Ammonia derived from glutaminolysis is a diffusible regulator of autophagy

Science Signaling

Volumn 3, Issue 119, 2010, Pages

  Eng, Christina H ^a   Yu, Ker ^a   Lucas, Judy ^a   White, Eileen ^b,c   Abraham, Robert T ^a  

^a PFIZER INC   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; AUTOPHAGY; CELL PROTECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AMMONIA; AUTOPHAGY; CELLS, CULTURED; GLUTAMINE; HUMANS; HYDROLYSIS;

MAMMALIA;

EID: 77953861522     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000911     Document Type: Article

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52. Acknowledgments: We thank L. Toral-Barza, C. Shi, and W.-G. Zhang for excellent technical support; E. Rosfjord and T. Zhou for statistical assistance; M. L. Mercado and R. Mathew for reagent provision; and E. Graziani for helpful discussions. Funding: This work was supported by Wyeth Oncology Discovery, the Pfizer Center for Integrative Biology and Biotherapeutics (CIBB) and the Pfizer Postdoctoral Program, and NIH R01 grant CA130893 to E. W. Author contributions: C. H. E. performed the experiments; J. L. generated and collected the tumor interstitial fluid samples, E. W. provided transgenic iBMK cell lines and commented on the manuscript; C. H. E., K. Y., and R. T. A. analyzed data and interpreted experimental results; C. H. E. and R. T. A. designed the experiments and wrote the paper.