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Volumn 54, Issue 2, 2015, Pages 265-272

Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells

Author keywords

Apoptosis; Autophagy; Breast cancer; Tocomin ; Tocotrienols; Vitamin E

Indexed keywords

3-METHYLADENINE; ADENINE; ALPHA TOCOTRIENOL; ANTINEOPLASTIC ANTIMETABOLITE; ANTIOXIDANT; TOCOMIN;

EID: 84939877243     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-014-0707-y     Document Type: Article
Times cited : (45)

References (47)
  • 1
    • 14944340238 scopus 로고    scopus 로고
    • Tocotrienol-rich fraction from palm oil and gene expression in human breast cancer cells
    • COI: 1:CAS:528:DC%2BD2MXivFWnuro%3D
    • Nesaretnam K, Ambra R, Selvaduray KR, Radhakrishnan A, Canali R, Virgili F (2004) Tocotrienol-rich fraction from palm oil and gene expression in human breast cancer cells. Ann NY Acad Sci 1031:143–157
    • (2004) Ann NY Acad Sci , vol.1031 , pp. 143-157
    • Nesaretnam, K.1    Ambra, R.2    Selvaduray, K.R.3    Radhakrishnan, A.4    Canali, R.5    Virgili, F.6
  • 3
    • 34347390404 scopus 로고    scopus 로고
    • Tocotrienols: the emerging face of natural vitamin E
    • COI: 1:CAS:528:DC%2BD1cXht1Wlu7k%3D
    • Sen CK, Khanna S, Rink C, Roy S (2007) Tocotrienols: the emerging face of natural vitamin E. Vitam Horm 76:203–261
    • (2007) Vitam Horm , vol.76 , pp. 203-261
    • Sen, C.K.1    Khanna, S.2    Rink, C.3    Roy, S.4
  • 4
    • 0038697894 scopus 로고    scopus 로고
    • Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants
    • COI: 1:CAS:528:DC%2BD3sXkt1yltL0%3D
    • Noguchi N, Hanyu R, Nonaka A, Okimoto Y, Kodama T (2003) Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. Free Radic Biol Med 34(12):1614–1620
    • (2003) Free Radic Biol Med , vol.34 , Issue.12 , pp. 1614-1620
    • Noguchi, N.1    Hanyu, R.2    Nonaka, A.3    Okimoto, Y.4    Kodama, T.5
  • 5
    • 33745176559 scopus 로고    scopus 로고
    • Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells
    • COI: 1:CAS:528:DC%2BD28XlvFGmsbc%3D
    • Srivastava JK, Gupta S (2006) Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun 346(2):447–453
    • (2006) Biochem Biophys Res Commun , vol.346 , Issue.2 , pp. 447-453
    • Srivastava, J.K.1    Gupta, S.2
  • 6
    • 3242693406 scopus 로고    scopus 로고
    • Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells
    • COI: 1:CAS:528:DC%2BD2cXmsV2jt70%3D
    • Sakai M, Okabe M, Yamasaki M, Tachibana H, Yamada K (2004) Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells. Anticancer Res 24(3a):1683–1688
    • (2004) Anticancer Res , vol.24 , Issue.3a , pp. 1683-1688
    • Sakai, M.1    Okabe, M.2    Yamasaki, M.3    Tachibana, H.4    Yamada, K.5
  • 8
    • 84860741720 scopus 로고    scopus 로고
    • Tocotrienols and breast cancer: the evidence to date
    • COI: 1:CAS:528:DC%2BC38XkslOguw%3D%3D
    • Nesaretnam K, Meganathan P, Veerasenan SD, Selvaduray KR (2012) Tocotrienols and breast cancer: the evidence to date. Genes Nutr 7(1):3–9. doi:10.1007/s12263-011-0224-z
    • (2012) Genes Nutr , vol.7 , Issue.1 , pp. 3-9
    • Nesaretnam, K.1    Meganathan, P.2    Veerasenan, S.D.3    Selvaduray, K.R.4
  • 10
    • 84860771460 scopus 로고    scopus 로고
    • Tocotrienols fight cancer by targeting multiple cell signaling pathways
    • COI: 1:CAS:528:DC%2BC38XkslOgtQ%3D%3D
