-
1
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B.; Kroemer, G. Autophagy in the pathogenesis of disease. Cell, 2008, 132(1), 27-42.
-
(2008)
Cell
, vol.132
, Issue.1
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
2
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
DOI 10.1038/nature06639, PII NATURE06639
-
Mizushima, N.; Levine, B.; Cuervo, A.; Klionsky, D. Autophagy fights disease through cellular self-digestion. Nature, 2008, 451(7182), 1069-1075. (Pubitemid 351317450)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
3
-
-
36248982150
-
Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1
-
DOI 10.1016/j.biocel.2007.07.020, PII S1357272507002579
-
Cao, Q.; Yu, C.; Xue, R.; Hsueh, W.; Pan, P.; Chen, Z.; Wang, S.; McNutt, M.; Gu, J. Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1. Int. J. Biochem. Cell. B., 2008, 40(2), 272-283. (Pubitemid 350137879)
-
(2008)
International Journal of Biochemistry and Cell Biology
, vol.40
, Issue.2
, pp. 272-283
-
-
Cao, Q.1
Yu, C.2
Xue, R.3
Hsueh, W.4
Pan, P.5
Chen, Z.6
Wang, S.7
McNutt, M.8
Gu, J.9
-
4
-
-
47149092405
-
Targeting the p27 E3 ligase SCFSkp2 results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy
-
Chen, Q.; Xie, W.; Kuhn, D.; Voorhees, P.; Lopez-Girona, A.; Mendy, D.; Corral, L.; Krenitsky, V.; Xu, W.; Moutouh-de Parseval, L. Targeting the p27 E3 ligase SCFSkp2 results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood, 2008, 111(9), 4690-4699.
-
(2008)
Blood
, vol.111
, Issue.9
, pp. 4690-4699
-
-
Chen, Q.1
Xie, W.2
Kuhn, D.3
Voorhees, P.4
Lopez-Girona, A.5
Mendy, D.6
Corral, L.7
Krenitsky, V.8
Xu, W.9
Moutouh-De Parseval, L.10
-
5
-
-
65149084441
-
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
-
Nahimana, A.; Attinger, A.; Aubry, D.; Greaney, P.; Ireson, C.; Thougaard, A.V.; Tjornelund, J.; Dawson, K.M.; Dupuis, M.; Duchosal, M.A. The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies. Blood, 2009, 113(14), 3276-3286.
-
(2009)
Blood
, vol.113
, Issue.14
, pp. 3276-3286
-
-
Nahimana, A.1
Attinger, A.2
Aubry, D.3
Greaney, P.4
Ireson, C.5
Thougaard, A.V.6
Tjornelund, J.7
Dawson, K.M.8
Dupuis, M.9
Duchosal, M.A.10
-
6
-
-
35548996805
-
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase
-
DOI 10.1038/sj.cdd.4402207, PII 4402207
-
Xu, Z.; Liang, J.; Haridas, V.; Gaikwad, A.; Connolly, F.; Mills, G.; Gutterman, J. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell. Death. Differ., 2007, 14(11), 1948-1957. (Pubitemid 350011670)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.11
, pp. 1948-1957
-
-
Xu, Z.-X.1
Liang, J.2
Haridas, V.3
Gaikwad, A.4
Connolly, F.P.5
Mills, G.B.6
Gutterman, J.U.7
-
7
-
-
34347394714
-
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHAto overcome Bcr-Abl-mediated drug resistance
-
DOI 10.1182/blood-2006-10-050260
-
Carew, J.; Nawrocki, S.; Kahue, C.; Zhang, H.; Yang, C.; Chung, L.; Houghton, J.; Huang, P.; Giles, F.; Cleveland, J. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood, 2007, 110(1), 313-322. (Pubitemid 47026849)
-
(2007)
Blood
, vol.110
, Issue.1
, pp. 313-322
-
-
Carew, J.S.1
Nawrocki, S.T.2
Kahue, C.N.3
Zhang, H.4
Yang, C.5
Chung, L.6
Houghton, J.A.7
Huang, P.8
Giles, F.J.9
Cleveland, J.L.10
-
8
-
-
68449083829
-
The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells
-
Jun, L.; Zhenghong, Q.; Zhongqin, L. The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer, 2008, 9.
