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Volumn 2015, Issue 3, 2015, Pages

Obesity genetics in mouse and human: Back and forth, and back again

Author keywords

Genetics; Genome wide association study; Human; Integrative biology; Knock out; Monogenic obesity; Mouse; Next generation sequencing; Polygenic obesity; Transgenic

Indexed keywords

ADAPTOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CHLORAMBUCIL; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; ETHYLNITROSOUREA; ETS VARIANT 5; LENTIVIRUS VECTOR; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; PROTEIN; SINGLE MINDED HOMOLOG 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84926681615     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.856     Document Type: Article
Times cited : (137)

References (314)
  • 1
    • 0036201581 scopus 로고    scopus 로고
    • Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites
    • Abney M, Ober C, McPeek MS. 2002. Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites. American Journal of Human Genetics 70(4):920-934 DOI 10.1086/339705.
    • (2002) American Journal of Human Genetics , vol.70 , Issue.4 , pp. 920-934
    • Abney, M.1    Ober, C.2    McPeek, M.S.3
  • 5
    • 84885011484 scopus 로고    scopus 로고
    • Gene × environment interactions in obesity: the state of the evidence
    • Ahmad S, Varga T, Franks P. 2013. Gene × environment interactions in obesity: the state of the evidence. Human Heredity 75:106-115 DOI 10.1159/000351070.
    • (2013) Human Heredity , vol.75 , pp. 106-115
    • Ahmad, S.1    Varga, T.2    Franks, P.3
  • 7
    • 16544378381 scopus 로고    scopus 로고
    • The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity
    • Allan MF, Eisen EJ, Pomp D. 2004. The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity. Obesity Research 12(9):1397-1407 DOI 10.1038/oby.2004.176.
    • (2004) Obesity Research , vol.12 , Issue.9 , pp. 1397-1407
    • Allan, M.F.1    Eisen, E.J.2    Pomp, D.3
  • 9
    • 69249208526 scopus 로고    scopus 로고
    • Gene-environment interactions and obesity-further aspects of genomewide association studies
    • Andreasen CH, Andersen G. 2009. Gene-environment interactions and obesity-further aspects of genomewide association studies. Nutrition (Burbank, Los Angeles County, Calif.) 25(10):998-1003 DOI 10.1016/j.nut.2009.06.001.
    • (2009) Nutrition (Burbank, Los Angeles County, Calif.) , vol.25 , Issue.10 , pp. 998-1003
    • Andreasen, C.H.1    Andersen, G.2
  • 17
    • 79960956111 scopus 로고    scopus 로고
    • Obesity in single gene disorder
    • New York: Academic Press
    • Beales P. 2010. Obesity in single gene disorder. In: Genes and obesity. New York: Academic Press, 125-147.
    • (2010) Genes and obesity , pp. 125-147
    • Beales, P.1
  • 19
    • 0022472986 scopus 로고
    • Biosynthetic fate of the amino-terminal fragment of pro-opiomelanocortin within the intermediate lobe of the mouse pituitary
    • Bennett HP. 1986. Biosynthetic fate of the amino-terminal fragment of pro-opiomelanocortin within the intermediate lobe of the mouse pituitary. Peptides 7(4):615-622 DOI 10.1016/0196-9781(86)90036-7.
    • (1986) Peptides , vol.7 , Issue.4 , pp. 615-622
    • Bennett, H.P.1
  • 24
    • 79751503682 scopus 로고    scopus 로고
    • News and views TALEs of genome targeting A mucosal gateway for vaccines
    • Boch J. 2011. News and views TALEs of genome targeting A mucosal gateway for vaccines. Nature Biotechnology 29(2):135-136 DOI 10.1038/nbt0211-135.
    • (2011) Nature Biotechnology , vol.29 , Issue.2 , pp. 135-136
    • Boch, J.1
  • 29
    • 0030678119 scopus 로고    scopus 로고
    • Independent and additive effects of central POMC and leptin pathways on murine obesity
    • Boston BA, Blaydon KM, Varnerin J, Cone RD. 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278(5343):1641-1644 DOI 10.1126/science.278.5343.1641.
    • (1997) Science , vol.278 , Issue.5343 , pp. 1641-1644
    • Boston, B.A.1    Blaydon, K.M.2    Varnerin, J.3    Cone, R.D.4
  • 31
  • 32
    • 0027049534 scopus 로고
    • Molecular characterization of the mouse agouti locus
    • Bultman SJ, Michaud EJ, Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-1204 DOI 10.1016/S0092-8674(05)80067-4.
    • (1992) Cell , vol.71 , Issue.7 , pp. 1195-1204
    • Bultman, S.J.1    Michaud, E.J.2    Woychik, R.P.3
  • 34
    • 77449101244 scopus 로고    scopus 로고
    • A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes
    • Butler A, Kozak LP. 2010. A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 59(2):323-329 DOI 10.2337/db09-1471.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 323-329
    • Butler, A.1    Kozak, L.P.2
  • 37
    • 79952110151 scopus 로고    scopus 로고
    • Mouse models for miRNA expression: the ROSA26 locus
    • Casola S. 2010. Mouse models for miRNA expression: the ROSA26 locus. Methods in Molecular Biology 667:145-163.
    • (2010) Methods in Molecular Biology , vol.667 , pp. 145-163
    • Casola, S.1
  • 44
    • 79956266403 scopus 로고    scopus 로고
    • Genetics of obesity: what have we learned?
    • Choquet H, Meyre D. 2011. Genetics of obesity: what have we learned? Current Genomics 12(3):169-179 DOI 10.2174/138920211795677895.
    • (2011) Current Genomics , vol.12 , Issue.3 , pp. 169-179
    • Choquet, H.1    Meyre, D.2
  • 48
    • 33846892749 scopus 로고    scopus 로고
    • The genetic landscape of type 2 diabetes in mice
    • Clee SM, Attie AD. 2007. The genetic landscape of type 2 diabetes in mice. Endocrine Reviews 28(1):48-83 DOI 10.1210/er.2006-0035.
    • (2007) Endocrine Reviews , vol.28 , Issue.1 , pp. 48-83
    • Clee, S.M.1    Attie, A.D.2
  • 51
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman DL. 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9(4):294-298 DOI 10.1007/BF01221857.
    • (1973) Diabetologia , vol.9 , Issue.4 , pp. 294-298
    • Coleman, D.L.1
  • 52
    • 0020045888 scopus 로고
    • Diabetes-obesity syndromes in mice
    • Coleman DL. 1982. Diabetes-obesity syndromes in mice. Diabetes 31:1-6 DOI 10.2337/diab.31.1.S1.
    • (1982) Diabetes , vol.31 , pp. 1-6
    • Coleman, D.L.1
  • 53
    • 0025627770 scopus 로고
    • Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse
    • Coleman DL, Eicher EM. 1990. Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. The Journal of Heredity 81(6):424-427.
    • (1990) The Journal of Heredity , vol.81 , Issue.6 , pp. 424-427
    • Coleman, D.L.1    Eicher, E.M.2
  • 54
    • 0014076277 scopus 로고
    • Studies with the mutation, diabetes, in the mouse
    • Coleman DL, Hummel KP. 1967. Studies with the mutation, diabetes, in the mouse. Diabetologia 3(2):238-248 DOI 10.1007/BF01222201.
