Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1588-1591

  Mortensen, Deborah S ^a   Sapienza, John ^a   Lee, Branden G S ^a   Perrin Ninkovic, Sophie M ^a   Harris, Roy ^a   Shevlin, Graziella ^a   Parnes, Jason S ^a   Whitefield, Brandon ^a   Hickman, Matt ^a   Khambatta, Gody ^a   Bisonette, Rene R ^a   Peng, Sophie ^a   Gamez, Jim C ^a   Leisten, Jim ^a   Narla, Rama Krishna ^a   Fultz, Kimberly E ^a   Sankar, Sabita ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

Kinase inhibitors; Mammalian target of rapamycin; mTOR kinase; Oncology; PI3K Akt mTOR pathway

Indexed keywords

ANTINEOPLASTIC AGENT; CC214 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROSTATE CANCER; SINGLE DRUG DOSE; STILLE REACTION; SUZUKI REACTION; TUMOR GROWTH;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; HUMANS; MALE; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HETEROLOGOUS;

MAMMALIA;

EID: 84874655872     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.110     Document Type: Article

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