, S.2    Srivastava, R.K.3
  • 111
    • 84866614835 scopus 로고    scopus 로고
    • Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells
    • Singh, B. N.; Kumar, D.; Shankar, S.; Srivastava, R. K. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochem. Pharmacol., 2012, 84 (9), 1154-1163.
    • (2012) Biochem. Pharmacol , vol.84 , Issue.9 , pp. 1154-1163
    • Singh, B.N.1    Kumar, D.2    Shankar, S.3    Srivastava, R.K.4
  • 112
    • 84890481359 scopus 로고    scopus 로고
    • Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK
    • Ge, J.; Liu, Y.; Li, Q.; Guo, X.; Gu, L.; Ma, Z. G.; Zhu, Y. P. Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK. Biomed. Environ. Sci., 2013, 26 (11), 902-911.
    • (2013) Biomed. Environ. Sci , vol.26 , Issue.11 , pp. 902-911
    • Ge, J.1    Liu, Y.2    Li, Q.3    Guo, X.4    Gu, L.5    Ma, Z.G.6    Zhu, Y.P.7
  • 113
    • 84897446670 scopus 로고    scopus 로고
    • Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells
    • Wang, M.; Yu, T.; Zhu, C. Y.; Sun, H.; Qiu, Y.; Zhu, X.; Li, J. C. Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells. Nutr. Cancer Int. J., 2014, 66 (3), 435-440.
    • (2014) Nutr. Cancer Int. J , vol.66 , Issue.3 , pp. 435-440
    • Wang, M.1    Yu, T.2    Zhu, C.Y.3    Sun, H.4    Qiu, Y.5    Zhu, X.6    Li, J.C.7
  • 114
  • 115
    • 84886872847 scopus 로고    scopus 로고
    • Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
    • Chu, Y. L.; Ho, C. T.; Chung, J. G.; Raghu, R.; Lo, Y. C.; Sheen, L. Y. Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy. J. Agric. Food Chem., 2013, 61 (41), 9839-9848.
    • (2013) J. Agric. Food Chem , vol.61 , Issue.41 , pp. 9839-9848
    • Chu, Y.L.1    Ho, C.T.2    Chung, J.G.3    Raghu, R.4    Lo, Y.C.5    Sheen, L.Y.6
  • 116
    • 84865650394 scopus 로고    scopus 로고
    • Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells
    • Chu, Y. L.; Ho, C. T.; Chung, J. G.; Rajasekaran, R.; Sheen, L. Y. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. J. Agric. Food Chem., 2012, 60 (34), 8363-8371.
    • (2012) J. Agric. Food Chem , vol.60 , Issue.34 , pp. 8363-8371
    • Chu, Y.L.1    Ho, C.T.2    Chung, J.G.3    Rajasekaran, R.4    Sheen, L.Y.5
  • 118
    • 84895803565 scopus 로고    scopus 로고
    • Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells
    • Yun, S. M.; Jung, J. H.; Jeong, S. J.; Sohn, E. J.; Kim, B.; Kim, S. H. Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells. Phytother. Res., 2014, 28 (3), 458-464.
    • (2014) Phytother. Res , vol.28 , Issue.3 , pp. 458-464
    • Yun, S.M.1    Jung, J.H.2    Jeong, S.J.3    Sohn, E.J.4    Kim, B.5    Kim, S.H.6
  • 121
    • 80052485674 scopus 로고    scopus 로고
    • The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells
    • Acharya, B. R.; Bhattacharyya, S.; Choudhury, D.; Chakrabarti, G. The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells. Apoptosis, 2011, 16 (9), 924-939.
    • (2011) Apoptosis , vol.16 , Issue.9 , pp. 924-939
    • Acharya, B.R.1    Bhattacharyya, S.2    Choudhury, D.3    Chakrabarti, G.4
  • 123
    • 84861310316 scopus 로고    scopus 로고
    • Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells
    • Yu, C. C.; Chiang, P. C.; Lu, P. H.; Kuo, M. T.; Wen, W. C.; Chen, P. N.; Guh, J. H. Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J. Nutr. Biochem., 2012, 23 (8), 900-907.
    • (2012) J. Nutr. Biochem , vol.23 , Issue.8 , pp. 900-907
    • Yu, C.C.1    Chiang, P.C.2    Lu, P.H.3    Kuo, M.T.4    Wen, W.C.5    Chen, P.N.6    Guh, J.H.7
  • 125
    • 84858857598 scopus 로고    scopus 로고
    • NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
    • Fokas, E.; Yoshimura, M.; Prevo, R.; Higgins, G.; Hackl, W.; Maira, S. M.; Bernhard, E. J.; McKenna, W. G.; Muschel, R. J. NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat. Oncol., 2012, 7.
    • (2012) Radiat. Oncol , pp. 7
    • Fokas, E.1    Yoshimura, M.2    Prevo, R.3    Higgins, G.4    Hackl, W.5    Maira, S.M.6    Bernhard, E.J.7    McKenna, W.G.8    Muschel, R.J.9
  • 126
    • 84877615768 scopus 로고    scopus 로고
    • NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro
    • Wang, W. J.; Long, L. M.; Yang, N.; Zhang, Q. Q.; Ji, W. J.; Zhao, J. H.; Qin, Z. H.; Wang, Z.; Chen, G.; Liang, Z. Q. NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro. Acta Pharmacol. Sin., 2013, 34 (5), 681-690.
    • (2013) Acta Pharmacol. Sin , vol.34 , Issue.5 , pp. 681-690
    • Wang, W.J.1    Long, L.M.2    Yang, N.3    Zhang, Q.Q.4    Ji, W.J.5    Zhao, J.H.6    Qin, Z.H.7    Wang, Z.8    Chen, G.9    Liang, Z.Q.10
  • 127
    • 67650786255 scopus 로고    scopus 로고
    • BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing
    • Martin, A. P.; Park, M. A.; Mitchell, C.; Walker, T.; Rahmani, M.; Thorburn, A.; Haussinger, D.; Reinehr, R.; Grant, S.; Dent, P. BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing. Mol. Pharmacol., 2009, 76 (2), 327-341.
