A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells

Autophagy

Volumn 5, Issue 3, 2009, Pages 314-320

  Lin, Jian ^a   Zheng, Zhibin ^b   Li, Yanjun ^a   Yu, Wenyu ^a   Zhong, Wu ^b   Tian, Songhai ^a   Zhao, Fang ^b   Ren, Xiaobai ^a   Xiao, Junhai ^b   Wang, Nan ^a   Liu, Siyang ^a   Wang, Lili ^b   Sheng, Fugeng ^c   Chen, Yingyu ^d   Jin, Changwen ^a   Li, Song ^b   Xia, Bin ^a  

^a PEKING UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^d PEKING UNIVERSITY   (China)

Author keywords

Autophagic cell death; Autophagy; Bcl 2; Bcl XL; Inhibitor; NMR

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN BCL XL INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; Z 36; 3 METHYLADENINE; 3-METHYLADENINE; 5 FLUORO 1 (3' DIMETHYLAMINO)PROPYL INDOLIN 2 ONE; 5-FLUORO-1-(3'-DIMETHYLAMINO)PROPYL-INDOLIN-2-ONE; ADENINE; DRUG DERIVATIVE; GREEN FLUORESCENT PROTEIN; INDOLE DERIVATIVE; PROTEIN BCL 2; PROTEIN BCL X; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL DEGENERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; HELA CELL; HUMAN; HUMAN CELL; STRUCTURE ANALYSIS; AUTOPHAGY; BIOSYNTHESIS; CHEMICAL MODEL; CONFORMATION; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; RNA INTERFERENCE; SURFACE PLASMON RESONANCE; TRANSMISSION ELECTRON MICROSCOPY;

ADENINE; ANTINEOPLASTIC AGENTS; AUTOPHAGY; BCL-X PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; INDOLES; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURFACE PLASMON RESONANCE;

EID: 65249099649     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.3.7888     Document Type: Article

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