Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application

Leukemia

Volumn 27, Issue 12, 2013, Pages 2397-2403

  Aronson, L I ^a   Davenport, E L ^a   Mirabella, F ^a   Morgan, G J ^a   Davies, F E ^a  

^a Brookes Lawley Building   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 3 METHYLADENINE; ACRIDINE ORANGE; ACTIVATING TRANSCRIPTION FACTOR 4; BAFILOMYCIN A1; BORTEZOMIB; CHLOROQUINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN P62; RAPAMYCIN; UBIQUITINATED PROTEIN; X BOX BINDING PROTEIN 1;

APOPTOSIS; AUTOPHAGOSOME; AUTOPHAGY; BONE MARROW CELL; CATALYSIS; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; DOWN REGULATION; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE EXPRESSION PROFILING; HOMEOSTASIS; HUMAN; IN VITRO STUDY; LETTER; MICROENVIRONMENT; MYELOMA CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; STROMA CELL; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

AUTOPHAGY; HUMANS; MULTIPLE MYELOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; TOR SERINE-THREONINE KINASES;

EID: 84890434182     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.150     Document Type: Letter

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