메뉴 건너뛰기




Volumn 14, Issue 11, 2011, Pages 2251-2269

Oncosuppressive functions of autophagy

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

EID: 79956159030     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3478     Document Type: Review
Times cited : (87)

References (266)
  • 1
    • 33847026354 scopus 로고    scopus 로고
    • Autophagy delays apoptotic death in breast cancer cells following DNA damage
    • Abedin MJ, Wang D, McDonnell MA, Lehmann U, and Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 14: 500-510, 2007.
    • (2007) Cell Death Differ , vol.14 , pp. 500-510
    • Abedin, M.J.1    Wang, D.2    McDonnell, M.A.3    Lehmann, U.4    Kelekar, A.5
  • 2
    • 39049144417 scopus 로고    scopus 로고
    • P53-dependent and p53-independent activation of autophagy by ARF
    • DOI 10.1158/0008-5472.CAN-07-2069
    • Abida WM and Gu W. p53-Dependent and p53-indepen-dent activation of autophagy by ARF. Cancer Res 68: 352-357, 2008. (Pubitemid 351380060)
    • (2008) Cancer Research , vol.68 , Issue.2 , pp. 352-357
    • Abida, W.M.1    Gu, W.2
  • 3
    • 37549063395 scopus 로고    scopus 로고
    • Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers
    • Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, Kim SS, Yoo NJ, and Lee SH. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 115: 1344-1349, 2007.
    • (2007) APMIS , vol.115 , pp. 1344-1349
    • Ahn, C.H.1    Jeong, E.G.2    Lee, J.W.3    Kim, M.S.4    Kim, S.H.5    Kim, S.S.6    Yoo, N.J.7    Lee, S.H.8
  • 4
    • 69449106873 scopus 로고    scopus 로고
    • Autophagy is required for extension of yeast chronological life span by rapamycin
    • Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA, Jr., and Aris JP. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5: 847-849, 2009.
    • (2009) Autophagy , vol.5 , pp. 847-849
    • Alvers, A.L.1    Wood, M.S.2    Hu, D.3    Kaywell, A.C.4    Dunn Jr., W.A.5    Aris, J.P.6
  • 5
    • 57449120942 scopus 로고    scopus 로고
    • Autophagy-induced tumor dormancy in ovarian cancer
    • Amaravadi RK. Autophagy-induced tumor dormancy in ovarian cancer. J Clin Invest 118: 3837-3840, 2008.
    • (2008) J Clin Invest , vol.118 , pp. 3837-3840
    • Amaravadi, R.K.1
  • 7
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B path-way
    • Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, and Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B path-way. J Biol Chem 276: 35243-35246, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 8
    • 0000730374 scopus 로고
    • Cytoplasmic components in hepatic cell lysosomes
    • Ashford TP and Porter KR. Cytoplasmic components in hepatic cell lysosomes. J Cell Biol 12: 198-202, 1962.
    • (1962) J Cell Biol , vol.12 , pp. 198-202
    • Ashford, T.P.1    Porter, K.R.2
  • 9
    • 61649122814 scopus 로고    scopus 로고
    • Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death
    • Baek SH, Kim EK, Goudreau JL, Lookingland KJ, Kim SW, and Yu SW. Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death. Autophagy 5: 277-279, 2009.
    • (2009) Autophagy , vol.5 , pp. 277-279
    • Baek, S.H.1    Kim, E.K.2    Goudreau, J.L.3    Lookingland, K.J.4    Kim, S.W.5    Yu, S.W.6
  • 10
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autop-hagy is mediated through hypoxia-inducible factor induc-tion of BNIP3 and BNIP3L via their BH3 domains
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, and Mazure NM. Hypoxia-induced autop-hagy is mediated through hypoxia-inducible factor induc-tion of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29: 2570-2581, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouyssegur, J.6    Mazure, N.M.7
  • 11
    • 41449095822 scopus 로고    scopus 로고
    • Autophagy functions in programmed cell death
    • Berry DL and Baehrecke EH. Autophagy functions in programmed cell death. Autophagy 4: 359-360, 2008. (Pubitemid 351458100)
    • (2008) Autophagy , vol.4 , Issue.3 , pp. 359-360
    • Berry, D.L.1    Baehrecke, E.H.2
  • 12
    • 36849088609 scopus 로고    scopus 로고
    • Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila
    • DOI 10.1016/j.cell.2007.10.048, PII S009286740701402X
    • Berry DL and Baehrecke EH. Growth arrest and autophagy are required for salivary gland cell degradation in Droso-phila. Cell 131: 1137-1148, 2007. (Pubitemid 350235023)
    • (2007) Cell , vol.131 , Issue.6 , pp. 1137-1148
    • Berry, D.L.1    Baehrecke, E.H.2
  • 13
    • 0037662713 scopus 로고    scopus 로고
    • Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
    • DOI 10.1042/BJ20021266
    • Beugnet A, Tee AR, Taylor PM, and Proud CG. Regulation of targets of mTOR (mammalian target of rapamycin) sig-nalling by intracellular amino acid availability. Biochem J 372: 555-566, 2003. (Pubitemid 36723901)
    • (2003) Biochemical Journal , vol.372 , Issue.2 , pp. 555-566
    • Beugnet, A.1    Tee, A.R.2    Taylor, P.M.3    Proud, C.G.4
  • 14
    • 34047095297 scopus 로고    scopus 로고
    • The Two TORCs and Akt
    • DOI 10.1016/j.devcel.2007.03.020, PII S1534580707001207
    • Bhaskar PT and Hay N. The two TORCs and Akt. Dev Cell 12: 487-502, 2007. (Pubitemid 46523652)
    • (2007) Developmental Cell , vol.12 , Issue.4 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 15
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • DOI 10.1083/jcb.200507002
    • Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, and Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171: 603-614, 2005. (Pubitemid 41668720)
    • (2005) Journal of Cell Biology , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 16
    • 33645926989 scopus 로고    scopus 로고
    • P62/SQSTM1: A missing link between protein aggregates and the autop-hagy machinery
    • Bjorkoy G, Lamark T, and Johansen T. p62/SQSTM1: a missing link between protein aggregates and the autop-hagy machinery. Autophagy 2: 138-139, 2006.
    • (2006) Autophagy , vol.2 , pp. 138-139
    • Bjorkoy, G.1    Lamark, T.2    Johansen, T.3
  • 17
    • 47749101220 scopus 로고    scopus 로고
    • In-flammation and cancer: The oncogene-driven connection
    • Borrello MG, Degl'Innocenti D, and Pierotti MA. In-flammation and cancer: the oncogene-driven connection. Cancer Lett 267: 262-270, 2008.
    • (2008) Cancer Lett , vol.267 , pp. 262-270
    • Borrello, M.G.1    Degl'Innocenti, D.2    Pierotti, M.A.3
  • 19
    • 67349171677 scopus 로고    scopus 로고
    • Beclin 1: A BH3-only protein that fails to induce apoptosis
    • Boya P and Kroemer G. Beclin 1: a BH3-only protein that fails to induce apoptosis. Oncogene 28: 2125-2127, 2009.
    • (2009) Oncogene , vol.28 , pp. 2125-2127
    • Boya, P.1    Kroemer, G.2
  • 20
    • 67949104883 scopus 로고    scopus 로고
    • Autop-hagy in tumour suppression and promotion
    • Brech A, Ahlquist T, Lothe RA, and Stenmark H. Autop-hagy in tumour suppression and promotion. Mol Oncol 3: 366-375, 2009.
