Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 13, 2000, Pages 7124-7129

  Wang, Jia Lun ^a   Liu, Dongxiang ^a   Zhang, Zhi Jia ^a   Shan, Simei ^a   Han, Xiaobing ^a   Srinivasula, Srinivasa M ^a   Croce, Carlo M ^a   Alnemri, Emad S ^a   Huang, Ziwei ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; PROTEIN BCL 2;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; COMPUTER SIMULATION; DRUG DESIGN; HL-60 CELLS; HUMANS; MICE; ORGANIC CHEMICALS; PEPTIDES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034691130     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.13.7124     Document Type: Article

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