Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase

Journal of Biological Chemistry

Volumn 285, Issue 14, 2010, Pages 10850-10861

  Wu, You Tong ^a   Tan, Hui Ling ^a   Shui, Guanghou ^a   Bauvy, Chantal ^c   Huang, Qing ^a   Wenk, Markus R ^b   Ong, Choon Nam ^a   Codogno, Patrice ^c   Shen, Han Ming ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGOSOMES; AUTOPHAGY; CLASS I; DUAL ROLE; IN-CELL; INHIBITORY EFFECT; PHOSPHOINOSITIDE 3-KINASE; RICH CONDITIONS; TEMPORAL EFFECTS; TEMPORAL PATTERN; WORTMANNIN;

NUTRIENTS;

3 METHYLADENINE; AUTOPHAGY PROTEIN 5; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P62; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL FUNCTION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENINE; ANDROSTADIENES; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; EMBRYO, MAMMALIAN; FIBROBLASTS; IMMUNOPRECIPITATION; LYSOSOMES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PHAGOSOMES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHODIESTERASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 77951217000     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.080796     Document Type: Article

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