    • (2009) Mol. Pharmacol , vol.76 , Issue.2 , pp. 327-341
    • Martin, A.P.1    Park, M.A.2    Mitchell, C.3    Walker, T.4    Rahmani, M.5    Thorburn, A.6    Haussinger, D.7    Reinehr, R.8    Grant, S.9    Dent, P.10
  • 128
    • 84878977228 scopus 로고    scopus 로고
    • Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway
    • Zhang, D. M.; Liu, J. S.; Deng, L. J.; Chen, M. F.; Yiu, A.; Cao, H. H.; Tian, H. Y.; Fung, K. P.; Kurihara, H.; Pan, J. X.; Ye, W. C. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis, 2013, 34 (6), 1331-1342.
    • (2013) Carcinogenesis , vol.34 , Issue.6 , pp. 1331-1342
    • Zhang, D.M.1    Liu, J.S.2    Deng, L.J.3    Chen, M.F.4    Yiu, A.5    Cao, H.H.6    Tian, H.Y.7    Fung, K.P.8    Kurihara, H.9    Pan, J.X.10    Ye, W.C.11
  • 129
    • 84902134638 scopus 로고    scopus 로고
    • Cyclovirobuxine D Induces Autophagy-Associated Cell Death via the Akt/mTOR Pathway in MCF-7 Human Breast Cancer Cells
    • Lu, J.; Sun, D. P.; Gao, S.; Gao, Y.; Ye, J. T.; Liu, P. Q. Cyclovirobuxine D Induces Autophagy-Associated Cell Death via the Akt/mTOR Pathway in MCF-7 Human Breast Cancer Cells. J. Pharmacol. Sci., 2014, 125 (1), 74-82.
    • (2014) J. Pharmacol. Sci , vol.125 , Issue.1 , pp. 74-82
    • Lu, J.1    Sun, D.P.2    Gao, S.3    Gao, Y.4    Ye, J.T.5    Liu, P.Q.6
  • 132
    • 80053304909 scopus 로고    scopus 로고
    • Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma
    • Guo, W.; Zhao, Y.; Zhang, Z.; Tan, N.; Zhao, F.; Ge, C.; Liang, L.; Jia, D.; Chen, T.; Yao, M.; Li, J.; He, X. Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma. Cancer Lett., 2011, 312 (1), 55-61.
    • (2011) Cancer Lett , vol.312 , Issue.1 , pp. 55-61
    • Guo, W.1    Zhao, Y.2    Zhang, Z.3    Tan, N.4    Zhao, F.5    Ge, C.6    Liang, L.7    Jia, D.8    Chen, T.9    Yao, M.10    Li, J.11    He, X.12
  • 133
    • 84871914618 scopus 로고    scopus 로고
    • UCP2 inhibition triggers ROSdependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells
    • Dando, I.; Fiorini, C.; Pozza, E. D.; Padroni, C.; Costanzo, C.; Palmieri, M.; Donadelli, M. UCP2 inhibition triggers ROSdependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells. Biochim. Biophys. Acta, 2013, 1833 (3), 672-679.
    • (2013) Biochim. Biophys. Acta , vol.1833 , Issue.3 , pp. 672-679
    • Dando, I.1    Fiorini, C.2    Pozza, E.D.3    Padroni, C.4    Costanzo, C.5    Palmieri, M.6    Donadelli, M.7
  • 134
    • 33846077612 scopus 로고    scopus 로고
    • Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1
    • Qian, W. B.; Liu, J. Q.; Jin, J.; Ni, W. M.; Xu, W. L. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk. Res., 2007, 31 (3), 329-339.
    • (2007) Leuk. Res , vol.31 , Issue.3 , pp. 329-339
    • Qian, W.B.1    Liu, J.Q.2    Jin, J.3    Ni, W.M.4    Xu, W.L.5
  • 135
    • 0038743077 scopus 로고    scopus 로고
    • Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    • Kanzawa, T.; Kondo, Y.; Ito, H.; Kondo, S.; Germano, I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res., 2003, 63 (9), 2103-2108.
    • (2003) Cancer Res , vol.63 , Issue.9 , pp. 2103-2108
    • Kanzawa, T.1    Kondo, Y.2    Ito, H.3    Kondo, S.4    Germano, I.5
  • 136
    • 13944256602 scopus 로고    scopus 로고
    • Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
    • Kanzawa, T.; Zhang, L.; Xiao, L.; Germano, I. M.; Kondo, Y.; Kondo, S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene, 2005, 24 (6), 980-991.
    • (2005) Oncogene , vol.24 , Issue.6 , pp. 980-991
    • Kanzawa, T.1    Zhang, L.2    Xiao, L.3    Germano, I.M.4    Kondo, Y.5    Kondo, S.6
  • 140
    • 84906878287 scopus 로고    scopus 로고
    • A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF)
    • Liu, Y.; Zhao, L.; Ju, Y.; Li, W.; Zhang, M.; Jiao, Y.; Zhang, J.; Wang, S.; Wang, Y.; Zhao, M.; Zhang, B.; Zhao, Y. A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF). Cell Death Dis., 2014, 5, e1361.
    • (2014) Cell Death Dis , vol.5
    • Liu, Y.1    Zhao, L.2    Ju, Y.3    Li, W.4    Zhang, M.5    Jiao, Y.6    Zhang, J.7    Wang, S.8    Wang, Y.9    Zhao, M.10    Zhang, B.11    Zhao, Y.12
  • 141
    • 84877297444 scopus 로고    scopus 로고
    • Pseudolaric acid B-induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells
    • Qi, M.; Fan, S.; Yao, G.; Li, Z.; Zhou, H.; Tashiro, S.; Onodera, S.; Xia, M.; Ikejima, T. Pseudolaric acid B-induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells. J. Pharmacol. Sci., 2013, 121 (3), 200-211.