    • Kannappan R, Gupta SC, Kim JH, Aggarwal BB (2012) Tocotrienols fight cancer by targeting multiple cell signaling pathways. Genes Nutr 7(1):43–52. doi:10.1007/s12263-011-0220-3
    • (2012) Genes Nutr , vol.7 , Issue.1 , pp. 43-52
    • Kannappan, R.1    Gupta, S.C.2    Kim, J.H.3    Aggarwal, B.B.4
  • 13
    • 79955594735 scopus 로고    scopus 로고
    • Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats
    • COI: 1:STN:280:DC%2BC3Mvns1SmtA%3D%3D
    • Taridi NM, Yahaya MF, Teoh SL, Latiff AA, Ngah WZ, Das S, Mazlan M (2011) Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats. La Clinica terapeutica 162(2):93–98
    • (2011) La Clinica terapeutica , vol.162 , Issue.2 , pp. 93-98
    • Taridi, N.M.1    Yahaya, M.F.2    Teoh, S.L.3    Latiff, A.A.4    Ngah, W.Z.5    Das, S.6    Mazlan, M.7
  • 14
    • 77953781390 scopus 로고    scopus 로고
    • Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice
    • COI: 1:CAS:528:DC%2BC3cXot1Cru7Y%3D
    • Ren Z, Pae M, Dao MC, Smith D, Meydani SN, Wu D (2010) Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr 140(7):1335–1341. doi:10.3945/jn.110.121434
    • (2010) J Nutr , vol.140 , Issue.7 , pp. 1335-1341
    • Ren, Z.1    Pae, M.2    Dao, M.C.3    Smith, D.4    Meydani, S.N.5    Wu, D.6
  • 15
    • 79952112251 scopus 로고    scopus 로고
    • Tocotrienols are good adjuvants for developing cancer vaccines
    • Hafid SR, Radhakrishnan AK, Nesaretnam K (2010) Tocotrienols are good adjuvants for developing cancer vaccines. BMC Cancer 10:5. doi:10.1186/1471-2407-10-5
    • (2010) BMC Cancer , vol.10 , pp. 5
    • Hafid, S.R.1    Radhakrishnan, A.K.2    Nesaretnam, K.3
  • 16
    • 16444387293 scopus 로고    scopus 로고
    • Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity
    • COI: 1:CAS:528:DC%2BD2MXjtFequr0%3D
    • Shah SJ, Sylvester PW (2005) Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med (Maywood) 230(4):235–241
    • (2005) Exp Biol Med (Maywood) , vol.230 , Issue.4 , pp. 235-241
    • Shah, S.J.1    Sylvester, P.W.2
  • 17
    • 4444341393 scopus 로고    scopus 로고
    • Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells
    • COI: 1:CAS:528:DC%2BD2cXnsVeit78%3D
    • Shah S, Sylvester PW (2004) Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells. Exp Biol Med (Maywood) 229(8):745–755
    • (2004) Exp Biol Med (Maywood) , vol.229 , Issue.8 , pp. 745-755
    • Shah, S.1    Sylvester, P.W.2
  • 18
    • 80051789323 scopus 로고    scopus 로고
    • Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway
    • COI: 1:CAS:528:DC%2BC3MXhtVagtrnK
    • Shin-Kang S, Ramsauer VP, Lightner J, Chakraborty K, Stone W, Campbell S, Reddy SA, Krishnan K (2011) Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway. Free Radic Biol Med 51(6):1164–1174. doi:10.1016/j.freeradbiomed.2011.06.008
    • (2011) Free Radic Biol Med , vol.51 , Issue.6 , pp. 1164-1174
    • Shin-Kang, S.1    Ramsauer, V.P.2    Lightner, J.3    Chakraborty, K.4    Stone, W.5    Campbell, S.6    Reddy, S.A.7    Krishnan, K.8
  • 19
    • 79958830335 scopus 로고    scopus 로고
    • Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells
    • COI: 1:CAS:528:DC%2BC3MXns1Smtr0%3D
    • Katuru R, Fernandes NV, Elfakhani M, Dutta D, Mills N, Hynds DL, King C, Mo H (2011) Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. Exp Biol Med 236(5):604–613. doi:10.1258/ebm.2011.010379
    • (2011) Exp Biol Med , vol.236 , Issue.5 , pp. 604-613