    • (1967) Diabetologia , vol.3 , Issue.2 , pp. 238-248
    • Coleman, D.L.1    Hummel, K.P.2
  • 55
    • 0015864927 scopus 로고
    • The influence of genetic background on the expression of the obese
    • Coleman DL, Hummel K. 1973. The influence of genetic background on the expression of the obese. Diabetologia 9:287-293 DOI 10.1007/BF01221856.
    • (1973) Diabetologia , vol.9 , pp. 287-293
    • Coleman, D.L.1    Hummel, K.2
  • 58
    • 79952342793 scopus 로고    scopus 로고
    • Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity
    • Cox RD, Church CD. 2011. Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Disease Models and Mechanisms 4(2):155-164 DOI 10.1242/dmm.000414.
    • (2011) Disease Models and Mechanisms , vol.4 , Issue.2 , pp. 155-164
    • Cox, R.D.1    Church, C.D.2
  • 61
    • 0032030839 scopus 로고    scopus 로고
    • Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    • Crews ST. 1998. Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Genes and Development 12(5):607-620 DOI 10.1101/gad.12.5.607.
    • (1998) Genes and Development , vol.12 , Issue.5 , pp. 607-620
    • Crews, S.T.1
  • 62
    • 0028928596 scopus 로고
    • Obesity in heterozygous carriers of the gene for the Bardet-Biedl syndrome
    • Croft JB, Morrell D, Chase CL, Swift M. 1995. Obesity in heterozygous carriers of the gene for the Bardet-Biedl syndrome. American Journal of Medical Genetics 55(1):12-15 DOI 10.1002/ajmg.1320550105.
    • (1995) American Journal of Medical Genetics , vol.55 , Issue.1 , pp. 12-15
    • Croft, J.B.1    Morrell, D.2    Chase, C.L.3    Swift, M.4
  • 64
    • 33748474258 scopus 로고    scopus 로고
    • Current and future approaches using genetically modified mice in endocrine research
    • Davey RA, MacLean HE. 2006. Current and future approaches using genetically modified mice in endocrine research. American Journal of Physiology. Endocrinology and Metabolism 291:E429-E438 DOI 10.1152/ajpendo.00124.2006.
    • (2006) American Journal of Physiology. Endocrinology and Metabolism , vol.291 , pp. E429-E438
    • Davey, R.A.1    MacLean, H.E.2
  • 69
    • 0345257097 scopus 로고    scopus 로고
    • Studies of natural allele effects in mice can be used to identify genes causing common human obesity
    • Diament AL, Fisler JS, Warden CH. 2003. Studies of natural allele effects in mice can be used to identify genes causing common human obesity. Obesity Reviews 4(4):249-255 DOI 10.1046/j.1467-789X.2003.00113.x.
    • (2003) Obesity Reviews , vol.4 , Issue.4 , pp. 249-255
    • Diament, A.L.1    Fisler, J.S.2    Warden, C.H.3
  • 70
    • 0002426820 scopus 로고
    • A new viable yellow mutation in the house mouse
    • Dickies MM. 1962. A new viable yellow mutation in the house mouse. The Journal of Heredity 53:84-86.
    • (1962) The Journal of Heredity , vol.53 , pp. 84-86
    • Dickies, M.M.1
  • 74
    • 84867130076 scopus 로고    scopus 로고
    • Exome sequencing and complex disease: practical aspects of rare variant association studies
    • Do R, Kathiresan S, Abecasis GR. 2012. Exome sequencing and complex disease: practical aspects of rare variant association studies. Human Molecular Genetics 21(R1):R1-R9 DOI 10.1093/hmg/dds387.
    • (2012) Human Molecular Genetics , vol.21 , Issue.R1 , pp. R1-R9
    • Do, R.1    Kathiresan, S.2    Abecasis, G.R.3
  • 76
    • 84884692647 scopus 로고    scopus 로고
    • Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle
    • Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost H-G, Al-Hasani H. 2013. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology 154(10):3502-3514 DOI 10.1210/en.2012-2147.
    • (2013) Endocrinology , vol.154 , Issue.10 , pp. 3502-3514
    • Dokas, J.1    Chadt, A.2    Nolden, T.3    Himmelbauer, H.4    Zierath, J.R.5    Joost, H.-G.6    Al-Hasani, H.7
  • 77
    • 12744274524 scopus 로고    scopus 로고
    • Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance
    • Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID. 2005. Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes 54(2):367-372 DOI 10.2337/diabetes.54.2.367.
    • (2005) Diabetes , vol.54 , Issue.2 , pp. 367-372
    • Dong, H.1    Maddux, B.A.2    Altomonte, J.3    Meseck, M.4    Accili, D.5    Terkeltaub, R.6    Johnson, K.7    Youngren, J.F.8    Goldfine, I.D.9
  • 79
    • 38349151344 scopus 로고    scopus 로고
    • Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain
    • Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut M-L, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. 2008. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatric Research 63(2):211-216 DOI 10.1203/PDR.0b013e31815ed62b.
    • (2008) Pediatric Research , vol.63 , Issue.2 , pp. 211-216
    • Dubern, B.1    Lubrano-Berthelier, C.2    Mencarelli, M.3    Ersoy, B.4    Frelut, M.-L.5    Bouglé, D.6    Costes, B.7    Simon, C.8    Tounian, P.9    Vaisse, C.10    Clement, K.11
  • 80
    • 42249087793 scopus 로고    scopus 로고
    • Estimation of significance thresholds for genomewide association scans
    • Dudbridge F, Gusnanto A. 2008. Estimation of significance thresholds for genomewide association scans. Genetic Epidemiology 32(3):227-234 DOI 10.1002/gepi.20297.
    • (2008) Genetic Epidemiology , vol.32 , Issue.3 , pp. 227-234
    • Dudbridge, F.1    Gusnanto, A.2
  • 81
    • 0035016103 scopus 로고    scopus 로고
    • A major locus for fasting insulin concentrations insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans
    • Duggirala R, Blangero J, Almasy L, Arya R, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP. 2001. A major locus for fasting insulin concentrations insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. American Journal of Human Genetics 68(5):1149-1164 DOI 10.1086/320100.
    • (2001) American Journal of Human Genetics , vol.68 , Issue.5 , pp. 1149-1164
    • Duggirala, R.1    Blangero, J.2    Almasy, L.3    Arya, R.4    Dyer, T.D.5    Williams, K.L.6    Leach, R.J.7    O'Connell, P.8    Stern, M.P.9
  • 83
    • 33847702915 scopus 로고    scopus 로고
    • Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N, N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro
    • Efthimiou M, Andrianopoulos C, Stephanou G, Demopoulos NA, Nikolaropoulos SS. 2007. Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N, N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro. Mutation Research 617(1-2):125-137 DOI 10.1016/j.mrfmmm.2007.01.009.
    • (2007) Mutation Research , vol.617 , Issue.1-2 , pp. 125-137
    • Efthimiou, M.1    Andrianopoulos, C.2    Stephanou, G.3    Demopoulos, N.A.4    Nikolaropoulos, S.S.5
  • 85
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411(6836):494-498 DOI 10.1038/35078107.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 87
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson JC, Hollopeter G, Palmiter RD. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274(5293):1704-1707 DOI 10.1126/science.274.5293.1704.