    • (2013) J. Pharmacol. Sci , vol.121 , Issue.3 , pp. 200-211
    • Qi, M.1    Fan, S.2    Yao, G.3    Li, Z.4    Zhou, H.5    Tashiro, S.6    Onodera, S.7    Xia, M.8    Ikejima, T.9
  • 144
    • 78951491924 scopus 로고    scopus 로고
    • Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways
    • Duan, W. J.; Li, Q. S.; Xia, M. Y.; Tashiro, S.; Onodera, S.; Ikejima, T. Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways. Biol. Pharm. Bull., 2011, 34 (1), 47-53.
    • (2011) Biol. Pharm. Bull , vol.34 , Issue.1 , pp. 47-53
    • Duan, W.J.1    Li, Q.S.2    Xia, M.Y.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 145
    • 79251511985 scopus 로고    scopus 로고
    • Silibinin activated ROS-p38-NF-kappaB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells
    • Duan, W. J.; Li, Q. S.; Xia, M. Y.; Tashiro, S.; Onodera, S.; Ikejima, T. Silibinin activated ROS-p38-NF-kappaB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells. J. Asian Nat. Prod. Res., 2011, 13 (1), 27-35.
    • (2011) J. Asian Nat. Prod. Res , vol.13 , Issue.1 , pp. 27-35
    • Duan, W.J.1    Li, Q.S.2    Xia, M.Y.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 146
    • 61649114199 scopus 로고    scopus 로고
    • Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells
    • Liu, B.; Cheng, Y.; Bian, H. J.; Bao, J. K. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy, 2009, 5 (2), 253-255.
    • (2009) Autophagy , vol.5 , Issue.2 , pp. 253-255
    • Liu, B.1    Cheng, Y.2    Bian, H.J.3    Bao, J.K.4
  • 147
    • 84899626963 scopus 로고    scopus 로고
    • Cyclometalated iridium(III)-beta-carboline complexes as potent autophagy-inducing agents
    • He, L.; Liao, S. Y.; Tan, C. P.; Lu, Y. Y.; Xu, C. X.; Ji, L. N.; Mao, Z. W. Cyclometalated iridium(III)-beta-carboline complexes as potent autophagy-inducing agents. Chem. Commun. (Camb.), 2014, 50 (42), 5611-5614.
    • (2014) Chem. Commun. (Camb.) , vol.50 , Issue.42 , pp. 5611-5614
    • He, L.1    Liao, S.Y.2    Tan, C.P.3    Lu, Y.Y.4    Xu, C.X.5    Ji, L.N.6    Mao, Z.W.7
  • 148
    • 84905504979 scopus 로고    scopus 로고
    • Nanomaterial-Induced Autophagy: A New Reversal MDR Tool in Cancer Therapy?
    • Panzarini, E.; Dini, L. Nanomaterial-Induced Autophagy: A New Reversal MDR Tool in Cancer Therapy? Mol. Pharm., 2014, 11 (8), 2527-2538.
    • (2014) Mol. Pharm , vol.11 , Issue.8 , pp. 2527-2538
    • Panzarini, E.1    Dini, L.2
  • 149
    • 84897673358 scopus 로고    scopus 로고
    • Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species
    • Yu, Y. B.; Duan, J. C.; Yu, Y.; Li, Y.; Liu, X. M.; Zhou, X. Q.; Ho, K. F.; Tian, L. W.; Sun, Z. W. Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species. J. Hazard. Mater., 2014, 270, 176-186.
    • (2014) J. Hazard. Mater , vol.270 , pp. 176-186
    • Yu, Y.B.1    Duan, J.C.2    Yu, Y.3    Li, Y.4    Liu, X.M.5    Zhou, X.Q.6    Ho, K.F.7    Tian, L.W.8    Sun, Z.W.9
  • 151
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • Maiuri, M. C.; Criollo, A.; Tasdemir, E.; Vicencio, J. M.; Tajeddine, N.; Hickman, J. A.; Geneste, O.; Kroemer, G. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy, 2007, 3 (4), 374-376.
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6    Geneste, O.7    Kroemer, G.8
  • 152
    • 78650170269 scopus 로고    scopus 로고
    • A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
    • Lian, J.; Wu, X.; He, F.; Karnak, D.; Tang, W.; Meng, Y.; Xiang, D.; Ji, M.; Lawrence, T. S.; Xu, L. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ., 2011, 18 (1), 60-71.
    • (2011) Cell Death Differ , vol.18 , Issue.1 , pp. 60-71
    • Lian, J.1    Wu, X.2    He, F.3    Karnak, D.4    Tang, W.5    Meng, Y.6    Xiang, D.7    Ji, M.8    Lawrence, T.S.9    Xu, L.10
  • 154
    • 84876492939 scopus 로고    scopus 로고
    • GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D-and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells
    • Schwartz-Roberts, J. L.; Shajahan, A. N.; Cook, K. L.; Warri, A.; Abu-Asab, M.; Clarke, R. GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D-and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells. Mol. Cancer Ther., 2013, 12 (4), 448-459.
    • (2013) Mol. Cancer Ther , vol.12 , Issue.4 , pp. 448-459
    • Schwartz-Roberts, J.L.1    Shajahan, A.N.2    Cook, K.L.3    Warri, A.4    Abu-Asab, M.5    Clarke, R.6
  • 155
    • 77952525706 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells
    • Pan, J. X.; Cheng, C. O.; Verstovsek, S.; Chen, Q.; Jin, Y. L.; Cao, Q. The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells. Cancer Lett., 2010, 293 (2), 167-174.
