Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Firat, Elke ^a   Weyerbrock, Astrid ^a   Gaedicke, Simone ^a   Grosu, Anca Ligia ^a   Niedermann, Gabriele ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 MORPHOLINO 8 PHENYLCHROMONE; CELL MARKER; CHLOROQUINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN LC3 II; SH 6; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER STEM CELL; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG POTENTIATION; ENZYME INHIBITION; GAMMA IRRADIATION; GENOTOXICITY; GLIOMA CELL; HUMAN; HUMAN CELL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; STEM LIKE GLIOMA CELL; UPREGULATION;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CHLOROQUINE; DRUG SYNERGISM; ENZYME INHIBITORS; GAMMA RAYS; GLIOMA; HUMANS; NEOPLASTIC STEM CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84867619238     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047357     Document Type: Article

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