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Volumn 25, Issue 19, 2011, Pages 1999-2010

The dynamic nature of autophagy in cancer

Author keywords

Autophagy; Cancer; Metabolism; Therapy; Tumor

Indexed keywords

BAFILOMYCIN A1; BECLIN 1; CHLOROQUINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; PROTEINASE INHIBITOR; RAS PROTEIN;

EID: 80053634368     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.17558811     Document Type: Review
Times cited : (503)

References (110)
  • 3
    • 40449086885 scopus 로고    scopus 로고
    • Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    • Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. 2008. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 68: 1485-1494.
    • (2008) Cancer Res , vol.68 , pp. 1485-1494
    • Apel, A.1    Herr, I.2    Schwarz, H.3    Rodemann, H.P.4    Mayer, A.5
  • 5
    • 79954422997 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy in protein quality control
    • Arias E, Cuervo AM. 2011. Chaperone-mediated autophagy in protein quality control. Curr Opin Cell Biol 23: 184-189.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 184-189
    • Arias, E.1    Cuervo, A.M.2
  • 6
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • Backer JM. 2008. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J 410: 1-17.
    • (2008) Biochem J , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 8
    • 33645926989 scopus 로고    scopus 로고
    • P62/SQSTM1: A missing link between protein aggregates and the autophagy machinery
    • Bjorkoy G, Lamark T, Johansen T. 2006. P62/SQSTM1: a missing link between protein aggregates and the autophagy machinery. Autophagy 2: 138-139.
    • (2006) Autophagy , vol.2 , pp. 138-139
    • Bjorkoy, G.1    Lamark, T.2    Johansen, T.3
  • 10
    • 78649357985 scopus 로고    scopus 로고
    • Protein quality control in the cytosol and the endoplasmic reticulum: Brothers in arms
    • Buchberger A, Bukau B, Sommer T. 2010. Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol Cell 40: 238-252.
    • (2010) Mol Cell , vol.40 , pp. 238-252
    • Buchberger, A.1    Bukau, B.2    Sommer, T.3
  • 11
    • 34347394714 scopus 로고    scopus 로고
    • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    • Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, Houghton JA, Huang P, Giles FJ, Cleveland JL. 2007. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110: 313-322.
    • (2007) Blood , vol.110 , pp. 313-322
    • Carew, J.S.1    Nawrocki, S.T.2    Kahue, C.N.3    Zhang, H.4    Yang, C.5    Chung, L.6    Houghton, J.A.7    Huang, P.8    Giles, F.J.9    Cleveland, J.L.10
  • 12
    • 78751556979 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cancer
    • Chen N, Karantza V. 2011. Autophagy as a therapeutic target in cancer. Cancer Biol Ther 11: 157-168.
    • (2011) Cancer Biol Ther , vol.11 , pp. 157-168
    • Chen, N.1    Karantza, V.2
  • 13
    • 79960097021 scopus 로고    scopus 로고
    • Role of autophagy in cancer prevention
    • Chen HY, White E. 2011. Role of autophagy in cancer prevention. Cancer Prev Res (Phila) 4: 973-983.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 973-983
    • Chen, H.Y.1    White, E.2
  • 14
    • 79960585318 scopus 로고    scopus 로고
    • Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
    • Cheong H, Lindsten T, Wu J, Lu C, Thompson CB. 2011. Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc Natl Acad Sci 108: 11121-11126.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 11121-11126
    • Cheong, H.1    Lindsten, T.2    Wu, J.3    Lu, C.4    Thompson, C.B.5
  • 15
    • 23944474593 scopus 로고    scopus 로고
    • Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-protea-some system and onto human diseases and drug targeting
    • Ciechanover A. 2005. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-protea-some system and onto human diseases and drug targeting. Cell Death Differ 12: 1178-1190.
    • (2005) Cell Death Differ , vol.12 , pp. 1178-1190
    • Ciechanover, A.1
  • 16
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • Collado M, Serrano M. 2010. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 10: 51-57.
    • (2010) Nat Rev Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 18
  • 22
    • 79951910694 scopus 로고    scopus 로고
    • Autophagy in immunity and cell-autonomous defense against intracellular microbes