    • (1996) Science , vol.274 , Issue.5293 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 88
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erikson J, Clegg K, Palmiter R. 1996. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-421 DOI 10.1038/381415a0.
    • (1996) Nature , vol.381 , pp. 415-421
    • Erikson, J.1    Clegg, K.2    Palmiter, R.3
  • 92
  • 94
    • 52449123919 scopus 로고    scopus 로고
    • Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity
    • Farooqi IS, O'Rahilly S. 2008. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nature Reviews Endocrinology 4:569-577.
    • (2008) Nature Reviews Endocrinology , vol.4 , pp. 569-577
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 98
    • 48749098611 scopus 로고    scopus 로고
    • Genetic architecture of adiposity and organ weight using combined generation QTL analysis
    • Fawcett GL, Roseman CC, Jarvis JP, Wang B, Wolf JB, Cheverud JM. 2008. Genetic architecture of adiposity and organ weight using combined generation QTL analysis. Obesity 16(8):1861-1868 DOI 10.1038/oby.2008.300.
    • (2008) Obesity , vol.16 , Issue.8 , pp. 1861-1868
    • Fawcett, G.L.1    Roseman, C.C.2    Jarvis, J.P.3    Wang, B.4    Wolf, J.B.5    Cheverud, J.M.6
  • 100
    • 0000184456 scopus 로고
    • BSB: a new mouse model of multigenic obesity
    • Fisler JS, Warden CH, Pace MJ, Lusis AJ. 1993. BSB: a new mouse model of multigenic obesity. Obesity Research 1(4):271-280 DOI 10.1002/j.1550-8528.1993.tb00621.x.
    • (1993) Obesity Research , vol.1 , Issue.4 , pp. 271-280
    • Fisler, J.S.1    Warden, C.H.2    Pace, M.J.3    Lusis, A.J.4
  • 101
    • 84867743261 scopus 로고    scopus 로고
    • Genome wide association studies in mice
    • Flint J, Eskin E. 2013. Genome wide association studies in mice. Nature Reviews Genetics 13(11):807-817 DOI 10.1038/nrg3335.
    • (2013) Nature Reviews Genetics , vol.13 , Issue.11 , pp. 807-817
    • Flint, J.1    Eskin, E.2
  • 104
    • 84926643990 scopus 로고    scopus 로고
    • Interaction between physical activity and genetic factors in complex metabolic disease
    • New York: Nova Publishers
    • Franks PW, Roth SM. 2008. Interaction between physical activity and genetic factors in complex metabolic disease. In: Physical activity and genetic factors in complex metabolic disease. New York: Nova Publishers, 155-173.
    • (2008) Physical activity and genetic factors in complex metabolic disease , pp. 155-173
    • Franks, P.W.1    Roth, S.M.2
  • 107
    • 20444458686 scopus 로고    scopus 로고
    • A dominant negative peroxisome proliferatoractivated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome
    • Freedman BD, Lee E-J, Park Y, Jameson JL. 2005. A dominant negative peroxisome proliferatoractivated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. The Journal of Biological Chemistry 280(17):17118-17125 DOI 10.1074/jbc. M407539200.
    • (2005) The Journal of Biological Chemistry , vol.280 , Issue.17 , pp. 17118-17125
    • Freedman, B.D.1    Lee, E.-J.2    Park, Y.3    Jameson, J.L.4
  • 111
  • 113
    • 0019847283 scopus 로고
    • Integration and stable germ line transmission of genes injected into mouse pronuclei
    • Gordon JW, Ruddle FH. 1981. Integration and stable germ line transmission of genes injected into mouse pronuclei. Science 214(4526):1244-1246 DOI 10.1126/science.6272397.
    • (1981) Science , vol.214 , Issue.4526 , pp. 1244-1246
    • Gordon, J.W.1    Ruddle, F.H.2
  • 119
    • 0019845629 scopus 로고
    • Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal
    • Harbers K, Jahner D, Jaenisch R. 1981. Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature 293:540-544 DOI 10.1038/293540a0.
    • (1981) Nature , vol.293 , pp. 540-544
    • Harbers, K.1    Jahner, D.2    Jaenisch, R.3
  • 121
    • 0017349397 scopus 로고
    • Laboratory animals exhibiting obesity and diabetes syndromes
    • Herberg L, Coleman DL. 1977. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism: Clinical and Experimental 26(1):59-99 DOI 10.1016/0026-0495(77)90128-7.
    • (1977) Metabolism: Clinical and Experimental , vol.26 , Issue.1 , pp. 59-99
    • Herberg, L.1    Coleman, D.L.2
  • 122
    • 0032577404 scopus 로고    scopus 로고
    • Environmental contributions to the obesity epidemic
    • Hill J. 1998. Environmental contributions to the obesity epidemic. Science 280:1371-1374 DOI 10.1126/science.280.5368.1371.
    • (1998) Science , vol.280 , pp. 1371-1374
    • Hill, J.1
  • 126
    • 0034016043 scopus 로고    scopus 로고
    • Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
    • Holder JL, Butte NF, Zinn AR. 2000. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Human Molecular Genetics 9(1):101-108 DOI 10.1093/hmg/9.1.101.
    • (2000) Human Molecular Genetics , vol.9 , Issue.1 , pp. 101-108
    • Holder, J.L.1    Butte, N.F.2    Zinn, A.R.3
  • 129
    • 84892492069 scopus 로고    scopus 로고
    • Testing gene-gene interactions in genome wide association studies
    • Hu JK, Wang X, Wang P. 2014. Testing gene-gene interactions in genome wide association studies. Genetic Epidemiology 38(2):123-134 DOI 10.1002/gepi.21786.
    • (2014) Genetic Epidemiology , vol.38 , Issue.2 , pp. 123-134
    • Hu, J.K.1    Wang, X.2    Wang, P.3
  • 130
    • 84873708995 scopus 로고    scopus 로고
    • Development of hybrid viral vectors for gene therapy
    • Huang S, Kamihira M. 2013. Development of hybrid viral vectors for gene therapy. Biotechnology Advances 31(2):208-223 DOI 10.1016/j.biotechadv.2012.10.001.
    • (2013) Biotechnology Advances , vol.31 , Issue.2 , pp. 208-223
    • Huang, S.1    Kamihira, M.2
  • 131
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • Hummel KP, Dickie MM, Coleman DL. 1966. Diabetes, a new mutation in the mouse. Science 153(3740):1127-1128 DOI 10.1126/science.153.3740.1127.
    • (1966) Science , vol.153 , Issue.3740 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 134
    • 0032446191 scopus 로고    scopus 로고
    • Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain
    • Igel M, Taylor BA, Phillips SJ, Becker W, Herberg L, Joost HG. 1998. Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain. Journal of Molecular Endocrinology 21(3):337-345 DOI 10.1677/jme.0.0210337.