    • (2009) Mol Oncol , vol.3 , pp. 366-375
    • Brech, A.1    Ahlquist, T.2    Lothe, R.A.3    Stenmark, H.4
  • 22
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov AV and Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134: 451-460, 2008.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 23
    • 2142815107 scopus 로고    scopus 로고
    • Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD
    • DOI 10.1126/science.1095569
    • Budanov AV, Sablina AA, Feinstein E, Koonin EV, and Chumakov PM. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596-600, 2004. (Pubitemid 38541920)
    • (2004) Science , vol.304 , Issue.5670 , pp. 596-600
    • Budanov, A.V.1    Sablina, A.A.2    Feinstein, E.3    Koonin, E.V.4    Chumakov, P.M.5
  • 25
    • 35348886043 scopus 로고    scopus 로고
    • Physiological functions of Atg6/Beclin 1: A unique autophagy-related protein
    • DOI 10.1038/cr.2007.78, PII CR200778
    • Cao Y and Klionsky DJ. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res 17: 839-849, 2007. (Pubitemid 47585112)
    • (2007) Cell Research , vol.17 , Issue.10 , pp. 839-849
    • Cao, Y.1    Klionsky, D.J.2
  • 26
    • 0036160679 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Pro- and anti-apoptotic
    • DOI 10.1038/sj/cdd/4400978
    • Castedo M, Ferri KF, and Kroemer G. Mammalian target of rapamycin (mTOR): pro-and anti-apoptotic. Cell Death Differ 9: 99-100, 2002. (Pubitemid 34144768)
    • (2002) Cell Death and Differentiation , vol.9 , Issue.2 , pp. 99-100
    • Castedo, M.1    Ferri, K.F.2    Kroemer, G.3
  • 27
    • 51449085299 scopus 로고    scopus 로고
    • The role of autophagy in mam-malian development: Cell makeover rather than cell death
    • Cecconi F and Levine B. The role of autophagy in mam-malian development: cell makeover rather than cell death. Dev Cell 15: 344-357, 2008.
    • (2008) Dev Cell , vol.15 , pp. 344-357
    • Cecconi, F.1    Levine, B.2
  • 28
    • 69349094578 scopus 로고    scopus 로고
    • Role and regula-tion of autophagy in cancer
    • Chen N and Karantza-Wadsworth V. Role and regula-tion of autophagy in cancer. Biochim Biophys Acta 1793: 1516-1523, 2009.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1516-1523
    • Chen, N.1    Karantza-Wadsworth, V.2
  • 30
    • 33845756437 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of p53 target genes in seminomatous and nonseminomatous germ cell tumors
    • DOI 10.1016/j.canlet.2006.03.028, PII S0304383506001984
    • Christoph F, Kempkensteffen C, Weikert S, Krause H, Schostak M, Miller K, and Schrader M. Frequent epigenetic inactivation of p53 target genes in seminomatous and nonseminomatous germ cell tumors. Cancer Lett 247: 137-142, 2007. (Pubitemid 44970516)
    • (2007) Cancer Letters , vol.247 , Issue.1-2 , pp. 137-142
    • Christoph, F.1    Kempkensteffen, C.2    Weikert, S.3    Krause, H.4    Schostak, M.5    Miller, K.6    Schrader, M.7
  • 31
  • 32
    • 33747457314 scopus 로고    scopus 로고
    • Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder
    • DOI 10.1002/ijc.21971
    • Christoph F, Weikert S, Kempkensteffen C, Krause H, Schostak M, Miller K, and Schrader M. Regularly methyl-ated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder. Int J Cancer 119: 1396-1402, 2006. (Pubitemid 44258817)
    • (2006) International Journal of Cancer , vol.119 , Issue.6 , pp. 1396-1402
    • Christoph, F.1    Weikert, S.2    Kempkensteffen, C.3    Krause, H.4    Schostak, M.5    Miller, K.6    Schrader, M.7
  • 33
    • 0035936783 scopus 로고    scopus 로고
    • NF1 tumor suppressor gene function: Narrowing the GAP
    • DOI 10.1016/S0092-8674(01)00245-8
    • Cichowski K and Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell 104: 593-604, 2001. (Pubitemid 32201953)
    • (2001) Cell , vol.104 , Issue.4 , pp. 593-604
    • Cichowski, K.1    Jacks, T.2
  • 35
    • 0000189281 scopus 로고
    • Cellular differentiation in the kidneys of newborn mice studies with the electron microscope
    • Clark SL, Jr. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J Bio-phys Biochem Cytol 3: 349-362, 1957.
    • (1957) J Bio-phys Biochem Cytol , vol.3 , pp. 349-362
    • Clark Jr., S.L.1
  • 36
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • DOI 10.1038/sj.cdd.4401751, PII 4401751
    • Codogno P and Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12 Suppl 2: 1509-1518, 2005. (Pubitemid 41553987)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 37
    • 55849126198 scopus 로고    scopus 로고
    • Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
    • Coppola D, Khalil F, Eschrich SA, Boulware D, Yeatman T, and Wang HG. Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer 113: 2665-2670, 2008.
    • (2008) Cancer , vol.113 , pp. 2665-2670
    • Coppola, D.1    Khalil, F.2    Eschrich, S.A.3    Boulware, D.4    Yeatman, T.5    Wang, H.G.6
  • 38
    • 3042818799 scopus 로고    scopus 로고
    • Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
    • DOI 10.1101/gad.1199104
    • Corradetti MN, Inoki K, Bardeesy N, DePinho RA, and Guan KL. Regulation of the TSC pathway by LKB1: evi-dence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18: 1533-1538, 2004. (Pubitemid 38868905)
    • (2004) Genes and Development , vol.18 , Issue.13 , pp. 1533-1538
    • Corradetti, M.N.1    Inoki, K.2    Bardeesy, N.3    DePinho, R.A.4    Guan, K.-L.5
  • 40
    • 68449084728 scopus 로고    scopus 로고
    • DRAM: A phyloge-netically ancient regulator of autophagy
    • Criollo A, Dessen P, and Kroemer G. DRAM: a phyloge-netically ancient regulator of autophagy. Cell Cycle 8: 2319-2320, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 2319-2320
    • Criollo, A.1    Dessen, P.2    Kroemer, G.3
  • 45
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully M, You H, Levine AJ, and Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6: 184-192, 2006. (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 46
    • 77049229661 scopus 로고
    • Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
    • De Duve C, Pressman BC, Gianetto R, Wattiaux R, and Appelmans F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J 60: 604-617, 1955.
    • (1955) Biochem J , vol.60 , pp. 604-617
    • De Duve, C.1    Pressman, B.C.2    Gianetto, R.3    Wattiaux, R.4    Appelmans, F.5
  • 50
    • 34250822281 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy
    • Dice JF. Chaperone-mediated autophagy. Autophagy 3: 295-299, 2007. (Pubitemid 46986334)
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 295-299
    • Dice, J.F.1
  • 51
    • 0141920730 scopus 로고    scopus 로고
    • Rab7 prevents growth factor-independent survival by inhibiting cell-au-tonomous nutrient transporter expression
    • Edinger AL, Cinalli RM, and Thompson CB. Rab7 prevents growth factor-independent survival by inhibiting cell-au-tonomous nutrient transporter expression. Dev Cell 5: 571-582, 2003.
    • (2003) Dev Cell , vol.5 , pp. 571-582
    • Edinger, A.L.1    Cinalli, R.M.2    Thompson, C.B.3
  • 54
    • 26844531363 scopus 로고    scopus 로고
    • Maturation of autophagic vacuoles in Mammalian cells
    • Eskelinen EL. Maturation of autophagic vacuoles in Mammalian cells. Autophagy 1: 1-10, 2005.
