NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

Molecular Cancer Therapeutics

Volumn 8, Issue 8, 2009, Pages 2204-2210

  Liu, Ta Jen ^a   Koul, Dimpy ^a   LaFortune, Tiffany ^a   Tiao, Ningyi ^a   Rui, Jun Shen ^a   Maira, Sauveur Michel ^b   Garcia Echevrria, Carlos ^b   Yung, W K Alfred ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOQUINOLINE DERIVATIVE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NVP BEZ235; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; S6 KINASE; S6 KINASE 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL CYCLE; CELL LINE, TUMOR; DOWN-REGULATION; ENZYME INHIBITORS; GLIOMA; HUMANS; IMIDAZOLES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; QUINOLINES;

EID: 68849091778     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0160     Document Type: Article

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