    • (1998) Journal of Molecular Endocrinology , vol.21 , Issue.3 , pp. 337-345
    • Igel, M.1    Taylor, B.A.2    Phillips, S.J.3    Becker, W.4    Herberg, L.5    Joost, H.G.6
  • 140
    • 78650527923 scopus 로고    scopus 로고
    • Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance
    • Jelinek D, Millward V, Birdi A, Trouard TP, Heidenreich RA, GarverWS. 2010. Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance. Human Molecular Genetics 20(2):312-321 DOI 10.1093/hmg/ddq466.
    • (2010) Human Molecular Genetics , vol.20 , Issue.2 , pp. 312-321
    • Jelinek, D.1    Millward, V.2    Birdi, A.3    Trouard, T.P.4    Heidenreich, R.A.5    Garver, W.S.6
  • 141
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. 2012. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816-821 DOI 10.1126/science.1225829.
    • (2012) Science , vol.337 , Issue.6096 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3    Hauer, M.4    Doudna, J.A.5    Charpentier, E.6
  • 142
    • 0034331003 scopus 로고    scopus 로고
    • Capitalizing on large-scale mouse mutagenesis screens
    • Justice MJ. 2000. Capitalizing on large-scale mouse mutagenesis screens. Nature Reviews. Genetics 1(2):109-115 DOI 10.1038/35038549.
    • (2000) Nature Reviews. Genetics , vol.1 , Issue.2 , pp. 109-115
    • Justice, M.J.1
  • 144
    • 77954261766 scopus 로고    scopus 로고
    • Identification of body fat mass as a major determinant of metabolic rate in mice
    • Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse B, Schwartz MW. 2010. Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59(7):1657-1666 DOI 10.2337/db09-1582.
    • (2010) Diabetes , vol.59 , Issue.7 , pp. 1657-1666
    • Kaiyala, K.J.1    Morton, G.J.2    Leroux, B.G.3    Ogimoto, K.4    Wisse, B.5    Schwartz, M.W.6
  • 145
    • 79952216996 scopus 로고    scopus 로고
    • Biology of obesity: lessons from animal models of obesity
    • Kanasaki K, Koya D. 2011. Biology of obesity: lessons from animal models of obesity. Journal of Biomedicine and Biotechnology 2011:1-11 DOI 10.1155/2011/197636.
    • (2011) Journal of Biomedicine and Biotechnology , vol.2011 , pp. 1-11
    • Kanasaki, K.1    Koya, D.2
  • 147
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie SG, Liebl DJ, Parada LF. 2000. BDNF regulates eating behavior and locomotor activity in mice. The EMBO Journal 19(6):1290-1300 DOI 10.1093/emboj/19.6.1290.
    • (2000) The EMBO Journal , vol.19 , Issue.6 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 149
    • 84857051743 scopus 로고    scopus 로고
    • Effective weight management practice: a review of the lifestyle intervention evidence
    • Kirk SFL, Penney TL, Mchugh T-LF, Sharma AM. 2012. Effective weight management practice: a review of the lifestyle intervention evidence. International Journal of Obesity 36(2):178-185 DOI 10.1038/ijo.2011.80.
    • (2012) International Journal of Obesity , vol.36 , Issue.2 , pp. 178-185
    • Kirk, S.F.L.1    Penney, T.L.2    Mchugh, T-L.F.3    Sharma, A.M.4
  • 155
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A. 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics 19(2):155-157 DOI 10.1038/509.
    • (1998) Nature Genetics , vol.19 , Issue.2 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Grüters, A.6
  • 157
    • 33748742610 scopus 로고    scopus 로고
    • Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
    • Kublaoui BM, Holder JL, Gemelli T, Zinn AR. 2006. Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons. Molecular Endocrinology 20(10):2483-2492 DOI 10.1210/me.2005-0483.
    • (2006) Molecular Endocrinology , vol.20 , Issue.10 , pp. 2483-2492
    • Kublaoui, B.M.1    Holder, J.L.2    Gemelli, T.3    Zinn, A.R.4
  • 158
    • 0036359284 scopus 로고    scopus 로고
    • Cre/loxp recombination system and gene targeting. In: Clarke A, ed. Methods in molecular biology
    • 2nd ed. Totowa: Humana Press Inc.
    • Kühn R, Torres R. 2002. Cre/loxp recombination system and gene targeting. In: Clarke A, ed. Methods in molecular biology. 2nd ed. Totowa: Humana Press Inc., 175-204.
    • (2002) , pp. 175-204
    • Kühn, R.1    Torres, R.2
  • 159
    • 0023239442 scopus 로고
    • Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children
    • Lander ES, Botstein D. 1987. Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science 236(4808):1567-1570 DOI 10.1126/science.2884728.
    • (1987) Science , vol.236 , Issue.4808 , pp. 1567-1570
    • Lander, E.S.1    Botstein, D.2
  • 160
  • 162
    • 79953752197 scopus 로고    scopus 로고
    • Use of mouse models in studying type 2 diabetes mellitus
    • Lee AWS, Cox RD. 2011. Use of mouse models in studying type 2 diabetes mellitus. Expert Reviews in Molecular Medicine 13(January):e1 DOI 10.1017/S1462399410001729.
    • (2011) Expert Reviews in Molecular Medicine , vol.13 , Issue.JANUARY
    • Lee, A.W.S.1    Cox, R.D.2
  • 165
    • 84865570079 scopus 로고    scopus 로고
    • Viral vectors for gene delivery to the central nervous system
    • Lentz TB, Gray SJ, Samulski RJ. 2012. Viral vectors for gene delivery to the central nervous system. Neurobiology of Disease 48(2):179-188 DOI 10.1016/j.nbd.2011.09.014.
    • (2012) Neurobiology of Disease , vol.48 , Issue.2 , pp. 179-188
    • Lentz, T.B.1    Gray, S.J.2    Samulski, R.J.3
  • 166
    • 84876176442 scopus 로고    scopus 로고
    • Challenges in reproducibility of genetic association studies: lessons learned from the obesity field
    • Li A, Meyre D. 2013. Challenges in reproducibility of genetic association studies: lessons learned from the obesity field. International Journal of Obesity (2005) 37(4):559-567 DOI 10.1038/ijo.2012.82.
    • (2013) International Journal of Obesity (2005) , vol.37 , Issue.4 , pp. 559-567
    • Li, A.1    Meyre, D.2
  • 167
    • 84904737042 scopus 로고    scopus 로고
    • Jumping on the train of personalized medicine: a primer for non-geneticist clinicians: Part 2
    • Li A, Meyre D. 2014. Jumping on the train of personalized medicine: a primer for non-geneticist clinicians: Part 2. Fundamental concepts in genetic epidemiology. Current Psychiatry Reviews 10(2):101-117 DOI 10.2174/1573400510666140319235334.
    • (2014) Fundamental concepts in genetic epidemiology. Current Psychiatry Reviews , vol.10 , Issue.2 , pp. 101-117
    • Li, A.1    Meyre, D.2
  • 169
    • 77956798214 scopus 로고    scopus 로고
    • Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study
    • Li S, Zhao JH, Luan Jian'an, Ekelund U, Luben RN, Khaw K-T, Wareham NJ, Loos RJF. 2010. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Medicine 7(8):1-9 DOI 10.1371/journal.pmed.1000332.