    • (2005) Autophagy , vol.1 , pp. 1-10
    • Eskelinen, E.L.1
  • 56
    • 41149093072 scopus 로고    scopus 로고
    • Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation
    • DOI 10.1002/cncr.23323
    • Feng W, Marquez RT, Lu Z, Liu J, Lu KH, Issa JP, Fishman DM, Yu Y, and Bast RC, Jr. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozy-gosity and promoter methylation. Cancer 112: 1489-1502, 2008. (Pubitemid 351441161)
    • (2008) Cancer , vol.112 , Issue.7 , pp. 1489-1502
    • Feng, W.1    Marquez, R.T.2    Lu, Z.3    Liu, J.4    Lu, K.H.5    Issa, J.-P.J.6    Fishman, D.M.7    Yu, Y.8    Bast Jr., R.C.9
  • 57
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK β1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • DOI 10.1158/0008-5472.CAN-06-4149
    • Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, and Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 67: 3043-3053, 2007. (Pubitemid 46724841)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    De Stanchina, E.3    Teresky, A.K.4    Jin, S.5    Lowe, S.6    Levine, A.J.7
  • 60
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • DOI 10.1038/sj.onc.1207542
    • Fingar DC and Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coor-dinator of cell growth and cell cycle progression. Oncogene 23: 3151-3171, 2004. (Pubitemid 38638827)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 62
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 li-pidation for membrane biogenesis in autophagy
    • Fujita N, Itoh T, Omori H, Fukuda M, Noda T, and Yoshimori T. The Atg16L complex specifies the site of LC3 li-pidation for membrane biogenesis in autophagy. Mol Biol Cell 19: 2092-2100, 2008.
    • (2008) Mol Biol Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1    Itoh, T.2    Omori, H.3    Fukuda, M.4    Noda, T.5    Yoshimori, T.6
  • 63
    • 0030919092 scopus 로고    scopus 로고
    • Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae
    • DOI 10.1016/S0378-1119(97)00031-0, PII S0378111997000310
    • Funakoshi T, Matsuura A, Noda T, and Ohsumi Y. Ana-lyses of APG13 gene involved in autophagy in yeast, Sac-charomyces cerevisiae. Gene 192: 207-213, 1997. (Pubitemid 27268244)
    • (1997) Gene , vol.192 , Issue.2 , pp. 207-213
    • Funakoshi, T.1    Matsuura, A.2    Noda, T.3    Ohsumi, Y.4
  • 64
    • 2542628931 scopus 로고    scopus 로고
    • Ras is involved in the negative control of autophagy through the class I PI3-kinase
    • DOI 10.1038/sj.onc.1207539
    • Furuta S, Hidaka E, Ogata A, Yokota S, and Kamata T. Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 23: 3898-3904, 2004. (Pubitemid 38747918)
    • (2004) Oncogene , vol.23 , Issue.22 , pp. 3898-3904
    • Furuta, S.1    Hidaka, E.2    Ogata, A.3    Yokota, S.4    Kamata, T.5
  • 65
    • 67649460932 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in neuronal injury
    • Galluzzi L, Blomgren K, and Kroemer G. Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 10: 481-494, 2009.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 481-494
    • Galluzzi, L.1    Blomgren, K.2    Kroemer, G.3
  • 71
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, Ding X, Chen S, and Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284: 12297-12305, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam Du, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 72
    • 50249137038 scopus 로고    scopus 로고
    • Induction of macroautophagy by exogenously introduced calcium
    • Gao W, Ding WX, Stolz DB, and Yin XM. Induction of macroautophagy by exogenously introduced calcium. Au-tophagy 4: 754-761, 2008.
    • (2008) Autophagy , vol.4 , pp. 754-761
    • Gao, W.1    Ding, W.X.2    Stolz, D.B.3    Yin, X.M.4
  • 74
    • 0032148385 scopus 로고    scopus 로고
    • The human p19(ARF) protein encoded by the β transcript of the p16(INK4a) gene is frequently lost in small cell lung cancer
    • Gazzeri S, Della Valle V, Chaussade L, Brambilla C, Larsen CJ, and Brambilla E. The human p19ARF protein encoded by the beta transcript of the p16INK4a gene is frequently lost in small cell lung cancer. Cancer Res 58: 3926-3931, 1998. (Pubitemid 28405650)
    • (1998) Cancer Research , vol.58 , Issue.17 , pp. 3926-3931
    • Gazzeri, S.1    Della Valle, V.2    Chaussade, L.3    Brambilla, C.4    Larsen, C.-J.5    Brambilla, E.6
  • 76
    • 51049118332 scopus 로고    scopus 로고
    • The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. "protein modifi-cations: Beyond the usual suspects" review series
    • Geng J and Klionsky DJ. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. "Protein modifi-cations: beyond the usual suspects" review series. EMBO Rep 9: 859-864, 2008.
    • (2008) EMBO Rep , vol.9 , pp. 859-864
    • Geng, J.1    Klionsky, D.J.2
  • 77
    • 70350004886 scopus 로고    scopus 로고
    • Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted thera-peutics
    • Gillings AS, Balmanno K, Wiggins CM, Johnson M, and Cook SJ. Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted thera-peutics. FEBS J 276: 6050-6062, 2009.
    • (2009) FEBS J , vol.276 , pp. 6050-6062
    • Gillings, A.S.1    Balmanno, K.2    Wiggins, C.M.3    Johnson, M.4    Cook, S.J.5
  • 80
    • 0024299286 scopus 로고
    • Prelysosomal convergence of autophagic and endocytic pathways
    • Gordon PB and Seglen PO. Prelysosomal convergence of autophagic and endocytic pathways. Biochem Biophys Res Commun 151: 40-47, 1988.
    • (1988) Biochem Biophys Res Commun , vol.151 , pp. 40-47
    • Gordon, P.B.1    Seglen, P.O.2
  • 81
    • 75849117800 scopus 로고    scopus 로고
    • Inflammation and oncogen-esis: A vicious connection
    • Grivennikov SI and Karin M. Inflammation and oncogen-esis: a vicious connection. Curr Opin Genet Dev 20: 65-71, 2010.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 65-71
    • Grivennikov, S.I.1    Karin, M.2
  • 85
    • 33745088813 scopus 로고    scopus 로고
    • Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy
    • Hanada T and Ohsumi Y. Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy 1: 110-118, 2005.
    • (2005) Autophagy , vol.1 , pp. 110-118
    • Hanada, T.1    Ohsumi, Y.2
  • 87
    • 43949145220 scopus 로고    scopus 로고
    • DAPK-1 binding to a linear pep-tide motif in MAP1B stimulates autophagy and membrane blebbing
    • Harrison B, Kraus M, Burch L, Stevens C, Craig A, Gordon-Weeks P, and Hupp TR. DAPK-1 binding to a linear pep-tide motif in MAP1B stimulates autophagy and membrane blebbing. J Biol Chem 283: 9999-10014, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 9999-10014
    • Harrison, B.1    Kraus, M.2    Burch, L.3    Stevens, C.4    Craig, A.5    Gordon-Weeks, P.6    Hupp, T.R.7
  • 92
    • 34250891313 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A universal regulator of autophagy?