    • Deretic V. 2011. Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev 240: 92-104.
    • (2011) Immunol Rev , vol.240 , pp. 92-104
    • Deretic, V.1
  • 23
    • 53549113031 scopus 로고    scopus 로고
    • The role of TOR in autophagy regulation from yeast to plants and mammals
    • Diaz-Troya S, Perez-Perez ME, Florencio FJ, Crespo JL. 2008. The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy 4: 851-865.
    • (2008) Autophagy , vol.4 , pp. 851-865
    • Diaz-Troya, S.1    Perez-Perez, M.E.2    Florencio, F.J.3    Crespo, J.L.4
  • 25
    • 79953306808 scopus 로고    scopus 로고
    • Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
    • Elgendy M, Sheridan C, Brumatti G, Martin SJ. 2011. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell 42: 23-35.
    • (2011) Mol Cell , vol.42 , pp. 23-35
    • Elgendy, M.1    Sheridan, C.2    Brumatti, G.3    Martin, S.J.4
  • 26
    • 81855194301 scopus 로고    scopus 로고
    • The autophagy conundrum in cancer: Influence of tumorigenic metabolic reprogramming
    • doi: 10.1038/onc.2011.220
    • Eng CH, Abraham RT. 2011. The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming. Oncogene. doi: 10.1038/onc.2011.220.
    • (2011) Oncogene
    • Eng, C.H.1    Abraham, R.T.2
  • 27
    • 77953861522 scopus 로고    scopus 로고
    • Ammonia derived from glutaminolysis is a diffusible regulator of autophagy
    • doi: 10.1126/scisignal.2000911
    • Eng CH, Yu K, Lucas J, White E, Abraham RT. 2010. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal 3: ra31. doi: 10.1126/scisignal.2000911.
    • (2010) Sci Signal , vol.3
    • Eng, C.H.1    Yu, K.2    Lucas, J.3    White, E.4    Abraham, R.T.5
  • 28
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci 102: 8204-8209.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 29
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 lipida-tion for membrane biogenesis in autophagy
    • Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T. 2008. The Atg16L complex specifies the site of LC3 lipida-tion for membrane biogenesis in autophagy. Mol Biol Cell 19: 2092-2100.
    • (2008) Mol Biol Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1    Itoh, T.2    Omori, H.3    Fukuda, M.4    Noda, T.5    Yoshimori, T.6
  • 30
    • 51049118332 scopus 로고    scopus 로고
    • The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: Beyond the usual suspects' review series
    • Geng J, Klionsky DJ. 2008. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9: 859-864.
    • (2008) EMBO Rep , vol.9 , pp. 859-864
    • Geng, J.1    Klionsky, D.J.2
  • 31
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. 2007. Defining the role of mTOR in cancer. Cancer Cell 12: 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 36
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. 2008. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 181: 497-510.
    • (2008) J Cell Biol , vol.181 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.4    Natsume, T.5    Guan, J.L.6    Mizushima, N.7
  • 38
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. 2009. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 46
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-141.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 48
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T. 2007. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3: 452-460.
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 49
    • 50249183899 scopus 로고    scopus 로고
    • Autophagy revisited: A conversation with Christian de Duve
    • Klionsky DJ. 2008. Autophagy revisited: a conversation with Christian de Duve. Autophagy 4: 740-743.
    • (2008) Autophagy , vol.4 , pp. 740-743
    • Klionsky, D.J.1
  • 53
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer G, Levine B. 2008. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 9: 1004-1010.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 54
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G, Marino G, Levine B. 2010. Autophagy and the integrated stress response. Mol Cell 40: 280-293.
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 56
    • 77953366801 scopus 로고    scopus 로고
    • A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
    • Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. 2010. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 30: 3275-3285.
    • (2010) Mol Cell Biol , vol.30 , pp. 3275-3285