    • (2010) Cancer Lett , vol.293 , Issue.2 , pp. 167-174
    • Pan, J.X.1    Cheng, C.O.2    Verstovsek, S.3    Chen, Q.4    Jin, Y.L.5    Cao, Q.6
  • 156
    • 33947404375 scopus 로고    scopus 로고
    • Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1
    • Kessel, D.; Reiners, J. J., Jr. Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1. Cancer Lett., 2007, 249 (2), 294-299.
    • (2007) Cancer Lett , vol.249 , Issue.2 , pp. 294-299
    • Kessel, D.1    Reiners, J.J.2
  • 158
    • 84856860371 scopus 로고    scopus 로고
    • The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells
    • Nyhan, M. J.; O'Donovan, T. R.; Elzinga, B.; Crowley, L. C.; O'Sullivan, G. C.; McKenna, S. L. The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells. Br. J. Cancer, 2012, 106 (4), 711-718.
    • (2012) Br. J. Cancer , vol.106 , Issue.4 , pp. 711-718
    • Nyhan, M.J.1    O'Donovan, T.R.2    Elzinga, B.3    Crowley, L.C.4    O'Sullivan, G.C.5    McKenna, S.L.6
  • 159
    • 84863101358 scopus 로고    scopus 로고
    • The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells
    • Zhong, J. T.; Xu, Y.; Yi, H. W.; Su, J.; Yu, H. M.; Xiang, X. Y.; Li, X. N.; Zhang, Z. C.; Sun, L. K. The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. Cancer Lett., 2012, 323 (2), 180-187.
    • (2012) Cancer Lett , vol.323 , Issue.2 , pp. 180-187
    • Zhong, J.T.1    Xu, Y.2    Yi, H.W.3    Su, J.4    Yu, H.M.5    Xiang, X.Y.6    Li, X.N.7    Zhang, Z.C.8    Sun, L.K.9
  • 160
    • 18244385490 scopus 로고    scopus 로고
    • Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis
    • Lu, H.; Lin, C.; Zheng, Z.; Li, S.; Guo, S.; Zhang, X.; Fu, M.; Liang, X.; Wu, M. Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis. J. Pharmacol. Sci., 2005, 97 (4), 533-540.
    • (2005) J. Pharmacol. Sci , vol.97 , Issue.4 , pp. 533-540
    • Lu, H.1    Lin, C.2    Zheng, Z.3    Li, S.4    Guo, S.5    Zhang, X.6    Fu, M.7    Liang, X.8    Wu, M.9
  • 163
    • 67651155954 scopus 로고    scopus 로고
    • Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy
    • Ding, W. X.; Ni, H. M.; Gao, W. T.; Chen, X. Y.; Kang, J. H.; Stolz, D. B.; Liu, J. S.; Yin, X. M. Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Mol. Cancer Ther., 2009, 8 (7), 2036-2045.
    • (2009) Mol. Cancer Ther , vol.8 , Issue.7 , pp. 2036-2045
    • Ding, W.X.1    Ni, H.M.2    Gao, W.T.3    Chen, X.Y.4    Kang, J.H.5    Stolz, D.B.6    Liu, J.S.7    Yin, X.M.8
  • 164
    • 75149175502 scopus 로고    scopus 로고
    • Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells
    • Zhu, K.; Dunner, K.; McConkey, D. J. Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene, 2010, 29 (3), 451-462.
    • (2010) Oncogene , vol.29 , Issue.3 , pp. 451-462
    • Zhu, K.1    Dunner, K.2    McConkey, D.J.3
  • 168
    • 84898911026 scopus 로고    scopus 로고
    • Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis
    • Liu, M.; Ma, S.; Liu, M.; Hou, Y.; Liang, B.; Su, X.; Liu, X. Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis. Oncol Lett, 2014, 7 (6), 1903-1910.
    • (2014) Oncol Lett , vol.7 , Issue.6 , pp. 1903-1910
    • Liu, M.1    Ma, S.2    Liu, M.3    Hou, Y.4    Liang, B.5    Su, X.6    Liu, X.7
  • 169
    • 84870591168 scopus 로고    scopus 로고
    • Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells
    • Shi, Y.; Tang, B.; Yu, P. W.; Tang, B.; Hao, Y. X.; Lei, X.; Luo, H. X.; Zeng, D. Z. Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS ONE, 2012, 7 (11), e51076.
    • (2012) PLoS ONE , vol.7 , Issue.11
    • Shi, Y.1    Tang, B.2    Yu, P.W.3    Tang, B.4    Hao, Y.X.5    Lei, X.6    Luo, H.X.7    Zeng, D.Z.8
  • 170
    • 0041734672 scopus 로고    scopus 로고
    • Vitamin D and vitamin D analogs as cancer chemopreventive agents
    • Guyton, K. Z.; Kensler, T. W.; Posner, G. H. Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutr. Rev., 2003, 61 (7), 227-238.
    • (2003) Nutr. Rev , vol.61 , Issue.7 , pp. 227-238
    • Guyton, K.Z.1    Kensler, T.W.2    Posner, G.H.3
  • 171
    • 0036756356 scopus 로고    scopus 로고
    • Vitamin D receptor: A potential target for intervention
    • discussion 130-121
    • Johnson, C. S.; Hershberger, P. A.; Bernardi, R. J.; McGuire, T. F.; Trump, D. L. Vitamin D receptor: a potential target for intervention. Urology, 2002, 60 (3 Suppl 1), 123-130; discussion 130-121.
    • (2002) Urology , vol.60 , Issue.3 , pp. 123-130
    • Johnson, C.S.1    Hershberger, P.A.2    Bernardi, R.J.3    McGuire, T.F.4    Trump, D.L.5
  • 172
    • 54449093435 scopus 로고    scopus 로고
    • Vitamin D3 induces autophagy of human myeloid leukemia cells
    • Wang, J.; Lian, H.; Zhao, Y.; Kauss, M. A.; Spindel, S. Vitamin D3 induces autophagy of human myeloid leukemia cells. J. Biol. Chem., 2008, 283 (37), 25596-25605.