    • Hoyer-Hansen M and Jaattela M. AMP-activated protein kinase: a universal regulator of autophagy? Autophagy 3: 381-383, 2007. (Pubitemid 46986350)
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 381-383
    • Hoyer-Hansen, M.1    Jaattela, M.2
  • 93
    • 48249156591 scopus 로고    scopus 로고
    • Autophagy: An emerging target for cancer therapy
    • Hoyer-Hansen M and Jaattela M. Autophagy: an emerging target for cancer therapy. Autophagy 4: 574-580, 2008.
    • (2008) Autophagy , vol.4 , pp. 574-580
    • Hoyer-Hansen, M.1    Jaattela, M.2
  • 94
    • 0346362997 scopus 로고    scopus 로고
    • Rapamycins: Mechanism of action and cellular resistance
    • Huang S, Bjornsti MA, and Houghton PJ. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2: 222-232, 2003.
    • (2003) Cancer Biol Ther , vol.2 , pp. 222-232
    • Huang, S.1    Bjornsti, M.A.2    Houghton, P.J.3
  • 95
    • 0037005133 scopus 로고    scopus 로고
    • Autophagy in yeast: A review of the molecular machinery
    • DOI 10.1247/csf.27.409
    • Huang WP and Klionsky DJ. Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct 27: 409-420, 2002. (Pubitemid 36267710)
    • (2002) Cell Structure and Function , vol.27 , Issue.6 , pp. 409-420
    • Huang, W.-P.1    Klionsky, D.J.2
  • 96
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki K, Li Y, Xu T, and Guan KL. RHEB GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17: 1829-1834, 2003. (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 97
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • DOI 10.1038/ncb839
    • Inoki K, Li Y, Zhu T, Wu J, and Guan KL. TSC2 is phos-phorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657, 2002. (Pubitemid 34993700)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 101
    • 33845193134 scopus 로고    scopus 로고
    • The Bad guy cooperates with good Cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis
    • DOI 10.1128/MCB.01025-06
    • Jiang P, Du W, Heese K, Wu M. The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol Cell Biol 26: 9071-9082, 2006. (Pubitemid 44851962)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.23 , pp. 9071-9082
    • Jiang, P.1    Du, W.2    Heese, K.3    Wu, M.4
  • 102
    • 33645905712 scopus 로고    scopus 로고
    • Autophagy, mitochondrial quality control, and on-cogenesis
    • Jin S. Autophagy, mitochondrial quality control, and on-cogenesis. Autophagy 2: 80-84, 2006.
    • (2006) Autophagy , vol.2 , pp. 80-84
    • Jin, S.1
  • 105
    • 33749242421 scopus 로고    scopus 로고
    • Nutrient control of macroautophagy in mammalian cells
    • DOI 10.1016/j.mam.2006.08.010, PII S0098299706000185
    • Kadowaki M, Karim MR, Carpi A, and Miotto G. Nutrient control of macroautophagy in mammalian cells. Mol As-pects Med 27: 426-443, 2006. (Pubitemid 44479873)
    • (2006) Molecular Aspects of Medicine , vol.27 , Issue.5-6 , pp. 426-443
    • Kadowaki, M.1    Razaul Karim, Md.2    Carpi, A.3    Miotto, G.4
  • 107
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
    • Kang MH and Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 15: 1126-1132, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 1126-1132
    • Kang, M.H.1    Reynolds, C.P.2
  • 110
    • 33947401472 scopus 로고    scopus 로고
    • Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells
    • Kawai A, Uchiyama H, Takano S, Nakamura N, and Ohkuma S. Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells. Autophagy 3: 154-157, 2007. (Pubitemid 46449110)
    • (2007) Autophagy , vol.3 , Issue.2 , pp. 154-157
    • Kawai, A.1    Uchiyama, H.2    Takano, S.3    Nakamura, N.4    Ohkuma, S.5
  • 112
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, and Sabatini DM. mTOR interacts with RAPTOR to form a nutrient-sensitive com-plex that signals to the cell growth machinery. Cell 110: 163-175, 2002. (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 113
    • 45049083880 scopus 로고    scopus 로고
    • Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
    • Kim MS, Jeong EG, Ahn CH, Kim SS, Lee SH, and Yoo NJ. Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum Pathol 39: 1059-1063, 2008.
    • (2008) Hum Pathol , vol.39 , pp. 1059-1063
    • Kim, M.S.1    Jeong, E.G.2    Ahn, C.H.3    Kim, S.S.4    Lee, S.H.5    Yoo, N.J.6
  • 114
    • 0034676037 scopus 로고    scopus 로고
    • The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cyto-plasm to vacuole targeting pathway
    • Kirisako T, Ichimura Y, Okada H, Kabeya Y, Mizushima N, Yoshimori T, Ohsumi M, Takao T, Noda T, and Ohsumi Y. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cyto-plasm to vacuole targeting pathway. J Cell Biol 151: 263-276, 2000.
    • (2000) J Cell Biol , vol.151 , pp. 263-276
    • Kirisako, T.1    Ichimura, Y.2    Okada, H.3    Kabeya, Y.4    Mizushima, N.5    Yoshimori, T.6    Ohsumi, M.7    Takao, T.8    Noda, T.9    Ohsumi, Y.10
  • 116
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • DOI 10.1038/nrm2245, PII NRM2245
    • Klionsky DJ. Autophagy: from phenomenology to molec-ular understanding in less than a decade. Nat Rev Mol Cell Biol 8: 931-937, 2007. (Pubitemid 47622558)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.11 , pp. 931-937
    • Klionsky, D.J.1
  • 117
    • 33745201600 scopus 로고    scopus 로고
    • Neurodegeneration: Good riddance to bad rubbish
    • Klionsky DJ. Neurodegeneration: good riddance to bad rubbish. Nature 441: 819-820, 2006.
    • (2006) Nature , vol.441 , pp. 819-820
    • Klionsky, D.J.1
  • 120
    • 33645120442 scopus 로고    scopus 로고
    • Microtubules facilitate autophagosome formation and fusion of autop-hagosomes with endosomes
    • Kochl R, Hu XW, Chan EY, and Tooze SA. Microtubules facilitate autophagosome formation and fusion of autop-hagosomes with endosomes. Traffic 7: 129-145, 2006.
    • (2006) Traffic , vol.7 , pp. 129-145
    • Kochl, R.1    Hu, X.W.2    Chan, E.Y.3    Tooze, S.A.4
  • 123
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • DOI 10.1152/physrev.00013.2006
    • Kroemer G, Galluzzi L, and Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 87: 99-163, 2007. (Pubitemid 46209992)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 125
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer G and Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 9: 1004-1010, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 126
    • 44449147036 scopus 로고    scopus 로고
    • Tumor Cell Metabolism: Cancer's Achilles' Heel
    • DOI 10.1016/j.ccr.2008.05.005, PII S1535610808001608
    • Kroemer G and Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13: 472-482, 2008. (Pubitemid 351766797)
    • (2008) Cancer Cell , vol.13 , Issue.6 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 127
    • 33645921920 scopus 로고    scopus 로고
    • Autophagy: An ER protein quality control process
    • Kruse KB, Brodsky JL, and McCracken AA. Autophagy: an ER protein quality control process. Autophagy 2: 135-137, 2006.
