A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1

International Journal of Cancer

Volumn 128, Issue 7, 2011, Pages 1724-1735

  Zhang, Zhichao ^a   Song, Ting ^a,b   Zhang, Tiantai ^c   Gao, Jin ^a   Wu, Guiye ^a   An, Lijia ^a   Du, Guanhua ^c  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b PEKING UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Bcl 2; BH3 mimetics; Mcl 1; pan Bcl 2 inhibitor

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; BIM PROTEIN; CASPASE 3; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIVER CARCINOMA; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; TUMOR XENOGRAFT;

ACENAPHTHENES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES;

EID: 79551485492     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25484     Document Type: Article

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