    • (2008) J. Biol. Chem , vol.283 , Issue.37 , pp. 25596-25605
    • Wang, J.1    Lian, H.2    Zhao, Y.3    Kauss, M.A.4    Spindel, S.5
  • 173
    • 84885639981 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells
    • Chiao, M. T.; Cheng, W. Y.; Yang, Y. C.; Shen, C. C.; Ko, J. L. Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells. Autophagy, 2013, 9 (10), 1509-1526.
    • (2013) Autophagy , vol.9 , Issue.10 , pp. 1509-1526
    • Chiao, M.T.1    Cheng, W.Y.2    Yang, Y.C.3    Shen, C.C.4    Ko, J.L.5
  • 176
    • 0037501319 scopus 로고    scopus 로고
    • The estrogen receptor: A model for molecular medicine
    • Jensen, E. V.; Jordan, V. C. The estrogen receptor: A model for molecular medicine. Clin. Cancer Res., 2003, 9 (6), 1980-1989.
    • (2003) Clin. Cancer Res , vol.9 , Issue.6 , pp. 1980-1989
    • Jensen, E.V.1    Jordan, V.C.2
  • 177
    • 84867866496 scopus 로고    scopus 로고
    • Induction of Autophagy and Cell Death by Tamoxifen in Cultured Retinal Pigment Epithelial and Photoreceptor Cells
    • Cho, K. S.; Yoon, Y. H.; Choi, J. A.; Lee, S. J.; Koh, J. Y. Induction of Autophagy and Cell Death by Tamoxifen in Cultured Retinal Pigment Epithelial and Photoreceptor Cells. Invest. Ophthalmol. Vis. Sci., 2012, 53 (9), 5344-5353.
    • (2012) Invest. Ophthalmol. Vis. Sci , vol.53 , Issue.9 , pp. 5344-5353
    • Cho, K.S.1    Yoon, Y.H.2    Choi, J.A.3    Lee, S.J.4    Koh, J.Y.5
  • 178
    • 77958562409 scopus 로고    scopus 로고
    • Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts
    • Son, M. J.; Lee, S. B.; Byun, Y. J.; Lee, H. O.; Kim, H. S.; Kwon, O. J.; Jeong, S. W. Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts. J. Biochem. Mol. Toxicol., 2010, 24 (5), 313-322.
    • (2010) J. Biochem. Mol. Toxicol , vol.24 , Issue.5 , pp. 313-322
    • Son, M.J.1    Lee, S.B.2    Byun, Y.J.3    Lee, H.O.4    Kim, H.S.5    Kwon, O.J.6    Jeong, S.W.7
  • 180
    • 84896776849 scopus 로고    scopus 로고
    • Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
    • Feng, Y.; Ke, C.; Tang, Q.; Dong, H.; Zheng, X.; Lin, W.; Ke, J.; Huang, J.; Jeung, S. C. J.; Zhang, H. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell Death Dis., 2014, 5.
    • (2014) Cell Death Dis , pp. 5
    • Feng, Y.1    Ke, C.2    Tang, Q.3    Dong, H.4    Zheng, X.5    Lin, W.6    Ke, J.7    Huang, J.8    Jeung, S.C.J.9    Zhang, H.10
  • 181
  • 182
    • 77953861522 scopus 로고    scopus 로고
    • Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
    • Eng, C. H.; Yu, K.; Lucas, J.; White, E.; Abraham, R. T. Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy. Sci. Signal., 2010, 3 (119).
    • (2010) Sci. Signal , vol.3 , Issue.119
    • Eng, C.H.1    Yu, K.2    Lucas, J.3    White, E.4    Abraham, R.T.5
  • 184
    • 84865527506 scopus 로고    scopus 로고
    • Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1, 4-Di-N-oxide Derivatives as Hypoxic Selective Antitumor Agents
    • Hu, Y. Z.; Xia, Q.; Shihao, S. G.; Liu, X. W.; Hu, Y. Z.; Sheng, R. Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1, 4-Di-N-oxide Derivatives as Hypoxic Selective Antitumor Agents. Molecules, 2012, 17 (8), 9683-9696.
    • (2012) Molecules , vol.17 , Issue.8 , pp. 9683-9696
    • Hu, Y.Z.1    Xia, Q.2    Shihao, S.G.3    Liu, X.W.4    Hu, Y.Z.5    Sheng, R.6
  • 185
    • 84894414818 scopus 로고    scopus 로고
    • Q6, a novel hypoxia-targeted drug, regulates hypoxiainducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma
    • Liu, X. W.; Cai, T. Y.; Zhu, H.; Cao, J.; Su, Y.; Hu, Y. Z.; He, Q. J.; Yang, B. Q6, a novel hypoxia-targeted drug, regulates hypoxiainducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma. Autophagy, 2014, 10 (1), 111-122.
    • (2014) Autophagy , vol.10 , Issue.1 , pp. 111-122
    • Liu, X.W.1    Cai, T.Y.2    Zhu, H.3    Cao, J.4    Su, Y.5    Hu, Y.Z.6    He, Q.J.7    Yang, B.8
  • 187
    • 84865326329 scopus 로고    scopus 로고
    • MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts
    • Wu, H.; Wang, F.; Hu, S.; Yin, C.; Li, X.; Zhao, S.; Wang, J.; Yan, X. MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts. Cell. Signal., 2012, 24 (11), 2179-2186.
