Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

Cancer Letters

Volumn 343, Issue 2, 2014, Pages 179-189

  Kumar, Dhruv ^a   Shankar, Sharmila ^b   Srivastava, Rakesh K ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Akt; AMPK; Autophagy; LC3; MTOR; PI3K

Indexed keywords

AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BECLIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ROTTLERIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER STEM CELL; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

MALLOTUS PHILIPPENSIS;

4′,6-DIAMIDINO-2-PHENYLINDOLE; 5′ ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE; AKT; AMPK; ATG; AUTOPHAGY; AUTOPHAGY RELATED GENE; BAF; BAFILOMYCIN; CANCER STEM CELLS; CHX; CSCS; CYCLOHEXIMIDE; DAPI; FBS; FETAL BOVINE SERUM; LC3; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; MTOR; PHOSPHATIDYLINOSITIDE 3-KINASES; PI3K; ROTT; ROTTLERIN;

ACETOPHENONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BENZOPYRANS; BLOTTING, WESTERN; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; MALE; PHOSPHATIDYLINOSITOL 3-KINASE; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84891826180     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.10.003     Document Type: Article

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