    • (2006) Autophagy , vol.2 , pp. 135-137
    • Kruse, K.B.1    Brodsky, J.L.2    McCracken, A.A.3
  • 129
    • 0031695202 scopus 로고    scopus 로고
    • Selective deletion of exon 1β of the p19(ARF) gene in metastatic melanoma cell lines
    • DOI 10.1002/(SICI)1098-2264(199811) 23:3<273::AID-GCC11>3.0.CO;2-N
    • Kumar R, Sauroja I, Punnonen K, Jansen C, and Hemminki K. Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines. Genes Chromosomes Cancer 23: 273-277, 1998. (Pubitemid 28465646)
    • (1998) Genes Chromosomes and Cancer , vol.23 , Issue.3 , pp. 273-277
    • Kumar, R.1    Sauroja, I.2    Punnonen, K.3    Jansen, C.4    Hemminki, K.5
  • 130
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • Kundu JK and Surh YJ. Inflammation: gearing the journey to cancer. Mutat Res 659: 15-30, 2008.
    • (2008) Mutat Res , vol.659 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 131
    • 33745962416 scopus 로고    scopus 로고
    • BH3-only proteins in cell death initiation, malignant disease and anticancer therapy
    • DOI 10.1038/sj.cdd.4401940, PII 4401940
    • Labi V, Erlacher M, Kiessling S, and Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 13: 1325-1338, 2006. (Pubitemid 44057468)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1325-1338
    • Labi, V.1    Erlacher, M.2    Kiessling, S.3    Villunger, A.4
  • 132
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mito-phagy, as a targeted defense against oxidative stress, mi-tochondrial dysfunction, and aging
    • Lemasters JJ. Selective mitochondrial autophagy, or mito-phagy, as a targeted defense against oxidative stress, mi-tochondrial dysfunction, and aging. Rejuvenation Res 8: 3-5, 2005.
    • (2005) Rejuvenation Res , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 133
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: Autophagy and cancer
    • DOI 10.1038/446745a, PII 446745A
    • Levine B. Cell biology: autophagy and cancer. Nature 446: 745-747, 2007. (Pubitemid 46582063)
    • (2007) Nature , vol.446 , Issue.7137 , pp. 745-747
    • Levine, B.1
  • 134
    • 12944308330 scopus 로고    scopus 로고
    • Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense
    • DOI 10.1016/j.cell.2005.01.005, PII S0092867405000437
    • Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120: 159-162, 2005. (Pubitemid 40174758)
    • (2005) Cell , vol.120 , Issue.2 , pp. 159-162
    • Levine, B.1
  • 135
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • DOI 10.1016/S1534-5807(04)00099-1, PII S1534580704000991
    • Levine B and Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autop-hagy. Dev Cell 6: 463-477, 2004. (Pubitemid 38456176)
    • (2004) Developmental Cell , vol.6 , Issue.4 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 136
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B and Kroemer G. Autophagy in the pathogenesis of disease. Cell 132: 27-42, 2008.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 137
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, and Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 8: 688-699, 2006.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 140
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, and Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676, 1999. (Pubitemid 129516338)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5    Hibshoosh, H.6    Levine, B.7
  • 142
    • 85025346963 scopus 로고
    • The ultrastructure of the oenocytes in the molt/intermolt cycle of an insect
    • Locke M. The ultrastructure of the oenocytes in the molt/intermolt cycle of an insect. Tissue Cell 1: 103-154, 1969.
    • (1969) Tissue Cell , vol.1 , pp. 103-154
    • Locke, M.1
  • 143
    • 0016665507 scopus 로고
    • The role of the Golgi complex in the isolation and digestion of organelles
    • Locke M and Sykes AK. The role of the Golgi complex in the isolation and digestion of organelles. Tissue Cell 7: 143-158, 1975.
    • (1975) Tissue Cell , vol.7 , pp. 143-158
    • Locke, M.1    Sykes, A.K.2
  • 146
    • 68249106060 scopus 로고    scopus 로고
    • BH3-only proteins in apoptosis and beyond: An overview
    • Lomonosova E and Chinnadurai G. BH3-only proteins in apoptosis and beyond: an overview. Oncogene 27 Suppl 1: S2-S19, 2008.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Lomonosova, E.1    Chinnadurai, G.2
  • 148
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • DOI 10.1016/j.cell.2004.11.046, PII S009286740401150X
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, and Thompson CB. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248, 2005. (Pubitemid 40174766)
    • (2005) Cell , vol.120 , Issue.2 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 149
    • 66049149464 scopus 로고    scopus 로고
    • Mitochondria: One of the origins for autophagosomal membranes?
    • Luo S, Chen Q, Cebollero E, and Xing D. Mitochondria: one of the origins for autophagosomal membranes? Mitochon-drion 9: 227-231, 2009.
    • (2009) Mitochondrion , vol.9 , pp. 227-231
    • Luo, S.1    Chen, Q.2    Cebollero, E.3    Xing, D.4
  • 151
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
    • DOI 10.1016/j.cell.2005.02.031
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, and Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121: 179-193, 2005. (Pubitemid 40546387)
    • (2005) Cell , vol.121 , Issue.2 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 152
    • 70349612498 scopus 로고    scopus 로고
    • Autophagy for the avoidance of neurodegeneration
    • Madeo F, Eisenberg T, and Kroemer G. Autophagy for the avoidance of neurodegeneration. Genes Dev 23: 2253-2259, 2009.
    • (2009) Genes Dev , vol.23 , pp. 2253-2259
    • Madeo, F.1    Eisenberg, T.2    Kroemer, G.3
  • 157
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • DOI 10.1038/nrm2239, PII NRM2239
    • Maiuri MC, Zalckvar E, Kimchi A, and Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752, 2007. (Pubitemid 47312826)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 158
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navi-gating downstream
    • Manning BD and Cantley LC. AKT/PKB signaling: navi-gating downstream. Cell 129: 1261-1274, 2007.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 160
    • 34547132328 scopus 로고    scopus 로고
    • Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3
    • DOI 10.1074/jbc.M701194200
    • Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mi-zushima N, and Lopez-Otin C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 282: 18573-18583, 2007. (Pubitemid 47100226)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18573-18583
    • Marino, G.1    Salvador-Montoliu, N.2    Fueyo, A.3    Knecht, E.4    Mizushima, N.5    Lopez-Otin, C.6
  • 161
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 21: 361-370, 2000. (Pubitemid 30137921)
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 361-370
    • Marnett, L.J.1
  • 162
    • 14844337826 scopus 로고    scopus 로고
    • ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
    • DOI 10.1038/sj.onc.1208256
    • Martoriati A, Doumont G, Alcalay M, Bellefroid E, Pelicci PG, and Marine JC. dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a tran-scription target of p53. Oncogene 24: 1461-1466, 2005. (Pubitemid 40343126)
    • (2005) Oncogene , vol.24 , Issue.8 , pp. 1461-1466
    • Martoriati, A.1    Doumont, G.2    Alcalay, M.3    Bellefroid, E.4    Pelicci, P.G.5    Marine, J.-C.6
  • 167
    • 77951228508 scopus 로고    scopus 로고
    • Hypoxia-induced autop-hagy: Cell death or cell survival?
    • Mazure NM and Pouyssegur J. Hypoxia-induced autop-hagy: cell death or cell survival? Curr Opin Cell Biol 22:177-180, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 177-180
    • Mazure, N.M.1    Pouyssegur, J.2
  • 168
    • 34547669249 scopus 로고    scopus 로고
    • The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain
    • Mellert H, Sykes SM, Murphy ME, and McMahon SB. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle 6: 1304-1306, 2007. (Pubitemid 47327961)
    • (2007) Cell Cycle , vol.6 , Issue.11 , pp. 1304-1306
    • Mellert, H.1    Sykes, S.M.2    Murphy, M.E.3    McMahon, S.B.4
  • 169
    • 67549110195 scopus 로고    scopus 로고
    • A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
    • Mercer CA, Kaliappan A, and Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 5: 649-662, 2009.
