Autophagy Protects against Oxaliplatin-Induced Cell Death via ER Stress and ROS in Caco-2 Cells

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Shi, Yan ^a   Tang, Bin ^a   Yu, Pei Wu ^a   Tang, Bo ^a   Hao, Ying Xue ^a   Lei, Xiao ^a   Luo, Hua Xing ^a   Zeng, Dong Zhu ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; BECLIN 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; OXALIPLATIN; PROTEIN P8; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TIRON;

ARTICLE; ATG5 GENE; AUTOPHAGY; BECLIN 1 GENE; CELL DEATH; CELL PROTECTION; CELL STRAIN CACO 2; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; RNA INTERFERENCE;

AUTOPHAGY; CACO-2 CELLS; COLORECTAL NEOPLASMS; CYTOPROTECTION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMANS; ORGANOPLATINUM COMPOUNDS; REACTIVE OXYGEN SPECIES;

EID: 84870591168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051076     Document Type: Article

References (30)

1. Grothey A, (2010) Reintroduction of oxaliplatin: a viable approach to the long-term management of metastatic colorectal cancer. Oncology 79: 389-399.
2. Hisamuddin IM, Yang VW, (2004) Genetics of colorectal cancer. MedGenMed 6: 13.
3. Pardini B, Naccarati A, Vodicka P, Kumar R, (2012) Gene expression variations: potentialities of master regulator polymorphisms in colorectal cancer risk. Mutagenesis 27: 161-167.
4. OConnell JB, Maggard MA, Ko CY, (2004) Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 96: 1420-1425.
5. Hu C, Zou MJ, Zhao L, Lu N, Sun YJ, et al. (2012) E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. Toxicol Lett 210: 78-86.
6. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, et al. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075.
7. Zhou S, Kuang M, Zhang B, Zhao L, Liang Z, et al. (2012) Autophagy in tumorigenesis and cancer therapy: Dr Jekyll or Mr Hyde? Cancer Lett.
8. Kung CP, Budina A, Balaburski G, Bergenstock MK, Murphy M, (2011) Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr 21: 71-100.
9. White E, Karp C, Strohecker AM, Guo Y, Mathew R, (2010) Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol 22: 212-217.
10. Chen N, Karantza V, (2011) Autophagy as a therapeutic target in cancer. Cancer Biol Ther 11: 157-168.
11. Cabello CM, Bair WB 3rd, Wondrak GT (2007) Experimental therapeutics: targeting the redox Achilles heel of cancer. Curr Opin Investig Drugs 8: 1022-1037.
12. Li ZY, Yang Y, Ming M, Liu B, (2011) Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochem Biophys Res Commun 414: 5-8.
13. Santos CX, Tanaka LY, Wosniak J, Laurindo FR, (2009) Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 11: 2409-2427.
14. Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P, (2008) Redox regulation of cell survival. Antioxid Redox Signal 10: 1343-1374.
15. Yokoyama T, Iwado E, Kondo Y, Aoki H, Hayashi Y, et al. (2008) Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells. Gene Ther 15: 1233-1239.
16. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175.
17. Chen Y, Azad MB, Gibson SB, (2010) Methods for detecting autophagy and determining autophagy-induced cell death. Can J Physiol Pharmacol 88: 285-295.
18. Bae YS, Oh H, Rhee SG, Yoo YD, (2011) Regulation of reactive oxygen species generation in cell signaling. Mol Cells 32: 491-509.
19. Levine B, Kroemer G, (2008) Autophagy in the pathogenesis of disease. Cell 132: 27-42.
20. Mahoney E, Lucas DM, Gupta SV, Wagner AJ, Herman SE, et al. (2012) ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. Blood 120: 1262-1273.
21. Hersey P, Zhang XD, (2008) Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma. Pigment Cell Melanoma Res 21: 358-367.
22. Ding ZB, Hui B, Shi YH, Zhou J, Peng YF, et al. (2011) Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation. Clin Cancer Res 17: 6229-6238.
23. He C, Klionsky DJ, (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
24. Huang J, Lam GY, Brumell JH, (2011) Autophagy signaling through reactive oxygen species. Antioxid Redox Signal 14: 2215-2231.
25. Azad MB, Chen Y, Gibson SB, (2009) Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 11: 777-790.
26. Lee J, Giordano S, Zhang J, (2012) Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 441: 523-540.
27. Kroemer G, Galluzzi L, Brenner C, (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87: 99-163.
28. Arango D, Wilson AJ, Shi Q, Corner GA, Aranes MJ, et al. (2004) Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. Br J Cancer 91: 1931-1946.
29. Marchetti P, Galla DA, Russo FP, Ricevuto E, Flati V, et al. (2004) Apoptosis induced by oxaliplatin in human colon cancer HCT15 cell line. Anticancer Res 24: 219-226.
30. Martins I, Kepp O, Schlemmer F, Adjemian S, Tailler M, et al. (2011) Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress. Oncogene 30: 1147-1158.