    • (2010) PLoS Medicine , vol.7 , Issue.8 , pp. 1-9
    • Li, S.1    Zhao, J.H.2    Jian'an, L.3    Ekelund, U.4    Luben, R.N.5    Khaw, K.-T.6    Wareham, N.J.7    Loos, R.J.F.8
  • 170
  • 172
    • 33744763342 scopus 로고    scopus 로고
    • Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
    • Lloyd DJ, Bohan S, Gekakis N. 2006. Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Human Molecular Genetics 15(11):1884-1893 DOI 10.1093/hmg/ddl111.
    • (2006) Human Molecular Genetics , vol.15 , Issue.11 , pp. 1884-1893
    • Lloyd, D.J.1    Bohan, S.2    Gekakis, N.3
  • 174
    • 84902532338 scopus 로고    scopus 로고
    • Timed deletion of twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning
    • Loebel DAF, Hor ACC, Bildsoe HK, Tam PPL. 2014. Timed deletion of twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning. PLoS ONE 9(6):e98945 DOI 10.1371/journal.pone.0098945.
    • (2014) PLoS ONE , vol.9 , Issue.6
    • Loebel, D.A.F.1    Hor, A.C.C.2    Bildsoe, H.K.3    Tam, P.P.L.4
  • 175
    • 61349130027 scopus 로고    scopus 로고
    • Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance
    • Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G. 2009. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 457(7233):1146-1149 DOI 10.1038/nature07617.
    • (2009) Nature , vol.457 , Issue.7233 , pp. 1146-1149
    • Luan, B.1    Zhao, J.2    Wu, H.3    Duan, B.4    Shu, G.5    Wang, X.6    Li, D.7    Jia, W.8    Kang, J.9    Pei, G.10
  • 176
    • 84890562372 scopus 로고    scopus 로고
    • Epistasis and quantitative traits: using model organisms to study gene-gene interactions
    • MacKay T. 2014. Epistasis and quantitative traits: using model organisms to study gene-gene interactions. Nature Reviews Genetics 15(1):22-33 DOI 10.1038/nrg3627.
    • (2014) Nature Reviews Genetics , vol.15 , Issue.1 , pp. 22-33
    • MacKay, T.1
  • 177
    • 67651108806 scopus 로고    scopus 로고
    • The genetics of quantitative traits: challenges and prospects
    • Mackay TFC, Stone EA, Ayroles JF. 2009. The genetics of quantitative traits: challenges and prospects. Nature Reviews. Genetics 10(8):565-577 DOI 10.1038/nrg2612.
    • (2009) Nature Reviews. Genetics , vol.10 , Issue.8 , pp. 565-577
    • Mackay, T.F.C.1    Stone, E.A.2    Ayroles, J.F.3
  • 179
    • 0033957339 scopus 로고    scopus 로고
    • Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit
    • Maddux BA, Goldfin ID. 2000. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 49(15):13-19 DOI 10.2337/diabetes.49.1.13.
    • (2000) Diabetes , vol.49 , Issue.15 , pp. 13-19
    • Maddux, B.A.1    Goldfin, I.D.2
  • 183
    • 0343628721 scopus 로고    scopus 로고
    • Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin
    • May C, Rivella S, Callegari J, Heller G, Gaensler KM, Luzzatto L, Sadelain M. 2000. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature 406(6791):82-86 DOI 10.1038/35017565.
    • (2000) Nature , vol.406 , Issue.6791 , pp. 82-86
    • May, C.1    Rivella, S.2    Callegari, J.3    Heller, G.4    Gaensler, K.M.5    Luzzatto, L.6    Sadelain, M.7
  • 184
    • 67649908458 scopus 로고    scopus 로고
    • A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient
    • Mazen I, El-Gammal M, Abdel-Hamid M, Amr K. 2009. A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient. Molecular Genetics and Metabolism 97(4):305-308 DOI 10.1016/j.ymgme.2009.04.002.
    • (2009) Molecular Genetics and Metabolism , vol.97 , Issue.4 , pp. 305-308
    • Mazen, I.1    El-Gammal, M.2    Abdel-Hamid, M.3    Amr, K.4
  • 189
    • 84884717093 scopus 로고    scopus 로고
    • Engineering subtle targeted mutations into the mouse genome
    • Menke DB. 2013. Engineering subtle targeted mutations into the mouse genome. Genesis 51(9):605-618 DOI 10.1002/dvg.22422.
    • (2013) Genesis , vol.51 , Issue.9 , pp. 605-618
    • Menke, D.B.1
  • 193
    • 1442349990 scopus 로고    scopus 로고
    • A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2
    • Meyre D, Lecoeur C, Delplanque J, Francke S, Vatin V, Durand E, Weill J, Dina C, Froguel P. 2004. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 53(3):803-811 DOI 10.2337/diabetes.53.3.803.
    • (2004) Diabetes , vol.53 , Issue.3 , pp. 803-811
    • Meyre, D.1    Lecoeur, C.2    Delplanque, J.3    Francke, S.4    Vatin, V.5    Durand, E.6    Weill, J.7    Dina, C.8    Froguel, P.9
  • 195
    • 0033989154 scopus 로고    scopus 로고
    • ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus
    • Michaud JL, DeRossi C, May NR, Holdener BC, Fan CM. 2000. ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mechanisms of Development 90(2):253-261 DOI 10.1016/S0925-4773(99)00328-7.
    • (2000) Mechanisms of Development , vol.90 , Issue.2 , pp. 253-261
    • Michaud, J.L.1    DeRossi, C.2    May, N.R.3    Holdener, B.C.4    Fan, C.M.5
  • 196
    • 0032532480 scopus 로고    scopus 로고
    • Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
    • Michaud JL, Rosenquist T, May NR, Fan CM. 1998. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes and Development 12(20):3264-3275 DOI 10.1101/gad.12.20.3264.
    • (1998) Genes and Development , vol.12 , Issue.20 , pp. 3264-3275
    • Michaud, J.L.1    Rosenquist, T.2    May, N.R.3    Fan, C.M.4
  • 197
    • 0027256438 scopus 로고
    • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
    • Miller MW, Duhl DM, Vrieling H, Cordes SP, Ollmann MM, Winkes BM, Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes and Development 7(3):454-467 DOI 10.1101/gad.7.3.454.
    • (1993) Genes and Development , vol.7 , Issue.3 , pp. 454-467
    • Miller, M.W.1    Duhl, D.M.2    Vrieling, H.3    Cordes, S.P.4    Ollmann, M.M.5    Winkes, B.M.6    Barsh, G.S.7
  • 198
    • 55849137212 scopus 로고    scopus 로고
    • Obesity and the metabolic syndrome in developing countries
    • Misra A, Khurana L. 2008. Obesity and the metabolic syndrome in developing countries. The Journal of Clinical Endocrinology and Metabolism 93(11 Suppl 1):S9-S30 DOI 10.1210/jc.2008-1595.
    • (2008) The Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.11 , pp. S9-S30
    • Misra, A.1    Khurana, L.2
  • 199
    • 80051548381 scopus 로고    scopus 로고
    • Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight
    • Mollah MBR, Ishikawa A. 2011. Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight. Mammalian Genome: Official Journal of the International Mammalian Genome Society 22(5-6):282-289 DOI 10.1007/s00335-011-9323-9.