-
(2008)
BMC Cancer
, vol.9
-
-
Jun, L.1
Zhenghong, Q.2
Zhongqin, L.3
-
9
-
-
57749085555
-
Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells
-
Sy, L.; Yan, S.; Lok, C.; Man, R.; Che, C. Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res., 2008, 68(24), 10229-10237.
-
(2008)
Cancer Res
, vol.68
, Issue.24
, pp. 10229-10237
-
-
Sy, L.1
Yan, S.2
Lok, C.3
Man, R.4
Che, C.5
-
10
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
DOI 10.1038/sj.cdd.4401359
-
Kanzawa, T.; Germano, I.; Komata, T.; Ito, H.; Kondo, Y.; Kondo, S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell. Death. Differ., 2004, 11(4), 448-457. (Pubitemid 38489422)
-
(2004)
Cell Death and Differentiation
, vol.11
, Issue.4
, pp. 448-457
-
-
Kanzawa, T.1
Germano, I.M.2
Komata, T.3
Ito, H.4
Kondo, Y.5
Kondo, S.6
-
11
-
-
56749170677
-
Autophagic cell death: The story of a misnomer
-
Kroemer, G.; Levine, B. Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol., 2008, 9(12), 1004-1010.
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, Issue.12
, pp. 1004-1010
-
-
Kroemer, G.1
Levine, B.2
-
12
-
-
34147193472
-
Autophagy and cancer
-
Levine, B. Autophagy and cancer. Nature, 2007, 446(7137), 745-747.
-
(2007)
Nature
, vol.446
, Issue.7137
, pp. 745-747
-
-
Levine, B.1
-
13
-
-
33744988159
-
Autophagy: Is it cancer's friend or foe?
-
Marx, J. Autophagy: is it cancer's friend or foe? Science, 2006, 312(5777), 1160-1161.
-
(2006)
Science
, vol.312
, Issue.5777
, pp. 1160-1161
-
-
Marx, J.1
-
14
-
-
34548100868
-
Modulating autophagy for therapeutic benefit
-
Carew, J.; Nawrocki, S.; Cleveland, J. Modulating autophagy for therapeutic benefit. Autophagy, 2007, 3(5), 464-467. (Pubitemid 47293728)
-
(2007)
Autophagy
, vol.3
, Issue.5
, pp. 464-467
-
-
Carew, J.S.1
Nawrocki, S.T.2
Cleveland, J.L.3
-
15
-
-
77952495224
-
Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
-
Hailey, D.; Rambold, A.; Satpute-Krishnan, P.; Mitra, K.; Sougrat, R.; Kim, P.; Lippincott-Schwartz, J. Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation. Cell, 2010, 141(4), 656-667.
-
(2010)
Cell
, vol.141
, Issue.4
, pp. 656-667
-
-
Hailey, D.1
Rambold, A.2
Satpute-Krishnan, P.3
Mitra, K.4
Sougrat, R.5
Kim, P.6
Lippincott-Schwartz, J.7
-
16
-
-
67649467294
-
Dynamics and diversity in autophagy mechanisms: Lessons from yeast
-
Nakatogawa, H.; Suzuki, K.; Kamada, Y.; Ohsumi, Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol., 2009, 10(7), 458-467.
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, Issue.7
, pp. 458-467
-
-
Nakatogawa, H.1
Suzuki, K.2
Kamada, Y.3
Ohsumi, Y.4
-
17
-
-
35848967804
-
How to interpret LC3 immunoblotting
-
Mizushima, N.; Yoshimori, T. How to Interpret LC3 Immunoblotting. Autophagy, 2007, 3(6), 542-545. (Pubitemid 350060049)
-
(2007)
Autophagy
, vol.3
, Issue.6
, pp. 542-545
-
-
Mizushima, N.1
Yoshimori, T.2
-
18
-
-
34250900953
-
LC3 an autophagosome marker can be incorporated into protein aggregates independent of autophagy
-
Kuma, A.; Matsui, M.; Mizushima, N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy. Autophagy, 2007, 3(4), 323-328.