    • (2012) Cell. Signal , vol.24 , Issue.11 , pp. 2179-2186
    • Wu, H.1    Wang, F.2    Hu, S.3    Yin, C.4    Li, X.5    Zhao, S.6    Wang, J.7    Yan, X.8
  • 189
    • 69449097865 scopus 로고    scopus 로고
    • Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells
    • Zhu, H.; Wu, H.; Liu, X. P.; Li, B. A.; Chen, Y.; Ren, X. C.; Liu, C. G.; Yang, J. M. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy, 2009, 5 (6), 816-823.
    • (2009) Autophagy , vol.5 , Issue.6 , pp. 816-823
    • Zhu, H.1    Wu, H.2    Liu, X.P.3    Li, B.A.4    Chen, Y.5    Ren, X.C.6    Liu, C.G.7    Yang, J.M.8
  • 190
    • 85046981182 scopus 로고    scopus 로고
    • miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
    • Korkmaz, G.; le Sage, C.; Tekirdag, K. A.; Agami, R.; Gozuacik, D. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy, 2012, 8 (2), 165-176.
    • (2012) Autophagy , vol.8 , Issue.2 , pp. 165-176
    • Korkmaz, G.1    le Sage, C.2    Tekirdag, K.A.3    Agami, R.4    Gozuacik, D.5
  • 191
    • 84868627011 scopus 로고    scopus 로고
    • MicroRNA regulation of autophagy
    • Frankel, L. B.; Lund, A. H. MicroRNA regulation of autophagy. Carcinogenesis, 2012, 33 (11), 2018-2025.
    • (2012) Carcinogenesis , vol.33 , Issue.11 , pp. 2018-2025
    • Frankel, L.B.1    Lund, A.H.2
  • 192
    • 84861567957 scopus 로고    scopus 로고
    • MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma
    • Fang, Y.; Xue, J. L.; Shen, Q.; Chen, J.; Tian, L. MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. Hepatology, 2012, 55 (6), 1852-1862.
    • (2012) Hepatology , vol.55 , Issue.6 , pp. 1852-1862
    • Fang, Y.1    Xue, J.L.2    Shen, Q.3    Chen, J.4    Tian, L.5
  • 193
    • 79551485492 scopus 로고    scopus 로고
    • A novel BH3 mimetic S1 potently induces Bax/Bakdependent apoptosis by targeting both Bcl-2 and Mcl-1
    • Zhang, Z. C.; Song, T.; Zhang, T. T.; Gao, J.; Wu, G. Y.; An, L. J.; Du, G. H. A novel BH3 mimetic S1 potently induces Bax/Bakdependent apoptosis by targeting both Bcl-2 and Mcl-1. Int. J. Cancer, 2011, 128 (7), 1724-1735.
    • (2011) Int. J. Cancer , vol.128 , Issue.7 , pp. 1724-1735
    • Zhang, Z.C.1    Song, T.2    Zhang, T.T.3    Gao, J.4    Wu, G.Y.5    An, L.J.6    Du, G.H.7
  • 194
    • 43649086471 scopus 로고    scopus 로고
    • Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells
    • Takezawa, J.; Ishimi, Y.; Yamada, K. Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells. Cancer Sci., 2008, 99 (5), 863-871.
    • (2008) Cancer Sci , vol.99 , Issue.5 , pp. 863-871
    • Takezawa, J.1    Ishimi, Y.2    Yamada, K.3
  • 195
    • 84882796035 scopus 로고    scopus 로고
    • Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents
    • Sun, H.; Wang, Z.; Yakisich, J. S. Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents. Anticancer Agents Med. Chem., 2013, 13 (7), 1048-1056.
    • (2013) Anticancer Agents Med. Chem , vol.13 , Issue.7 , pp. 1048-1056
    • Sun, H.1    Wang, Z.2    Yakisich, J.S.3
  • 197
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3 '-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot, A.; Ogier-Denis, E.; Blommaart, E. F. C.; Meijer, A. J.; Codogno, P. Distinct classes of phosphatidylinositol 3 '-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem., 2000, 275 (2), 992-998.
    • (2000) J. Biol. Chem , vol.275 , Issue.2 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.C.3    Meijer, A.J.4    Codogno, P.5
  • 198
    • 77951217000 scopus 로고    scopus 로고
    • Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
    • Wu, Y. T.; Tan, H. L.; Shui, G. H.; Bauvy, C.; Huang, Q.; Wenk, M. R.; Ong, C. N.; Codogno, P.; Shen, H. M. Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase. J. Biol. Chem., 2010, 285 (14), 10850-10861.
    • (2010) J. Biol. Chem , vol.285 , Issue.14 , pp. 10850-10861
    • Wu, Y.T.1    Tan, H.L.2    Shui, G.H.3    Bauvy, C.4    Huang, Q.5    Wenk, M.R.6    Ong, C.N.7    Codogno, P.8    Shen, H.M.9
  • 199
    • 49949105827 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
    • Li, J.; Ni, M.; Lee, B.; Barron, E.; Hinton, D. R.; Lee, A. S. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ., 2008, 15 (9), 1460-1471.
    • (2008) Cell Death Differ , vol.15 , Issue.9 , pp. 1460-1471
    • Li, J.1    Ni, M.2    Lee, B.3    Barron, E.4    Hinton, D.R.5    Lee, A.S.6
  • 200
    • 84878992314 scopus 로고    scopus 로고
    • Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy
    • Selvakumaran, M.; Amaravadi, R. K.; Vasilevskaya, I. A.; O'Dwyer, P. J. Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. Clin. Cancer Res., 2013, 19 (11), 2995-3007.
    • (2013) Clin. Cancer Res , vol.19 , Issue.11 , pp. 2995-3007
    • Selvakumaran, M.1    Amaravadi, R.K.2    Vasilevskaya, I.A.3    O'Dwyer, P.J.4
  • 201
    • 84939877243 scopus 로고    scopus 로고
    • Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells
    • Tran, A. T.; Ramalinga, M.; Kedir, H.; Clarke, R.; Kumar, D. Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells. Eur. J. Nutr., 2014.