    • (2011) Mammalian Genome: Official Journal of the International Mammalian Genome Society , vol.22 , Issue.5-6 , pp. 282-289
    • Mollah, M.B.R.1    Ishikawa, A.2
  • 204
    • 0034054962 scopus 로고    scopus 로고
    • Analysing complex genetic traits with chromosome substitution strains
    • Nadeau JH, Singer JB, Matin A, Lander ES. 2000. Analysing complex genetic traits with chromosome substitution strains. Nature 24:221-225.
    • (2000) Nature , vol.24 , pp. 221-225
    • Nadeau, J.H.1    Singer, J.B.2    Matin, A.3    Lander, E.S.4
  • 208
    • 58149359144 scopus 로고    scopus 로고
    • Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions
    • O'Rahilly S, Farooqi IS. 2008. Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions. Diabetes 57(11):2905-2910 DOI 10.2337/db08-0210.
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 2905-2910
    • O'Rahilly, S.1    Farooqi, I.S.2
  • 213
    • 0037279626 scopus 로고    scopus 로고
    • One hundred years of mouse genetics: an intellectual history I. The classical period (1902-1980).
    • Paigen K. 2003. One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980). Genetics 163:1-7.
    • (2003) Genetics , vol.163 , pp. 1-7
    • Paigen, K.1
  • 220
    • 40949141148 scopus 로고    scopus 로고
    • Natural polygenic models
    • New York: C.R.C Press
    • Pomp D. 2007. Natural polygenic models. In: Obesity: genomics and postgenomics. New York: CRC Press, 125-142.
    • (2007) Obesity: genomics and postgenomics , pp. 125-142
    • Pomp, D.1
  • 226
    • 40549136002 scopus 로고    scopus 로고
    • Reduced body weight is a common effect of gene knockout in mice
    • Reed DR, Lawler MP, Tordoff MG. 2008. Reduced body weight is a common effect of gene knockout in mice. BMC Genetics 9(4) DOI 10.1186/1471-2156-9-4.
    • (2008) BMC Genetics , vol.9 , Issue.4
    • Reed, D.R.1    Lawler, M.P.2    Tordoff, M.G.3
  • 228
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • Ren D, Li M, Duan C, Rui L. 2005. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metabolism 2(2):95-104 DOI 10.1016/j.cmet.2005.07.004.
    • (2005) Cell Metabolism , vol.2 , Issue.2 , pp. 95-104
    • Ren, D.1    Li, M.2    Duan, C.3    Rui, L.4
  • 230
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity hyperactivity
    • Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R, Lechan RM, Jaenisch R. 2001. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity hyperactivity. Molecular Endocrinology 15(10):1748-1757 DOI 10.1210/mend.15.10.0706.
    • (2001) Molecular Endocrinology , vol.15 , Issue.10 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3    Kelly, J.4    Bates, B.5    Kuehn, R.6    Lechan, R.M.7    Jaenisch, R.8
  • 231
    • 0037363496 scopus 로고    scopus 로고
    • Congenic mice: cutting tools for complex immune disorders
    • Rogner UC, Avner P. 2003. Congenic mice: cutting tools for complex immune disorders. Nature Reviews. Immunology 3:243-252 DOI 10.1038/nri1031.
    • (2003) Nature Reviews. Immunology , vol.3 , pp. 243-252
    • Rogner, U.C.1    Avner, P.2
  • 233
    • 34548348780 scopus 로고    scopus 로고
    • The mouse ascending: perspectives for human-disease models
    • Rosenthal N, Brown S. 2007. The mouse ascending: perspectives for human-disease models. Nature Cell Biology 9(9):993-999 DOI 10.1038/ncb437.
    • (2007) Nature Cell Biology , vol.9 , Issue.9 , pp. 993-999
    • Rosenthal, N.1    Brown, S.2
  • 236
    • 84860211766 scopus 로고    scopus 로고
    • High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families
    • Saeed S, Butt TA, Anwer M, Arslan M, Froguel P. 2012. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Molecular Genetics and Metabolism 106(1):121-126 DOI 10.1016/j.ymgme.2012.03.001.
    • (2012) Molecular Genetics and Metabolism , vol.106 , Issue.1 , pp. 121-126
    • Saeed, S.1    Butt, T.A.2    Anwer, M.3    Arslan, M.4    Froguel, P.5
  • 241
    • 0034684619 scopus 로고    scopus 로고
    • Ets target genes: past, present and future
    • Sementchenko VI, Watson DK. 2000. Ets target genes: past, present and future. Oncogene 19(55):6533-6548 DOI 10.1038/sj.onc.1204034.
    • (2000) Oncogene , vol.19 , Issue.55 , pp. 6533-6548
    • Sementchenko, V.I.1    Watson, D.K.2
  • 242
    • 0035437193 scopus 로고    scopus 로고
    • Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin
    • Seppen J, Barry SC, Harder B, Osborne WR. 2001. Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin. Blood 98(3):594-596 DOI 10.1182/blood. V98.3.594.
    • (2001) Blood , vol.98 , Issue.3 , pp. 594-596
    • Seppen, J.1    Barry, S.C.2    Harder, B.3    Osborne, W.R.4
  • 244
    • 0035515347 scopus 로고    scopus 로고
    • The ETS-domain transcription factor family
    • Sharrocks AD. 2001. The ETS-domain transcription factor family. Nature Reviews: Molecular Cell Biology 2(11):827-837 DOI 10.1038/35099076.
    • (2001) Nature Reviews: Molecular Cell Biology , vol.2 , Issue.11 , pp. 827-837
    • Sharrocks, A.D.1
  • 246
    • 80052855150 scopus 로고    scopus 로고
    • Next-generation human genetics
    • Shendure J. 2011. Next-generation human genetics. Genome Biology 12(9):408 DOI 10.1186/gb-2011-12-9-408.
    • (2011) Genome Biology , vol.12 , Issue.9 , pp. 408
    • Shendure, J.1
  • 248
    • 11144355685 scopus 로고    scopus 로고
    • Genetic dissection of complex traits with chromosome substitution strains of mice
    • Singer J, Hill A, Burrage L, Olszens K, Song J, Justice M, Nadeau J et al. 2004. Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445-449 DOI 10.1126/science.1093139.
    • (2004) Science , vol.304 , pp. 445-449
    • Singer, J.1    Hill, A.2    Burrage, L.3    Olszens, K.4    Song, J.5    Justice, M.6    Nadeau, J.7
  • 249
    • 80053030497 scopus 로고    scopus 로고
    • Exome sequencing: a transformative technology
    • Singleton A. 2011. Exome sequencing: a transformative technology. The Lancet Neurology 10(10):942-946 DOI 10.1016/S1474-4422(11)70196-X.
    • (2011) The Lancet Neurology , vol.10 , Issue.10 , pp. 942-946
    • Singleton, A.1
  • 251
    • 0023959725 scopus 로고
    • Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
    • Smith A, Funder J. 1988. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocrine Reviews 9(1):159-179 DOI 10.1210/edrv-9-1-159.