-
(2007)
Autophagy
, vol.3
, Issue.4
, pp. 323-328
-
-
Kuma, A.1
Matsui, M.2
Mizushima, N.3
-
19
-
-
37649024076
-
Small molecule regulators of autophagy identified by an image-based high-throughput screen
-
Zhang, L.; Yu, J.; Pan, H.; Hu, P.; Hao, Y.; Cai, W.; Zhu, H.; Yu, A.D.; Xie, X.; Ma, D.; Yuan, J. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc. Natl. Acad. Sci. U. S. A., 2007, 104(48), 19023-19028.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A
, vol.104
, Issue.48
, pp. 19023-19028
-
-
Zhang, L.1
Yu, J.2
Pan, H.3
Hu, P.4
Hao, Y.5
Cai, W.6
Zhu, H.7
Yu, A.D.8
Xie, X.9
Ma, D.10
Yuan, J.11
-
20
-
-
77954597127
-
An Autophagy-Enhancing Drug Promotes Degradation of Mutant {alpha}1-Antitrypsin Z and Reduces Hepatic Fibrosis
-
Hidvegi, T.; Ewing, M.; Hale, P.; Dippold, C.; Beckett, C.; Kemp, C.; Maurice, N.; Mukherjee, A.; Goldbach, C.; Watkins, S.; Michalopoulos, G.; Perlmutter, D.H. An Autophagy-Enhancing Drug Promotes Degradation of Mutant {alpha}1-Antitrypsin Z and Reduces Hepatic Fibrosis. Science, 329(5988), 229-232.
-
Science
, vol.329
, Issue.5988
, pp. 229-232
-
-
Hidvegi, T.1
Ewing, M.2
Hale, P.3
Dippold, C.4
Beckett, C.5
Kemp, C.6
Maurice, N.7
Mukherjee, A.8
Goldbach, C.9
Watkins, S.10
Michalopoulos, G.11
Perlmutter, D.H.12
-
21
-
-
34248994604
-
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
-
DOI 10.1038/nchembio883, PII NCHEMBIO883
-
Sarkar, S.; Perlstein, E.; Imarisio, S.; Pineau, S.; Cordenier, A.; Maglathlin, R.; Webster, J.; Lewis, T.; O'Kane, C.; Schreiber, S. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat. Chem. Biol., 2007, 3(6), 331-338. (Pubitemid 46789270)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.6
, pp. 331-338
-
-
Sarkar, S.1
Perlstein, E.O.2
Imarisio, S.3
Pineau, S.4
Cordenier, A.5
Maglathlin, R.L.6
Webster, J.A.7
Lewis, T.A.8
O'Kane, C.J.9
Schreiber, S.L.10
Rubinsztein, D.C.11
-
22
-
-
69249153394
-
A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1
-
Wang, J.; Whiteman, M.; Lian, H.; Wang, G.; Singh, A.; Huang, D.; Denmark, T. A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J. Biol. Chem., 2009, 284(32), 21412-21424.
-
(2009)
J. Biol. Chem
, vol.284
, Issue.32
, pp. 21412-21424
-
-
Wang, J.1
Whiteman, M.2
Lian, H.3
Wang, G.4
Singh, A.5
Huang, D.6
Denmark, T.7
-
23
-
-
0027388946
-
Do all programmed cell deaths occur via apoptosis?
-
DOI 10.1073/pnas.90.3.980
-
Schwartz, L.; Smith, S.; Jones, M.; Osborne, B. Do all programmed cell deaths occur via apoptosis? Proc. Natl. Acad. Sci. U. S. A., 1993, 90(3), 980-984. (Pubitemid 23053934)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.3
, pp. 980-984
-
-
Schwartz, L.M.1
Smith, S.W.2
Jones, M.E.E.3
Osborne, B.A.4
-
24
-
-
0035409448
-
Programmed cell death and apoptosis: Origins of the theory
-
DOI 10.1038/35080097
-
Lockshin, R.; Zakeri, Z. Programmed cell death and apoptosis: origins of the theory. Nat. Rev. Mol. Cell Biol., 2001, 2(7), 545-550. (Pubitemid 33673405)
-
(2001)
Nature Reviews Molecular Cell Biology
, vol.2
, Issue.7
, pp. 545-550
-
-
Lockshin, R.A.1
Zakeri, Z.2
-
25
-
-
2142643169
-
A first insight into the molecular mechanisms of apoptosis
-
Yuan, J.; Horvitz, H. A first insight into the molecular mechanisms of apoptosis. Cell, 2004, 116(2 Suppl), S53-S59.
