-
1
-
-
33745188225
-
Induction of apoptosis by intracellular potassium ion depletion: using the fluorescent dye PBFI in a 96-well plate method in cultured lung cancer cells
-
Andersson B., Janson V., Behnam-Motlagh P., Henriksson R., and Grankvist K. Induction of apoptosis by intracellular potassium ion depletion: using the fluorescent dye PBFI in a 96-well plate method in cultured lung cancer cells. Toxicol. In Vitro 20 (2006) 986-994
-
(2006)
Toxicol. In Vitro
, vol.20
, pp. 986-994
-
-
Andersson, B.1
Janson, V.2
Behnam-Motlagh, P.3
Henriksson, R.4
Grankvist, K.5
-
2
-
-
0032849010
-
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
-
Aramburu J., Yaffe M.B., Lopez-Rodriguez C., Cantley L.C., Hogan P.G., and Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 (1999) 2129-2133
-
(1999)
Science
, vol.285
, pp. 2129-2133
-
-
Aramburu, J.1
Yaffe, M.B.2
Lopez-Rodriguez, C.3
Cantley, L.C.4
Hogan, P.G.5
Rao, A.6
-
4
-
-
0033522924
-
Titrating the effects of mitochondrial complex I impairment in the cell physiology
-
Barrientos A., and Moraes C. Titrating the effects of mitochondrial complex I impairment in the cell physiology. J. Biol. Chem. 274 (1999) 16188-16197
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16188-16197
-
-
Barrientos, A.1
Moraes, C.2
-
5
-
-
0031972736
-
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
-
Bowker-Kinley M.M., Davis W.I., Wu P., Harris R.A., and Popov K.M. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem. J. 329 (1998) 191-196
-
(1998)
Biochem. J.
, vol.329
, pp. 191-196
-
-
Bowker-Kinley, M.M.1
Davis, W.I.2
Wu, P.3
Harris, R.A.4
Popov, K.M.5
-
6
-
-
0029776469
-
Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery
-
Brandes R., and Bers D.M. Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery. Biophys. J. 71 (1996) 1024-1035
-
(1996)
Biophys. J.
, vol.71
, pp. 1024-1035
-
-
Brandes, R.1
Bers, D.M.2
-
7
-
-
33746329868
-
Energy converting NADH:quinone oxidoreductase (complex I)
-
Brandt U. Energy converting NADH:quinone oxidoreductase (complex I). Annu. Rev. Biochem. 75 (2006) 69-92
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 69-92
-
-
Brandt, U.1
-
8
-
-
0347991786
-
Hydrogen peroxide modulates the Kv1.5 channel expressed in a mammalian cell line
-
Caouette D., Dongmo C., Berube J., Fournier D., and Daleau P. Hydrogen peroxide modulates the Kv1.5 channel expressed in a mammalian cell line. Naunyn Schmiedebergs Arch. Pharmacol. 368 (2003) 479-486
-
(2003)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.368
, pp. 479-486
-
-
Caouette, D.1
Dongmo, C.2
Berube, J.3
Fournier, D.4
Daleau, P.5
-
9
-
-
0024148694
-
Mitochondrial membrane potential in living cells
-
Chen L.B. Mitochondrial membrane potential in living cells. Annu. Rev. Cell Biol. 4 (1988) 155-181
-
(1988)
Annu. Rev. Cell Biol.
, vol.4
, pp. 155-181
-
-
Chen, L.B.1
-
10
-
-
13644266770
-
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease
-
Clayton R., Clark J.B., and Sharpe M. Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. J. Neurochem. 92 (2005) 840-849
-
(2005)
J. Neurochem.
, vol.92
, pp. 840-849
-
-
Clayton, R.1
Clark, J.B.2
Sharpe, M.3
-
12
-
-
9644278114
-
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
-
Dohi T., Beltrami E., Wall N.R., Plescia J., and Altieri D.C. Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J. Clin. Invest. 114 (2004) 1117-1127
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1117-1127
-
-
Dohi, T.1
Beltrami, E.2
Wall, N.R.3
Plescia, J.4
Altieri, D.C.5
-
13
-
-
4043135203
-
Mitochondria as cancer drug targets
-
Don A.S., and Hogg P.J. Mitochondria as cancer drug targets. Trends Mol. Med. 10 (2004) 372-378
-
(2004)
Trends Mol. Med.