    • (2009) Autophagy , vol.5 , pp. 649-662
    • Mercer, C.A.1    Kaliappan, A.2    Dennis, P.B.3
  • 174
    • 0032545292 scopus 로고    scopus 로고
    • A new protein conjugation system in human: The counterpart of the yeast Apg12p conjugation system essential for autophagy
    • DOI 10.1074/jbc.273.51.33889
    • Mizushima N, Sugita H, Yoshimori T, and Ohsumi Y. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for au-tophagy. J Biol Chem 273: 33889-33892, 1998. (Pubitemid 29008848)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 33889-33892
    • Mizushima, N.1    Sugita, H.2    Yoshimori, T.3    Ohsumi, Y.4
  • 178
    • 46749085091 scopus 로고    scopus 로고
    • Mechanisms of p53-mediated mitochondrial membrane permeabilization
    • DOI 10.1038/cr.2008.77, PII CR200877
    • Morselli E, Galluzzi L, and Kroemer G. Mechanisms of p53-mediated mitochondrial membrane permeabilization. Cell Res 18: 708-710, 2008. (Pubitemid 351948232)
    • (2008) Cell Research , vol.18 , Issue.7 , pp. 708-710
    • Morselli, E.1    Galluzzi, L.2    Kroemer, G.3
  • 182
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • DOI 10.1016/S1097-2765(01)00214-3
    • Nakano K and Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694, 2001. (Pubitemid 32706359)
    • (2001) Molecular Cell , vol.7 , Issue.3 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 183
    • 34447099450 scopus 로고    scopus 로고
    • Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion
    • DOI 10.1016/j.cell.2007.05.021, PII S0092867407006587
    • Nakatogawa H, Ichimura Y, and Ohsumi Y. Atg8, a ubiquitin-like protein required for autophagosome forma-tion, mediates membrane tethering and hemifusion. Cell 130: 165-178, 2007. (Pubitemid 47031316)
    • (2007) Cell , vol.130 , Issue.1 , pp. 165-178
    • Nakatogawa, H.1    Ichimura, Y.2    Ohsumi, Y.3
  • 184
    • 0036253107 scopus 로고    scopus 로고
    • SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation
    • DOI 10.1247/csf.27.29
    • Nara A, Mizushima N, Yamamoto A, Kabeya Y, Ohsumi Y, and Yoshimori T. SKD1 AAA ATPase-dependent en-dosomal transport is involved in autolysosome formation. Cell Struct Funct 27: 29-37, 2002. (Pubitemid 34498352)
    • (2002) Cell Structure and Function , vol.27 , Issue.1 , pp. 29-37
    • Nara, A.1    Mizushima, N.2    Yamamoto, A.3    Kabeya, Y.4    Ohsumi, Y.5    Yoshimori, T.6
  • 185
    • 33847743064 scopus 로고    scopus 로고
    • Hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling
    • DOI 10.1016/j.ceb.2007.02.019, PII S0955067407000312
    • Nobukuni T, Kozma SC, and Thomas G. hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol 19: 135-141, 2007. (Pubitemid 46386413)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.2 , pp. 135-141
    • Nobukuni, T.1    Kozma, S.C.2    Thomas, G.3
  • 186
    • 1642559773 scopus 로고
    • The proximal tubule cell in experimental hydronephrosis
    • Novikoff AB. The proximal tubule cell in experimental hydronephrosis. J Biophys Biochem Cytol 6: 136-138, 1959.
    • (1959) J Biophys Biochem Cytol , vol.6 , pp. 136-138
    • Novikoff, A.B.1
  • 189
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitin-like systems
    • DOI 10.1038/35056522
    • Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2: 211-216, 2001. (Pubitemid 33675746)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.3 , pp. 211-216
    • Ohsumi, Y.1
  • 190
    • 77951234553 scopus 로고    scopus 로고
    • Membrane trafficking events that partake in autophagy
    • Orsi A, Polson HE, and Tooze SA. Membrane trafficking events that partake in autophagy. Curr Opin Cell Biol 22: 150-156, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 150-156
    • Orsi, A.1    Polson, H.E.2    Tooze, S.A.3
  • 191
    • 52149101812 scopus 로고    scopus 로고
    • Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
    • Papandreou I, Lim AL, Laderoute K, and Denko NC Hy-poxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ 15: 1572-1581, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 1572-1581
    • Papandreou, I.1    Lim, A.L.2    Laderoute, K.3    Denko, N.C.4
  • 193
    • 0038269032 scopus 로고    scopus 로고
    • Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
    • DOI 10.1074/jbc.M210998200
    • Pattingre S, Bauvy C, and Codogno P. Amino acids inter-fere with the ERK1/2-dependent control of macro-autophagy by controlling the activation of Raf-1 in human colon cancer HT-29cells. J Biol Chem 278: 16667-16674, 2003. (Pubitemid 36799530)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.19 , pp. 16667-16674
    • Pattingre, S.1    Bauvy, C.2    Codogno, P.3
  • 194
    • 38749136302 scopus 로고    scopus 로고
    • Regulation of macroautophagy by mTOR and Beclin 1 complexes
    • DOI 10.1016/j.biochi.2007.08.014, PII S0300908407002283
    • Pattingre S, Espert L, Biard-Piechaczyk M, and Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90: 313-323, 2008. (Pubitemid 351181247)
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 313-323
    • Pattingre, S.1    Espert, L.2    Biard-Piechaczyk, M.3    Codogno, P.4
  • 195
  • 196
    • 34249945104 scopus 로고    scopus 로고
    • The cancer cell's "power plants" as promising therapeutic targets: An overview
    • DOI 10.1007/s10863-007-9070-5, The Cancer Cell's Power Plants as Promising Therapeutic Targets
    • Pedersen PL. The cancer cell's "power plants" as promising therapeutic targets: an overview. J Bioenerg Biomembr 39: 1-12, 2007. (Pubitemid 46877182)
    • (2007) Journal of Bioenergetics and Biomembranes , vol.39 , Issue.1 , pp. 1-12
    • Pedersen, P.L.1
  • 197
    • 57549101230 scopus 로고    scopus 로고
    • Small-molecule inhibitors of PDK1
    • Peifer C and Alessi DR. Small-molecule inhibitors of PDK1. Chem Med Chem 3: 1810-1838, 2008.
    • (2008) Chem Med Chem , vol.3 , pp. 1810-1838
    • Peifer, C.1    Alessi, D.R.2
  • 198
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pa7thways that control macroautophagy in HT-29 cells
    • DOI 10.1074/jbc.275.2.992
    • Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, and Codogno P. Distinct classes of phosphatidylinositol 3'-ki-nases are involved in signaling pathways that control macroautophagy in HT-29cells. J Biol Chem 275: 992-998, 2000. (Pubitemid 30051145)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.2 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.C.3    Meijer, A.J.4    Codogno, P.5
  • 199
    • 44649094568 scopus 로고    scopus 로고
    • P53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: The role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter
    • DOI 10.1515/BC.2008.039
    • Pietrzak M and Puzianowska-Kuznicka M. p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter. Biol Chem 389: 383-393, 2008. (Pubitemid 351773909)
    • (2008) Biological Chemistry , vol.389 , Issue.4 , pp. 383-393
    • Pietrzak, M.1    Puzianowska-Kuznicka, M.2
  • 201
    • 65249097276 scopus 로고    scopus 로고
    • ARF, autophagy and tumor suppression
    • Pimkina J and Murphy ME. ARF, autophagy and tumor suppression. Autophagy 5: 397-399, 2009.