-
(2004)
Cell
, vol.116
, Issue.2 SUPPL.
-
-
Yuan, J.1
Horvitz, H.2
-
26
-
-
0029068871
-
Identification andinhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
-
Nicholson, D.; Ali, A.; Thornberry, N.; Vaillancourt, J.; Ding, C.; Gallant, M.; Gareau, Y.; Griffin, P.; Labelle, M.; Lazebnik, Y. Identification andinhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature, 1995, 376, 37-43.
-
(1995)
Nature
, vol.376
, pp. 37-43
-
-
Nicholson, D.1
Ali, A.2
Thornberry, N.3
Vaillancourt, J.4
Ding, C.5
Gallant, M.6
Gareau, Y.7
Griffin, P.8
Labelle, M.9
Lazebnik, Y.10
-
27
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
DOI 10.1016/S1534-5807(04)00099-1, PII S1534580704000991
-
Levine, B.; Klionsky, D. Development by Self-Digestion:: Molecular Mechanisms and Biological Functions of Autophagy. Dev. Cell, 2004, 6(4), 463-477. (Pubitemid 38456176)
-
(2004)
Developmental Cell
, vol.6
, Issue.4
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
28
-
-
77953713630
-
C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms
-
Tian, Y.; Li, Z.; Hu, W.; Ren, H.; Tian, E.; Zhao, Y.; Lu, Q.; Huang, X.; Yang, P.; Li, X.; Wang, X.; Kovács, A.L.; Yu, L.; Zhang, H. C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell, 2010, 141(6), 1042-1055.
-
(2010)
Cell
, vol.141
, Issue.6
, pp. 1042-1055
-
-
Tian, Y.1
Li, Z.2
Hu, W.3
Ren, H.4
Tian, E.5
Zhao, Y.6
Lu, Q.7
Huang, X.8
Yang, P.9
Li, X.10
Wang, X.11
Kovács, A.L.12
Yu, L.13
Zhang, H.14
-
29
-
-
8344242220
-
Autophagy in health and disease: A double-edged sword
-
DOI 10.1126/science.1099993
-
Shintani, T.; Klionsky, D.J. Autophagy in Health and Disease: A Double- Edged Sword. Science, 2004, 306(5698), 990-995. (Pubitemid 39482894)
-
(2004)
Science
, vol.306
, Issue.5698
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
30
-
-
36448943299
-
-
Wadsworth, V.; White, E. Role of autophagy in cancer. Nat. Rev. Cancer
-
Mathew, R.; Karantza-Wadsworth, V.; White, E. Role of autophagy in cancer. Nat. Rev. Cancer, 2007, 7(12), 961-967.
-
(2007)
, vol.7
, Issue.12
, pp. 961-967
-
-
Mathew, R.1
Karantza-2
-
31
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
DOI 10.1172/JCI200320039
-
Qu, X.; Yu, J.; Bhagat, G.; Furuya, N.; Hibshoosh, H.; Troxel, A.; Rosen, J.; Eskelinen, E.-L.; Mizushima, N.; Ohsumi, Y.; Cattoretti, G.; Levine, B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. The Journal of Clinical Investigation, 2003, 112(12), 1809-1820. (Pubitemid 38063704)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
Rosen, J.7
Eskelinen, E.-L.8
Mizushima, N.9
Ohsumi, Y.10
Cattoretti, G.11
Levine, B.12
-
32
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang, X.H.; Jackson, S.; Seaman, M.; Brown, K.; Kempkes, B.; Hibshoosh, H.; Levine, B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature, 1999, 402(6762), 672-676. (Pubitemid 129516338)
-
(1999)
Nature
, vol.402
, Issue.6762
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
33
-
-
38149141767
-
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
-
Maclean, K.; Dorsey, F.; Cleveland, J.; Kastan, M. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J. Clin. Invest., 2008, 118(1), 79-88.
