Cytoprotective and nonprotective autophagy in cancer therapy

Autophagy

Volumn 9, Issue 9, 2013, Pages 1263-1265

  Gewirtz, David A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Chemosensitization; Chloroquine; Cytoprotective autophagy; Cytotoxic autophagy; Nonprotective autophagy; Radiosensitization

Indexed keywords

3 METHYLADENINE; AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BAFILOMYCIN; CHLOROQUINE; CISPLATIN; ERLOTINIB; FREE RADICAL; HYDROXYCHLOROQUINE; MONOCARBOXYLATE TRANSPORTER 2; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOPHAGY; BREAST CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER THERAPY; CELL DEATH; CELL METABOLISM; CELL PROTECTION; CELL SURVIVAL; CHEMOSENSITIZATION; CLINICAL TRIAL (TOPIC); COLONY FORMING UNIT; COLORECTAL CANCER; DRUG BLOOD LEVEL; HUMAN; LUNG SMALL CELL CANCER; NONHUMAN; RADIOSENSITIZATION; REVIEW; TREATMENT RESPONSE; TUMOR CELL; TUMOR GROWTH;

CHEMOSENSITIZATION; CHLOROQUINE; CYTOPROTECTIVE AUTOPHAGY; CYTOTOXIC AUTOPHAGY; NONPROTECTIVE AUTOPHAGY; RADIOSENSITIZATION;

ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; CHLOROQUINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; HUMANS; NEOPLASMS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84884340172     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.25233     Document Type: Review

References (15)

1. www.clinicaltrials.gov
2. Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 2008; 13: 1-9; PMID:17990121; http://dx.doi.org/10.1007/s10495-007-0154-9
3. Rouschop KM, Ramaekers CH, Schaaf MB, Keulers TG, Savelkouls KG, Lambin P, et al. Autophagy is required during cycling hypoxia to lower production of reactive oxygen species. Radiother Oncol 2009; 92: 411-6; PMID:19616335; http://dx.doi.org/10.1016/j.radonc.2009.06.029
4. Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-dehydroxy-curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS One 2013; 8:e53664; PMID:23326480; http://dx.doi.org/10.1371/journal.pone.0053664
5. Huo HZ, Wang B, Qin J, Guo SY, Liu WY, Gu Y. AMP-activated protein kinase (AMPK)/Ulk1- dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells. Mol Cell Biochem 2013; 378: 171-81; PMID:23508272; http://dx.doi.org/10.1007/s11010-013-1608-8
6. Chen W, Feng L, Nie H, Zheng X. Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore. Carcinogenesis 2012; 33: 2190-8; PMID:22869602; http://dx.doi.org/10.1093/carcin/bgs264
7. Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther 2013; 344: 544- 52; PMID:23291713; http://dx.doi.org/10.1124/jpet.112.199802
8. Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 2012; 8: 200-12; PMID:22252008; http://dx.doi.org/10.4161/ auto.8.2.18554
9. Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, et al. The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? J Pharmacol Exp Ther 2012; 343: 763- 78; PMID:22927544; http://dx.doi.org/10.1124/jpet.112.197590
10. Lee I, Lee S-J, Kang WK, Park C. Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo. Mol Cancer Ther 2012; 11: 2342-51; PMID:22964484; http://dx.doi.org/10.1158/1535-7163.MCT-12-0488
11. Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, et al. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res 2012; 72: 1773-83; PMID:22447568; http://dx.doi.org/10.1158/0008-5472.CAN-11-3831
12. Munster T, Gibbs JP, Shen D, Baethge BA, Botstein GR, Caldwell J, et al. Hydroxychloroquine concentration- response relationships in patients with rheumatoid arthritis. Arthritis Rheum 2002; 46: 1460- 9; PMID:12115175; http://dx.doi.org/10.1002/art.10307 (Pubitemid 34620191)
13. Zinn RL, Gardner EE, Dobromilskaya I, Murphy S, Marchionni L, Hann CL, et al. Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Mol Cancer 2013; 12: 16; PMID:23452820; http://dx.doi.org/10.1186/1476- 4598-12-16
14. Zou Y, Ling YH, Sironi J, Schwartz EL, Perez-Soler R, Piperdi B. The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to Erlotinib. J Thorac Oncol 2013; 8: 693-702; PMID:23575415; http://dx.doi.org/10.1097/JTO.0b013e31828c7210
15. McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, et al. Autophagy inhibitor Lys05 has singleagent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A 2012; 109: 8253-8; PMID:22566612; http://dx.doi.org/10.1073/pnas.1118193109