    • (1988) Endocrine Reviews , vol.9 , Issue.1 , pp. 159-179
    • Smith, A.1    Funder, J.2
  • 252
    • 84860733554 scopus 로고    scopus 로고
    • Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort
    • Sonestedt E, Lyssenko V, Ericson U, Gullberg B, Wirfält E, Groop L, Orho-Melander M. 2012. Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort. The Journal of Clinical Endocrinology and Metabolism 97(5):E810-E818 DOI 10.1210/jc.2011-2444.
    • (2012) The Journal of Clinical Endocrinology and Metabolism , vol.97 , Issue.5 , pp. E810-E818
    • Sonestedt, E.1    Lyssenko, V.2    Ericson, U.3    Gullberg, B.4    Wirfält, E.5    Groop, L.6    Orho-Melander, M.7
  • 257
    • 0035487038 scopus 로고    scopus 로고
    • Gene-trap mutagenesis: past, present and beyond
    • Stanford WL, Cohn JB, Cordes SP. 2001. Gene-trap mutagenesis: past, present and beyond. Nature Reviews. Genetics 2(10):756-768 DOI 10.1038/35093548.
    • (2001) Nature Reviews. Genetics , vol.2 , Issue.10 , pp. 756-768
    • Stanford, W.L.1    Cohn, J.B.2    Cordes, S.P.3
  • 261
    • 0004045702 scopus 로고    scopus 로고
    • Genetic manipulation of animals
    • New York: Wiley-Liss.
    • Strachan T, Read A. 1999. Genetic manipulation of animals. In: Human molecular genetics. vol. 2. New York: Wiley-Liss.
    • (1999) Human molecular genetics , vol.2
    • Strachan, T.1    Read, A.2
  • 262
    • 78649464259 scopus 로고    scopus 로고
    • Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling
    • Stratigopoulos G, Leduc CA, Cremona ML, Chung WK, Leibel RL. 2011. Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. The Journal of Biological Chemistry 286(3):2155-2170 DOI 10.1074/jbc. M110.188482.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.3 , pp. 2155-2170
    • Stratigopoulos, G.1    Leduc, C.A.2    Cremona, M.L.3    Chung, W.K.4    Leibel, R.L.5
  • 268
    • 84866013226 scopus 로고    scopus 로고
    • Recent advances in targeted genome engineering in mammalian systems
    • Sun N, Abil Z, Zhao H. 2012. Recent advances in targeted genome engineering in mammalian systems. Biotechnology Journal 7(9):1074-1087 DOI 10.1002/biot.201200038.
    • (2012) Biotechnology Journal , vol.7 , Issue.9 , pp. 1074-1087
    • Sun, N.1    Abil, Z.2    Zhao, H.3
  • 270
    • 0142087920 scopus 로고    scopus 로고
    • Invited review: identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains
    • Svenson K, Bogue M, Peters L. 2003. Invited review: identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains. Journal of Applied Physiology 94:1650-1659.
    • (2003) Journal of Applied Physiology , vol.94 , pp. 1650-1659
    • Svenson, K.1    Bogue, M.2    Peters, L.3
  • 271
    • 84899428005 scopus 로고    scopus 로고
    • Current trends in obesity: body composition assessment, weight regulation, and emerging techniques in managing severe obesity
    • Switzer NJ, Mangat HS, Karmali S. 2013. Current trends in obesity: body composition assessment, weight regulation, and emerging techniques in managing severe obesity. Journal of Interventional Gastroenterology 3(1):34-36 DOI 10.7178/jig.106.
    • (2013) Journal of Interventional Gastroenterology , vol.3 , Issue.1 , pp. 34-36
    • Switzer, N.J.1    Mangat, H.S.2    Karmali, S.3
  • 272
    • 84871187647 scopus 로고    scopus 로고
    • Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation
    • Takeshita S, Suzuki T, Kitayama S, Moritani M. 2012. Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation. Genes & Genetic Systems 87:253-264 DOI 10.1266/ggs.87.253.
    • (2012) Genes & Genetic Systems , vol.87 , pp. 253-264
    • Takeshita, S.1    Suzuki, T.2    Kitayama, S.3    Moritani, M.4
  • 274
    • 24944561852 scopus 로고    scopus 로고
    • Genetic Epidemiology 2 Genetic linkage studies
    • Teare MD, Barrett JH, Road BH, Sheffield S. 2005. Genetic Epidemiology 2 Genetic linkage studies. Lancet 366(9490):1036-1044 DOI 10.1016/S0140-6736(05)67382-5.
    • (2005) Lancet , vol.366 , Issue.9490 , pp. 1036-1044
    • Teare, M.D.1    Barrett, J.H.2    Road, B.H.3    Sheffield, S.4
  • 276
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embroyonic stem cells
    • Thomas K, Capecchi M. 1987. Site-directed mutagenesis by gene targeting in mouse embroyonic stem cells. Cell 51:503-512 DOI 10.1016/0092-8674(87)90646-5.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.1    Capecchi, M.2
  • 279
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamicspecific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung Y-CL, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GSH. 2010. Hypothalamicspecific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS ONE 5(1):e8771 DOI 10.1371/journal.pone.0008771.
    • (2010) PLoS ONE , vol.5 , Issue.1
    • Tung, Y-C.L.1    Ayuso, E.2    Shan, X.3    Bosch, F.4    O'Rahilly, S.5    Coll, A.P.6    Yeo, G.S.H.7
  • 281
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity WRN, is a 3' ?5' exonuclease
    • Vaisse C, Clement K, Guy-grand B, Froguel P. 1998. A frameshift mutation in human MC4R is associated with a dominant form of obesity WRN, is a 3' ?5' exonuclease. Nature Genetics 20:113-114 DOI 10.1038/2407.
    • (1998) Nature Genetics , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-grand, B.3    Froguel, P.4
  • 283
    • 84867111958 scopus 로고    scopus 로고
    • Candidate genes for obesity-susceptibility show enriched association within a large genome-Wide association study for BMI
    • Vimaleswaran KS, Tachmazidou I, Zhao JH, Hirschhorn JN, Dudbridge F, Loos RJF. 2012. Candidate genes for obesity-susceptibility show enriched association within a large genome-Wide association study for BMI. Human Molecular Genetics 21(20):4537-4542 DOI 10.1093/hmg/dds283.
    • (2012) Human Molecular Genetics , vol.21 , Issue.20 , pp. 4537-4542
    • Vimaleswaran, K.S.1    Tachmazidou, I.2    Zhao, J.H.3    Hirschhorn, J.N.4    Dudbridge, F.5    Loos, R.J.F.6
  • 285
    • 84865072344 scopus 로고    scopus 로고
    • Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11ß-hydroxysteroid dehydrogenase type 1 expression development of obesity
    • Vogel H, Scherneck S, Kanzleiter T, Benz V, Kluge R, Stadion M, Kryvych S, Bluher M, Kloting N, Joost H-G, Schurmann A. 2012. Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11ß-hydroxysteroid dehydrogenase type 1 expression development of obesity. Human Molecular Genetics 21(17):3845-3857 DOI 10.1093/hmg/dds213.