-
(2008)
J. Clin. Invest
, vol.118
, Issue.1
, pp. 79-88
-
-
MacLean, K.1
Dorsey, F.2
Cleveland, J.3
Kastan, M.4
-
35
-
-
0037451783
-
Autophagy: A barrier or an adaptive response to cancer
-
DOI 10.1016/S0304-419X(03)00004-0
-
Ogier-Denis, E.; Codogno, P. Autophagy: a barrier or an adaptive response to cancer* 1. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2003, 1603(2), 113-128. (Pubitemid 36266686)
-
(2003)
Biochimica et Biophysica Acta - Reviews on Cancer
, vol.1603
, Issue.2
, pp. 113-128
-
-
Ogier-Denis, E.1
Codogno, P.2
-
36
-
-
0036547417
-
Death and anti-death: Tumour resistance to apoptosis
-
Igney, F.H.; Krammer, P.H. Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer, 2002, 2(4), 277-288. (Pubitemid 37328781)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.4
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
37
-
-
38049027838
-
Proautophagic drugs: A novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas
-
Lefranc, F.; Facchini, V.; Kiss, R. Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. The Oncologist, 2007, 12(12), 1395-1403.
-
(2007)
The Oncologist
, vol.12
, Issue.12
, pp. 1395-1403
-
-
Lefranc, F.1
Facchini, V.2
Kiss, R.3
-
38
-
-
27644466759
-
Autophagy and signaling: Their role in cell survival and cell death
-
DOI 10.1038/sj.cdd.4401751, PII 4401751
-
Codogno, P.; Meijer, A. Autophagy and signaling: their role in cell survival and cell death. Cell. Death. Differ., 2005, 12, 1509-1518. (Pubitemid 41553987)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.SUPPL. 2
, pp. 1509-1518
-
-
Codogno, P.1
Meijer, A.J.2
-
39
-
-
41449118098
-
NAD depletion by FK866 induces autophagy
-
Billington, R.; Genazzani, A.; Travelli, C.; Condorelli, F. NAD depletion by FK866 induces autophagy. Autophagy, 2008, 4(3), 385-387. (Pubitemid 351458108)
-
(2008)
Autophagy
, vol.4
, Issue.3
, pp. 385-387
-
-
Billington, R.A.1
Genazzani, A.A.2
Travelli, C.3
Condorelli, F.4
-
40
-
-
54449093435
-
Vitamin D3 induces autophagy of human myeloid leukemia cells
-
Wang, J.; Lian, H.; Zhao, Y.; Kauss, M.; Spindel, S. Vitamin D3 induces autophagy of human myeloid leukemia cells. J. Biol. Chem., 2008, 283(37), 25596-25605.
-
(2008)
J. Biol. Chem
, vol.283
, Issue.37
, pp. 25596-25605
-
-
Wang, J.1
Lian, H.2
Zhao, Y.3
Kauss, M.4
Spindel, S.5
-
41
-
-
43949123587
-
Fenretinide induces autophagic cell death in caspase-defective breast cancer cells
-
Fazi, B.; Bursch, W.; Fimia, G.; Nardacci, R.; Piacentini, M.; Di Sano, F.; Piredda, L. Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy, 2008, 4(4), 435-441. (Pubitemid 351705140)
-
(2008)
Autophagy
, vol.4
, Issue.4
, pp. 435-441
-
-
Fazi, B.1
Bursch, W.2
Fimia, G.M.3
Nardacci, R.4
Piacentini, M.5
Di Sano, F.6
Piredda, L.7
-
42
-
-
33745258655
-
The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance
-
DOI 10.1158/0008-5472.CAN-05-4186
-
Maiso, P.; Carvajal-Vergara, X.; Ocio, E.; Lopez-Perez, R.; Mateo, G.; Gutierrez, N.; Atadja, P.; Pandiella, A.; San Miguel, J. The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res., 2006, 66(11), 5781-5789. (Pubitemid 43927132)
-
(2006)
Cancer Research
, vol.66
, Issue.11
, pp. 5781-5789
-
-
Maiso, P.1
Carvajal-Vergara, X.2
Ocio, E.M.3
Lopez-Perez, R.4
Mateo, G.5
Gutierrez, N.6
Atadja, P.7
Pandiella, A.8
San Miguel, J.F.9
-
43
-
-