    • Katuru, R.1    Fernandes, N.V.2    Elfakhani, M.3    Dutta, D.4    Mills, N.5    Hynds, D.L.6    King, C.7    Mo, H.8
  • 20
    • 55749115443 scopus 로고    scopus 로고
    • Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product
    • COI: 1:CAS:528:DC%2BD1cXhsVaqtrfI
    • Elangovan S, Hsieh TC, Wu JM (2008) Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product. Anticancer Res 28(5A):2641–2647
    • (2008) Anticancer Res , vol.28 , Issue.5A , pp. 2641-2647
    • Elangovan, S.1    Hsieh, T.C.2    Wu, J.M.3
  • 21
    • 84875313028 scopus 로고    scopus 로고
    • Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity
    • COI: 1:CAS:528:DC%2BC3sXksVKktL8%3D
    • Loganathan R, Selvaduray KR, Nesaretnam K, Radhakrishnan AK (2013) Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. Cell Prolif 46(2):203–213. doi:10.1111/cpr.12014
    • (2013) Cell Prolif , vol.46 , Issue.2 , pp. 203-213
    • Loganathan, R.1    Selvaduray, K.R.2    Nesaretnam, K.3    Radhakrishnan, A.K.4
  • 22
    • 84870713976 scopus 로고    scopus 로고
    • Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells
    • COI: 1:CAS:528:DC%2BC38XhsFSnt7%2FK
    • Gopalan A, Yu W, Jiang Q, Jang Y, Sanders BG, Kline K (2012) Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. Mol Nutr Food Res 56(12):1803–1811. doi:10.1002/mnfr.201200350
    • (2012) Mol Nutr Food Res , vol.56 , Issue.12 , pp. 1803-1811
    • Gopalan, A.1    Yu, W.2    Jiang, Q.3    Jang, Y.4    Sanders, B.G.5    Kline, K.6
  • 23
    • 77049086006 scopus 로고    scopus 로고
    • Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells
    • COI: 1:CAS:528:DC%2BC3cXitlSks74%3D
    • Liu HK, Wang Q, Li Y, Sun WG, Liu JR, Yang YM, Xu WL, Sun XR, Chen BQ (2010) Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem 21(3):206–213. doi:10.1016/j.jnutbio.2008.11.004
    • (2010) J Nutr Biochem , vol.21 , Issue.3 , pp. 206-213
    • Liu, H.K.1    Wang, Q.2    Li, Y.3    Sun, W.G.4    Liu, J.R.5    Yang, Y.M.6    Xu, W.L.7    Sun, X.R.8    Chen, B.Q.9
  • 24
    • 80052416538 scopus 로고    scopus 로고
    • Differentially expressed micoRNAs in human oocytes
    • Xu YW, Wang B, Ding CH, Li T, Gu F, Zhou C (2011) Differentially expressed micoRNAs in human oocytes. J Assist Reprod Genet 28(6):559–566. doi:10.1007/s10815-011-9590-0
    • (2011) J Assist Reprod Genet , vol.28 , Issue.6 , pp. 559-566
    • Xu, Y.W.1    Wang, B.2    Ding, C.H.3    Li, T.4    Gu, F.5    Zhou, C.6
  • 25
    • 4544324946 scopus 로고    scopus 로고
    • Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice
    • COI: 1:CAS:528:DC%2BD2cXnvFeitrs%3D
    • Nesaretnam K, Ambra R, Selvaduray KR, Radhakrishnan A, Reimann K, Razak G, Virgili F (2004) Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39(5):459–467
    • (2004) Lipids , vol.39 , Issue.5 , pp. 459-467
    • Nesaretnam, K.1    Ambra, R.2    Selvaduray, K.R.3    Radhakrishnan, A.4    Reimann, K.5    Razak, G.6    Virgili, F.7
  • 26
    • 1642579535 scopus 로고    scopus 로고
    • Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells
    • COI: 1:CAS:528:DC%2BD3sXpvF2qsLY%3D
    • Takahashi K, Loo G (2004) Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmacol 67(2):315–324
    • (2004) Biochem Pharmacol , vol.67 , Issue.2 , pp. 315-324
    • Takahashi, K.1    Loo, G.2
  • 28
    • 3843146442 scopus 로고    scopus 로고
    • Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association
    • COI: 1:CAS:528:DC%2BD2cXisFGmsLo%3D
    • Agarwal MK, Agarwal ML, Athar M, Gupta S (2004) Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle 3(2):205–211
    • (2004) Cell Cycle , vol.3 , Issue.2 , pp. 205-211
    • Agarwal, M.K.1    Agarwal, M.L.2    Athar, M.3    Gupta, S.4
  • 29
    • 83355171561 scopus 로고    scopus 로고
    • Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells
    • COI: 1:CAS:528:DC%2BC3MXhs1Shur%2FM
    • Patacsil D, Tran AT, Cho YS, Suy S, Saenz F, Malyukova I, Ressom H, Collins SP, Clarke R, Kumar D (2012) Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells. J Nutr Biochem 23(1):93–100. doi:10.1016/j.jnutbio.2010.11.012
    • (2012) J Nutr Biochem , vol.23 , Issue.1 , pp. 93-100
    • Patacsil, D.1    Tran, A.T.2    Cho, Y.S.3    Suy, S.4    Saenz, F.5    Malyukova, I.6    Ressom, H.7    Collins, S.P.8    Clarke, R.9    Kumar, D.10
  • 30
    • 33846211417 scopus 로고    scopus 로고
    • ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
    • COI: 1:CAS:528:DC%2BD2sXkslCitw%3D%3D
    • Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T (2007) ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 14(2):230–239. doi:10.1038/sj.cdd.4401984
    • (2007) Cell Death Differ , vol.14 , Issue.2 , pp. 230-239
    • Kouroku, Y.1    Fujita, E.2    Tanida, I.3    Ueno, T.4    Isoai, A.5    Kumagai, H.6    Ogawa, S.7    Kaufman, R.J.8    Kominami, E.9    Momoi, T.10
  • 33
    • 83455169115 scopus 로고    scopus 로고
    • IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux
    • Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK (2012) IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux. Hum Mol Genet 21(1):101–114. doi:10.1093/hmg/ddr445
    • (2012) Hum Mol Genet , vol.21 , Issue.1 , pp. 101-114
    • Lee, H.1    Noh, J.Y.2    Oh, Y.3    Kim, Y.4    Chang, J.W.5    Chung, C.W.6    Lee, S.T.7    Kim, M.8    Ryu, H.9    Jung, Y.K.10
  • 34
    • 80053420059 scopus 로고    scopus 로고
    • Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
    • COI: 1:CAS:528:DC%2BC38XisFSnt70%3D
    • Shi YH, Ding ZB, Zhou J, Hui B, Shi GM, Ke AW, Wang XY, Dai Z, Peng YF, Gu CY, Qiu SJ, Fan J (2011) Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 7(10):1159–1172. doi:10.4161/auto.7.10.16818
    • (2011) Autophagy , vol.7 , Issue.10 , pp. 1159-1172
    • Shi, Y.H.1    Ding, Z.B.2    Zhou, J.3    Hui, B.4    Shi, G.M.5    Ke, A.W.6    Wang, X.Y.7    Dai, Z.8    Peng, Y.F.9    Gu, C.Y.10    Qiu, S.J.11    Fan, J.12
  • 37
    • 71249122207 scopus 로고    scopus 로고
    • Autophagy inhibition in combination cancer treatment
    • COI: 1:CAS:528:DC%2BC3cXnt1Kgsr8%3D
    • Livesey KM, Tang D, Zeh HJ, Lotze MT (2009) Autophagy inhibition in combination cancer treatment. Curr Opin Investig Drugs 10(12):1269–1279
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.12 , pp. 1269-1279
    • Livesey, K.M.1    Tang, D.2    Zeh, H.J.3    Lotze, M.T.4
  • 38
    • 70449704645 scopus 로고    scopus 로고
    • Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells
    • COI: 1:CAS:528:DC%2BD1MXhtlSiur3N
    • Ren Y, Huang F, Liu Y, Yang Y, Jiang Q, Xu C (2009) Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells. BMB Rep 42(9):599–604
    • (2009) BMB Rep , vol.42 , Issue.9 , pp. 599-604
    • Ren, Y.1    Huang, F.2    Liu, Y.3    Yang, Y.4    Jiang, Q.5    Xu, C.6