    • Lau, A.1    Wang, X.J.2    Zhao, F.3    Villeneuve, N.F.4    Wu, T.5    Jiang, T.6    Sun, Z.7    White, E.8    Zhang, D.D.9
  • 57
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. 2008. Autophagy in the pathogenesis of disease. Cell 132: 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 58
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. 2010. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330: 1340-1344.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 59
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B, Mizushima N, Virgin HW. 2011. Autophagy in immunity and inflammation. Nature 469: 323-335.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 60
    • 79956224883 scopus 로고    scopus 로고
    • Targeting autophagy during cancer therapy to improve clinical outcomes
    • Levy JM, Thorburn A. 2011. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther 131: 130-141.
    • (2011) Pharmacol Ther , vol.131 , pp. 130-141
    • Levy, J.M.1    Thorburn, A.2
  • 62
    • 0031031041 scopus 로고    scopus 로고
    • The autophagic and endocytic pathways converge at the nascent autophagic vacuoles
    • Liou W, Geuze HJ, Geelen MJ, Slot JW. 1997. The autophagic and endocytic pathways converge at the nascent autophagic vacuoles. J Cell Biol 136: 61-70.
    • (1997) J Cell Biol , vol.136 , pp. 61-70
    • Liou, W.1    Geuze, H.J.2    Geelen, M.J.3    Slot, J.W.4
  • 64
    • 38149141767 scopus 로고    scopus 로고
    • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphoma-genesis
    • Maclean KH, Dorsey FC, Cleveland JL, Kastan MB. 2008. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphoma-genesis. J Clin Invest 118: 79-88.
    • (2008) J Clin Invest , vol.118 , pp. 79-88
    • Maclean, K.H.1    Dorsey, F.C.2    Cleveland, J.L.3    Kastan, M.B.4
  • 69
    • 79959999581 scopus 로고    scopus 로고
    • Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum
    • Mijaljica D, Prescott M, Devenish RJ. 2011. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 7: 673-682.
    • (2011) Autophagy , vol.7 , pp. 673-682
    • Mijaljica, D.1    Prescott, M.2    Devenish, R.J.3
  • 70
    • 4344712684 scopus 로고    scopus 로고
    • Methods for monitoring autophagy
    • Mizushima N. 2004. Methods for monitoring autophagy. Int J Biochem Cell Biol 36: 2491-2502.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2491-2502
    • Mizushima, N.1
  • 71
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T. 2007. How to interpret LC3 immunoblotting. Autophagy 3: 542-545.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 73
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. 2008. Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 74
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. 2010. Methods in mammalian autophagy research. Cell 140: 313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 76
    • 67649467294 scopus 로고    scopus 로고
    • Dynamics and diversity in autophagy mechanisms: Lessons from yeast
    • Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. 2009. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10: 458-467.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 458-467
    • Nakatogawa, H.1    Suzuki, K.2    Kamada, Y.3    Ohsumi, Y.4
  • 78
    • 77951227871 scopus 로고    scopus 로고
    • TOR-dependent control of autophagy: Biting the hand that feeds
    • Neufeld TP. 2010. TOR-dependent control of autophagy: biting the hand that feeds. Curr Opin Cell Biol 22: 157-168.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 157-168
    • Neufeld, T.P.1
  • 79
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW. 2007. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 204: 25-31.
    • (2007) J Exp Med , vol.204 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.W.5
  • 81
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD, White E. 2010. Autophagy and metabolism. Science 330: 1344-1348.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 82
    • 65349155174 scopus 로고    scopus 로고
    • Early endosomes and endo-somal coatomer are required for autophagy
    • Razi M, Chan EY, Tooze SA. 2009. Early endosomes and endo-somal coatomer are required for autophagy. J Cell Biol 185: 305-321.
    • (2009) J Cell Biol , vol.185 , pp. 305-321
    • Razi, M.1    Chan, E.Y.2    Tooze, S.A.3
  • 85
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141: 290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 86