47249094223
-
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
-
DOI 10.1038/cdd.2008.51, PII CDD200851
-
Scarlatti, F.; Maffei, R.; Beau, I.; Codogno, P.; Ghidoni, R. Role of noncanonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell. Death. Differ., 2008, 15(8), 1318-1329. (Pubitemid 351984760)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.8
, pp. 1318-1329
-
-
Scarlatti, F.1
Maffei, R.2
Beau, I.3
Codogno, P.4
Ghidoni, R.5
-
44
-
-
0037061646
-
Inhibition of protein-protein association by small molecules: Approaches and progress
-
DOI 10.1021/jm010468s
-
Toogood, P. Inhibition of Protein- Protein Association by Small Molecules: Approaches and Progress? J. Med. Chem, 2002, 45(8), 1543-1558. (Pubitemid 34293520)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.8
, pp. 1543-1558
-
-
Toogood, P.L.1
-
45
-
-
0031593675
-
1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
-
Yamamoto, A.; Tagawa, Y.; Yoshimori, T.; Moriyama, Y.; Masaki, R.; Tashiro, Y. Bafilomycin A 1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct., 1998, 23(1), 33-42. (Pubitemid 28223394)
-
(1998)
Cell Structure and Function
, vol.23
, Issue.1
, pp. 33-42
-
-
Yamamoto, A.1
Tagawa, Y.2
Yoshimori, T.3
Moriyama, Y.4
Masaki, R.5
Tashiro, Y.6
-
46
-
-
45849107594
-
The mTOR signaling network: Insights from its role during embryonic development
-
Hwang, M.; Perez, C.; Moretti, L.; Lu, B. The mTOR signaling network: insights from its role during embryonic development. Curr. Med. Chem., 2008, 15(12), 1192-1208.
-
(2008)
Curr. Med. Chem
, vol.15
, Issue.12
, pp. 1192-1208
-
-
Hwang, M.1
Perez, C.2
Moretti, L.3
Lu, B.4
-
47
-
-
0034683568
-
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
-
Kamada, Y.; Funakoshi, T.; Shintani, T.; Nagano, K.; Ohsumi, M.; Ohsumi, Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol., 2000, 150(6), 1507-1513.
-
(2000)
J. Cell Biol
, vol.150
, Issue.6
, pp. 1507-1513
-
-
Kamada, Y.1
Funakoshi, T.2
Shintani, T.3
Nagano, K.4
Ohsumi, M.5
Ohsumi, Y.6
-
48
-
-
17144427728
-
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
-
Takeuchi, H.; Kondo, Y.; Fujiwara, K.; Kanzawa, T.; Aoki, H.; Mills, G.B.; Kondo, S. Synergistic Augmentation of Rapamycin-Induced Autophagy in Malignant Glioma Cells by Phosphatidylinositol 3-Kinase/Protein Kinase B Inhibitors. Cancer Res., 2005, 65(8), 3336-3346. (Pubitemid 40524618)
-
(2005)
Cancer Research
, vol.65
, Issue.8
, pp. 3336-3346
-
-
Takeuchi, H.1
Kondo, Y.2
Fujiwara, K.3
Kanzawa, T.4
Aoki, H.5
Mills, G.B.6
Kondo, S.7
-
49
-
-
68849091778
-
NVP-BEZ235, a novel dual phosphatidylinositol 3- kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
-
Liu, T.; Koul, D.; LaFortune, T.; Tiao, N.; Shen, R.; Maira, S.; Garcia- Echevrria, C.; Yung, W. NVP-BEZ235, a novel dual phosphatidylinositol 3- kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol. Cancer Ther., 2009, 8(8), 2204-2210.
-
(2009)
Mol. Cancer Ther
, vol.8
, Issue.8
, pp. 2204-2210
-
-
Liu, T.1
Koul, D.2
Lafortune, T.3
Tiao, N.4
Shen, R.5
Maira, S.6
Garcia- Echevrria, C.7
Yung, W.8
-
50
-
-
33645648062
-
Dose escalation of a curcuminoid formulation
-
Lao, C.; Ruffin, M.; Normolle, D.; Heath, D.; Murray, S.; Bailey, J.; Boggs, M.; Crowell, J.; Rock, C.; Brenner, D. Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med., 2006, 6(1), 10.
