Cucurbitacin i induces protective autophagy in glioblastoma in Vitro and in Vivo

Journal of Biological Chemistry

Volumn 289, Issue 15, 2014, Pages 10607-10619

  Yuan, Guang ^a,b   Yan, Shao Feng ^a   Xue, Hao ^a   Zhang, Ping ^a   Sun, Jin Tang ^a   Li, Gang ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; PROTEINS;

AMP-ACTIVATED PROTEIN KINASE; APOPTOTIC CELL DEATH; BCL-2 FAMILY PROTEINS; CO-IMMUNOPRECIPITATION ASSAYS; GLIOBLASTOMA MULTIFORME; HYPOXIA-INDUCIBLE FACTOR 1; SELECTIVE INHIBITORS; TARGET OF RAPAMYCIN;

PATIENT TREATMENT;

3 METHYLADENINE; ANTINEOPLASTIC AGENT; BECLIN 1; CHLOROQUINE; CUCURBITACIN I; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL ACTIVATION; CELL DEATH; CELL MIGRATION; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION;

APOPTOSIS; AUTOPHAGY; CHLOROQUINE; CUCURBITACIN I; GLIOBLASTOMA; HYPOXIA-INDUCIBLE FACTOR (HIF); SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHLOROQUINE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TRITERPENES;

EID: 84898640642     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.528760     Document Type: Article

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