Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth

Journal of Biological Chemistry

Volumn 289, Issue 32, 2014, Pages 22306-22318

  Shukla, Sudhanshu ^a   Patric, Irene Rosita Pia ^a   Patil, Vikas ^a   Shwetha, Shivayogi D ^c   Hegde, Alangar S ^b   Chandramouli, Bangalore A ^c   Arivazhagan, Arimappamagan ^c   Santosh, Vani ^c   Somasundaram, Kumaravel ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b SRI SATHYA SAI INSTITUTE OF HIGHER MEDICAL SCIENCES   (India)

^c NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CELL GROWTH; GROWTH KINETICS; METHYLATION;

AUTOPHAGY; AUTOPHAGY GENES; DEGRADATION PROCESS; DOWN-REGULATION; ECTOPIC EXPRESSIONS; GLIOBLASTOMAS; GLIOMA CELLS; TUMOR GROWTH;

TUMORS;

CATALASE; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; ULK1 PROTEIN, HUMAN; ULK2 PROTEIN, HUMAN; ULK2 PROTEIN, MOUSE;

ANIMAL; APOPTOSIS; ASTROCYTE; AUTOPHAGY; BRAIN TUMOR; CASE CONTROL STUDY; CELL PROLIFERATION; CELL TRANSFORMATION; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; GENE SILENCING; GENETICS; GLIOBLASTOMA; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; PATHOLOGY; PROMOTER REGION; TRANSFORMED CELL LINE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; ASTROCYTES; AUTOPHAGY; BRAIN NEOPLASMS; CASE-CONTROL STUDIES; CATALASE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; GENE SILENCING; GLIOBLASTOMA; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES;

EID: 84905841277     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.567032     Document Type: Article

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