-
(2006)
BMC Complement. Altern. Med
, vol.6
, Issue.1
, pp. 10
-
-
Lao, C.1
Ruffin, M.2
Normolle, D.3
Heath, D.4
Murray, S.5
Bailey, J.6
Boggs, M.7
Crowell, J.8
Rock, C.9
Brenner, D.10
-
51
-
-
6044276740
-
Phase i clinical trial of oral curcumin
-
Sharma, R.; Euden, S.; Platton, S.; Cooke, D.; Shafayat, A.; Hewitt, H.; Marczylo, T.; Morgan, B.; Hemingway, D.; Plummer, S. Phase I clinical trial of oral curcumin. Clin. Cancer Res., 2004, 10(20), 6847-6854.
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.20
, pp. 6847-6854
-
-
Sharma, R.1
Euden, S.2
Platton, S.3
Cooke, D.4
Shafayat, A.5
Hewitt, H.6
Marczylo, T.7
Morgan, B.8
Hemingway, D.9
Plummer, S.10
-
52
-
-
0037236792
-
Anticancer potential of curcumin: Preclinical and clinical studies
-
Aggarwal, B.; Kumar, A.; Bharti, A. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res., 2003, 23(1A), 363-398. (Pubitemid 36361976)
-
(2003)
Anticancer Research
, vol.23
, Issue.1 A
, pp. 363-398
-
-
Aggarwal, B.B.1
Kumar, A.2
Bharti, A.C.3
-
53
-
-
34347238938
-
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and extracellular signal-regulated kinase signaling pathways
-
Aoki, H.; Takada, Y.; Kondo, S.; Sawaya, R.; Aggarwal, B.; Kondo, Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol. Pharmacol., 2007, 72(1), 29.
-
(2007)
Mol. Pharmacol
, vol.72
, Issue.1
, pp. 29
-
-
Aoki, H.1
Takada, Y.2
Kondo, S.3
Sawaya, R.4
Aggarwal, B.5
Kondo, Y.6
-
54
-
-
67651121842
-
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy
-
Ellis, L.; Bots, M.; Lindemann, R.; Bolden, J.; Newbold, A.; Cluse, L.; Scott, C.; Strasser, A.; Atadja, P.; Lowe, S. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood, 2009, 114(2), 380-393.
-
(2009)
Blood
, vol.114
, Issue.2
, pp. 380-393
-
-
Ellis, L.1
Bots, M.2
Lindemann, R.3
Bolden, J.4
Newbold, A.5
Cluse, L.6
Scott, C.7
Strasser, A.8
Atadja, P.9
Lowe, S.10
-
55
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
DOI 10.1038/nature01960
-
Howitz, K.; Bitterman, K.; Cohen, H.; Lamming, D.; Lavu, S.; Wood, J.; Zipkin, R.; Chung, P.; Kisielewski, A.; Zhang, L. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature, 2003, 425(6954), 191-196. (Pubitemid 37150899)
-
(2003)
Nature
, vol.425
, Issue.6954
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.-L.10
Scherer, B.11
Sinclair, D.A.12
-
56
-
-
0034967925
-
The ubiquitin-proteasome pathway and proteasome inhibitors
-
DOI 10.1002/med.1009
-
Myung, J.; Kim, K.; Crews, C. The ubiquitin-proteasome pathway and proteasome inhibitors. Med. Res. Rev., 2001, 21(4), 245-273. (Pubitemid 32565494)
-
(2001)
Medicinal Research Reviews
, vol.21
, Issue.4
, pp. 245-273
-
-
Myung, J.1
Kim, K.B.2
Crews, C.M.3
-
57
-
-
67650267785
-
An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity
-
Du, Y.; Yang, D.; Li, L.; Luo, G.; Li, T.; Fan, X.; Wang, Q.; Zhang, X.; Wang, Y.; Le, W. An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity. Autophagy, 2009, 5(5), 663-675.
