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Volumn 44, Issue 5, 2014, Pages 1599-1606

Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells

Author keywords

3 methyladenine; Apigenin; Apoptosis; Autophagy; Cell cycle; Colon cancer cells

Indexed keywords

3 METHYLADENINE; APIGENIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; CELL CYCLE PROTEIN 25C; CELL MARKER; CYCLIN B1; FLAVONOID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; P21 ACTIVATED KINASE; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN LC3; PROTEIN LC3 II; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84899110232     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2339     Document Type: Article
Times cited : (125)

References (43)
  • 1
    • 0033933197 scopus 로고    scopus 로고
    • Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines
    • DOI 10.1002/1098-2744(200006)28:2<102::AID-MC6>
    • Wang W, Heideman L, Chung CS, Pelling JC, Koehler KJ and Birt DF: Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol Carcinog 28: 102-110, 2000. (Pubitemid 30432478)
    • (2000) Molecular Carcinogenesis , vol.28 , Issue.2 , pp. 102-110
    • Wang, W.1    Heideman, L.2    Chung, C.S.3    Pelling, J.C.4    Koehler, K.J.5    Birt, D.F.6
  • 2
    • 84888058645 scopus 로고    scopus 로고
    • Apigenin potentiates the growth inhibitory effects by IKK-beta-mediated NF-kappaB activation in pancreatic cancer cells
    • Wu DG, Yu P, Li JW, et al: Apigenin potentiates the growth inhibitory effects by IKK-beta-mediated NF-kappaB activation in pancreatic cancer cells. Toxicol Lett 224: 157-164, 2014.
    • (2014) Toxicol Lett , vol.224 , pp. 157-164
    • Wu, D.G.1    Yu, P.2    Li, J.W.3
  • 3
    • 84885073826 scopus 로고    scopus 로고
    • Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
    • Maggioni D, Garavello W, Rigolio R, Pignataro L, Gaini R and Nicolini G: Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. Int J Oncol 43: 1675-1682, 2013.
    • (2013) Int J Oncol , vol.43 , pp. 1675-1682
    • Maggioni, D.1    Garavello, W.2    Rigolio, R.3    Pignataro, L.4    Gaini, R.5    Nicolini, G.6
  • 4
    • 84873053877 scopus 로고    scopus 로고
    • Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria
    • Das S, Das J, Samadder A, Boujedaini N and Khuda-Bukhsh AR: Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria. Exp Biol Med (Maywood) 237: 1433-1448, 2012.
    • (2012) Exp Biol Med (Maywood) , vol.237 , pp. 1433-1448
    • Das, S.1    Das, J.2    Samadder, A.3    Boujedaini, N.4    Khuda-Bukhsh, A.R.5
  • 5
    • 84862329696 scopus 로고    scopus 로고
    • Apigenin decreases cell viability and telomerase activity in human leukemia cell lines
    • Jayasooriya RG, Kang SH, Kang CH, et al: Apigenin decreases cell viability and telomerase activity in human leukemia cell lines. Food Chem Toxicol 50: 2605-2611, 2012.
    • (2012) Food Chem Toxicol , vol.50 , pp. 2605-2611
    • Jayasooriya, R.G.1    Kang, S.H.2    Kang, C.H.3
  • 6
    • 0036144234 scopus 로고    scopus 로고
    • 2/m arrest by the chemopreventive flavonoid apigenin
    • DOI 10.1002/mc.10016
    • McVean M, Weinberg WC and Pelling JC: A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. Mol Carcinog 33: 36-43, 2002. (Pubitemid 34052305)
    • (2002) Molecular Carcinogenesis , vol.33 , Issue.1 , pp. 36-43
    • McVean, M.1    Weinberg, W.C.2    Pelling, J.C.3
  • 7
    • 84878362447 scopus 로고    scopus 로고
    • Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells
    • Zhu Y, Mao Y, Chen H, et al: Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells. Cancer Cell Int 13: 54, 2013.
    • (2013) Cancer Cell Int , vol.13 , pp. 54
    • Zhu, Y.1    Mao, Y.2    Chen, H.3
  • 8
    • 84875054444 scopus 로고    scopus 로고
    • Apigenin induces c-Myc-mediated apoptosis in FRO anaplastic thyroid carcinoma cells
    • Kim SH, Kang JG, Kim CS, et al: Apigenin induces c-Myc-mediated apoptosis in FRO anaplastic thyroid carcinoma cells. Mol Cell Endocrinol 369: 130-139, 2013.
    • (2013) Mol Cell Endocrinol , vol.369 , pp. 130-139
    • Kim, S.H.1    Kang, J.G.2    Kim, C.S.3
  • 9
    • 50249087534 scopus 로고    scopus 로고
    • Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
    • Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC and Pelling JC: Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Mol Carcinog 47: 686-700, 2008.
    • (2008) Mol Carcinog , vol.47 , pp. 686-700
    • Mirzoeva, S.1    Kim, N.D.2    Chiu, K.3    Franzen, C.A.4    Bergan, R.C.5    Pelling, J.C.6