, vol.10
, pp. 372-378
-
-
Don, A.S.1
Hogg, P.J.2
-
14
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom R.L., Bauer D.E., Buzzai M., Karnauskas R., Harris M.H., Plas D.R., Zhuang H., Cinalli R.M., Alavi A., Rudin C.M., and Thompson C.B. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 64 (2004) 3892-3899
-
(2004)
Cancer Res.
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
15
-
-
0024597774
-
Nicotinamide adenine dinucleotide fluorescence spectroscopy and imaging of isolated cardiac myocytes
-
Eng J., Lynch R.M., and Balaban R.S. Nicotinamide adenine dinucleotide fluorescence spectroscopy and imaging of isolated cardiac myocytes. Biophys. J. 55 (1989) 621-630
-
(1989)
Biophys. J.
, vol.55
, pp. 621-630
-
-
Eng, J.1
Lynch, R.M.2
Balaban, R.S.3
-
16
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 4 (2004) 891-899
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
17
-
-
0041810124
-
The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death
-
Granville D.J., and Gottlieb R.A. The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death. Curr. Med. Chem. 10 (2003) 1527-1533
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 1527-1533
-
-
Granville, D.J.1
Gottlieb, R.A.2
-
18
-
-
27544480785
-
The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression
-
Heerdt B.G., Houston M.A., and Augenlicht L.H. The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression. Cancer Res. 65 (2005) 9861-9867
-
(2005)
Cancer Res.
, vol.65
, pp. 9861-9867
-
-
Heerdt, B.G.1
Houston, M.A.2
Augenlicht, L.H.3
-
19
-
-
14744284637
-
Multifaceted roles of glycolytic enzymes
-
Kim J.W., and Dang C.V. Multifaceted roles of glycolytic enzymes. Trends Biochem. Sci. 30 (2005) 142-150
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 142-150
-
-
Kim, J.W.1
Dang, C.V.2
-
20
-
-
30744469862
-
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
-
Knoechel T.R., Tucker A.D., Robinson C.M., Phillips C., Taylor W., Bungay P.J., Kasten S.A., Roche T.E., and Brown D.G. Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. Biochemistry 45 (2006) 402-415
-
(2006)
Biochemistry
, vol.45
, pp. 402-415
-
-
Knoechel, T.R.1
Tucker, A.D.2
Robinson, C.M.3
Phillips, C.4
Taylor, W.5
Bungay, P.J.6
Kasten, S.A.7
Roche, T.E.8
Brown, D.G.9
-
21
-
-
14044249546
-
Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
-
Komarova S.V., Pereverzev A., Shum J.W., Sims S.M., and Dixon S.J. Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc. Natl. Acad. Sci. USA 102 (2005) 2643-2648
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2643-2648
-
-
Komarova, S.V.1
Pereverzev, A.2
Shum, J.W.3
Sims, S.M.4
Dixon, S.J.5
-
22
-
-
13444272912
-
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma
-
Koukourakis M.I., Giatromanolaki A., Sivridis E., Gatter K.C., and Harris A.L. Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma. Neoplasia 7 (2005) 1-6
-
(2005)
Neoplasia
, vol.7
, pp. 1-6
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Gatter, K.C.4
Harris, A.L.5
-
23
-
-
0036903625
-
Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state
-
Kushnareva Y., Murphy A.N., and Andreyev A. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem. J. 368 (2002) 545-553
-
(2002)
Biochem. J.
, vol.368
, pp. 545-553
-
-
Kushnareva, Y.1
Murphy, A.N.2
Andreyev, A.3
-
25
-
-
20644466433
-
NFAT proteins: key regulators of T-cell development and function
-
Macian F. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 5 (2005) 472-484
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 472-484
-
-
Macian, F.1
-
26
-
-
6344257102
-
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
-
McMurtry M.S., Bonnet S., Wu X., Dyck J.R., Haromy A., Hashimoto K., and Michelakis E.D. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ. Res. 95 (2004) 830-840
-
(2004)
Circ. Res.