-
(2009)
Autophagy
, vol.5
, Issue.5
, pp. 663-675
-
-
Du, Y.1
Yang, D.2
Li, L.3
Luo, G.4
Li, T.5
Fan, X.6
Wang, Q.7
Zhang, X.8
Wang, Y.9
Le, W.10
-
58
-
-
34548299555
-
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
-
DOI 10.2353/ajpath.2007.070188
-
Ding, W.; Ni, H.; Gao, W.; Yoshimori, T.; Stolz, D.; Ron, D.; Yin, X. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am. J. Pathol., 2007, 171(2), 513-524. (Pubitemid 47344684)
-
(2007)
American Journal of Pathology
, vol.171
, Issue.2
, pp. 513-524
-
-
Ding, W.-X.1
Ni, H.-M.2
Gao, W.3
Yoshimori, T.4
Stolz, D.B.5
Ron, D.6
Yin, X.-M.7
-
59
-
-
33846320884
-
The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones
-
DOI 10.1016/j.nbd.2006.09.018, PII S096999610600235X
-
Fortun, J.; Verrier, J.; Go, J.; Madorsky, I.; Dunn, W.; Notterpek, L. The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones. Neurobiol. Dis., 2007, 25(2), 252-265. (Pubitemid 46124007)
-
(2007)
Neurobiology of Disease
, vol.25
, Issue.2
, pp. 252-265
-
-
Fortun, J.1
Verrier, J.D.2
Go, J.C.3
Madorsky, I.4
Dunn, W.A.5
Notterpek, L.6
-
60
-
-
33847711060
-
The power to reduce: Pyridine nucleotides - Small molecules with a multitude of functions
-
DOI 10.1042/BJ20061638
-
Pollak, N.; Dölle, C.; Ziegler, M. The power to reduce: pyridine nucleotides small molecules with a multitude of functions. Biochem. J., 2007, 402(Pt 2), 205-218. (Pubitemid 46383418)
-
(2007)
Biochemical Journal
, vol.402
, Issue.2
, pp. 205-218
-
-
Pollak, N.1
Dolle, C.2
Ziegler, M.3
-
61
-
-
41549138483
-
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
-
DOI 10.1073/pnas.0712145105
-
Lee, I.H.; Cao, L.; Mostoslavsky, R.; Lombard, D.B.; Liu, J.; Bruns, N.E.; Tsokos, M.; Alt, F.W.; Finkel, T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U. S. A., 2008, 105(9), 3374-3379. (Pubitemid 351723560)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.9
, pp. 3374-3379
-
-
In, H.L.1
Cao, L.2
Mostoslavsky, R.3
Lombard, D.B.4
Liu, J.5
Bruns, N.E.6
Tsokos, M.7
Alt, F.W.8
Finkel, T.9
-
62
-
-
78650511065
-
Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers
-
Chen, G.; Xia, H.; Cai, Y.; Ma, D.; Yuan, J.; Yuan, C. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers. Bioorg. Med. Chem. Lett.
-
Bioorg. Med. Chem. Lett
-
-
Chen, G.1
Xia, H.2
Cai, Y.3
Ma, D.4
Yuan, J.5
Yuan, C.6
-
63
-
-
78049231804
-
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
-
Tsvetkov, A.S.; Miller, J.; Arrasate, M.; Wong, J.S.; Pleiss, M.A.; Finkbeiner, S. A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc. Natl. Acad. Sci. U. S. A., 107(39), 16982-16987.
-
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, Issue.39
, pp. 16982-16987
-
-
Tsvetkov, A.S.1
Miller, J.2
Arrasate, M.3
Wong, J.S.4
Pleiss, M.A.5
Finkbeiner, S.6
-
64
-
-
77954237882
-
Network organization of the human autophagy system
-
Behrends, C.; Sowa, M.E.; Gygi, S.P.; Harper, J.W. Network organization of the human autophagy system. Nature, 2010, 466(7302), 68-76.
-
(2010)
Nature
, vol.466
, Issue.7302
, pp. 68-76
-
-
Behrends, C.1
Sowa, M.E.2
Gygi, S.P.3
Harper, J.W.4
|