    • 34848920863 scopus 로고    scopus 로고
    • ROS, mitochondria and the regulation of autophagy
    • Scherz-Shouval R, Elazar Z. 2007. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 17: 422-427.
    • (2007) Trends Cell Biol , vol.17 , pp. 422-427
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 87
    • 78650890352 scopus 로고    scopus 로고
    • Regulation of autophagy by ROS: Physiology and pathology
    • Scherz-Shouval R, Elazar Z. 2011. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 36: 30- 38.
    • (2011) Trends Biochem Sci , vol.36 , pp. 30-38
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 88
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. 2011. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331: 1565-1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 89
    • 79955961530 scopus 로고    scopus 로고
    • Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo
    • Sheen JH, Zoncu R, Kim D, Sabatini DM. 2011. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell 19: 613-628.
    • (2011) Cancer Cell , vol.19 , pp. 613-628
    • Sheen, J.H.1    Zoncu, R.2    Kim, D.3    Sabatini, D.M.4
  • 91
    • 70349919804 scopus 로고    scopus 로고
    • Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
    • Simonsen A, Tooze SA. 2009. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol 186: 773-782.
    • (2009) J Cell Biol , vol.186 , pp. 773-782
    • Simonsen, A.1    Tooze, S.A.2
  • 92
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector Beclin 1: A novel BH3-only protein
    • doi: 10.1038/ onc.2009.51
    • Sinha S, Levine B. 2008. The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 27: S137-S148. doi: 10.1038/ onc.2009.51.
    • (2008) Oncogene , vol.27
    • Sinha, S.1    Levine, B.2
  • 95
    • 0027771665 scopus 로고
    • Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis-a cross sectional study
    • Tett SE, Day RO, Cutler DJ. 1993. Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis-a cross sectional study. J Rheumatol 20: 1874-1879.
    • (1993) J Rheumatol , vol.20 , pp. 1874-1879
    • Tett, S.E.1    Day, R.O.2    Cutler, D.J.3
  • 96
    • 61649086413 scopus 로고    scopus 로고
    • Regulation of HMGB1 release by autophagy
    • Thorburn J, Frankel AE, Thorburn A. 2009a. Regulation of HMGB1 release by autophagy. Autophagy 5: 247-249.
    • (2009) Autophagy , vol.5 , pp. 247-249
    • Thorburn, J.1    Frankel, A.E.2    Thorburn, A.3
  • 98
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander-Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 99
    • 79960401862 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    • Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. 2011. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 25: 1510-1527.
    • (2011) Genes Dev , vol.25 , pp. 1510-1527
    • Wei, H.1    Wei, S.2    Gan, B.3    Peng, X.4    Zou, W.5    Guan, J.L.6
  • 101
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: A new therapeutic target in cancer
    • Wise DR, Thompson CB. 2010. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci 35: 427-433.
    • (2010) Trends Biochem Sci , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 103
    • 79952585579 scopus 로고    scopus 로고
    • Integration of clearance mechanisms: The proteasome and autophagy
    • doi: 10.1101.cshperspect.a006734
    • Wong E, Cuervo AM. 2010. Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb Perspect Biol 2: a006734. doi: 10.1101.cshperspect.a006734.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Wong, E.1    Cuervo, A.M.2
  • 105
    • 79961116194 scopus 로고    scopus 로고
    • A critical role for autophagy in pancreatic cancer
    • Yang S, Kimmelman AC. 2011. A critical role for autophagy in pancreatic cancer. Autophagy 7: 912-913.
    • (2011) Autophagy , vol.7 , pp. 912-913
    • Yang, S.1    Kimmelman, A.C.2
  • 106
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macro-autophagy
    • Yang Z, Klionsky DJ. 2010a. Eaten alive: a history of macro-autophagy. Nat Cell Biol 12: 814-822.
    • (2010) Nat Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 107
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ. 2010b. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 110
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N. 2003. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci 100: 15077-15082.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.