Silibinin activated ROS-p38-NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells

Journal of Asian Natural Products Research

Volumn 13, Issue 1, 2011, Pages 27-35

  Duan, Wen Jun ^a   Li, Qi Sheng ^a   Xia, Ming Yu ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^a   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

autophagy; H2O2; NF B; O 2O. ; p38; silibinin

Indexed keywords

3 METHYLADENINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BECLIN 1; HYDROGEN PEROXIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYROLIDINE DITHIOCARBAMATE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SILIBININ; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; FIBROSARCOMA; HT1080 CELL; HUMAN; HUMAN CELL; LIGHT CHAIN; POSITIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; AUTOPHAGY; CELL DEATH; FIBROSARCOMA; HUMANS; HYDROGEN PEROXIDE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SILYMARIN; SUPEROXIDES;

EID: 79251511985     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2010.540757     Document Type: Article

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