  • 10
    • 33646574281 scopus 로고    scopus 로고
    • The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand
    • DOI 10.1158/1535-7163.MCT-05-0431
    • Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M and Sakai T: The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. Mol Cancer Ther 5: 945-951, 2006. (Pubitemid 43724594)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.4 , pp. 945-951
    • Horinaka, M.1    Yoshida, T.2    Shiraishi, T.3    Nakata, S.4    Wakada, M.5    Sakai, T.6
  • 11
    • 83755163788 scopus 로고    scopus 로고
    • Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells
    • Xu Y, Xin Y, Diao Y, et al: Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells. PLoS One 6: e29169, 2011.
    • (2011) PLoS One , vol.6
    • Xu, Y.1    Xin, Y.2    Diao, Y.3
  • 12
    • 84890475550 scopus 로고    scopus 로고
    • Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263
    • Shao H, Jing K, Mahmoud E, Huang H, Fang X and Yu C: Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263. Mol Cancer Ther 12: 2640-2650, 2013.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2640-2650
    • Shao, H.1    Jing, K.2    Mahmoud, E.3    Huang, H.4    Fang, X.5    Yu, C.6
  • 13
    • 84860797409 scopus 로고    scopus 로고
    • Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin
    • Chan LP, Chou TH, Ding HY, et al: Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. Biochim Biophys Acta 1820: 1081-1091, 2012.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 1081-1091
    • Chan, L.P.1    Chou, T.H.2    Ding, H.Y.3
  • 14
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N: Autophagy: process and function. Genes Dev 21: 2861-2873, 2007.
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 15
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • DOI 10.1126/science.1099993
    • Shintani T and Klionsky DJ: Autophagy in health and disease: a double-edged sword. Science 306: 990-995, 2004. (Pubitemid 39482894)
    • (2004) Science , vol.306 , Issue.5698 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 16
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z and Klionsky DJ: Autophagosome formation: core machinery and adaptations. Nat Cell Biol 9: 1102-1109, 2007. (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 18
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 19
    • 23644443068 scopus 로고    scopus 로고
    • The significance of autophagy in cancer
    • DOI 10.1002/mc.20097
    • Ng G and Huang J: The significance of autophagy in cancer. Mol Carcinog 43: 183-187, 2005. (Pubitemid 41134425)
    • (2005) Molecular Carcinogenesis , vol.43 , Issue.4 , pp. 183-187
    • Ng, G.1    Huang, J.2
  • 20
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • DOI 10.1038/sj.onc.1207521
    • Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23: 2891-2906, 2004. (Pubitemid 38638851)
    • (2004) Oncogene , vol.23 , Issue.16 REV. ISS. 2 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 22
    • 84864321495 scopus 로고    scopus 로고
    • Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2009
    • Jung KW, Park S, Kong HJ, et al: Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2009. Cancer Res Treat 44: 11-24, 2012.
    • (2012) Cancer Res Treat , vol.44 , pp. 11-24
    • Jung, K.W.1    Park, S.2    Kong, H.J.3
  • 23
    • 84873968303 scopus 로고    scopus 로고
    • Increasing trend of colorectal cancer incidence in Korea, 1999-2009
    • Shin A, Kim KZ, Jung KW, et al: Increasing trend of colorectal cancer incidence in Korea, 1999-2009. Cancer Res Treat 44: 219-226, 2012.
    • (2012) Cancer Res Treat , vol.44 , pp. 219-226
    • Shin, A.1    Kim, K.Z.2    Jung, K.W.3
  • 26
    • 84873528238 scopus 로고    scopus 로고
    • Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling
    • Lin JF, Tsai TF, Liao PC, et al: Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling. Carcinogenesis 34: 406-414, 2013.
    • (2013) Carcinogenesis , vol.34 , pp. 406-414
    • Lin, J.F.1    Tsai, T.F.2    Liao, P.C.3
  • 27
    • 84875993097 scopus 로고    scopus 로고
    • The novel BH-3 mimetic apogossy-polone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells
    • Cheng P, Ni Z, Dai X, et al: The novel BH-3 mimetic apogossy-polone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells. Cell Death Dis 4: e489, 2013.
    • (2013) Cell Death Dis , vol.4
    • Cheng, P.1    Ni, Z.2    Dai, X.3
  • 28
    • 84883829774 scopus 로고    scopus 로고
    • Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells
    • Cao X, Liu B, Cao W, et al: Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells. Chin J Cancer Res 25: 212-222, 2013.
    • (2013) Chin J Cancer Res , vol.25 , pp. 212-222
    • Cao, X.1    Liu, B.2    Cao, W.3
  • 30
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky DJ, Abeliovich H, Agostinis P, et al: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175, 2008.
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3
  • 31
    • 34548100868 scopus 로고    scopus 로고
    • Modulating autophagy for therapeutic benefit
    • Carew JS, Nawrocki ST and Cleveland JL: Modulating autophagy for therapeutic benefit. Autophagy 3: 464-467, 2007. (Pubitemid 47293728)
    • (2007) Autophagy , vol.3 , Issue.5 , pp. 464-467
    • Carew, J.S.1    Nawrocki, S.T.2    Cleveland, J.L.3
  • 32
    • 34248157606 scopus 로고    scopus 로고
    • Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells
    • Shukla S and Gupta S: Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle 6: 1102-1114, 2007. (Pubitemid 46708584)
    • (2007) Cell Cycle , vol.6 , Issue.9 , pp. 1102-1114
    • Shukla, S.1    Gupta, S.2
  • 33
    • 25844509315 scopus 로고    scopus 로고
    • Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes
    • DOI 10.1002/mc.20123
    • Van Dross RT, Hong X and Pelling JC: Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. Mol Carcinog 44: 83-91, 2005. (Pubitemid 41397173)
    • (2005) Molecular Carcinogenesis , vol.44 , Issue.2 , pp. 83-91
    • Van Dross, R.T.1    Hong, X.2    Pelling, J.C.3
  • 34
    • 84862779346 scopus 로고    scopus 로고
    • Evidence for activation of mutated p53 by apigenin in human pancreatic cancer
    • King JC, Lu QY, Li G, et al: Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochim Biophys Acta 1823: 593-604, 2012.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 593-604
    • King, J.C.1    Lu, Q.Y.2    Li, G.3
  • 35
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • DOI 10.1038/sj.onc.1210220, PII 1210220
    • Adams JM and Cory S: The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337, 2007. (Pubitemid 46328466)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 37
    • 77149128638 scopus 로고    scopus 로고
    • Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells
    • Nishikawa T, Tsuno NH, Okaji Y, et al: Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. Ann Surg Oncol 17: 592-602, 2010.
    • (2010) Ann Surg Oncol , vol.17 , pp. 592-602
    • Nishikawa, T.1    Tsuno, N.H.2    Okaji, Y.3
  • 38
    • 67650751080 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
    • Galluzzi L, Aaronson SA, Abrams J, et al: Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 16: 1093-1107, 2009.
    • (2009) Cell Death Differ , vol.16 , pp. 1093-1107
    • Galluzzi, L.1    Aaronson, S.A.2    Abrams, J.3
  • 39
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • DOI 10.1096/fj.04-2175com
    • Fang J, Xia C, Cao Z, Zheng JZ, Reed E and Jiang BH: Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 19: 342-353, 2005. (Pubitemid 40316522)
    • (2005) FASEB Journal , vol.19 , Issue.3 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.-H.6
  • 40
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B and Guan KL: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-141, 2011.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 41
    • 58749088233 scopus 로고    scopus 로고
    • Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
    • Shingu T, Fujiwara K, Bogler O, et al: Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer 124: 1060-1071, 2009.
    • (2009) Int J Cancer , vol.124 , pp. 1060-1071
    • Shingu, T.1    Fujiwara, K.2    Bogler, O.3
  • 42
    • 77953289524 scopus 로고    scopus 로고
    • Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
    • Li J, Hou N, Faried A, Tsutsumi S and Kuwano H: Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 46: 1900-1909, 2010.
    • (2010) Eur J Cancer , vol.46 , pp. 1900-1909
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Kuwano, H.5
  • 43
    • 60449092595 scopus 로고    scopus 로고
    • Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells
    • Li J, Hou N, Faried A, Tsutsumi S, Takeuchi T and Kuwano H: Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Ann Surg Oncol 16: 761-771, 2009.
    • (2009) Ann Surg Oncol , vol.16 , pp. 761-771
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Takeuchi, T.5    Kuwano, H.6


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