, vol.95
, pp. 830-840
-
-
McMurtry, M.S.1
Bonnet, S.2
Wu, X.3
Dyck, J.R.4
Haromy, A.5
Hashimoto, K.6
Michelakis, E.D.7
-
27
-
-
20444483234
-
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
-
McMurtry M.S., Archer S.L., Altieri D.C., Bonnet S., Haromy A., Harry G., Bonnet S., Puttagunta L., and Michelakis E.D. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J. Clin. Invest. 115 (2005) 1479-1491
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1479-1491
-
-
McMurtry, M.S.1
Archer, S.L.2
Altieri, D.C.3
Bonnet, S.4
Haromy, A.5
Harry, G.6
Bonnet, S.7
Puttagunta, L.8
Michelakis, E.D.9
-
28
-
-
0037188928
-
Diversity in mitochondrial function explains differences in vascular oxygen sensing
-
Michelakis E.D., Hampl V., Nsair A., Wu X., Harry G., Haromy A., Gurtu R., and Archer S.L. Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ. Res. 90 (2002) 1307-1315
-
(2002)
Circ. Res.
, vol.90
, pp. 1307-1315
-
-
Michelakis, E.D.1
Hampl, V.2
Nsair, A.3
Wu, X.4
Harry, G.5
Haromy, A.6
Gurtu, R.7
Archer, S.L.8
-
30
-
-
23044493988
-
Superoxide targets calcineurin signaling in vascular endothelium
-
Namgaladze D., Shcherbyna I., Kienhofer J., Hofer H.W., and Ullrich V. Superoxide targets calcineurin signaling in vascular endothelium. Biochem. Biophys. Res. Commun. 334 (2005) 1061-1067
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.334
, pp. 1061-1067
-
-
Namgaladze, D.1
Shcherbyna, I.2
Kienhofer, J.3
Hofer, H.W.4
Ullrich, V.5
-
31
-
-
28544436922
-
Activation of glycogen synthase kinase 3β disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
-
Pastorino J.G., Hoek J.B., and Shulga N. Activation of glycogen synthase kinase 3β disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res. 65 (2005) 10545-10554
-
(2005)
Cancer Res.
, vol.65
, pp. 10545-10554
-
-
Pastorino, J.G.1
Hoek, J.B.2
Shulga, N.3
-
32
-
-
0030056515
-
Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
-
Pitkanen S., and Robinson B.H. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J. Clin. Invest. 98 (1996) 345-351
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 345-351
-
-
Pitkanen, S.1
Robinson, B.H.2
-
33
-
-
0036515618
-
Cell metabolism in the regulation of programmed cell death
-
Plas D.R., and Thompson C.B. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol. Metab. 13 (2002) 75-78
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 75-78
-
-
Plas, D.R.1
Thompson, C.B.2
-
34
-
-
0037461359
-
2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats
-
2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation 107 (2003) 2037-2044
-
(2003)
Circulation
, vol.107
, pp. 2037-2044
-
-
Pozeg, Z.I.1
Michelakis, E.D.2
McMurtry, M.S.3
Thebaud, B.4
Wu, X.C.5
Dyck, J.R.6
Hashimoto, K.7
Wang, S.8
Moudgil, R.9
Harry, G.10
-
35
-
-
0038721967
-
Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas
-
Preussat K., Beetz C., Schrey M., Kraft R., Wolfl S., Kalff R., and Patt S. Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. Neurosci. Lett. 346 (2003) 33-36
-
(2003)
Neurosci. Lett.
, vol.346
, pp. 33-36
-
-
Preussat, K.1
Beetz, C.2
Schrey, M.3
Kraft, R.4
Wolfl, S.5
Kalff, R.6
Patt, S.7
-
36
-
-
0037453589
-
NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro
-
Pu W.T., Ma Q., and Izumo S. NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro. Circ. Res. 92 (2003) 725-731
-
(2003)
Circ. Res.