    • (2009) Autophagy , vol.5 , pp. 397-399
    • Pimkina, J.1    Murphy, M.E.2
  • 203
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
    • DOI 10.1016/j.cell.2006.12.044, PII S009286740700178X
    • Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, and Levine B. Autophagy gene-dependent clearance of apoptotic cells during embryonic develop-ment. Cell 128: 931-946, 2007. (Pubitemid 46341412)
    • (2007) Cell , vol.128 , Issue.5 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3    Luby-Phelps, K.4    Cheng, P.5    Hogan, R.N.6    Gilpin, C.7    Levine, B.8
  • 204
    • 39849107888 scopus 로고    scopus 로고
    • BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells
    • DOI 10.1038/sj.onc.1210783, PII 1210783
    • Rashmi R, Pillai SG, Vijayalingam S, Ryerse J, and Chin-nadurai G. BH3-only protein BIK induces caspase-inde-pendent cell death with autophagic features in Bcl-2 null cells. Oncogene 27: 1366-1375, 2008. (Pubitemid 351317469)
    • (2008) Oncogene , vol.27 , Issue.10 , pp. 1366-1375
    • Rashmi, R.1    Pillai, S.G.2    Vijayalingam, S.3    Ryerse, J.4    Chinnadurai, G.5
  • 205
    • 0035141040 scopus 로고    scopus 로고
    • ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
    • DOI 10.1038/35050500
    • Raveh T, Droguett G, Horwitz MS, DePinho RA, and Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transforma-tion. Nat Cell Biol 3: 1-7, 2001. (Pubitemid 32114825)
    • (2001) Nature Cell Biology , vol.3 , Issue.1 , pp. 1-7
    • Raveh, T.1    Droguett, G.2    Horwitz, M.S.3    DePinho, R.A.4    Kimchi, A.5
  • 207
    • 33646523798 scopus 로고    scopus 로고
    • A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
    • Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, and Kimchi A. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 22: 463-475, 2006.
    • (2006) Mol Cell , vol.22 , pp. 463-475
    • Reef, S.1    Zalckvar, E.2    Shifman, O.3    Bialik, S.4    Sabanay, H.5    Oren, M.6    Kimchi, A.7
  • 210
    • 43949112966 scopus 로고    scopus 로고
    • LAMP-2: A control step fot phagosome and autophagosome maturation
    • Saftig P, Beertsen W, and Eskelinen EL. LAMP-2: a control step for phagosome and autophagosome maturation. Au-tophagy 4: 510-512, 2008. (Pubitemid 351705148)
    • (2008) Autophagy , vol.4 , Issue.4 , pp. 510-512
    • Saftig, P.1    Beertsen, W.2    Eskelinen, E.-L.3
  • 211
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • DOI 10.1097/01.cco.0000198021.99347.b9, PII 0000162220060100000013
    • Samuels Y and Ericson K. Oncogenic PI3K and its role in cancer. Curr Opin Oncol 18: 77-82, 2006. (Pubitemid 43740454)
    • (2006) Current Opinion in Oncology , vol.18 , Issue.1 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 213
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov DD, Guertin DA, Ali SM, and Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 214
    • 55849109650 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma
    • Schneider A, Younis RH, and Gutkind JS. Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 10: 1295-1302, 2008.
    • (2008) Neoplasia , vol.10 , pp. 1295-1302
    • Schneider, A.1    Younis, R.H.2    Gutkind, J.S.3
  • 215
    • 0027528817 scopus 로고
    • NF1: A prevalent cause of tumorigenesis in human cancers?
    • DOI 10.1038/ng0293-97
    • Seizinger BR. NF1: a prevalent cause of tumorigenesis in human cancers? Nat Genet 3: 97-99, 1993. (Pubitemid 23079787)
    • (1993) Nature Genetics , vol.3 , Issue.2 , pp. 97-99
    • Seizinger, B.R.1
  • 217
    • 58149084586 scopus 로고    scopus 로고
    • Decreased expression of autophagy-related proteins in malignant ep-ithelial ovarian cancer
    • Shen Y, Li DD, Wang LL, Deng R, and Zhu XF. Decreased expression of autophagy-related proteins in malignant ep-ithelial ovarian cancer. Autophagy 4: 1067-1068, 2008.
    • (2008) Autophagy , vol.4 , pp. 1067-1068
    • Shen, Y.1    Li, D.D.2    Wang, L.L.3    Deng, R.4    Zhu, X.F.5
  • 218
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • DOI 10.1126/science.1099993
    • Shintani T and Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 306: 990-995, 2004. (Pubitemid 39482894)
    • (2004) Science , vol.306 , Issue.5698 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 219
    • 0033214582 scopus 로고    scopus 로고
    • Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast
    • DOI 10.1093/emboj/18.19.5234
    • Shintani T, Mizushima N, Ogawa Y, Matsuura A, Noda T, and Ohsumi Y. Apg10p, a novel protein-conjugating en-zyme essential for autophagy in yeast. Embo J 18: 5234-5241, 1999. (Pubitemid 29465574)
    • (1999) EMBO Journal , vol.18 , Issue.19 , pp. 5234-5241
    • Shintani, T.1    Mizushima, N.2    Ogawa, Y.3    Matsuura, A.4    Noda, T.5    Ohsumi, Y.6
  • 221
    • 34047216406 scopus 로고    scopus 로고
    • P53 alterations in human cancer: More questions than answers
    • DOI 10.1038/sj.onc.1210280, PII 1210280
    • Soussi T. p53 alterations in human cancer: more questions than answers. Oncogene 26: 2145-2156, 2007. (Pubitemid 46536642)
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2145-2156
    • Soussi, T.1
  • 223
    • 0035890849 scopus 로고    scopus 로고
    • A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53
    • Sugars KL, Budhram-Mahadeo V, Packham G, and Latch-man DS. A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53. Nucleic Acids Res 29: 4530-4540,2001. (Pubitemid 33095013)
    • (2001) Nucleic Acids Research , vol.29 , Issue.22 , pp. 4530-4540
    • Sugars, K.L.1    Budhram-Mahadeo, V.2    Packham, G.3    Latchman, D.S.4
  • 225
    • 38049031797 scopus 로고    scopus 로고
    • BARgaining membranes for autophagosome formation: Regulation of autophagy and tumorigenesis by Bif-1/Endophilin B1
    • Takahashi Y, Meyerkord CL, and Wang HG. BARgaining membranes for autophagosome formation: regulation of autophagy and tumorigenesis by Bif-1/Endophilin B1. Autophagy 4: 121-124, 2008.
    • (2008) Autophagy , vol.4 , pp. 121-124
    • Takahashi, Y.1    Meyerkord, C.L.2    Wang, H.G.3
  • 226
    • 0026668042 scopus 로고
    • Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
    • Takeshige K, Baba M, Tsuboi S, Noda T, and Ohsumi Y. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol 119: 301-311, 1992.