    • (2014) Eur. J. Nutr
    • Tran, A.T.1    Ramalinga, M.2    Kedir, H.3    Clarke, R.4    Kumar, D.5
  • 202
    • 84908051096 scopus 로고    scopus 로고
    • Inhibition of autophagy by 3-MA potentiates purvalanolinduced apoptosis in Bax deficient HCT 116 colon cancer cells
    • Coker-Gurkan, A.; Arisan, E. D.; Obakan, P.; Guvenir, E.; Unsal, N. P. Inhibition of autophagy by 3-MA potentiates purvalanolinduced apoptosis in Bax deficient HCT 116 colon cancer cells. Exp. Cell Res., 2014.
    • (2014) Exp. Cell Res
    • Coker-Gurkan, A.1    Arisan, E.D.2    Obakan, P.3    Guvenir, E.4    Unsal, N.P.5
  • 204
    • 84899091326 scopus 로고    scopus 로고
    • Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia
    • Shao, S.; Li, S.; Qin, Y. W.; Wang, X. R.; Yang, Y. N.; Bai, H. T.; Zhou, L. L.; Zhao, C. X.; Wang, C. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int. J. Oncol., 2014, 44 (5), 1661-1668.
    • (2014) Int. J. Oncol , vol.44 , Issue.5 , pp. 1661-1668
    • Shao, S.1    Li, S.2    Qin, Y.W.3    Wang, X.R.4    Yang, Y.N.5    Bai, H.T.6    Zhou, L.L.7    Zhao, C.X.8    Wang, C.9
  • 205
    • 0023192318 scopus 로고
    • Stimulation by Glucagon And Adenosine-3', 5'-Cyclic Monophosphate Of Protein-Degradation In Reuber-H35 Hepatoma Monolayers
    • Wong, S. S. C.; Woo, P. T. L. Stimulation by Glucagon And Adenosine-3', 5'-Cyclic Monophosphate Of Protein-Degradation In Reuber-H35 Hepatoma Monolayers. Int. J. Biochem., 1987, 19 (5), 443-447.
    • (1987) Int. J. Biochem , vol.19 , Issue.5 , pp. 443-447
    • Wong, S.S.C.1    Woo, P.T.L.2
  • 206
    • 79955460678 scopus 로고    scopus 로고
    • Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1
    • McFarlane, S.; Aitken, J.; Sutherland, J. S.; Nicholl, M. J.; Preston, V. G.; Preston, C. M. Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1. J. Virol., 2011, 85 (9), 4212-4221.
    • (2011) J. Virol , vol.85 , Issue.9 , pp. 4212-4221
    • McFarlane, S.1    Aitken, J.2    Sutherland, J.S.3    Nicholl, M.J.4    Preston, V.G.5    Preston, C.M.6
  • 207
    • 84896089543 scopus 로고    scopus 로고
    • Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation
    • Watanabe-Asano, T.; Kuma, A.; Mizushima, N. Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation. Biochem. Biophys. Res. Commun., 2014, 445 (2), 334-339.
    • (2014) Biochem. Biophys. Res. Commun , vol.445 , Issue.2 , pp. 334-339
    • Watanabe-Asano, T.1    Kuma, A.2    Mizushima, N.3
  • 208
    • 77952168284 scopus 로고    scopus 로고
    • The Histone Deacetylase Inhibitor MGCD0103 Induces Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells through a Mitochondria-Mediated Caspase Activation Cascade
    • El-Khoury, V.; Moussay, E.; Janji, B.; Palissot, V.; Aouali, N.; Brons, N. H. C.; Van Moer, K.; Pierson, S.; Van Dyck, E.; Berchem, G. The Histone Deacetylase Inhibitor MGCD0103 Induces Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells through a Mitochondria-Mediated Caspase Activation Cascade. Mol. Cancer Ther., 2010, 9 (5), 1349-1360.
    • (2010) Mol. Cancer Ther , vol.9 , Issue.5 , pp. 1349-1360
    • El-Khoury, V.1    Moussay, E.2    Janji, B.3    Palissot, V.4    Aouali, N.5    Brons, N.H.C.6    Van Moer, K.7    Pierson, S.8    Van Dyck, E.9    Berchem, G.10
  • 209
    • 84905679330 scopus 로고    scopus 로고
    • Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia
    • El-Khoury, V.; Pierson, S.; Szwarcbart, E.; Brons, N. H.; Roland, O.; Cherrier-De Wilde, S.; Plawny, L.; Van Dyck, E.; Berchem, G. Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia, 2014, 28 (8), 1636-1646.
    • (2014) Leukemia , vol.28 , Issue.8 , pp. 1636-1646
    • El-Khoury, V.1    Pierson, S.2    Szwarcbart, E.3    Brons, N.H.4    Roland, O.5    Cherrier-De Wilde, S.6    Plawny, L.7    Van Dyck, E.8    Berchem, G.9
  • 213
    • 8044257699 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
    • Blommaart, E. F.; Krause, U.; Schellens, J. P.; Vreeling-Sindelarova, H.; Meijer, A. J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem., 1997, 243 (1-2), 240-246.
    • (1997) Eur. J. Biochem , vol.243 , Issue.1-2 , pp. 240-246
    • Blommaart, E.F.1    Krause, U.2    Schellens, J.P.3    Vreeling-Sindelarova, H.4    Meijer, A.J.5
  • 214
    • 33645120442 scopus 로고    scopus 로고
    • Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
    • Kochl, R.; Hu, X. W.; Chan, E. Y. W.; Tooze, S. A. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic, 2006, 7 (2), 129-145.
