Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Feng, Y ^a   Ke, C ^a   Tang, Q ^a   Dong, H ^a   Zheng, X ^a   Lin, W ^a   Ke, J ^a   Huang, J ^a   Yeung, S C J ^b   Zhang, H ^a,c  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c CANCER HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

apoptosis; autophagy; Bcl 2; esophageal squamous cell carcinoma; metformin; Stat3

Indexed keywords

METFORMIN; PROTEIN BCL 2; SMALL INTERFERING RNA; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EPITHELIUM CELL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; METFORMIN; MICE; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84896776849     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.59     Document Type: Article

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