    • (2012) Human Molecular Genetics , vol.21 , Issue.17 , pp. 3845-3857
    • Vogel, H.1    Scherneck, S.2    Kanzleiter, T.3    Benz, V.4    Kluge, R.5    Stadion, M.6    Kryvych, S.7    Bluher, M.8    Kloting, N.9    Joost, H.-G.10    Schurmann, A.11
  • 288
    • 76249116215 scopus 로고    scopus 로고
    • A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2
    • Walters RG, Jacquemont S, Valsesia A, Smith AJDE, Martinet D. 2010. A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2. Nature 463(7281):671-675 DOI 10.1038/nature08727.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 671-675
    • Walters, R.G.1    Jacquemont, S.2    Valsesia, A.3    Smith, A.J.D.E.4    Martinet, D.5
  • 290
    • 0027214744 scopus 로고
    • Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model
    • Warden CH, Fisler JS, Pace MJ, Svenson KL, Lusis AJ. 1993. Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model. The Journal of Clinical Investigation 92(2):773-779 DOI 10.1172/JCI116649.
    • (1993) The Journal of Clinical Investigation , vol.92 , Issue.2 , pp. 773-779
    • Warden, C.H.1    Fisler, J.S.2    Pace, M.J.3    Svenson, K.L.4    Lusis, A.J.5
  • 294
    • 67749129442 scopus 로고    scopus 로고
    • Geneva: World Health Organization
    • World Health Organization. 2011. Obesity and overweight: factsheet. Geneva: World Health Organization. Available at http://www.who.int/mediacentre/factsheets/fs311/en/.
    • (2011) Obesity and overweight: factsheet
  • 295
    • 34247471241 scopus 로고    scopus 로고
    • A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice
    • Wuschke S, Dahm S, Schmidt C, Joost H-G, Al-Hasani H. 2007. A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice. International Journal of Obesity 31(5):829-841 DOI 10.1038/sj.ijo.0803473.
    • (2007) International Journal of Obesity , vol.31 , Issue.5 , pp. 829-841
    • Wuschke, S.1    Dahm, S.2    Schmidt, C.3    Joost, H.-G.4    Al-Hasani, H.5
  • 296
    • 9144243533 scopus 로고    scopus 로고
    • Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24
    • Xiang K, Wang Y, Zheng T, Jia W, Li J, Chen L, Shen K, Wu S, Lin X, Zhang G, Wang C, Wang S, Lu H, Fang Q, Shi Y, Zhang R, Xu J, Weng Q. 2004. Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes 53(1):228-234 DOI 10.2337/diabetes.53.1.228.
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 228-234
    • Xiang, K.1    Wang, Y.2    Zheng, T.3    Jia, W.4    Li, J.5    Chen, L.6    Shen, K.7    Wu, S.8    Lin, X.9    Zhang, G.10    Wang, C.11    Wang, S.12    Lu, H.13    Fang, Q.14    Shi, Y.15    Zhang, R.16    Xu, J.17    Weng, Q.18
  • 298
    • 36949019606 scopus 로고    scopus 로고
    • Gene trap mutagenesis in mice: new perspectives and tools in cancer research
    • Yamamura K, Araki K. 2008. Gene trap mutagenesis in mice: new perspectives and tools in cancer research. Cancer Science 99(1):1-6 DOI 10.1111/j.1349-7006.2007.00611.x.
    • (2008) Cancer Science , vol.99 , Issue.1 , pp. 1-6
    • Yamamura, K.1    Araki, K.2
  • 300
    • 70449643275 scopus 로고    scopus 로고
    • An integrated view of the correlations between genomic and phenomic variables
    • Yang D, Jiang Y, He F. 2009. An integrated view of the correlations between genomic and phenomic variables. Journal of Genetics and Genomics 36(11):645-651 DOI 10.1016/S1673-8527(08)60156-3.
    • (2009) Journal of Genetics and Genomics , vol.36 , Issue.11 , pp. 645-651
    • Yang, D.1    Jiang, Y.2    He, F.3
  • 301
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L, Diehl N, Brennan MB, Hochgeschwender U. 1999. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nature Medicine 5(9):1066-1070 DOI 10.1038/12506.
    • (1999) Nature Medicine , vol.5 , Issue.9 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 305
    • 2942525579 scopus 로고    scopus 로고
    • Characterization of epistasis influencing complex spontaneous obesity in the BSB model
    • Yi N, Diament A, Chiu S, Kim K, Allison DB, Fisler JS, Warden CH. 2004. Characterization of epistasis influencing complex spontaneous obesity in the BSB model. Genetics 167(1):399-409 DOI 10.1534/genetics.167.1.399.
    • (2004) Genetics , vol.167 , Issue.1 , pp. 399-409
    • Yi, N.1    Diament, A.2    Chiu, S.3    Kim, K.4    Allison, D.B.5    Fisler, J.S.6    Warden, C.H.7
  • 307
    • 84863585305 scopus 로고    scopus 로고
    • Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner
    • Yoganathan P, Karunakaran S, Clee Ho. 2012. Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner. Nutrition and Metabolism 9(1):1 DOI 10.1186/1743-7075-9-65.
    • (2012) Nutrition and Metabolism , vol.9 , Issue.1 , pp. 1
    • Yoganathan, P.1    Karunakaran, S.2    Ho, C.3
  • 309
    • 84885593706 scopus 로고    scopus 로고
    • Prevalence of rare MC3R variants in obese cases and lean controls
    • Zegers D, Beckers S, Hendrickx R. 2013. Prevalence of rare MC3R variants in obese cases and lean controls. Endocrine 44(2):386-390 DOI 10.1007/s12020-012-9862-1.
    • (2013) Endocrine , vol.44 , Issue.2 , pp. 386-390
    • Zegers, D.1    Beckers, S.2    Hendrickx, R.3
  • 310
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432 DOI 10.1038/372425a0.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.6
  • 311
    • 84904798083 scopus 로고    scopus 로고
    • CRISPR/Cas9 for genome editing: progress, implications and challenges
    • Zhang F, Wen Y, Guo X. 2014. CRISPR/Cas9 for genome editing: progress, implications and challenges. Human Molecular Genetics 15(23):1-7 DOI 10.1093/hmg/ddu125.
    • (2014) Human Molecular Genetics , vol.15 , Issue.23 , pp. 1-7
    • Zhang, F.1    Wen, Y.2    Guo, X.3
  • 312
    • 36249020808 scopus 로고    scopus 로고
    • Candidate gene identification approach: progress and challenges
    • Zhu M, Zhao S. 2007. Candidate gene identification approach: progress and challenges. International Journal of Biological Sciences 3(7):420-427 DOI 10.7150/ijbs.3.420.
    • (2007) International Journal of Biological Sciences , vol.3 , Issue.7 , pp. 420-427
    • Zhu, M.1    Zhao, S.2
  • 314
    • 23344433484 scopus 로고    scopus 로고
    • Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations
    • Zou F, Gelfond JAL, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW. 2005. Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations. Genetics 170:1299-1311 DOI 10.1534/genetics.104.035709.
    • (2005) Genetics , vol.170 , pp. 1299-1311
    • Zou, F.1    Gelfond, J.A.L.2    Airey, D.C.3    Lu, L.4    Manly, K.F.5    Williams, R.W.6    Threadgill, D.W.7


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