  • 39
    • 79960920096 scopus 로고    scopus 로고
    • Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma
    • COI: 1:CAS:528:DC%2BC3MXptlyltrc%3D
    • Hou YJ, Dong LW, Tan YX, Yang GZ, Pan YF, Li Z, Tang L, Wang M, Wang Q, Wang HY (2011) Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma. Lab Invest 91(8):1146–1157. doi:10.1038/labinvest.2011.97
    • (2011) Lab Invest , vol.91 , Issue.8 , pp. 1146-1157
    • Hou, Y.J.1    Dong, L.W.2    Tan, Y.X.3    Yang, G.Z.4    Pan, Y.F.5    Li, Z.6    Tang, L.7    Wang, M.8    Wang, Q.9    Wang, H.Y.10
  • 41
    • 79551473364 scopus 로고    scopus 로고
    • Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway
    • COI: 1:CAS:528:DC%2BC3MXhtlKlsr8%3D
    • Chen LH, Loong CC, Su TL, Lee YJ, Chu PM, Tsai ML, Tsai PH, Tu PH, Chi CW, Lee HC, Chiou SH (2011) Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway. Biochem Pharmacol 81(5):594–605. doi:10.1016/j.bcp.2010.12.011
    • (2011) Biochem Pharmacol , vol.81 , Issue.5 , pp. 594-605
    • Chen, L.H.1    Loong, C.C.2    Su, T.L.3    Lee, Y.J.4    Chu, P.M.5    Tsai, M.L.6    Tsai, P.H.7    Tu, P.H.8    Chi, C.W.9    Lee, H.C.10    Chiou, S.H.11
  • 43
    • 0034532738 scopus 로고    scopus 로고
    • Tocotrienols inhibit growth of ZR-75-1 breast cancer cells
    • COI: 1:CAS:528:DC%2BD3MXkvF2rsg%3D%3D
    • Nesaretnam K, Dorasamy S, Darbre PD (2000) Tocotrienols inhibit growth of ZR-75-1 breast cancer cells. Int J Food Sci Nutr 51(Suppl):S95–S103
    • (2000) Int J Food Sci Nutr , vol.51 , pp. S95-S103
    • Nesaretnam, K.1    Dorasamy, S.2    Darbre, P.D.3
  • 44
    • 0031744718 scopus 로고    scopus 로고
    • Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status
    • COI: 1:CAS:528:DyaK1cXjsV2nsb8%3D
    • Nesaretnam K, Stephen R, Dils R, Darbre P (1998) Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33(5):461–469
    • (1998) Lipids , vol.33 , Issue.5 , pp. 461-469
    • Nesaretnam, K.1    Stephen, R.2    Dils, R.3    Darbre, P.4
  • 45
    • 80054947242 scopus 로고    scopus 로고
    • The enhancement of the oral bioavailability of gamma-tocotrienol in mice by gamma-cyclodextrin inclusion
    • COI: 1:CAS:528:DC%2BC3MXhsFSktr%2FO
    • Miyoshi N, Wakao Y, Tomono S, Tatemichi M, Yano T, Ohshima H (2011) The enhancement of the oral bioavailability of gamma-tocotrienol in mice by gamma-cyclodextrin inclusion. J Nutr Biochem 22(12):1121–1126. doi:10.1016/j.jnutbio.2010.09.011
    • (2011) J Nutr Biochem , vol.22 , Issue.12 , pp. 1121-1126
    • Miyoshi, N.1    Wakao, Y.2    Tomono, S.3    Tatemichi, M.4    Yano, T.5    Ohshima, H.6
  • 46
    • 84892426039 scopus 로고    scopus 로고
    • Bioavailability of tocotrienols: evidence in human studies
    • Fu JY, Che HL, Tan DM, Teng KT (2014) Bioavailability of tocotrienols: evidence in human studies. Nutr Metab 11(1):5. doi:10.1186/1743-7075-11-5
    • (2014) Nutr Metab , vol.11 , Issue.1 , pp. 5
    • Fu, J.Y.1    Che, H.L.2    Tan, D.M.3    Teng, K.T.4
  • 47
    • 0035140716 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status
    • COI: 1:CAS:528:DC%2BD3MXht1ShsrY%3D
    • Yap SP, Yuen KH, Wong JW (2001) Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. J Pharm Pharmacol 53(1):67–71
    • (2001) J Pharm Pharmacol , vol.53 , Issue.1 , pp. 67-71
    • Yap, S.P.1    Yuen, K.H.2    Wong, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.