    • (2006) Traffic , vol.7 , Issue.2 , pp. 129-145
    • Kochl, R.1    Hu, X.W.2    Chan, E.Y.W.3    Tooze, S.A.4
  • 215
    • 0015496390 scopus 로고
    • Lysosomes, pH and the anti-malarial action of chloroquine
    • Homewood, C. A.; Warhurst, D. C.; Peters, W.; Baggaley, V. C. Lysosomes, pH and the anti-malarial action of chloroquine. Nature, 1972, 235 (5332), 50-52.
    • (1972) Nature , vol.235 , Issue.5332 , pp. 50-52
    • Homewood, C.A.1    Warhurst, D.C.2    Peters, W.3    Baggaley, V.C.4
  • 217
    • 84867619238 scopus 로고    scopus 로고
    • Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote gamma-irradiation-induced cell death in primary stem-like glioma cells
    • Firat, E.; Weyerbrock, A.; Gaedicke, S.; Grosu, A. L.; Niedermann, G. Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote gamma-irradiation-induced cell death in primary stem-like glioma cells. PLoS ONE, 2012, 7 (10), e47357.
    • (2012) PLoS ONE , vol.7 , Issue.10
    • Firat, E.1    Weyerbrock, A.2    Gaedicke, S.3    Grosu, A.L.4    Niedermann, G.5
  • 218
    • 84871940714 scopus 로고    scopus 로고
    • Chloroquine in cancer therapy: A double-edged sword of autophagy
    • Kimura, T.; Takabatake, Y.; Takahashi, A.; Isaka, Y. Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res., 2013, 73 (1), 3-7.
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 3-7
    • Kimura, T.1    Takabatake, Y.2    Takahashi, A.3    Isaka, Y.4
  • 219
    • 84890810356 scopus 로고    scopus 로고
    • The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation-and chemotherapy-induced cell death
    • Qiao, S.; Tao, S.; Rojo de la Vega, M.; Park, S. L.; Vonderfecht, A. A.; Jacobs, S. L.; Zhang, D. D.; Wondrak, G. T. The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation-and chemotherapy-induced cell death. Autophagy, 2013, 9 (12), 2087-2102.
    • (2013) Autophagy , vol.9 , Issue.12 , pp. 2087-2102
    • Qiao, S.1    Tao, S.2    Rojo de la Vega, M.3    Park, S.L.4    Vonderfecht, A.A.5    Jacobs, S.L.6    Zhang, D.D.7    Wondrak, G.T.8
  • 220
    • 0031593675 scopus 로고    scopus 로고
    • Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
    • Yamamoto, A.; Tagawa, Y.; Yoshimori, T.; Moriyama, Y.; Masaki, R.; Tashiro, Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct., 1998, 23 (1), 33-42.
    • (1998) Cell Struct. Funct , vol.23 , Issue.1 , pp. 33-42
    • Yamamoto, A.1    Tagawa, Y.2    Yoshimori, T.3    Moriyama, Y.4    Masaki, R.5    Tashiro, Y.6
  • 221
    • 84903267463 scopus 로고    scopus 로고
    • Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells
    • Xie, Z.; Xie, Y.; Xu, Y.; Zhou, H.; Xu, W.; Dong, Q. Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells. Mol. Med. Rep., 2014, 10 (2), 1103-1107.
    • (2014) Mol. Med. Rep , vol.10 , Issue.2 , pp. 1103-1107
    • Xie, Z.1    Xie, Y.2    Xu, Y.3    Zhou, H.4    Xu, W.5    Dong, Q.6
  • 222
    • 84885027692 scopus 로고    scopus 로고
    • The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells
    • Kallifatidis, G.; Hoepfner, D.; Jaeg, T.; Guzman, E. A.; Wright, A. E. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs, 2013, 11, 3500-3516.
    • (2013) Mar. Drugs , vol.11 , pp. 3500-3516
    • Kallifatidis, G.1    Hoepfner, D.2    Jaeg, T.3    Guzman, E.A.4    Wright, A.E.5
  • 223
    • 84900405752 scopus 로고    scopus 로고
    • Marine Drugs, 2014, 12 (4), 2305-2307.
    • (2014) Marine Drugs , vol.12 , Issue.4 , pp. 2305-2307
  • 225
    • 84872127937 scopus 로고    scopus 로고
    • Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases
    • Wang, Z.; Zhang, J.; Wang, Y.; Xing, R.; Yi, C.; Zhu, H.; Chen, X.; Guo, J.; Guo, W.; Li, W.; Wu, L.; Lu, Y.; Liu, S. Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases. Carcinogenesis, 2013, 34 (1), 128-138.
    • (2013) Carcinogenesis , vol.34 , Issue.1 , pp. 128-138
    • Wang, Z.1    Zhang, J.2    Wang, Y.3    Xing, R.4    Yi, C.5    Zhu, H.6    Chen, X.7    Guo, J.8    Guo, W.9    Li, W.10    Wu, L.11    Lu, Y.12    Liu, S.13
  • 226
    • 84870867428 scopus 로고    scopus 로고
    • Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: Novel considerations
    • Juhasz, G. Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: novel considerations. Autophagy, 2012, 8 (12), 1875-1876.
    • (2012) Autophagy , vol.8 , Issue.12 , pp. 1875-1876
    • Juhasz, G.1
  • 227
    • 33947497050 scopus 로고    scopus 로고
    • Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival
    • Ding, W. X.; Ni, H. M.; Gao, W.; Hou, Y. F.; Melan, M. A.; Chen, X.; Stolz, D. B.; Shao, Z. M.; Yin, X. M. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J. Biol. Chem., 2007, 282 (7), 4702-4710.
    • (2007) J. Biol. Chem , vol.282 , Issue.7 , pp. 4702-4710
    • Ding, W.X.1    Ni, H.M.2    Gao, W.3    Hou, Y.F.4    Melan, M.A.5    Chen, X.6    Stolz, D.B.7    Shao, Z.M.8    Yin, X.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.