Tanshinone IIA induces autophagic cell death via activation of ampk and erk and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells

Phytotherapy Research

Volumn 28, Issue 3, 2014, Pages 458-464

  Yun, Sun Mi ^a   Jung, Ji Hoon ^a   Jeong, Soo Jin ^a,b   Sohn, Eun Jung ^a   Kim, Bonglee ^a   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Basic Herbal Research Group Korea Institute of Korean Medicine   (South Korea)

Author keywords

AMPK; autophagy; ERK; LC3 II; mTOR; p70 S6K; tanshinone IIA

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 3 METHYLADENINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN LC3; PROTEIN P90; RAF PROTEIN; S6 KINASE; TANSHINONE IIA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CHRONIC MYELOID LEUKEMIA; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEUKEMIA CELL LINE; LUNG CANCER; MOLECULAR MECHANICS; MULTIPLE MYELOMA; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

MAMMALIA;

AMPK; AUTOPHAGY; ERK; LC3 II; MTOR; P70 S6K; TANSHINONE IIA;

ADENINE; AMP-ACTIVATED PROTEIN KINASES; AUTOPHAGY; CELL LINE, TUMOR; DITERPENES, ABIETANE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LEUKEMIA; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TOR SERINE-THREONINE KINASES;

EID: 84895803565     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5015     Document Type: Article

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