Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

Cell Research

Volumn 23, Issue 4, 2013, Pages 508-523

  Zhou, Jing ^a   Tan, Shi Hao ^a,b   Nicolas, Valérie ^c,d   Bauvy, Chantal ^d,e   Yang, Nai Di ^a   Zhang, Jianbin ^a   Xue, Yuan ^f   Codogno, Patrice ^d,e   Shen, Han Ming ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c IPSIT   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e INSERM   (France)

^f REED COLLEGE   (United States)

Author keywords

autophagosome; autophagy; lysosome; mTORC1

Indexed keywords

1 (4 (4 PROPIONYLPIPERAZIN 1 YL) 3 (TRIFLUOROMETHYL)PHENYL) 9 (QUINOLIN 3 YL)BENZO(H)(1,6)NAPHTHYRIDIN 2(1H) ONE; 1-(4-(4-PROPIONYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL)-9-(QUINOLIN-3-YL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; 2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; ATG5 PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; INDOLE DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, HUMAN; MTORC1 COMPLEX, HUMAN; MULTIPROTEIN COMPLEX; NAPHTHYRIDINE DERIVATIVE; PURINE DERIVATIVE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; TFEB PROTEIN, HUMAN; TOR COMPLEX 2; UBIQUITIN PROTEIN LIGASE;

ANIMAL; ARTICLE; AUTOPHAGY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; LYSOSOME; MEMBRANE FUSION; METABOLISM; MOUSE; PHAGOSOME; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; FIBROBLASTS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INDOLES; LYSOSOMES; MEMBRANE FUSION; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MULTIPROTEIN COMPLEXES; NAPHTHYRIDINES; PHAGOSOMES; PURINES; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; UBIQUITIN-ACTIVATING ENZYMES;

MAMMALIA;

EID: 84876408458     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2013.11     Document Type: Article

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