A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Science

Volumn 316, Issue 5826, 2007, Pages 889-894

  Frayling, Timothy M ^a   Timpson, Nicholas J ^b,c   Weedon, Michael N ^a   Zeggini, Eleftheria ^b,d   Freathy, Rachel M ^a   Lindgren, Cecilia M ^b,d   Perry, John R B ^a   Elliott, Katherine S ^b   Lango, Hana ^a   Rayner, Nigel W ^b,d   Shields, Beverley ^a   Harries, Lorna W ^a   Barrett, Jeffrey C ^b   Ellard, Sian ^a,e   Groves, Christopher J ^d   Knight, Bridget ^a   Patch, Ann Marie ^a,e   Ness, Andrew R ^f   Ebrahim, Shah ^g   Lawlor, Debbie A ^c   Ring, Susan M ^c   Ben Shlomo, Yoav ^c   Jarvelin, Marjo Riitta ^h,i   Sovio, Ulla ^h,i   Bennett, Amanda J ^d   Melzer, David ^a   Ferrucci, Luigi ^j   Loos, Ruth J F ^k   Barroso, Inês ^l   Wareham, Nicholas J ^k   Karpe, Fredrik ^d   Owen, Katharine R ^d   Cardon, Lon R ^b   Walker, Mark ^m   Hitman, Graham A ⁿ   Palmer, Colin N A ^o   Doney, Alex S F ^o   Morris, Andrew D ^o   Smith, George Davey ^c   Hattersley, Andrew T ^a   McCarthy, Mark I ^b,d   more..

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

^g LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^h IMPERIAL COLLEGE LONDON   (United Kingdom)

ⁱ UNIVERSITY OF OULU   (Finland)

^j NATIONAL INSTITUTES OF HEALTH   (United States)

^k UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^l WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^m NEWCASTLE UNIVERSITY   (United Kingdom)

ⁿ ROYAL LONDON HOSPITAL   (United Kingdom)

^o UNIVERSITY OF DUNDEE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; BODY MASS; CHILD HEALTH; COHORT ANALYSIS; GENOME; HEALTH RISK; OBESITY;

ADULT DISEASE; ARTICLE; BODY MASS; CHILDHOOD DISEASE; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL;

ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; ALLELES; BIRTH WEIGHT; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; HOMOZYGOTE; HUMANS; INFANT, NEWBORN; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 34248594090     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1141634     Document Type: Article

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20. Collection of the type 2 diabetes cases was supported by Diabetes UK, British Diabetic Association Research, and the UK Medical Research Council (Biomedical Collections Strategic Grant G0000649). The UK Type 2 Diabetes Genetics Consortium collection was supported by the Wellcome Trust (Biomedical Collections Grant GR072960). The ALSPAC study was supported by the UK Medical Research Council (MRC), the Wellcome Trust, and the University of Bristol. The British Women's Heart and Health Study was funded by the Department of Health and the British Heart Foundation. The Caerphilly study was funded by MRC and the British Heart Foundation. The Caerphilly study was undertaken by the former MRC Epidemiology Unit (South Wales) and was funded by the MRC. The data archive is maintained by the Department of Social Medicine, University of Bristol. The Exeter Family Study of Childhood Health was supported by NHS Research and Development and the Wellcome Trust. The work on the Northern Finland birth cohort study was supported by the Academy of Finland (104781), MRC (G0500539), and the Wellcome Trust (Project Grant GR069224). Oxford Biobank was supported by the British Heart Foundation. The Invecchiare in Chianti (InCHIANTI) study was supported by contract funding from the U.S. National Institute on Aging (NIA), and the research was supported in part by the Intramural Research Program, NIA, NIH. The European Prospective Investigation of Cancer (EPIQ-Norfolk cohort study is supported by program grants from MRC and Cancer Research UK. The EPIC-Norfolk obesity case-cohort study and its genotyping was funded by the Wellcome Trust and MRC. The genome-wide association genotyping was supported by the Wellcome Trust (076113), and replication genotyping was supported by the Wellcome Trust, Diabetes UK, the European Commission (EURODIA LSHG-CT-2004-S181S3), and the Peninsula Medical School. Personal funding comes from the Wellcome Trust (A.T.H., Research Leave Fellow; I.B., Investigator; E.Z., Research Career Development Fellow; L.R.C., Principal Research Fellow); MRC (J.R.B.P.); Diabetes UK (R.M.F.); and Throne-Hoist Foundation (C.M.L.). L.W.H. is a Research Councils UK Diabetes and Metabolism Academic Fellow. M.N.W. is Vandervell Foundation Research Fellow at the Peninsula Medical School. C.N.A.P. and A.D.M. are supported by the Scottish executive as part of the Generation Scotland Initiative. We acknowledge the assistance of many colleagues involved in sample collection, phenotyping, and DNA extraction in all the different studies. We thank K. Parnell, C. Kimber, A. Murray, K. Northstone, and C. Boustred for technical assistance. We thank S. Howell, M. Murphy, and A. Wilson (Diabetes UK) for their long-term support for these studies. We also acknowledge the efforts of J. Collier, P. Robinson, S. Asquith, and others at Kbiosciences. Accession numbers for deposited sequence variants from dbSNP are Exon3_A 69374768, 3_UTR_A 69374769, 3_UTR_B 69374770, and 3_UTR_G 69374771.