    • (1992) J Cell Biol , vol.119 , pp. 301-311
    • Takeshige, K.1    Baba, M.2    Tsuboi, S.3    Noda, T.4    Ohsumi, Y.5
  • 227
    • 0037134443 scopus 로고    scopus 로고
    • Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p
    • DOI 10.1074/jbc.M200385200
    • Tanida I, Tanida-Miyake E, Komatsu M, Ueno T, and Ko-minami E. Human Apg3p/Aut1p homologue is an au-thentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem 277: 13739-13744, 2002. (Pubitemid 34967976)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.16 , pp. 13739-13744
    • Tanida, I.1    Tanida-Miyake, E.2    Komatsu, M.3    Ueno, T.4    Kominami, E.5
  • 234
    • 0027936092 scopus 로고
    • Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
    • DOI 10.1016/0014-5793(94)00672-5
    • Thumm M, Egner R, Koch B, Schlumpberger M, Straub M, Veenhuis M, and Wolf DH. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett 349: 275-280, 1994. (Pubitemid 24263277)
    • (1994) FEBS Letters , vol.349 , Issue.2 , pp. 275-280
    • Thumm, M.1
  • 235
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
    • DOI 10.1016/0014-5793(93)80398-E
    • Tsukada M and Ohsumi Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333: 169-174, 1993. (Pubitemid 23306962)
    • (1993) FEBS Letters , vol.333 , Issue.1-2 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 238
    • 65249108735 scopus 로고    scopus 로고
    • Autophagy genes in immunity
    • Virgin HW and Levine B. Autophagy genes in immunity. Nat Immunol 10: 461-470, 2009.
    • (2009) Nat Immunol , vol.10 , pp. 461-470
    • Virgin, H.W.1    Levine, B.2
  • 240
    • 0037033030 scopus 로고    scopus 로고
    • The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways
    • DOI 10.1074/jbc.M208191200
    • Wang CW, Stromhaug PE, Shima J, and Klionsky DJ. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem 277: 47917-47927, 2002. (Pubitemid 36159320)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.49 , pp. 47917-47927
    • Wang, C.-W.1    Stromhaug, P.E.2    Shima, J.3    Klionsky, D.J.4
  • 241
    • 69249153394 scopus 로고    scopus 로고
    • A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1
    • Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D, and Denmark T. A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem 284: 21412-21424, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 21412-21424
    • Wang, J.1    Whiteman, M.W.2    Lian, H.3    Wang, G.4    Singh, A.5    Huang, D.6    Denmark, T.7
  • 242
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 123: 309-314, 1956.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 244
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
    • DOI 10.1016/j.molcel.2008.06.001, PII S1097276508003894
    • Wei Y, Pattingre S, Sinha S, Bassik M, and Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30: 678-688, 2008. (Pubitemid 351818252)
    • (2008) Molecular Cell , vol.30 , Issue.6 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 245
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of au-tophagy modulation in cancer
    • White E and DiPaola RS. The double-edged sword of au-tophagy modulation in cancer. Clin Cancer Res 15: 5308-5316, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    Dipaola, R.S.2
  • 246
    • 27544446991 scopus 로고    scopus 로고
    • Life in the balance: How BH3-only proteins induce apoptosis
    • DOI 10.1016/j.ceb.2005.10.001, PII S095506740500150X
    • Willis SN and Adams JM. Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617-625, 2005. (Pubitemid 41540411)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.6 , pp. 617-625
    • Willis, S.N.1    Adams, J.M.2
  • 249
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z and Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 9: 1102-1109, 2007. (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 250
    • 53549090139 scopus 로고    scopus 로고
    • Dissecting autophago-some formation: The missing pieces
    • Xie Z, Nair U, and Klionsky DJ. Dissecting autophago-some formation: the missing pieces. Autophagy 4: 920-922, 2008.
    • (2008) Autophagy , vol.4 , pp. 920-922
    • Xie, Z.1    Nair, U.2    Klionsky, D.J.3
  • 251
    • 0025217177 scopus 로고
    • Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry
    • Yamamoto A, Masaki R, and Tashiro Y. Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemis-try. J Histochem Cytochem 38: 573-580, 1990. (Pubitemid 20106508)
    • (1990) Journal of Histochemistry and Cytochemistry , vol.38 , Issue.4 , pp. 573-580
    • Yamamoto, A.1    Masaki, R.2    Tashiro, Y.3
  • 252
    • 34247133465 scopus 로고    scopus 로고
    • Regulation of class III (Vps34) PI3Ks
    • DOI 10.1042/BST0350239
    • Yan Y and Backer JM. Regulation of class III (Vps34) PI3Ks. Biochem Soc Trans 35: 239-241, 2007. (Pubitemid 46596478)
    • (2007) Biochemical Society Transactions , vol.35 , Issue.2 , pp. 239-241
    • Yan, Y.1    Backer, J.M.2
  • 253
    • 74949090299 scopus 로고    scopus 로고
    • An overview of the molecular mechanism of autophagy
    • Yang Z and Klionsky DJ. An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 335: 1-32, 2009.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 1-32
    • Yang, Z.1    Klionsky, D.J.2
  • 254
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z and Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 256
    • 71649112895 scopus 로고    scopus 로고
    • 3D tomography reveals connections between the phago-phore and endoplasmic reticulum
    • Yla-Anttila P, Vihinen H, Jokitalo E, and Eskelinen EL. 3D tomography reveals connections between the phago-phore and endoplasmic reticulum. Autophagy 5: 1180-1185, 2009.
    • (2009) Autophagy , vol.5 , pp. 1180-1185
    • Yla-Anttila, P.1    Vihinen, H.2    Jokitalo, E.3    Eskelinen, E.L.4
  • 257
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: Molecular ma-chinery for self-eating
    • Yorimitsu T and Klionsky DJ. Autophagy: molecular ma-chinery for self-eating. Cell Death Differ 12 Suppl 2: 1542-1552, 2005.
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 259
    • 67650270918 scopus 로고    scopus 로고
    • Phos-phorylation of Beclin 1 by DAP-kinase promotes autop-hagy by weakening its interactions with Bcl-2 and Bcl-XL
    • Zalckvar E, Berissi H, Eisenstein M, and Kimchi A. Phos-phorylation of Beclin 1 by DAP-kinase promotes autop-hagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy 5: 720-722, 2009.
    • (2009) Autophagy , vol.5 , pp. 720-722
    • Zalckvar, E.1    Berissi, H.2    Eisenstein, M.3    Kimchi, A.4
  • 260
  • 261
    • 42049095495 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy
    • DOI 10.1158/0008-5472.CAN-07-6163
    • Zeng X and Kinsella TJ. Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. Cancer Res 68: 2384-2390, 2008. (Pubitemid 351521813)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2384-2390
    • Zeng, X.1    Kinsella, T.J.2
  • 262
    • 67549101188 scopus 로고    scopus 로고
    • Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
    • Zhang J and Ney PA. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 16: 939-946, 2009.
    • (2009) Cell Death Differ , vol.16 , pp. 939-946
    • Zhang, J.1    Ney, P.A.2
  • 263
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • DOI 10.1038/ncb999
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, and Pan D. RHEB is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5: 578-581, 2003. (Pubitemid 36781094)
    • (2003) Nature Cell Biology , vol.5 , Issue.6 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 264
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and RUBICON associated with Beclin 1-phosphatidylinositol-3-kinase complex
    • Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, and Yue Z. Distinct regulation of autophagic activity by Atg14L and RUBICON associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 11: 468-476, 2009.
    • (2009) Nat Cell Biol , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6    Heintz, N.7    Yue, Z.8
  • 266
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: Immunoselection and immunosubversion
    • DOI 10.1038/nri1936, PII NRI1936
    • Zitvogel L, Tesniere A, and Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubver-sion. Nat Rev Immunol 6: 715-727, 2006. (Pubitemid 44453458)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.10 , pp. 715-727
    • Zitvogel, L.1    Tesniere, A.2    Kroemer, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.