, vol.92
, pp. 725-731
-
-
Pu, W.T.1
Ma, Q.2
Izumo, S.3
-
39
-
-
0027453493
-
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart
-
Saddik M., Gamble J., Witters L.A., and Lopaschuk G.D. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J. Biol. Chem. 268 (1993) 25836-25845
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25836-25845
-
-
Saddik, M.1
Gamble, J.2
Witters, L.A.3
Lopaschuk, G.D.4
-
40
-
-
0037314215
-
Neuronal degeneration and mitochondrial dysfunction
-
Schon E.A., and Manfredi G. Neuronal degeneration and mitochondrial dysfunction. J. Clin. Invest. 111 (2003) 303-312
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 303-312
-
-
Schon, E.A.1
Manfredi, G.2
-
41
-
-
0033519705
-
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
-
Shimizu S., Narita M., and Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399 (1999) 483-487
-
(1999)
Nature
, vol.399
, pp. 483-487
-
-
Shimizu, S.1
Narita, M.2
Tsujimoto, Y.3
-
42
-
-
0024452528
-
The pharmacology of dichloroacetate
-
Stacpoole P.W. The pharmacology of dichloroacetate. Metabolism 38 (1989) 1124-1144
-
(1989)
Metabolism
, vol.38
, pp. 1124-1144
-
-
Stacpoole, P.W.1
-
45
-
-
33646830260
-
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
-
Stacpoole P.W., Kerr D.S., Barnes C., Bunch S.T., Carney P.R., Fennell E.M., Felitsyn N.M., Gilmore R.L., Greer M., Henderson G.N., et al. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 117 (2006) 1519-1531
-
(2006)
Pediatrics
, vol.117
, pp. 1519-1531
-
-
Stacpoole, P.W.1
Kerr, D.S.2
Barnes, C.3
Bunch, S.T.4
Carney, P.R.5
Fennell, E.M.6
Felitsyn, N.M.7
Gilmore, R.L.8
Greer, M.9
Henderson, G.N.10
-
46
-
-
0032587982
-
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
-
Vander Heiden M.G., Chandel N.S., Schumacker P.T., and Thompson C.B. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3 (1999) 159-167
-
(1999)
Mol. Cell
, vol.3
, pp. 159-167
-
-
Vander Heiden, M.G.1
Chandel, N.S.2
Schumacker, P.T.3
Thompson, C.B.4
-
47
-
-
11844307184
-
+ channels in regulating tumour cell proliferation and apoptosis
-
+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch. 448 (2004) 274-286
-
(2004)
Pflugers Arch.
, vol.448
, pp. 274-286
-
-
Wang, Z.1
-
48
-
-
0036733645
-
+ channel, a regulator of tumor cell apoptosis and proliferation
-
+ channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res. 62 (2002) 4843-4848
-
(2002)
Cancer Res.
, vol.62
, pp. 4843-4848
-
-
Wang, H.1
Zhang, Y.2
Cao, L.3
Han, H.4
Wang, J.5
Yang, B.6
Nattel, S.7
Wang, Z.8
-
50
-
-
0000521423
-
Mediation of neuronal apoptosis by enhancement of outward potassium current
-
Yu S.P., Yeh C.H., Sensi S.L., Gwag B.J., Canzoniero L.M., Farhangrazi Z.S., Ying H.S., Tian M., Dugan L.L., and Choi D.W. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 278 (1997) 114-117
-
(1997)
Science
, vol.278
, pp. 114-117
-
-
Yu, S.P.1
Yeh, C.H.2
Sensi, S.L.3
Gwag, B.J.4
Canzoniero, L.M.5
Farhangrazi, Z.S.6
Ying, H.S.7
Tian, M.8
Dugan, L.L.9
Choi, D.W.10
-
51
-
-
0035229427
-
The mitochondrion in apoptosis: how Pandora's box opens
-
Zamzami N., and Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nat. Rev. Mol. Cell Biol. 2 (2001) 67-71
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 67-71
-
-
Zamzami, N.1
Kroemer, G.2
|